External gel for skin wounds, and preparation method of external gel
A technology for external use of gels and skin wounds, which is applied in the directions of skin diseases, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Use effect, poor stability of active ingredients, etc., to achieve the effect of simple preparation method, reduced wound healing days, good stability and uniformity
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Embodiment 1
[0046] Embodiment 1: the preparation of the external gel for skin wound
[0047] 1. Composition of raw materials (by weight):
[0048] 2 parts of active component A, 5 parts of active component B, 12 parts of calendula extract, 18 parts of centella asiatica extract, 63 parts of excipients; of which:
[0049] The active component A is formed by mixing polymyxin B sulfate, neomycin sulfate and bacitracin in a mass ratio of 0.65:5.36:7.7; the polymyxin B sulfate is 50000 units / branch, and the Neomycin sulfate is 35000 units / support, and the bacitracin is 5000 units / support.
[0050]The active component B is formed by mixing lidocaine hydrochloride and menthol at a mass ratio of 1:1.
[0051] The calendula extract is prepared by the following method:
[0052] Dry and pulverize Calendula officinalis, extract 3 times with 10 times by weight of ethanol with a volume concentration of 95%, the extraction temperature is 80°C, and the extraction time is 1 h each time, the extracts are...
Embodiment 2
[0062] Embodiment 2: the preparation of the external gel for skin wound
[0063] 1. Composition of raw materials (by weight):
[0064] 1 part of active component A, 6 parts of active component B, 10 parts of calendula extract, 20 parts of centella asiatica extract, 60 parts of excipients; including:
[0065] The active component A is mixed by polymyxin B sulfate and neomycin sulfate in a mass ratio of 0.65:5.36; the polymyxin B sulfate is 50000 units / support, and the neomycin sulfate is 35000 units / piece.
[0066] The active component B is pramoxine hydrochloride.
[0067] The calendula extract is prepared by the following method:
[0068] Dry and pulverize Calendula officinalis, extract 4 times with 8 weight times of ethanol with a volume concentration of 95%, the extraction temperature is 70°C, and the extraction time is 1 h each time, the extracts are combined, and the extracts are concentrated to a relative density of 1.1 -1.2 (measured at 50°C), to obtain alcoholic ex...
Embodiment 3
[0076] Embodiment 3: the preparation of the external gel for skin wound
[0077] 1. Composition of raw materials (by weight):
[0078] 3 parts of active component A, 4 parts of active component B, 14 parts of calendula extract, 16 parts of centella asiatica extract, 60 parts of excipients; of which:
[0079] The active component A is formed by mixing neomycin sulfate and bacitracin at a mass ratio of 5.36:7.7; the neomycin sulfate is 35,000 units per branch, and the bacitracin is 5,000 units per branch.
[0080] The active component B is formed by mixing procaine hydrochloride and menthol at a mass ratio of 1:1.
[0081] The calendula extract is prepared by the following method:
[0082] Dry and pulverize Calendula officinalis, extract twice with 95% ethanol with a volume concentration of 9 times the weight, the extraction temperature is 80°C, and the extraction time is 1 h each time, the extracts are combined, and the extracts are concentrated to a relative density of 1.1 ...
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