37 results about "Radiation equivalent dose" patented technology

The present invention relates to a delivery system which includes a bioactive drug or cosmetic substance presented in the form of submicron oil spheres alone, or drugs or cosmetic substances in a combination with the oil spheres in an aqueous suspension or emulsion. Optionally, a skin penetration enhancer may be included in such formulations. Such preparations achieve improved bioavailability and exert larger pharmacological effects than an equivalent dose of the drug or cosmetic formulated in conventional creams, lotions or oleaginous bases.

While a pharmacist may know of other medications approved by the FDA for the same medical condition, the pharmacist typically does not know what the therapeutically equivalent dose of those products is when compared to the originally prescribed item In addition to this lack of equivalent dosage information, the pharmacist also is unable to determine if any of those other FDA approved items will save the consumer any money. Accordingly, embodiments of the invention can provide pharmacists and/or consumers with equivalent dosage information as well as pricing information for the equivalent dosage. Accordingly, based at least in part on this information, consumers may have an incentive to and may decide to purchase to another prescription drug, thereby shifting market share to a preferred prescription drug or pharmaceutical manufacturer or provider.

This invention provides a prodrug that help arthritis patients without increasing cardiovascular and gastrointestinal risk. A novel group of hybrid nitric oxide-releasing non-steroidal anti-inflammatory drugs (NO-NSAIDs), moiety attached via a one -carbon methylene spacer to the carboxylic acid group of the traditional NSAIDs aspirin, ibuprofen and indomethacin were synthesized. The ester prodrugs showed equipotent anti-inflammatory activities in vivo to that of the parent aspirin, ibuprofen and indomethacin. The simultaneous release of parent drug and nitric oxide from the NO- prodrugs constitutes a potentially beneficial property for the prophylactic prevention of thrombus formation and adverse cardiovascular events such as stroke and myocardial infarction. Data acquired in an in vivo ulcer index (UI) assay showed that this group of ester prodrugs in which no lesions were observed when compared to the parent drugs at equivalent doses. Accordingly, these hybrid NO-NSAID prodrugs possessing a diazen-1-ium-1,2-diolate moiety, represents a new approach for the rational design of anti-inflammatory drugs with reduced gastric ulcerogenicity.

A process for forming multiparticulates of azithromycin and a controlled release dosage form comprising multiparticulates of azithromycin and a pharmaceutically acceptable excipient are disclosed. The dosage form decreases the incidence and/or severity of GI side effects relative to currently available immediate release azithromycin dosage forms that deliver an equivalent dose. The dosage forms operate by effecting azithromycin release at a rate sufficiently slow to ameliorate side effects, yet sufficiently fast to achieve good bioavailability.

The invention relates to a traditional Chinese medicine for treating white hair, mainly comprising black sesame, mulberry, and fleece-flower root in the equivalent dose. Standard dose of honey satisfies the condition that the ground powders of the black sesame, the mulberry and the fleece-flower root can be mixed into pills. 360g of ground powder of the black sesame, 360g of ground powder of the mulberry, and 360g of ground powder of the fleece-flower root are mixed with the honey to form pills; and the pills are taken continuously for three months. The clinic application of the traditional Chinese medicine for treating white hair shows that: if a patient having white hair continuously takes the medicine for three months, the symptom can be relieved during the period of taking the medicine, and the white hair of the patient can completely turn into black hair after three months, furthermore, the medicine has especially obvious curative effect and low price without poison or side effect.

