12 results about "Chilblains" patented technology

The present invention relates to compounds of formula (I), and stereoisomers, tautomers, N- oxides, and pharmaceutically acceptable salts thereof that are useful for modulating, preferably inhibiting three-prime repair exonuclease (TREX1). The present invention further relates to compounds of formula (I) for use as a medicament and to pharmaceutical compositions comprising said compounds. Further, the present invention relates to compounds of formula (I) and pharmaceutical compositions comprising said compounds for use in the treatment of cancer, such as breast, small cell lung cancer and colorectal cancer, in particular cancers with chromosomal instability, TREX1-mediated autoimmune diseases, inflammatory myocarditis, Aicardi-Goutières syndrome (AGS), familial chilblain lupus (FCL), systemic lupus erythematosus (SLE) and retinal vasculopathy with cerebral leukodystrophy (RVCL).

The present invention relates to compounds of formula 1: # imgabs0 # and their use as STING antagonists, for example, the composition is used for treating diseases selected from the group consisting of systemic lupus erythematosus (SLE), (single and double gene) interferon diseases (including STING-related vascular disease (SAVI), Aicardi-Goutires syndrome (AGS), COPA syndrome and familial chilblain-like lupus, DNASE2 or ATAD3A gene mutated type I interferon disease, age-related macular degeneration (AMD), retinopathy, glaucoma, lupus erythematosus, lupus erythematosus, lupus erythematosus, lupus erythematosus, lupus erythematosus, lupus erythematosus, lupus erythematosus, lupus erythematosus, lupus erythematosus, lupus erythematosus, and lupus erythematosus. Amyotrophic lateral sclerosis (ALS), diabetes, obesity, inflammatory bowel disease (IBD), chronic obstructive pulmonary disease (COPD), Bloom syndrome, sicca syndrome, Parkinson's disease, heart failure and cancer, systemic sclerosis (SSc), dermatomyositis, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), chronic plus acute liver failure (ACLF), interstitial lung disease (ILD), idiopathic pulmonary fibrosis (IPF), and the like. , aging / muscle disease, sepsis, heart failure, rheumatoid arthritis, and osteoarthritis.

The present application belongs to the technical field of dermatosis treatment products, and particularly relates to a soft pelleted medicine and a preparation method thereof. The soft pelleted medicine is prepared from the following raw materials in parts by weight: 20-40 parts of Ramulus cinnamomi, 25-35 parts of Radix astragali, 5-15 parts of Semen persicae, 5-15 parts of Ophiopogon, 5-15 parts of Carthamus tinctorius, 15-30 parts of calcined Radix paeoniae alba, 10-20 parts of Radix angelicae sinensis, 15-30 parts of Radix rehmanniae preparata, 20-40 parts of Radix codonopsis, 5-15 parts of Radix paeoniae alba, 5-10 parts of Ephedra, 5-10 parts of Radix rubiae, 5-15 parts of Centella asiatica, 2-5 parts of Radix et Rhizoma aconiti, 5-10 parts of Salvinia natans, and 5-10 parts of Rhizoma zingiberis. The soft pelleted medicine provided by the present application has the main effects of warming yang and benefiting qi, promoting blood circulation to remove meridian obstruction, dispelling cold and dampness, removing blood stasis and promoting tissue regeneration, and is used for treating dermatosis such as scleroderma, frostbite, Raynaud's disease, skin atrophy, and the like, and particularly has remarkable effects on scleroderma, frostbite, Raynaud's disease, and skin atrophy.

The present invention belongs to the field of surface skin repair and wound treatment, and specifically relates to a new type of wound dressing, a preparation method and application thereof. The preparation method comprises: preparation and preliminary purification of hemoglobin, fine purification of hemoglobin, degassing treatment, virus inactivation, preparation of wound dressing stock solution and preparation of wound dressing. The wound dressing can be used for wound treatment on the skin surface, especially for the treatment of chronic wounds, especially for the treatment of chronic wounds with delayed healing for more than 8 weeks, especially for ulcers caused by basic metabolic diseases such as diabetes, neuropathic or ischemic ulcers, leg venous insufficiency, ulcers caused by external pressure after skin and tissue aging (such as pressure sores, bedsores), second-degree and below burns, frostbite, etc., especially foot ulcers caused by diabetes; it can also be used for scar repair on the skin surface, and can also be used for repairing difficult-to-heal wounds after surgery.

