Compound lidocaine nano liposome gel and preparation method thereof

A technology of nano-liposome and lidocaine, applied in the field of medicine, can solve the problems of unsatisfactory stability of lidocaine liposome gel encapsulation rate and the like, achieve good anesthetic effect, good drug effect and less toxic and side effects Effect

Pending Publication Date: 2021-02-12
中国人民解放军第三〇五医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the problem of unsatisfactory encapsulation rate stability of existing lidocaine liposome gel at normal temperature, and propose a kind of compound recipe lidocaine nano liposome gel and its preparation method

Method used

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  • Compound lidocaine nano liposome gel and preparation method thereof
  • Compound lidocaine nano liposome gel and preparation method thereof

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Effect test

Embodiment 1

[0021] A kind of compound lidocaine nano-liposome gel proposed by the present invention comprises the following raw materials in parts by weight: 5 parts of lidocaine hydrochloride, 40 parts of tetracaine hydrochloride, 20 parts of tetracaine base, 20 parts of lidocaine base 1 part of dyclonine hydrochloride, 15 parts of procaine hydrochloride, 200 parts of soybean lecithin, 100 parts of cholesterol, 10 parts of xanthan gum, 1 part of carbomer, 10 parts of sodium carboxymethylcellulose;

[0022] The preparation method of compound lidocaine nano liposome gel comprises the following steps:

[0023] S1, according to 5 parts of lidocaine hydrochloride, 40 parts of tetracaine hydrochloride, 20 parts of tetracaine base, 20 parts of lidocaine base, 1 part of dyclonine hydrochloride, 15 parts of procaine hydrochloride, 200 parts of soybean lecithin parts, 100 parts of cholesterol, 10 parts of xanthan gum, 1 part of carbomer, and 10 parts of sodium carboxymethylcellulose Weigh each raw...

Embodiment 2

[0028] A kind of compound lidocaine nano-liposome gel proposed by the present invention comprises the following raw materials in parts by weight: 20 parts of lidocaine hydrochloride, 20 parts of tetracaine hydrochloride, 10 parts of tetracaine base, 10 parts of lidocaine base 10 parts of dyclonine hydrochloride, 8 parts of procaine hydrochloride, 120 parts of soybean lecithin, 50 parts of cholesterol, 5 parts of xanthan gum, 5 parts of carbomer, 5 parts of sodium carboxymethylcellulose;

[0029] The preparation method of compound lidocaine nano liposome gel comprises the following steps:

[0030] S1, according to 20 parts of lidocaine hydrochloride, 20 parts of tetracaine hydrochloride, 10 parts of tetracaine base, 10 parts of lidocaine base, 10 parts of dyclonine hydrochloride, 8 parts of procaine hydrochloride, 120 parts of soybean lecithin 5 parts, 50 parts of cholesterol, 5 parts of xanthan gum, 5 parts of carbomer, 5 parts of sodium carboxymethyl cellulose Weigh each raw ...

Embodiment 3

[0035] A kind of compound lidocaine nano-liposome gel proposed by the present invention comprises the following raw materials in parts by weight: 40 parts of lidocaine hydrochloride, 5 parts of tetracaine hydrochloride, 1 part of tetracaine base, 1 part of lidocaine base 20 parts of dyclonine hydrochloride, 1 part of procaine hydrochloride, 10 parts of soybean lecithin, 5 parts of cholesterol, 1 part of xanthan gum, 10 parts of carbomer, 1 part of sodium carboxymethyl cellulose;

[0036] The preparation method of compound lidocaine nano liposome gel comprises the following steps:

[0037] S1. According to 40 parts of lidocaine hydrochloride, 5 parts of tetracaine hydrochloride, 1 part of tetracaine base, 1 part of lidocaine base, 20 parts of dyclonine hydrochloride, 1 part of procaine hydrochloride, and 10 parts of soybean lecithin 1 part, 5 parts of cholesterol, 1 part of xanthan gum, 10 parts of carbomer, and 1 part of sodium carboxymethyl cellulose Weigh each raw material a...

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Abstract

The invention provides compound lidocaine nano-liposome gel and a preparation method thereof. The nano-liposome gel is prepared from the following raw materials: lidocaine hydrochloride, tetracaine hydrochloride, tetracaine base, lidocaine base, dyclonine hydrochloride, procaine hydrochloride, soyabean lecithin, cholesterol, xanthan gum, carbomer and sodium carboxymethyl cellulose. The preparationmethod of the nano-liposome gel comprises the following steps: S1, preparing raw materials; s2, mixing soyabean lecithin and cholesterol to obtain a mixture A; s3, dissolving carbomer to obtain a mixture B; and S4, adding lidocaine hydrochloride, tetracaine hydrochloride, dyclonine hydrochloride, procaine hydrochloride and the mixture B into the mixture A, performing stirring, adding tetracaine alkali and lidocaine alkali, performing cooling, adding xanthan gum and sodium carboxymethyl cellulose, performing stirring, and performing homogenizing to obtain the compound lidocaine nano-liposome gel. The nano-liposome gel provided by the invention is good in stability in a normal-temperature state and a low-temperature state.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a compound lidocaine nano liposome gel and a preparation method thereof. Background technique [0002] Lidocaine is a derivative of cocaine, but without the hallucinogenic and addictive components of cocaine. It has the advantages of strong penetrating power, fast action, wide spread and stable properties, so lidocaine is often used as a local anesthetic and antiarrhythmic drug. However, due to the well-known shortcomings of its injection, its application is limited. Liposome is a commonly used carrier for targeted drugs. When combined with gel, it can reduce the toxic and side effects of drugs, improve bioavailability, and play a role of long-term sustained release. Therefore, many researchers have prepared liposomes in recent years. Obtained lidocaine liposome gel. There are also literatures that specifically report the research and determination of the components and encap...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4453A61K9/06A61K9/127A61K47/38B82Y5/00B82Y40/00A61P23/00
CPCA61K9/06A61K9/127A61K31/167A61K31/245A61K31/4453A61K47/38A61P23/00B82Y5/00B82Y40/00A61K2300/00
Inventor 刘畅马瑞张振华张弦赵强翟文慧
Owner 中国人民解放军第三〇五医院
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