46 results about "Radiation equivalent dose" patented technology

The present invention relates to a delivery system which includes a bioactive drug or cosmetic substance presented in the form of submicron oil spheres alone, or drugs or cosmetic substances in a combination with the oil spheres in an aqueous suspension or emulsion. Optionally, a skin penetration enhancer may be included in such formulations. Such preparations achieve improved bioavailability and exert larger pharmacological effects than an equivalent dose of the drug or cosmetic formulated in conventional creams, lotions or oleaginous bases.

The present disclosure is drawn to pharmaceutical compositions and oral dosage forms containing testosterone undecanoate, as well as related methods of treatment. In one embodiment, the oral dosage form can include a therapeutically effective amount of testosterone undecanoate and a pharmaceutically acceptable carrier. The dosage form can be formulated such that, when measured using a USP Type II apparatus in 1000 mL of 8 wt % Triton X-100 in water at 37° C. and 100 rpm, the oral dosage form releases at least 20% more testosterone undecanoate after the first 120 minutes than an equivalent dose testosterone undecanoate containing oral dosage form without the pharmaceutically acceptable carrier.

While a pharmacist may know of other medications approved by the FDA for the same medical condition, the pharmacist typically does not know what the therapeutically equivalent dose of those products is when compared to the originally prescribed item In addition to this lack of equivalent dosage information, the pharmacist also is unable to determine if any of those other FDA approved items will save the consumer any money. Accordingly, embodiments of the invention can provide pharmacists and / or consumers with equivalent dosage information as well as pricing information for the equivalent dosage. Accordingly, based at least in part on this information, consumers may have an incentive to and may decide to purchase to another prescription drug, thereby shifting market share to a preferred prescription drug or pharmaceutical manufacturer or provider.

A method of administering a suspension of paclitaxel particles into the peritoneum is provided. A corresponding method of treating a disease, disorder or condition that is therapeutically responsive to paclitaxel is also provided. The methods provide improvements over comparator formulations containing an equivalent dose of paclitaxel.

This invention provides a prodrug that help arthritis patients without increasing cardiovascular and gastrointestinal risk. A novel group of hybrid nitric oxide-releasing non-steroidal anti-inflammatory drugs (NO-NSAIDs), moiety attached via a one -carbon methylene spacer to the carboxylic acid group of the traditional NSAIDs aspirin, ibuprofen and indomethacin were synthesized. The ester prodrugs showed equipotent anti-inflammatory activities in vivo to that of the parent aspirin, ibuprofen and indomethacin. The simultaneous release of parent drug and nitric oxide from the NO- prodrugs constitutes a potentially beneficial property for the prophylactic prevention of thrombus formation and adverse cardiovascular events such as stroke and myocardial infarction. Data acquired in an in vivo ulcer index (UI) assay showed that this group of ester prodrugs in which no lesions were observed when compared to the parent drugs at equivalent doses. Accordingly, these hybrid NO-NSAID prodrugs possessing a diazen-1-ium-1,2-diolate moiety, represents a new approach for the rational design of anti-inflammatory drugs with reduced gastric ulcerogenicity.

The invention consists of an area dosimeter for measuring the ambient equivalent dose (H*(10)) of photon radiation with a diffuser, a detector card with at least one pair of detection elements, preferably LiF-chips,whereby the first of the two detection elements is positioned between two filters in order to spectrally filter the photon radiation,whereby the second of the two detection elements is not positioned between such filters as those of the first detection element, in order that the photon radiation arriving at the second detection element have a different spectral distribution as the spectrally filtered photon radiation arriving at the first detection element. The two measurement values are used to obtain a weighted sum in order to achieve an optimized response characteristic, in particular in the range below 30 keV and if applicable in the range above 1.3 MeV.

A process for forming multiparticulates of azithromycin and a controlled release dosage form comprising multiparticulates of azithromycin and a pharmaceutically acceptable excipient are disclosed. The dosage form decreases the incidence and / or severity of GI side effects relative to currently available immediate release azithromycin dosage forms that deliver an equivalent dose. The dosage forms operate by effecting azithromycin release at a rate sufficiently slow to ameliorate side effects, yet sufficiently fast to achieve good bioavailability.

The present disclosure is drawn to pharmaceutical compositions and oral dosage forms containing testosterone undecanoate, as well as related methods of treatment. In one embodiment, the oral dosage form can include a therapeutically effective amount of testosterone undecanoate and a pharmaceutically acceptable carrier. The dosage form can be formulated such that, when measured using a USP Type II apparatus in 1000 mL of 8 wt % Triton X-100 in water at 37° C. and 100 rpm, the oral dosage form releases at least 20% more testosterone undecanoate after the first 120 minutes than an equivalent dose testosterone undecanoate containing oral dosage form without the pharmaceutically acceptable carrier.

The invention relates to a traditional Chinese medicine for treating white hair, mainly comprising black sesame, mulberry, and fleece-flower root in the equivalent dose. Standard dose of honey satisfies the condition that the ground powders of the black sesame, the mulberry and the fleece-flower root can be mixed into pills. 360g of ground powder of the black sesame, 360g of ground powder of the mulberry, and 360g of ground powder of the fleece-flower root are mixed with the honey to form pills; and the pills are taken continuously for three months. The clinic application of the traditional Chinese medicine for treating white hair shows that: if a patient having white hair continuously takes the medicine for three months, the symptom can be relieved during the period of taking the medicine, and the white hair of the patient can completely turn into black hair after three months, furthermore, the medicine has especially obvious curative effect and low price without poison or side effect.

The invention belongs to the technical field of pharmaceutic preparation, and particularly relates to a thermo-sensitive type dyclonine hydrochloride gel. The gel is prepared from, by weight, 1%-5% of dyclonine hydrochloride, 1%-10% of thermo-sensitive gel substrate, 5%-10% of viscosity modifier, 0.1%-1% of pH modifier, 0.01%-0.1% of preservative, 0.1%-5% of flavoring agent, 2%-8% of medical defoamer and the balance water. The thermo-sensitive type dyclonine hydrochloride gel is a partial anaesthetic, and is used for laryngeal anesthesia and lubrication during upper gastrointestinal endoscopy; at room temperature, the preparation is in a liquid state, and when temperature rises to animal heat, the preparation can become gel in a cavity or a affected part; under the condition of equivalent dose volume, residence time and cover area ratio are increased drastically; the thermo-sensitive type dyclonine hydrochloride gel has the advantages of being strong in anesthesia, fast in efficacy exertion, good in bubble removing effect, appropriate in mouthfeel and the like, improves the compliance of patients, and is worth clinical application and popularization.

A non-visible particle detection device includes an optical module capable of converting an ionizing radiation into visible light. The optical module includes has an attachment unit that is configured to removably attach the optical module to the image capturing module of a mobile device. The image capturing module generates a photon digital image based on the photons converted from the ionizing radiation. The mobile device can be implemented with a radiation dose determining module to execute a radiation dose equivalent calculation method. Based on the pixel brightness analysis of the photon digital image, the radiation equivalent dose can be determined. This method sums up the total brightness of all pixels in the images, determines whether the total brightness is smaller than the minimum effective brightness, and determines the radiation equivalent dose when the total brightness is equal to or larger than the minimum effective brightness.

The is described a process for determining a validated Reduction Equivalent Dose for reducing the concentration of a target contaminant contained in a fluid in a radiation fluid treatment system. In one embodiment, the process comprises the steps of: (a) determining a short wavelength Reduction Equivalent Dose for the target contaminant or a challenge contaminant in a first region of the electromagnetic spectrum having a wavelength of less than or equal to about 240 nm; (b) determining a long wavelength Reduction Equivalent Dose for the target contaminant or a challenge contaminant in a second region of the electromagnetic spectrum having a wavelength of greater than about 240 nm; and (c) summing the short wavelength Reduction Equivalent Dose and the long wavelength Reduction Equivalent Dose to produce the validated Reduction Equivalent Dose for the target contaminant. In a preferred embodiment, the present invention provides a useful approach for determining the relevant Reduction Equivalent Dose (RED) for Cryptosporidium disinfection and accomplishes this by using the discovered relation between the short wavelength sensor signal and the short wavelength RED, and subtracting the short wavelength RED from the RED determined using a challenge microbe with synthetic lamp sleeves, to obtain the long wavelength RED applicable to Cryptosporidium disinfection. In a bioassay, one would only need the short wavelength sensor reading and the challenge microbe RED using synthetic lamp sleeves to determine the applicable RED, once the relationship between the short wavelength sensor reading and the short wavelength RED was established.

