Paste film for treating oral ulcer and preparation method thereof

Abstract

The invention discloses a paste film for treating oral ulcer and a preparation method thereof. The paste film comprises 5-8g of dyclonine hydrochloride, 5-10g of chlortetracycline hydrochloride, 3-5g of metronidazole, 0.1-0.3g of dexamethasone sodium phosphate, 30-60g of sodium alginate, 100-150ml of ethanol, 30-80ml of glycerin and the balance purified water, wherein the total volume of the above ingredients is 1000ml. The invention also provides a preparation method of the paste film. The preparation method comprises the following steps of 1, taking sodium alginate, soaking the sodium alginate in ethanol and grinding the moistened sodium alginate in a mortar, 2, taking dyclonine hydrochloride, dissolving the dyclonine hydrochloride by ethanol, and slowly adding the solution into the ground sodium alginate obtained by the step 1, 3, dissolving metronidazole and dexamethasone sodium phosphate in water, slowly adding the solution into the mixed solution obtained by the steps 1 and 2 and carrying out continuous grinding, 4, taking chlortetracycline hydrochloride, adding glycerinum into the chlortetracycline hydrochloride for moistening, slowly adding the mixture into the mixed solution obtained by the step 3 and carrying out continuous stirring to obtain a uniform mixture, and 5, preparing a film, carrying out drying and carrying out split charging. The paste film can be used for treating oral ulcer or oral inflammation and has effects of diminishing inflammation and relieving pain. The paste film can be pasted to an affected part. The preparation method has simple processes and substantial curative effects.

Description

technical field [0001] The invention relates to a film for treating oral ulcer and a preparation method thereof, belonging to the technical field of medicine preparation. Background technique [0002] Oral ulcer, also known as aphthous ulcer, is the disease with the highest incidence rate in oral mucosal diseases. It is easy to occur in young people, but it is not uncommon for the elderly to suffer from this disease. It is a chronic inflammation characterized by repeated painful ulcers on the oral mucosa. Because it has the law of periodic recurrence, it is often crowned with "recurrent" to indicate its specific manifestations. It is more likely to occur on the inside of the lips, the tip of the tongue, the edge of the tongue, the belly of the tongue, the buccal mucosa, and the soft palate, and rarely occurs on the gums and the hard palate. Small ulcers are small red spots at the beginning, with burning discomfort, and then gradually expand into small superficial ulcers, th...

AI Technical Summary

Problems solved by technology

[0003] In order to alleviate the pain of aphthous sores during eating, clinicians often use 10% silver nitrate aqueous solution to burn the local wound, or gargle with 0.1% potassium permanganate solution, compound boric acid solution, etc. to speed up the healing. Oral local stay, little effect

However, traditional Chinese medicine treats oral ulcers with powders, such as Bingboran Powder, which has a good effect, but it is inconvenient to cover the powders, and it is not easy to distribute slowly to enhance the efficacy of the medicine.

Because there is no suitable dosage form, the treatment of oral ulcers is not complete each time, which is also a reason for the high recurrence rate of the disease

Looking at the various drugs currently used to treat oral ulcers, there are many varieties, and they have good curative effects on various oral ulcers. For recurrent oral ulcers, the intermission period can be prolonged and the recurrence can be reduced, but the goal of radical cure has not yet been achieved.