Thermo-sensitive type dyclonine hydrochloride gel

A technology of dyclonine hydrochloride and thermosensitive gel matrix, which is applied in the field of dyclonine hydrochloride gel preparations, can solve the problems of difficulty in covering the inner surface of the cavity, reduced anesthesia effect, increased medication cost, etc., and achieves reliable diagnosis results and improved Compliance, irritation and discomfort relief

Inactive Publication Date: 2017-04-26
TIANJIN PHARMA GROUP XINZHENG
View PDF3 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to its own physical properties, the glue stays in the esophagus and intestinal tract for a short time after oral administration or enema, and its fluidity is too high, making it difficult to cover the entire inner surface of the cavity, resulting in reduced anesthesia effect
If you want to achieve better results without changing the dosage form, you need to increase the dosage, which increases the cost of medication. At the same time, because dyclonine hydrochloride itself has a bitter taste, the patient will still have a certain sense of discomfort when taking it after the concentration is increased.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Thermo-sensitive type dyclonine hydrochloride gel
  • Thermo-sensitive type dyclonine hydrochloride gel
  • Thermo-sensitive type dyclonine hydrochloride gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A temperature-sensitive dyclonine hydrochloride gel, which is composed of the following ingredients in weight percentage: dyclonine hydrochloride 1%, poloxamer 407 2.5%, poloxamer 188 0.5%, polyvinyl alcohol 5 %, citric acid 0.3%, sodium citrate 0.1%, ethylparaben 0.03%, glycerin 2.5%, stevia 0.08%, menthol 0.05%, sweet orange flavored water-soluble essence 0.5%, polyoxyethylene polyoxygen Propylene pentaerythritol ether 3%, the balance is purified water.

[0024] The preparation method of above-mentioned thermosensitive type dyclonine hydrochloride gel specifically comprises the following steps:

[0025] 1) Dissolve the weighed temperature-sensitive gel matrix (poloxamer 407 and poloxamer 188) in an appropriate amount of purified water at 4°C, stir evenly, and put it into a preparation tank for later use;

[0026] 2) Dissolve the viscosity modifier (polyvinyl alcohol) with an appropriate amount of hot (40-60°C) purified water and add it to the preparation tank;

[00...

Embodiment 2

[0030] A temperature-sensitive dyclonine hydrochloride gel, which is composed of the following components by weight percentage: 1% dyclonine hydrochloride, 2% poloxamer 407, 0.3% poloxamer 188, polyvinyl alcohol 6 %, citric acid 0.2%, sodium citrate 0.2%, ethylparaben 0.05%, stevia 0.05%, glycerin 2%, sweet orange flavor water-soluble essence 0.3%, polyoxyethylene polyoxypropylene pentaerythritol ether 5 %, and the balance is purified water.

[0031] Refer to Example 1 for the preparation method of the above temperature-sensitive dyclonine hydrochloride gel.

Embodiment 3

[0033] A temperature-sensitive dyclonine hydrochloride gel, which is composed of the following ingredients in weight percentage: dyclonine hydrochloride 1%, poloxamer 407 1.8%, poloxamer 188 0.1%, polyvinyl alcohol 5 %, citric acid 0.3%, sodium citrate 0.2%, ethylparaben 0.01%, glycerin 2%, sucralose 0.05%, menthol 0.05%, sweet orange flavored water-soluble essence 0.5%, polyoxyethylene poly Oxypropylene pentaerythritol ether 4%, the balance is purified water.

[0034] Refer to Example 1 for the preparation method of the above temperature-sensitive dyclonine hydrochloride gel.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the technical field of pharmaceutic preparation, and particularly relates to a thermo-sensitive type dyclonine hydrochloride gel. The gel is prepared from, by weight, 1%-5% of dyclonine hydrochloride, 1%-10% of thermo-sensitive gel substrate, 5%-10% of viscosity modifier, 0.1%-1% of pH modifier, 0.01%-0.1% of preservative, 0.1%-5% of flavoring agent, 2%-8% of medical defoamer and the balance water. The thermo-sensitive type dyclonine hydrochloride gel is a partial anaesthetic, and is used for laryngeal anesthesia and lubrication during upper gastrointestinal endoscopy; at room temperature, the preparation is in a liquid state, and when temperature rises to animal heat, the preparation can become gel in a cavity or a affected part; under the condition of equivalent dose volume, residence time and cover area ratio are increased drastically; the thermo-sensitive type dyclonine hydrochloride gel has the advantages of being strong in anesthesia, fast in efficacy exertion, good in bubble removing effect, appropriate in mouthfeel and the like, improves the compliance of patients, and is worth clinical application and popularization.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a thermosensitive dyclonine hydrochloride gel preparation. Background technique [0002] Thermosensitive gel is a new dosage form studied in recent years. At room temperature, the preparation is in a liquid state with good fluidity. When the temperature rises to body temperature, the fluidity and adhesion increase, and it can form a gel in the cavity or affected area. Gel-like, so that under the same dosage volume conditions, the residence time and coverage area ratio are greatly increased. Therefore, both the dosage and drug concentration of the preparation can be significantly reduced, which can not only improve the adaptability of patients, but also reduce the cost of the preparation. [0003] Dyclonine hydrochloride is a local anesthetic that has been reported to significantly reduce discomfort in patients undergoing upper gastrointestinal endoscopy. The...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/06A61K31/4453A61K47/10A61K47/36A61P23/02
CPCA61K9/08A61K9/0053A61K9/06A61K31/4453A61K47/10A61K47/36
Inventor 王瑞玲李俊霞白艳鹤周遂成张继业田广林
Owner TIANJIN PHARMA GROUP XINZHENG
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap