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Application of indinavir in preparing anti-malarial medicine

A technology of indinavir and medicine, which is applied in the application field of medicine or pharmaceutical composition, can solve the problems of not inhibiting malaria parasites, reducing the peak of malaria parasite infection, unsatisfactory results, etc.

Inactive Publication Date: 2007-12-12
GUANGZHOU INST OF BIOMEDICINE & HEALTH CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In 2004 and 2005, some scholars found that some protease inhibitors could inhibit the growth of Plasmodium in the Plasmodium cultured in vitro, and carried out drug experiments of Saquinavir, Ritonavir and lopinavir in the mouse malaria model, but the results were not satisfactory
Except for Ritonavir and Ritonavir / lopinavir combination, which partially reduced the peak of Plasmodium infection, other drugs did not inhibit Plasmodium

Method used

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  • Application of indinavir in preparing anti-malarial medicine
  • Application of indinavir in preparing anti-malarial medicine
  • Application of indinavir in preparing anti-malarial medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0013] 12 rhesus monkeys aged 3-5 were inoculated intravenously for 10 7 After cynomolgus monkeys had Plasmodium parasites, they were randomly divided into 4 groups, namely Indinavir (240mg / kg / d q8h), Indinavir (120mg / kg / d q8h), Indinavir (60mg / kg / d q8h) and negative control group (nasal feeding physiological saline). The treatment was started when the infection rate of Plasmodium reached 1%, and the treatment was continued for 7 days. Blood smears were prepared daily, and the infection rate of red blood cells was counted. The blood test for 3 consecutive days was negative for Plasmodium. