37 results about "Delayed healing" patented technology

The present invention discloses an in-situ osteoplastic active calcium phosphate cement and its preparation process and application. Sodium alginate, collagen, hydrocellulose, polypeptide molecular beam, etc. are used to embed BMP, FGF, TGF-beta and other composite to maintain the activity of bioactive factor. Embedded bioactive factor is made to compound with CPC powder and mix with curing liquid to form paste capable of being moulded at will and self hardened in human body environment and humidity. Inside body, the bioactive factor can induce formation of blood vessel and new bone, formation of active tissue and functional reconstruction. The used CPC cured body may be used as calcium source and phosphorus source for forming new bone and speeding bone tissue formation. The present invention is applied for filling and repairing of bone.

Methods, compounds, compositions, kits and articles of manufacture comprising one or more gap junction modulating agents for treatment of wounds that do not heal at expected rates, including chronic wounds, delayed healing wounds, incompletely healing wounds, and dehiscent wounds in a subject in need thereof.

Connexin modulation for the treatment of wounds that do not heal at expected rates, including delayed healing wounds, incompletely healing wounds, and chronic wounds, and associated methods, compositions and articles.

Connexin modulation for the treatment of wounds that do not heal at expected rates, including delayed healing wounds, incompletely healing wounds, and chronic wounds, and associated methods, compositions and articles.

Methods, compounds, compositions, kits and articles of manufacture comprising one or more gap junction modulating agents for treatment of wounds that do not heal at expected rates, including chronic wounds, delayed healing wounds, incompletely healing wounds, and dehiscent wounds in a subject in need thereof.

The method of treating delayed healing of a wound associated with diabetes includes administering to the wound a composition comprising an anti-senescence compound and a pharmaceutically acceptable carrier. The anti-senescence compound may be 18α-Glycyrrhetinic acid, a Caveolin-1 (Cav-1) inhibitory compound, or a Polymerase I Transcript Release Factor (PTRF-1) inhibitory compound. The anti-senescence compound may be effective in preventing and / or reversing premature cellular senescence. The anti-senescence compound may be effective in promoting healing of a wound, e.g., delayed or incompletely healed wound. The anti-senescence compound may be effective in promoting healing of a delayed healing wound or chronic wound of a diabetic patient, such as a diabetic ulcer or venous ulcer.

The invention discloses a drug-loaded polymer micelle for treating cardiovascular diseases and a preparation method and application thereof, and relates to the technical field of cardiovascular therapy. In particular, the polymer micelle is encapsulated with a novel hydrogen sulfide release aspirin, can be applied to a cardiovascular pathological change environment with a low pH and high oxidativestress environment, has a balanced regulation function on vascular physiology, and can be used for long-acting, sustained-release and targeted treatment of the cardiovascular diseases; in particular,the drug-loaded polymer micelles is expected to reduce or avoid the risks of intravascular restenosis, endothelium delayed healing and late thrombosis.

The invention discloses an external multi-functional ointment for clearing away heat and toxic materials, which is prepared by vaseline, camphor, borneol, menthol and boric acid. The external multi-functional ointment for clearing away the heat and the toxic materials has the functions of promoting the blood circulation, relieving the stasis of blood, dredging the stagnation, restoring the menstrual flow, alleviating pains, changing the blood supply of the periphery of an affected part and enhancing the regeneration of the injured face of a wound. The healing of the wound can be quickly promoted, and the function of growth is also promoted by means of medicines. The external multi-functional ointment for clearing away the heat and the toxic materials has the actions of resisting inflammation, relieving swellings, sterilizing, alleviating pains, relieving itching, clearing away toxic materials, promoting the blood circulation, relieving the stasis of blood, converging and the like. The clinical healing time of the injured face of the wound can be shortened. The external multi-functional ointment for clearing away the heat and the toxic materials also has the characteristic of preventing the occurrence of scars. To various classes of traumas which are not healed for a long time, the healing period can be shortened by 1 / 5, and a traditional concept of healing injury in the sinews or bones after 100 days is broken. The external multi-functional ointment for clearing away the heat and the toxic materials has an obvious curative effect to various classes of traumas or wounds which are not healed after operation, incision infection after operation and wounds with delayed healing and is especially suitable for a patient with traumatic injury. The curative effect is definite, the effect of acting is quick, the stability is strong, the pain of the patient is little, and the expense is low. The external multi-functional ointment for clearing away the heat and the toxic materials has no sequela, anaphylactic reaction and toxic or side effect after healing. The effective rate reaches 99 percent, and the cure rate reaches more than 96 percent.

