This invention provides a method for preparing a
metformin compound hypoglycemic oral solution, relating to the pharmaceutical field, comprising: step S1, pretreatment of
traditional Chinese medicine components; step S2,
enzymatic hydrolysis of the first group of
traditional Chinese medicine components; step S3, supercritical extraction; step S4, preparation of mixed traditional Chinese medicines; step S5, preparation of inclusion complex; step S6, compound formulation; and step S7, post-
processing. This method synergistically combines extracts from seven traditional Chinese medicines—
bitter melon,
phellodendron bark,
astragalus root,
kudzu root,
rehmannia root,
ginseng, and
privet fruit—with
metformin hydrochloride to form a
metformin compound hypoglycemic oral solution, balancing the
synergy, safety, and stability of traditional Chinese and Western medicines, thereby improving
hypoglycemic effects while reducing the incidence of gastrointestinal adverse reactions to metformin.