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Ointment for promoting rapid healing of scabby chilblain

A technology for ointment and chilblain, applied in the field of external medicine, can solve the problem of not being able to effectively prevent infection of the affected area, and achieve the effects of preventing damage, strong affinity, and preventing bacterial infection

Inactive Publication Date: 2012-03-07
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patent number is: 200710055825.3 A skin care lotion for treating frostbite and chilblain, none of its ingredients contain protein necessary for skin healing, and it cannot effectively prevent infection of the affected area

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Mix 8g of lanolin, 8g of liquid paraffin, and 64g of petrolatum as a matrix, dry heat sterilization at 150°C for 1.5 hours, and then let it cool in a sterile environment; dissolve 480,000 units of gentamicin and 3g of silk fibroin in distilled water , when the temperature of the substrate drops to about 37°C, slowly add the gentamicin and silk fibroin solution into the substrate, and stir while adding to make it evenly mixed.

Embodiment 2

[0012] Mix 80g of lanolin, 80g of liquid paraffin, and 640g of Vaseline as a matrix, dry heat sterilization at 150°C for 1.5 hours, and then let it cool in a sterile environment; dissolve 30 million units of chloramphenicol and 30g of silk fibroin in an appropriate amount of distilled water, When the temperature of the substrate drops to about 37°C, slowly add the chloramphenicol and silk fibroin solution into the substrate, and stir while adding to make it evenly mixed.

Embodiment 3

[0014] Mix 40g of lanolin, 40g of liquid paraffin, and 320g of Vaseline as a matrix, dry heat sterilization at 150°C for 1.5 hours, and then let it cool in a sterile environment; dissolve 15 million units of erythromycin and 15g of silk fibroin in an appropriate amount of distilled water, When the temperature of the substrate drops to about 37°C, slowly add the erythromycin and silk fibroin solution into the substrate, and stir while adding to make it evenly mixed.

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PUM

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Abstract

The invention discloses ointment for promoting the rapid healing of a scabby chilblain, which comprises 8 grams of lanolin, 8 grams of liquid paraffin, 64 grams of vaseline, 3 grams of silk fibroin, and 480,000 units of gentamicin or equivalent dose of antibiotics. In the ointment, amino acids contained in the silk fibroin have high affinity to skin, and can supplement the amino acids required bythe recovery of damaged skin; the gentamicin or the other antibiotics can prevent bacterial infection; and the vaseline, the liquid paraffin and the lanolin function as excipients, and can soften theskin with the chilblain and prevent the skin from being damaged due to dryness.

Description

technical field [0001] The invention relates to a medicine for external use, in particular to an ointment for promoting quick healing of chilblains after crusting. Background technique [0002] Studies have shown that frostbite is caused by spasmodic contraction of local small arteries under the stimulation of damp and cold, blood flow is blocked, tissue hypoxia, and tissue cells are damaged, and then the small veins spasm, resulting in telangiectasia between small arteries and veins. Increased permeability, tissue edema, platelet aggregation, increased blood viscosity, and the formation of purplish red edematous erythema. After the treatment of chilblain with drugs, part of the skin in the affected area will be necrotic and scab, especially when the scab falls off, the exposed skin is extremely fragile, which is easily damaged and causes infection. Most of the medicines for the treatment of frostbite at present do not consider the auxiliary treatment to the skin after the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/17A61K9/06A61K47/44A61P17/02A61K31/165A61K31/7036
Inventor 段秦龙徐水段宇龚毅虞志伟曹帅
Owner SOUTHWEST UNIV
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