The invention provides application of polyethylene glycol artesunate as shown in Formula (I) in preparation of an anti-pulmonary fibrosis medicine. The polyethylene glycol artesunate can obviously reduce the degree of pulmonary fibrosis, the pulmonary index, and the content of hydroxyproline and malondialdehyde in pulmonary tissues of a pulmonary fibrosis mouse caused by bleomycin, and improve the survival, the spleen index and the thymus index of the pulmonary fibrosis mouse. Moreover, under the equivalent dose, the polyethylene glycol artesunate and artesunate are significantly different. In addition, the polyethylene glycol artesunate is high in water solubility, high in bioavailability, long in half-life period and low in administration frequency.

The present invention relates to a method and system for predicting the probability of normal tissue damage based on deep learning, belonging to the technical field of medical data processing. The method includes: obtaining the tumor dose data, basic information, and tumor diagnosis information of a patient; the tumor dose data is formulated by a doctor based on the patient's tumor diagnosis information before radiotherapy for the patient; the basic information includes at least the patient's age; based on the tumor dose data, obtaining the dose volume histogram of the patient; based on the dose volume histogram, obtaining the volume parameters and biological equivalent dose of the patient's normal tissue; inputting the volume parameters and biological equivalent dose of the patient's normal tissue, the patient's basic information, and tumor diagnosis information into a normal tissue damage probability prediction model constructed based on deep learning to obtain the damage probability of the patient's normal tissue. Compared with traditional statistical models or empirical formulas, the prediction accuracy of this method is higher, and it can more accurately evaluate the damage probability of normal tissue.

The invention relates to a new application of traditional Chinese indian lettuce in the pharmaceutical field, in particular to the application of drugs for curing or preventing diabetes. Experiments prove that rats suffering from diabetes due to streptozotocin significantly decrease urinary output, put on weight gradually and significantly decrease blood sugar level after being fed with the aqueous extract of traditional Chinese indian lettuce. Experiments also prove that no evident toxic side effect produces after rats are fed with the traditional Chinese indian lettuce by 200 times more thanan adult equivalent dose by the maximum gavage amount to the rat (0.4 ml / 10g).

The invention discloses a nuclear facility decommissioned human body exposure dose assessment method, and particularly relates to a simulation method for simplifying nuclear decommissioned workers into a programmed model and dynamically calculating the human body exposure dose based on a point-nuclear integration method. The method comprises the steps of adopting a programming model to construct avirtual human model; converting the key organization of the programming model into a series of detection points; calculating the equivalent dose of a key tissue detection point by adopting a point-kernel integration method; calculating the effective dose of the virtual human when the decommissioning activity is ended, and realizing the assessment of the irradiated dose of the worker in the decommissioning process. The method comprises three modules of decommissioning environment modeling, programmed human body model modeling and human body exposure dose calculation, and dynamic calculation ofthe exposure dose of a worker wearing nuclear radiation protective clothing in the nuclear facility decommissioning process is achieved.

The invention discloses a method for reducing radiation dose. The method includes the step: acquiring first image data related to a region of interest (ROI) of a first object. The first image data corresponds to a first equivalent dose, and the first image data can be acquired by a first device. The method may further include the steps of obtaining a noise reduction model associated with the first image data and determining second image data corresponding to a second equivalent dose based on the first image data and the noise reduction model, wherein the second equivalent dose being higher than the first equivalent dose. In some embodiments, the method may further include the steps of determining information related to a region of interest (ROI) of the first object based on the second image data, and recording the information related to the region of interest (ROI) of the first object. According to the method, the low-dose image is converted into the high-dose image through the noise reduction model, and the patient can be prevented from being exposed to excessive radiation under the condition that the image with the same quality or higher quality is obtained.

The invention discloses an externally-applied traditional Chinese medicine composition for treating mastitis. The composition comprises the following traditional Chinese medicine components by weight: 15-20g of ligusticum wallichii, 15-30g of curcuma zedoary, 15-30g of rhizoma sparganii, 1-3g of flos daturae, 5-15g of clove, 15-30g of honeysuckle stem, 15-30g of patrinia and 5-15g of dandelion, wherein the traditional Chinese medicine components are the raw powder of the traditional Chinese medicinal materials or traditional Chinese medicine extracts equivalent to the equivalent doses of the traditional Chinese medicinal materials. The invention further discloses an administration mode of the externally-applied traditional Chinese medicine composition for treating mastitis.

The invention discloses an externally-applied traditional Chinese medicine composition for treating traumatic injury. The composition comprises the following traditional Chinese medicine components by weight: 10-15g of radix scrophulariae, 10-50g of mint, 10-35g of borneol, 20-60g of semen lepidii and 10-40g of scaphium scaphigerum, wherein the traditional Chinese medicine components are the raw powder of the traditional Chinese medicinal materials or traditional Chinese medicine extracts equivalent to the equivalent doses of the traditional Chinese medicinal materials. The invention further discloses an administration mode of the externally-applied traditional Chinese medicine composition for treating traumatic injury.

The invention discloses an externally-applied traditional Chinese medicine composition for treating heart disease. The composition comprises the following traditional Chinese medicine components by weight: 5-15g of scaphium scaphigerum, 15-30g of astragalus membranaceus, 15-20g of madder, 30-60g of scrophularia ningpoensis, 5-10g of pseudo-ginseng and 5-10g of spina date seed, wherein the traditional Chinese medicine components are the raw powder of the traditional Chinese medicinal materials or traditional Chinese medicine extracts equivalent to the equivalent doses of the traditional Chinese medicinal materials. The invention further discloses an administration mode of using the traditional Chinese medicine composition for treating heart disease.

Neutron-induced radiation detectors (NiRDs) and radiation dosimetry systems containing the same are described. Examples of NiRDs can include numerous components based on location, function, dimension, and / or constituent materials. A NiRD can be configured to directly measure an absorbed dose (or rate) of particular ionizing reaction products induced by neutrons. The NiRD can utilize various detection schemes for measuring the deposited energy of the reaction products, such as gaseous ionization, semiconducting, scintillating, or homogenous versions of these detection schemes. The NiRD can measure the deposited energy of the reaction products in forward emission, backward emission, or both. Examples of radiation dosimetry systems can include one or more NiRDs, a gamma ray detector, and readout electronics coupled to each of the radiation detectors. Example implementations of the radiation dosimetry systems are described for determining an equivalent dose (or rate) of a neutron beam generated for boron neutron capture therapy (BNCT).

The invention discloses a preservation method of traditional Chinese medicine decoction pieces. The method comprises the following steps: step one, carrying out drying treatment on the traditional Chinese medicine decoction pieces, vertically stacking the traditional Chinese medicine decoction pieces together, packaging with a paper box, and carrying out radiation treatment with 60 Co-gamma rays,wherein the absorbed dose of radiation is 1.0 to 1.5 kGy, a rotating shaft is inserted in the middle part of the paper box in a penetrated manner, and the paper box rotates around the rotating shaft;step two, carrying out vacuum sealing on the traditional Chinese medicine decoction pieces after treatment in the step one, and carrying out secondary radiation treatment, wherein the absorbed dose ofradiation is 2.0 to 2.5 kGy; and step three, putting the traditional Chinese medicine decoction pieces obtained in the step two into a sealed container, inflating a gas mixture of 72% of nitrogen, 25% of carbon dioxide gas and 3% of oxygen into the sealed container, and sealing for storage. According to the method, the uniformity is guaranteed by using mutual compensation of upper and lower surfaces in an equivalent dose area, so that the preservation effect is improved.

The application provides an exposure dose control method based on an exposure dose control system, which comprises the following steps: controlling a shutter to open; receiving an energy value collected by an energy sensor, determining an accumulated exposure dose value based on the energy value; determining whether the accumulated exposure dose value is not less than a target dose value; if the accumulated exposure dose value is not less than the target dose value, controlling the shutter to start to close; taking the accumulated exposure dose value corresponding to a shake delay end moment after the shutter is completely closed as an actual accumulated exposure dose value; determining an exposure dose error value based on the actual accumulated exposure dose value; determining whether the exposure dose error value meets a requirement; if the exposure dose error value does not meet the requirement, updating an equivalent dose value and returning to execute the first step; if the exposure dose error value meets the requirement, applying the equivalent dose value to an exposure system. Through the exposure dose control method based on the exposure dose control system, the problem of low exposure dose control precision is solved.

