Thermo-sensitive type dyclonine hydrochloride gel

Abstract

The invention belongs to the technical field of pharmaceutic preparation, and particularly relates to a thermo-sensitive type dyclonine hydrochloride gel. The gel is prepared from, by weight, 1%-5% of dyclonine hydrochloride, 1%-10% of thermo-sensitive gel substrate, 5%-10% of viscosity modifier, 0.1%-1% of pH modifier, 0.01%-0.1% of preservative, 0.1%-5% of flavoring agent, 2%-8% of medical defoamer and the balance water. The thermo-sensitive type dyclonine hydrochloride gel is a partial anaesthetic, and is used for laryngeal anesthesia and lubrication during upper gastrointestinal endoscopy; at room temperature, the preparation is in a liquid state, and when temperature rises to animal heat, the preparation can become gel in a cavity or a affected part; under the condition of equivalent dose volume, residence time and cover area ratio are increased drastically; the thermo-sensitive type dyclonine hydrochloride gel has the advantages of being strong in anesthesia, fast in efficacy exertion, good in bubble removing effect, appropriate in mouthfeel and the like, improves the compliance of patients, and is worth clinical application and popularization.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a thermosensitive dyclonine hydrochloride gel preparation. Background technique [0002] Thermosensitive gel is a new dosage form studied in recent years. At room temperature, the preparation is in a liquid state with good fluidity. When the temperature rises to body temperature, the fluidity and adhesion increase, and it can form a gel in the cavity or affected area. Gel-like, so that under the same dosage volume conditions, the residence time and coverage area ratio are greatly increased. Therefore, both the dosage and drug concentration of the preparation can be significantly reduced, which can not only improve the adaptability of patients, but also reduce the cost of the preparation. [0003] Dyclonine hydrochloride is a local anesthetic that has been reported to significantly reduce discomfort in patients undergoing upper gastrointestinal endoscopy. The...

AI Technical Summary

Problems solved by technology

Due to its own physical properties, the glue stays in the esophagus and intestinal tract for a short time after oral administration or enema, and its fluidity is too high, making it difficult to cover the entire inner surface of the cavity, resulting in reduced anesthesia effect

If you want to achieve better results without changing the dosage form, you need to increase the dosage, which increases the cost of medication. At the same time, because dyclonine hydrochloride itself has a bitter taste, the patient will still have a certain sense of discomfort when taking it after the concentration is increased.

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