The invention provides hydrogel with ROS response and a preparation method and application thereof, during preparation, carbodiimide is used as a catalyst, catechol groups are grafted on chitosan macromolecules, and solubility and adhesion of chitosan are improved. Cystamine is used as a cross-linking agent, and amino of cystamine and benzoquinone formed after catechol groups are oxidized are subjected to Michael addition reaction to form a cross-linked network, so that the hydrogel is formed. The invention further discloses the hydrogel with ROS response prepared by the method and application of the hydrogel. The disulfide bond contained in cystamine can be broken and converted into sulfinic acid under the action of active oxygen, so that the structure of the hydrogel is destroyed, the hydrogel can play an intelligent drug release role in an atherosclerosis site where more active oxygen substances are generated, burst release of the drug in a diseased region is avoided, and risks of restenosis in blood vessels, delayed healing of endothelium, advanced thrombus and the like are expected to be reduced.

In general, various embodiments of the present invention comprise an external fixation device, an internal fixation device, and a lower extremity stabilizer. The external fixation device is connected to the lower extremity stabilizer and the external fixation device is adjustably connected to the internal fixation device. The internal fixation device is capable of being attached to at least one bone in a patient's foot, ankle, and / or lower extremity. The system is capable of simultaneously compressing and stabilizing at least one bone for treating Charcot neuroarthropathy, fractures, revisional foot and ankle surgery including but not limited to malunions, nonunions, delayed unions, fibrous unions, avascular necrosis, resected osteomyelitis, incorporated autogenous and / or allogenic bone grafts for arthrodesis procedures, pseudoarthrosis and bones with decreased mineral density and cortical stiffness, and / or the like for any reconstructive and / or elective foot and ankle surgery where a compression arthrodesis is needed. The external fixation device and / or lower extremity stabilizer can be removed after a certain period of time, leaving the internal fixation system within the body for prolonged stabilization and maintenance of the arthrodesis site(s).

The invention relates to blood-activating pain-stopping powder which is prepared from, by weight, 1-5 parts of musk, 1-5 parts of borrneol, 15-25 parts of pangolin, 15-25 parts of Radix notoginseng, 2-6 parts of Huxvomica fruit, 5-15 parts of prepared frankincence and myrrh, 5-15 parts of Herba ephedra, 10-20 parts of Herba asari, 5-15 parts of Radix euphorbiae lantu, 5-15 parts of Radix aconiti, 2-6 parts of lead oxide, 2-6 parts of Ferula assafoetida and 5-15 parts of nidus vespae. The blood-activating pain-stopping powder has the advantages that all raw materials which are selected and used conform to regulations of drug administration laws, comprehensive effect of Chinese medicinal herbs is utilized to treat tendon and bone contracture at late stage of bone fracture, delayed healing of bone fracture or pain, and the blood-activating pain-stopping powder is reasonable in formulation, has efficacy of activating blood, dispersing stasis, relaxing collaterals and stopping pain and is high in dredging ability; the blood-activating pain-stopping powder is short in treatment course, good in effect and free of toxic and side effect when being used for treating.