The invention discloses an externally applied traditional Chinese medicine composition for treating dermatophytosis. The composition is prepared from the following traditional Chinese medicine components by weight: 15-30g of Sichuan lovage rhizome, 20-30g of quispualis indica, 5-20g of wild aconite roots, 10-20g of folium artemisiae argyi and 10-30g of radix scrophulariae. The traditional Chinese medicine components are raw powder of traditional Chinese medicinal materials or traditional Chinese medicinal extracts equivalent to equivalent doses of traditional Chinese medicinal materials. The invention further discloses a delivery way of the externally applied traditional Chinese medicine composition for treating dermatophytosis.

The invention relates to a radiation detection device and provides a wide-range TEPC (tissue-equivalent proportional counter) and an application thereof in order to solve the problem that an existing TEPC is hard to give consideration to radiation field measurement with larger differences of fluence rate and equivalent dose rate levels. The wide-range TEPC comprises a casing, a voltage division circuit, a multichannel signal collection system as well as a conductive tissue equivalent material negative plate, a conductive tissue equivalent material plate, a GEM membrane and a positive plate which are located in the casing and overlaid in sequence from top to bottom. The application method of the wide-range TEPC comprises steps as follows: step one, the wide-range TEPC is placed in a to-be-detected radiation field; step two, signals are collected; step three, the signals are processed. The wide-range TEPC has a quite wide measuring range, can realize measurement of the radiation fields with low fluence rate and high fluence rate conveniently, is smaller in size, relatively simple in structure, easy to manufacture and quite wide in applicable range, and can be applicable to radiation monitoring of various occasions.

The invention provides an exposure dose control method based on an exposure dose control system. The method comprises the following steps: controlling a shutter to open; receiving an energy value collected by an energy sensor, and determining an accumulated exposure dose value based on the energy value; determining whether the accumulated exposure dose value is not less than a target dose value; if the accumulated exposure dose value is not less than the target dose value, controlling the shutter to start to close; taking the accumulated exposure dose value corresponding to the jitter delay ending moment after the shutter is completely closed as an actual accumulated exposure dose value; determining an exposure dose error value based on the actual accumulated exposure dose value; determining whether the exposure dose error value meets requirements or not; if the exposure dose error value does not meet the requirement, updating the equivalent dose value, and returning to execute the first step; and if the exposure dose error value meets the requirement, applying the equivalent dose value to the exposure system. Through the exposure dose control method based on the exposure dose control system, the problem of low exposure dose control precision is solved.

The invention discloses an externally-applied traditional Chinese medicine composition for treating rheumatism. The composition comprises the following traditional Chinese medicine components by weight: 15-35g of radix scrophulariae, 20-40g of radix cyathulae, 15-50g of radix saposhnikoviae, 15-30g of notopterygium root, 5-15g of radix angelicae pubescentis and 15-30g of cynomorium songaricum. The traditional Chinese medicine components are the raw powder of the traditional Chinese medicinal materials or traditional Chinese medicine extracts equivalent to the equivalent doses of the traditional Chinese medicinal materials. The invention further discloses an administration mode of the externally-applied traditional Chinese medicine composition for treating rheumatism.

A system for treating a target tissue with a charged particle beam, wherein the target tissue includes tumoral cells surrounded by or encloses healthy cells of healthy tissue, the system comprising a computer configured to receive a total target dose, receive a fraction number irradiation fractions for treating, receive a maximum healthy fraction dose and a maximum healthy total dose, receive an equivalence coefficient (α), divide the total target dose into the target fraction doses, and determine a ratio of a target fraction dose to be deposited at a conventional deposition rate and a complementary ratio of the target fraction dose to be deposited at a high deposition rate based on an equivalent fraction dose, the maximum healthy fraction dose, a total equivalent dose, and the maximum healthy total dose.