The invention discloses a Vaseline-containing skin care product with the effects of relieving itching and removing chilblain and a preparation method of the Vaseline-containing skin care product, and relates to the technical field of skin care products. Comprising 35%-55% of vaseline, 3%-8% of a bacillus fermentation product, 1%-3% of a mint leaf extract, 2%-5% of a Chinese ilex leaf extract, 0.5%-1.5% of rose essential oil, 4%-10% of an emulsifier, 0.5%-2.5% of a transdermal enhancer and a proper amount of water. The traditional Chinese medicine composition can inhibit the release of histamine, alleviate the inflammatory response of chilblain parts, and improve the prevention and treatment effect of chilblain; moreover, the components are combined together to achieve the effects of diminishing inflammation, removing necrotic tissue and promoting granulation, so that a relatively long storage life can be achieved even if a preservative is not added.

The invention belongs to the technical field of skin disease treatment products, and particularly relates to a soft-skin pill and a preparation method thereof. The soft skin pill is prepared from the following raw materials in parts by weight: 20-40 parts of cassia twig, 25-35 parts of astragalus membranaceus, 5-15 parts of peach kernel, 5-15 parts of garter snake, 5-15 parts of safflower, 15-30 parts of burnt white peony root, 10-20 parts of angelica sinensis, 15-30 parts of prepared rehmannia root, 20-40 parts of codonopsis pilosula, 5-15 parts of prepared radix aconiti lateralis praeparata slice, 5-10 parts of ephedra, 5-10 parts of ground beetle, 5-15 parts of centella asiatica, 2-5 parts of asarum, 5-10 parts of duckweed and 5-10 parts of dried ginger. The skin softening pill provided by the invention has the main effects of warming yang and tonifying qi, promoting blood circulation to remove meridian obstruction, dispelling cold and dampness, removing blood stasis and promoting tissue regeneration, is used for skin diseases such as scleroderma, chilblain, Raynaud's disease and skin atrophy, and particularly has a remarkable curative effect on the scleroderma, the chilblain, the Raynaud's disease and the skin atrophy.

The invention belongs to the technical field of hemorrhoid ointment preparation, and discloses a preparation method of swelling-eliminating and muscle-moistening ointment. The detumescence and muscle moistening paste is prepared from the following components in parts by weight: 50 to 300 parts of radix notoginseng, 80 to 300 parts of radix angelicae sinensis, 30 to 300 parts of radix rehmanniae, 20 to 300 parts of radix scrophulariae, 50 to 300 parts of radix angelicae, 20 to 300 parts of rhizoma bletillae, 30 to 300 parts of radix arnebiae seu lithospermi, 1000 to 3000 parts of sesame oil and 50 to 300 parts of natural beewax. The traditional Chinese medicine has the main effects of clearing intestines, eliminating hemorrhoids, relieving swelling and pain, promoting blood circulation to remove blood stasis, stopping bleeding, nourishing blood, promoting tissue regeneration, removing scars, relieving itching and removing stasis. The traditional Chinese medicine composition is mainly used for treating diseases such as anal swelling and pain, hemorrhoid bleeding and the like, including internal hemorrhoids, external hemorrhoids and mixed hemorrhoids, and also has remarkable curative effects on eliminating other pathological red swelling, pain and itching such as acne, skin trauma, cheilitis, mosquito bites, mild burns and scalds, mild chilblain, eczema, dry skin and the like. Pure natural traditional Chinese medicine plants are selected, active ingredients of the plants are extracted, and no preservative or hormone is added, so that the traditional Chinese medicine composition is safer and more secure when being applied by the majority of people.