The invention discloses firstly non-coding RNA for treating delayed healing of diabetic wounds and diabetes-related complications and application of the non-coding RNA. Upon animal experiments, the non-coding RNA disclosed by the invention is proved to be effective on promoting healing of diabetic wounds, and the non-coding RNA is of great significance for the treatment of delayed healing of wounds in patients of diabetes and for the treatment of ulcer, erosion, gangrene and diabetic foot caused by the diabetes.

The invention discloses a screw assembly for bone fixation and a bone fixing device. The screw assembly for bone fixation comprises a non-degradable nut and a degradable absorption screw main body, wherein the nut is detachably connected with one end of the screw main body, and the outer peripheral surface of the screw main body is provided with external threads. The bone fixing device comprises abone fracture plate and the screw assembly, wherein the bone fracture plate is penetrated by a plurality of fixing through holes along the thickness direction of the bone fracture plate; and after ascrew main body of the screw assembly is matched with one fixing through hole, one end, far away from the nut, of the screw main body protrudes out of the bone fracture plate. The inventive screw assembly can be used for bone fixation, has stable mechanical property and low cost, is used for matching with a bone fracture plate to realize bone fixation, and can promote fracture healing and accelerate callus remodeling or remodeling, so that delayed healing or nonhealing of fracture is avoided.

The invention discloses a static power exchange thighbone intramedullary nail, which comprises a nail main body, wherein a coronal plane at the far end of the nail main body is provided with a first sliding lock hole and a third sliding lock hole; a vertical plane at the far end of the nail main body is provided with a second sliding lock hole and a fourth sliding lock hole; the first sliding lock hole, the second sliding lock hole, the third sliding lock hole and the fourth sliding lock hole are long holes; the end part of the long holes are circular-arc-shaped; the third sliding lock hole is longer than the first sliding lock hole; the fourth sliding lock hole is longer than the second sliding lock hole; the vertical plane at the far end of the nail main body is provided with a positioning platform; and the center of the positioning platform is provided with a third static lock hole. Due to the adoption of the static power exchange thighbone intramedullary nail disclosed by the invention, early static fixation of bones can be realized, motorization can be performed in case of delayed healing of bone fractures, static fixation is performed after motorization is performed appropriately, motorization can be performed once again, static fixation is performed after motorization is performed appropriately, and controllable adjustment is performed on dynamic and static fixation, so that rapid healing of bone fractures is facilitated.

The invention discloses a bidirectional adjustable elastic intramedullary nail. The bidirectional adjustable elastic intramedullary nail comprises an intramedullary nail main nail of a hollow structure; the intramedullary nail main nail comprises an intramedullary nail near end and an intramedullary nail body which are of an integrated structure; the diameter of the intramedullary nail near end islarger than the diameter of the intramedullary nail body; a penetrating power screw hole is formed in the intramedullary nail near end; an adjusting hole is formed in the part, away from the intramedullary nail near end, of the intramedullary nail body; a power bone screw is installed in the power screw hole and can move in the axial direction of the power screw hole; a tail cap is installed on the side of the intramedullary nail near end; an elastic body is arranged between the tail cap and the power bone screw; an absorbable gasket is arranged below the power bone screw; the absorbable gasket supports the power bone screw; and an adjusting device for adjusting the stress of the fracture end is arranged on the intramedullary nail body. The stress of the fracture end can be adjusted according to specific situation of fracture, stress shielding of the fracture end is avoided, fracture healing is accelerated, delayed healing and non-healing of the fracture are reduced, and the occurrence rate of re-fracture after intramedullary nail removal is reduced.

The present invention discloses an in-situ osteoplastic active calcium phosphate cement and its preparation process and application. Sodium alginate, collagen, hydrocellulose, polypeptide molecular beam, etc. are used to embed BMP, FGF, TGF-beta and other composite to maintain the activity of bioactive factor. Embedded bioactive factor is made to compound with CPC powder and mix with curing liquid to form paste capable of being moulded at will and self hardened in human body environment and humidity. Inside body, the bioactive factor can induce formation of blood vessel and new bone, formation of active tissue and functional reconstruction. The used CPC cured body may be used as calcium source and phosphorus source for forming new bone and speeding bone tissue formation. The present invention is applied for filling and repairing of bone.

The invention discloses an intestine fistulization device, and relates to the technical field of fistulization devices, theintestine fistulization device comprises a catheter joint, an eduction tube or an ostomy bag, one end of the catheter joint is used for penetrating through a body surface fistulization incision and is respectively in sealed connection with the incision and a port of an intestine, and the other end of the catheter joint is communicated with the eduction tube or the ostomy bag. According to the invention, the fistulization opening and the incision are relatively separated, the incision is conveniently protected, the catheter implanted into the intestinal canal is detachably connected with the ostomy bag or the eduction tube provided with the excretion valve, and therefore the ostomy bag can be conveniently replaced, and excretion of intestinal contents can be conveniently controlled; so that incision infection and delayed healing are avoided, and the surgical risk is reduced.

The invention discloses a multifunctional antiseptic and detersive medicament for external use, which is prepared by phenol, camphor, borneol and alcohol. The medicament has the functions of regulating vital energy, invigorating circulation of blood, removing stasis, sterilizing and callusing and the like, has significant curative effects for various traumas or postoperative recovery and non-healing wounds, and delayed healing of wounds. The invention also has curative effects of preventing and treating otitis media, skin infection, fire burn, pesticide burn, tumours, cancers, syphilis, traumatic injuries, and various non-healing surgical cuts, and is capable of shortening healing time of the wounds, so that healing periods of various long-term non-healing traumas can be shortened by one fifth; furthermore, long-term clinical observation and treatment prove that the multifunctional antiseptic and detersive medicament is more definite in treatment effect, takes effect more instantly, stronger in stability, less in pain of patients and lower in cost; no sequelae, anaphylaxis and toxic and side effects are produced after healing, so that the patients are easy to accept; and the effective rate reaches up to 99% and the cure rate reaches above 96%.

The invention provides an external heat-clearing swelling-diminishing traditional Chinese medicine composition and a using method thereof, and belongs to the technical field of medicines. The composition is prepared from the following raw materials by weight: 12-18g of rheum officinale, 30-40g of moutan bark, 12-18g of scutellaria baicalensis, 30-45g of angelica sinensis, 12-18g of eupolyphaga, 12-18g of earthworm, 30-45g of caulis sinomenii, 20-30g of fructus aurantii immaturus, 12-18g of licorice root, 30-45g of radices trichosanthis, 30-45g of radix bupleuri, 30-45g of rhizoma alismatis, 30-45g of semen plantaginis, 18-24g of peach kernel, 45-54g of salviae miltiorrhizae, 30-45g of rhizoma atractylodis, 90-120g of rhizoma smilacis glabrae, 90-120g of phaseolus calcaratus, 10-20g of borneol and 1500-2000g of sodium sulfate. By means of external application, the traditional Chinese medicine composition is capable of remarkably shortening the interval between bone fracture and an operation, relieving tissue inflammatory response and quickly establishing new blood circulation, so that occurrence of tissue necrosis, infection, cut delayed healing and other complications after the operation can be effectively avoided, pains of patients can be relieved, and the treatment effect of a high-energy tibial plateau fracture operation can be improved.

The invention relates to a recombinant short peptide, and a production method and application thereof. The coding gene of the recombinant short peptide is shown as SEQ ID NO:1, and the recombinant short peptide is obtained by performing codon optimization on an rEGF nucleotide sequence and adding an escherichia coli preference stop codon TAA at the 3' end. The recombinant short peptide is obtainedby inserting the SEQ ID NO:1 between enzyme cutting sites NdeI and XhoI of an expression vector pET-24b to obtain a recombinant expression plasmid, converting the recombinant expression plasmid intoa competent escherichia coli BL21 by a calcium chloride method to obtain a positive bacterium, performing induction expression or fermentation culture, and performing separating and purifying. The recombinant short peptide has good stability at room temperature, and has great advantages in solving symptoms of delayed healing, nonhealing and the like of a wound surface.

