The invention discloses a mosquito repellent and antipruritic sunscreen cream formula, which comprises the following raw materials in parts by weight: 2-ethylhexyl palmitate 40-44 parts, polydimethylsiloxane 12-16 parts, reactive berry polyphenol 20-24 parts, hydroxyphenyl propyl ester 12-16 parts, hyaluronic acid 14-18 parts, daclonine hydrochloride 16-20 parts, camphor 5-9 parts, peppermint oil12-16 parts, leaves of eucalyptus citriodora 8-12 parts, callicarpa nudiflora 12-16 parts, thymol 13-17 parts, wormwood oil 4-8 parts; wild chrysanthemum 14-18 parts, cnidium monnieri 9-13 parts and an appropriate amount of water. Based on the original 2-ethylhexyl palmitate, polydimethylsiloxane, reactive berry polyphenol, hydroxyphenyl propyl ester, hyaluronic acid and water, the dacronine hydrochloride, camphor, peppermint oil, leaves of eucalyptus citriodora, callicarpa nudiflora, thymol, wormwood oil, wild chrysanthemum and cnidium monnieri are added, which can prevent mosquito bites andrelieve itching, so that sunscreen has mosquito repellent and antipruritic effects.