The is described a process for determining a validated Reduction Equivalent Dose for reducing the concentration of a target contaminant contained in a fluid in a radiation fluid treatment system. In one embodiment, the process comprises the steps of: (a) determining a short wavelength Reduction Equivalent Dose for the target contaminant or a challenge contaminant in a first region of the electromagnetic spectrum having a wavelength of less than or equal to about 240 nm; (b) determining a long wavelength Reduction Equivalent Dose for the target contaminant or a challenge contaminant in a second region of the electromagnetic spectrum having a wavelength of greater than about 240 nm; and (c) summing the short wavelength Reduction Equivalent Dose and the long wavelength Reduction Equivalent Dose to produce the validated Reduction Equivalent Dose for the target contaminant. In a preferred embodiment, the present invention provides a useful approach for determining the relevant Reduction Equivalent Dose (RED) for Cryptosporidium disinfection and accomplishes this by using the discovered relation between the short wavelength sensor signal and the short wavelength RED, and subtracting the short wavelength RED from the RED determined using a challenge microbe with synthetic lamp sleeves, to obtain the long wavelength RED applicable to Cryptosporidium disinfection. In a bioassay, one would only need the short wavelength sensor reading and the challenge microbe RED using synthetic lamp sleeves to determine the applicable RED, once the relationship between the short wavelength sensor reading and the short wavelength RED was established.

The invention provides application of polyethylene glycol artesunate as shown in Formula (I) in preparation of an anti-pulmonary fibrosis medicine. The polyethylene glycol artesunate can obviously reduce the degree of pulmonary fibrosis, the pulmonary index, and the content of hydroxyproline and malondialdehyde in pulmonary tissues of a pulmonary fibrosis mouse caused by bleomycin, and improve the survival, the spleen index and the thymus index of the pulmonary fibrosis mouse. Moreover, under the equivalent dose, the polyethylene glycol artesunate and artesunate are significantly different. In addition, the polyethylene glycol artesunate is high in water solubility, high in bioavailability, long in half-life period and low in administration frequency.

The invention relates to a new application of traditional Chinese indian lettuce in the pharmaceutical field, in particular to the application of drugs for curing or preventing diabetes. Experiments prove that rats suffering from diabetes due to streptozotocin significantly decrease urinary output, put on weight gradually and significantly decrease blood sugar level after being fed with the aqueous extract of traditional Chinese indian lettuce. Experiments also prove that no evident toxic side effect produces after rats are fed with the traditional Chinese indian lettuce by 200 times more thanan adult equivalent dose by the maximum gavage amount to the rat (0.4 ml/10g).

The invention discloses a nuclear facility decommissioned human body exposure dose assessment method, and particularly relates to a simulation method for simplifying nuclear decommissioned workers into a programmed model and dynamically calculating the human body exposure dose based on a point-nuclear integration method. The method comprises the steps of adopting a programming model to construct avirtual human model; converting the key organization of the programming model into a series of detection points; calculating the equivalent dose of a key tissue detection point by adopting a point-kernel integration method; calculating the effective dose of the virtual human when the decommissioning activity is ended, and realizing the assessment of the irradiated dose of the worker in the decommissioning process. The method comprises three modules of decommissioning environment modeling, programmed human body model modeling and human body exposure dose calculation, and dynamic calculation ofthe exposure dose of a worker wearing nuclear radiation protective clothing in the nuclear facility decommissioning process is achieved.

The invention discloses an externally-applied traditional Chinese medicine composition for treating mastitis. The composition comprises the following traditional Chinese medicine components by weight: 15-20g of ligusticum wallichii, 15-30g of curcuma zedoary, 15-30g of rhizoma sparganii, 1-3g of flos daturae, 5-15g of clove, 15-30g of honeysuckle stem, 15-30g of patrinia and 5-15g of dandelion, wherein the traditional Chinese medicine components are the raw powder of the traditional Chinese medicinal materials or traditional Chinese medicine extracts equivalent to the equivalent doses of the traditional Chinese medicinal materials. The invention further discloses an administration mode of the externally-applied traditional Chinese medicine composition for treating mastitis.

The invention discloses an externally-applied traditional Chinese medicine composition for treating traumatic injury. The composition comprises the following traditional Chinese medicine components by weight: 10-15g of radix scrophulariae, 10-50g of mint, 10-35g of borneol, 20-60g of semen lepidii and 10-40g of scaphium scaphigerum, wherein the traditional Chinese medicine components are the raw powder of the traditional Chinese medicinal materials or traditional Chinese medicine extracts equivalent to the equivalent doses of the traditional Chinese medicinal materials. The invention further discloses an administration mode of the externally-applied traditional Chinese medicine composition for treating traumatic injury.