The invention discloses a novel adjustable intramedullary nail. The intramedullary nail comprises an intramedullary nail main nail of a hollow structure, and the intramedullary nail main nail comprises an intramedullary nail near end and an intramedullary nail body; the intramedullary nail near end and the intramedullary nail body are of an integrated structure, and the diameter of the intramedullary nail near end is larger than that of the intramedullary nail body. A plurality of through power screw holes are formed in the intramedullary nail near end. An adjusting hole is formed in the portion, away from the near end of the intramedullary nail, of the intramedullary nail body. Power bone screws are installed in the power screw holes and can move in the axial direction of the power screwholes. A tail cap is installed on the side of the intramedullary nail near end, a first elastomer is arranged between the tail cap and one power bone screw, and an absorbable gasket is arranged on thefar side of the power bone screw, and supports the power bone screw. An adjusting device for adjusting the stress of the fracture end is arranged on the intramedullary nail body, and can adjust the stress of the fracture end according to the specific situation of a fracture. Stress shielding of the fracture end is avoided, fracture healing is accelerated, delayed healing and non-healing of the fracture are reduced, and the occurrence rate of re-fracture after the intramedullary nail is removed is reduced.

The invention discloses a top end one-way adjusting type elastic outer fixing support fixing arm, an outer fixing support comprises an adjusting rod, a stress guide rod, a sliding fit thread sleeve, an elastic device, a fixing rod and a fixing structure for fixing the adjusting rod, the outer fixing support further comprises an adjusting device, and the adjusting device pushes the stress guide rod to move in the axial direction of the stress guide rod. The stress guide rod is located in the adjusting rod, one end of the adjusting rod is in sliding connection with the sliding-fit threaded sleeve, the other end of the adjusting rod is provided with an adjusting device in threaded connection with the adjusting rod, and the sliding-fit threaded sleeve is arranged at one end of the fixing rod in a sleeving mode. When a fractured bone is subjected to axial stress, the bone fracture healing device can stimulate generation of callus at a fractured end, avoid osteoporosis caused by stress shielding of the external fixing frame, accelerate fracture healing, increase the strength of healing sclerotin and effectively prevent delayed healing or non-healing of the fracture.

The invention discloses a novel bone transport intramedullary nail. The novel bone transport intramedullary nail comprises a main intramedullary nail; the main intramedullary nail is of a hollow structure and comprises an intramedullary nail near end and an intramedullary nail main body; the intramedullary nail near end and the intramedullary nail main body are of an integrated structure; the diameter of the intramedullary nail near end is larger than that of the intramedullary nail main body; a power screw hole and a static screw hole which are through are formed in the intramedullary nail near end; an adjusting hole is formed in the portion, away from the intramedullary nail near end, of the intramedullary nail main body; a power bone screw is installed in the power screw hole and can move in the axial direction of the power screw hole; a tail cap is installed at the intramedullary nail near end; an elastomer I is arranged between the tail cap and the power bone screw; and a bone transport device for adjusting movement of a fracture end is arranged on the intramedullary nail main body. An elastic device can give stress stimulation to the bone segment, avoid stress shielding, accelerate fracture healing, reduce delayed healing and non-healing of fracture and reduce the occurrence rate of fracture after the intramedullary nail is removed.