The utility model belongs to the technical field of clinical nursing, and particularly relates to a heat preservation earmuff capable of preventing pressure sores, which comprises a muff cylinder sleeved on an ear, the muff cylinder is made of flexible materials, one end of the muff cylinder is an open end, the other end of the muff cylinder is provided with an elastic soft cushion to form a closed end, and a bandage is arranged on the outer side of the open end of the muff cylinder. And the bandage can tighten the opening end of the cover cylinder around the outer side of the opening end of the cover cylinder. The elastic soft cushion is used for buffering and decompressing auricles of the side-lying patient, pressure borne by the auricles of the side-lying patient is reduced, and therefore auricle pressure sores are prevented. When the patient lies on the side, the cover cylinder is stressed and naturally deforms, large pressure cannot be generated on the ear roots, and pressure sores caused by the fact that the pressure on the ear roots is large are avoided. By adjusting the tightening degree of the bandage, a relatively closed space can be formed in the earmuff after tightening, the exchange speed of ear heat and external cold air is reduced, a better heat preservation effect is achieved, and the situation that a patient feels uncomfortable due to chilblain on the ears in the environment with the relatively low room temperature is avoided.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition and application and a preparation method thereof. The traditional Chinese medicine composition is mainly prepared from the following components in parts by weight: 3-35 parts of garden burnet, 2-22 parts of pawpaw, 2-18 parts of radix curcumae, 1-26 parts of radix stephaniae tetrandrae, 2-16 parts of rhizoma atractylodis, 3-13 parts of rhizoma bletillae, 5-23 parts of rhizoma corydalis, 2-20 parts of cortex phellodendri, 1-12 parts of borneol, 25-60 parts of calcined gypsum, 30-70 parts of calamine, 3-18 parts of frankincense, 2-15 parts of myrrh and 2-17 parts of dragon's blood. The traditional Chinese medicine is prepared from the following components in parts by weight: 2-16 parts of hematoxylon, 3-13 parts of rhizoma sparganii, 3-15 parts of notopterygium root, 2-16 parts of pseudo-ginseng and 85-150 parts of sesame oil. The traditional Chinese medicine composition disclosed by the invention is suitable for various long-term non-healing wounds with unknown reasons, such as long-term non-healing wounds caused by postoperative, infection, burn and diabetic foot, and sore and ulcer diseases such as chilblain, ecthyma, bedsore and the like, and has a remarkable curative effect.

The invention belongs to the technical field of daily chemical products, and particularly relates to antibacterial gel and a preparation method thereof.The antibacterial gel is formed by processing main materials and auxiliary materials, and the auxiliary materials comprise, by weight, 50% of deionized water, 10% of cynanchum atratum extract, 10% of wax chrysanthemum extract, 10% of fructus cnidii extract, 5% of mint extract, 5% of purslane extract and 10% of silver ions; the main material is a periplaneta americana extract, and the weight ratio of the main material to the auxiliary material is 3: 100; the product disclosed by the invention has a particularly good effect on vaginitis, colporrhagia, peculiar smell, pruritus and cervical erosion; auxiliary curative effects are achieved on male and female hemorrhoids and male prostate; the wound hemostasis and rapid wound healing effects are obvious; the traditional Chinese medicine composition has a relatively good repairing effect on burns and scalds, red and swollen ulcers, bedsores, chilblain and herpes zoster; the traditional Chinese medicine composition has a good repairing effect on ulcer and ulceration and retina injury caused by diabetic complications.

The present invention relates to the compound of Formula 1 and STING antagonists, for example, systemic lupus erythematosus (SLE), (monogeneic and digeneic) interferon disorders (including STING-associated vascular disorders that develop in infancy (SAVI), Eicardi-Goutier syndrome (AGS), COPA syndrome, and familial chilblain lupus), type 1 interferon disorders with mutations in DNASE2 or ATAD3A genes, age-related macular degeneration (AMD), retinopathy, glaucoma, amyotrophic lateral sclerosis (ALS), diabetes mellitus, obesity, and inflammatory bowel disease. This relates to the use of these as STING antagonists for the treatment of diseases selected from the group consisting of intestinal diseases (IBD), chronic obstructive pulmonary disease (COPD), Bloom syndrome, Sjögren's syndrome, Parkinson's disease, heart failure and cancer, systemic sclerosis (SSc), dermatomyositis, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), acute exacerbation of chronic liver failure (ACLF), interstitial lung disease (ILD), idiopathic pulmonary fibrosis (IPF), age-related / muscle disorders, sepsis, heart failure, rheumatoid arthritis and osteoarthritis. JPEG2026510538000418.jpg45150

The present invention relates to compounds of formula (I). The compounds can be used to antagonize the stimulator of interferon genes (STING) protein and thereby treat liver fibrosis, fatty liver disease, non-alcoholic steatohepatitis (NASH), pulmonary fibrosis, lupus, sepsis, rheumatoid arthritis (RA), type I diabetes, STING-associated vasculopathy of infancy (SAVI), Aicardi-Gutierrez syndrome (AGS), familial chilblain lupus (FCL), systemic lupus erythematosus (SLE), retinal vasculopathy, neuroinflammation, systemic inflammatory response syndrome, pancreatitis, cardiovascular disease, renal fibrosis, stroke and age-related macular degeneration (AMD).