The invention discloses an externally-applied traditional Chinese medicine composition for treating heart disease. The composition comprises the following traditional Chinese medicine components by weight: 5-15g of scaphium scaphigerum, 15-30g of astragalus membranaceus, 15-20g of madder, 30-60g of scrophularia ningpoensis, 5-10g of pseudo-ginseng and 5-10g of spina date seed, wherein the traditional Chinese medicine components are the raw powder of the traditional Chinese medicinal materials or traditional Chinese medicine extracts equivalent to the equivalent doses of the traditional Chinese medicinal materials. The invention further discloses an administration mode of using the traditional Chinese medicine composition for treating heart disease.

The invention discloses a preservation method of traditional Chinese medicine decoction pieces. The method comprises the following steps: step one, carrying out drying treatment on the traditional Chinese medicine decoction pieces, vertically stacking the traditional Chinese medicine decoction pieces together, packaging with a paper box, and carrying out radiation treatment with 60 Co-gamma rays,wherein the absorbed dose of radiation is 1.0 to 1.5 kGy, a rotating shaft is inserted in the middle part of the paper box in a penetrated manner, and the paper box rotates around the rotating shaft;step two, carrying out vacuum sealing on the traditional Chinese medicine decoction pieces after treatment in the step one, and carrying out secondary radiation treatment, wherein the absorbed dose ofradiation is 2.0 to 2.5 kGy; and step three, putting the traditional Chinese medicine decoction pieces obtained in the step two into a sealed container, inflating a gas mixture of 72% of nitrogen, 25% of carbon dioxide gas and 3% of oxygen into the sealed container, and sealing for storage. According to the method, the uniformity is guaranteed by using mutual compensation of upper and lower surfaces in an equivalent dose area, so that the preservation effect is improved.

The invention discloses an externally-applied traditional Chinese medicine composition for treating rheumatism. The composition comprises the following traditional Chinese medicine components by weight: 15-35g of radix scrophulariae, 20-40g of radix cyathulae, 15-50g of radix saposhnikoviae, 15-30g of notopterygium root, 5-15g of radix angelicae pubescentis and 15-30g of cynomorium songaricum. The traditional Chinese medicine components are the raw powder of the traditional Chinese medicinal materials or traditional Chinese medicine extracts equivalent to the equivalent doses of the traditional Chinese medicinal materials. The invention further discloses an administration mode of the externally-applied traditional Chinese medicine composition for treating rheumatism.

The invention relates to application of indinavir in preparing medicament or medicinal composition for treating malaria. The application comprises establishing monkey model with malaria infection, treating with Indinavir dripfeed administeration, detecting infection rate of plasmodium red blood cell through blood smear, comparing with negative control group, getting indicator such as parasite density, parasite clearance time, red-cell count and temperature, detecting therapeutic action and effective therapeutic dose of Indinavir to monkey malaria infection. Effective dose of indinavir for treating human malaria is no less than 20mg/kg/d according to equivalent dose converting equation of different genus animals. The invention provides new target spot and research direction for exploiting antiperiodic, and settles foundation for discussing combined application of indinavir and other antiperiodic.

The invention discloses a space charged particle telescope based on cadmium zinc telluride. An opening is formed in the top end of an outer cover of the space charged particle telescope, a mounting base is arranged in the outer cover, a Si semiconductor detector, a first CZT detector and a second CZT detector are arranged on the mounting base, and the Si semiconductor detector and the first CZT detector form a first delta EE detector system; and the first CZT detector and the second CZT detector form a second group of delta EE detector systems, and the first delta EE detector system and the second delta EE detector system are matched to respectively measure charged particles with different energies. According to the invention, charged particles, thermal neutrons, gamma rays and other components in a space environment can be measured. The telescope can effectively measure information such as energy transfer linear density spectrum (LET), equivalent dose, charged particle energy spectrum, total dose, dose rate and the like of charged particles in space, has very important significance for astronaut radiation risk assessment, and can improve the resolution of the particle energy spectrum and enhance the particle identification capability compared with a traditional scintillation crystal system.