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Compound lidocaine gel used for pets, and preparation method and quality control method thereof

A technology of lidocaine gel and lidocaine hydrochloride, which is applied to medical preparations with no active ingredients, medical preparations containing active ingredients, anesthetics, etc., and can solve problems such as dependence on imports or human medicines

Inactive Publication Date: 2021-01-15
马保臣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are very few medicines specially used for pet treatment in my country, and most of them rely on imports or human medicines.

Method used

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  • Compound lidocaine gel used for pets, and preparation method and quality control method thereof
  • Compound lidocaine gel used for pets, and preparation method and quality control method thereof
  • Compound lidocaine gel used for pets, and preparation method and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Compound gel (2% lidocaine+5% enrofloxacin) (100g) prescription composition is as follows:

[0043] Take 1kg compound lidocaine gel as an example, lidocaine hydrochloride 0.02kg; enrofloxacin 0.05kg; carbomer 0.01kg; propylene glycol 250mL; azone 15mL; polyethylene glycol 400 40mL; Add purified water to 1kg.

[0044] Preparation:

[0045] (1) Weigh the prescribed amount of Carbomer 940 and slowly add it into 200mL of water (stir while adding), stir until it becomes a paste, seal it, and swell until there are no particles;

[0046] (2) Enrofloxacin that takes prescription quantity adds 150mL propylene glycol and stirs for subsequent use;

[0047] (3) Weigh the prescribed amount of lidocaine hydrochloride and add 200mL of water to dissolve, add 100mL of propylene glycol, 40mL of polyethylene glycol 400, and 1.5mL of azone, stir well, then add fully swollen Carbomer 940, and homogenize Stir thoroughly until there are no particles;

[0048] (4) Use triethanolamine to ad...

Embodiment 2

[0052] A kind of compound lidocaine gel and preparation thereof, comprises the following steps:

[0053]Take 1kg compound lidocaine gel as an example, lidocaine hydrochloride 0.02kg; enrofloxacin 0.02kg; carbomer 0.008kg; propylene glycol 250mL; azone 10mL; polyethylene glycol 400 30mL; Add purified water to 1kg.

[0054] (1) Weigh the prescribed amount of Carbomer 940 and slowly add it into 200mL of water (stir while adding), stir until it becomes a paste, seal it, and swell until there are no particles;

[0055] (2) Enrofloxacin that takes prescription quantity adds 150mL propylene glycol and stirs for subsequent use;

[0056] (3) Weigh the prescribed amount of lidocaine hydrochloride and add 200mL of water to dissolve, add 100mL of propylene glycol, 30mL of polyethylene glycol 400, and 10mL of azone, stir well, then add fully swollen Carbomer 940, and the homogenizer is fully Stir until there are no particles;

[0057] (4) Use triethanolamine to adjust the pH in an appro...

Embodiment 3

[0061] A kind of compound lidocaine gel and preparation thereof, comprises the following steps:

[0062] Take 1kg compound lidocaine gel as an example, lidocaine hydrochloride 0.02kg; enrofloxacin 0.06kg; carbomer 0.01kg; propylene glycol 250mL; azone 15mL; polyethylene glycol 400 50mL; Add purified water to 1kg.

[0063] (1) Weigh the prescribed amount of Carbomer 940 and slowly add it into 200mL of water (stir while adding), stir until it becomes a paste, seal it, and swell until there are no particles;

[0064] (2) Enrofloxacin that takes prescription quantity adds 150mL propylene glycol and stirs for subsequent use;

[0065] (3) Weigh the prescribed amount of lidocaine hydrochloride and add 200mL of water to dissolve, add 100mL of propylene glycol, 50mL of polyethylene glycol 400, and 15mL of azone, stir well, then add fully swollen Carbomer 940, and the homogenizer is fully Stir until there are no particles;

[0066] (4) Use triethanolamine to adjust the pH in an appro...

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Abstract

The invention relates to the field of pharmaceutical preparations, in particular to a compound lidocaine gel used for surface anesthesia and bacteria resistance of pets, and a preparation method and quality control method thereof. The compound lidocaine gel disclosed by the invention comprises the following components: lidocaine hydrochloride, antibiotics, a gel matrix and a transdermal enhancer;the antibiotics are selected from one of or a mixture of two or more of enrofloxacin, ofloxacin and pefloxacin mesylate. The compound lidocaine gel disclosed by the invention is used for laryngeal lubrication and peripheral nerve anesthesia during tracheal intubation; when a catheter and a nasal feeding tube are inserted, the compound lidocaine gel is used for mucous membrane lubrication and anesthesia to reduce the discomfort and mucous membrane hyperemia of an animal; For a severe anal gland disease, when the anal gland needs to be manually extruded, the compound lidocaine gel is used for rectum lubrication and local anesthesia; and the compound lidocaine gel is used for surface anesthesia of part of ophthalmologic operations, and the gel can maintain local tissues moist in comparison with an injection.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a topical anesthetic and antibacterial compound lidocaine gel for pets, a preparation method and a quality control method thereof. Background technique [0002] With the improvement of economic conditions and people's quality of life, especially with the arrival of my country's population aging era, pet dogs and cats, as the main companion animals, have become "members" of many families. At the same time, various pet diseases also threaten the health of pets and humans. At present, there are very few medicines dedicated to pet treatment in my country, and most of them rely on imports or human medicine. In particular, the local lubricating anesthetic that is often needed in small animal clinics is currently used or human lidocaine hydrochloride gel. For this reason, we combined lidocaine hydrochloride with local anesthetic effect and animal-specific quinolone antibioti...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61K45/06A61K9/06A61K47/32A61K47/36A61K47/38A61K47/42A61P23/02A61P31/02A61P31/04A61P29/00A61P7/10A61K31/167A61K31/4704
CPCA61K31/167A61K31/4704A61K45/06A61K31/496A61K9/06A61K47/32A61K47/38A61K47/42A61K47/36A61K9/0053A61K9/0034A61K9/0031A61K9/0048A61P23/02A61P31/02A61P31/04A61P29/00A61P7/10A61K2300/00
Inventor 马保臣金礼琴董玉兰宋子域黄学林吴秋萍乔秋萍金星钱炜博邓小露
Owner 马保臣
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