The invention discloses a split type pressure regulating steel plate. The split type pressure regulating steel plate comprises a steel plate body, a first pressure regulating device and a second pressure regulating device; the first pressure regulating device is arranged on one side of the steel plate body; the second pressure regulating device is arranged on the other side of the steel plate body; the first pressure regulating device is connected with the second pressure regulating device through a traction rod; pressure regulating screw holes are formed in the steel plate body; bone screws are installed in the pressure adjusting screw holes; and the first pressure adjusting device and the second pressure adjusting device are used for adjusting the radial stress of the bone screws in thepressure adjusting screw holes. The device is easy to fix and convenient to operate. The steel plate body is fixed to a bone by fixing the bone screws in the screw holes, and the radial stress of thebone screws in the pressure adjusting screw holes is adjusted through the pressure adjusting devices in the pressure adjusting holes, so that the axial stress of the fracture end is adjusted and controlled, stress shielding of the fracture end is avoided, fracture healing is accelerated, fracture non-healing and delayed healing are reduced, the occurrence rate of fracture after the steel plate isremoved is reduced, and the fracture healing time is shortened.

The invention discloses a Chinese medicinal composition for treating delayed healing and nonunion of fracture and a preparation method and application thereof. The Chinese medicinal composition is prepared by taking astragalus and codonopsis pilosula as monarchs, taking prepared rehmannia root, dogwood, deer-horn glue, himalayan teasel root and cassia bark as ministers, taking white paeony root, Chinese angelica, ground beetle, suberect spatholobus stem and bitter orange as auxiliary materials and blending the medicinal materials by using liquoric root, wherein astragalus and codonopsis pilosula have the effects of invigorating spleen and tonifying kidney, reinforcing qi and nourishing blood; prepared rehmannia root, dogwood, deer-horn glue, himalayan teasel root and cassia bark have the effects of reinforcing kidney to replenish essence, and regeneration of new bones can be promoted by reinforcing kidney according to the principle of kidney governing bones to generate marrow so as to promote early healing of fracture; white paeony root, Chinese angelica, ground beetle and suberect spatholobus stem have the effects of replenishing and harmonizing blood, dispelling stasis and dredging collaterals, and bitter orange has the effect of promoting the circulation of qi. As proved by clinical test, the Chinese medicinal composition is beneficial to the growth of bones, and an ideal treatment effect on delayed healing and nonunion of fracture is achieved.

The invention discloses a sinew and bone joining pill for treating fracture. The sinew and bone joining pill is prepared by raw materials of frankincense, myrrh, teasel root, ligusticum wallichii, angelica, native copper, pawpaw, dragon's blood, safflower carthamus, processed semen strychni, acacia catechu, cassia twig, eucommia ulmoides, radix achyranthis bidentatae, liquorice, lumbricus, cooked rhubarb, cinnabar and ground beeltle. The sinew and bone joining pill is low in cost, has no toxic side effect, treats both symptoms and root causes, has a special effect for delayed healing of old fracture and mid-late fracture, brings a good news to masses of fracture patients, and is good in economic benefit.

The invention discloses a bone setting plaster and a preparation method thereof. The bone setting plaster comprises traditional Chinese medicine bone setting paste and fresh ginger paste, wherein magnets are arranged in the traditional Chinese medicine bone setting paste which is distributed on non-woven fabric, the upper end of the traditional Chinese medicine bone setting paste is covered with apearlescent protective film A, the fresh ginger paste is distributed on a nonwoven perforated pressure-sensitive adhesive tape, the upper end of the fresh ginger paste is covered with a pearlescent protective film B, the bone setting plaster is sealed in a sealed bag and stored, and the traditional Chinese medicine bone setting paste is prepared from rhizoma drynariae, radix angelicae sinensis, ground beetle and cortex eucommiae. By means of the bone setting plaster, the clinical healing standard can be met in about one month for most fracture patients after operative or manipulative reduction; the bone setting plaster is short in external application time, takes effect quickly, is convenient to use and can also have a healing effect on delayed healing or non-healing of fracture; a few medicines are used but have specific effects, and the medicines are common, low in cost and convenient to produce massively; the traditional Chinese medicine bone setting paste and the fresh ginger paste are sealed and stored separately, the fresh ginger paste is not needed to prepare for instant use and is convenient to use; the magnets are arranged and can promote blood circulation, alleviate swelling and relieve pain.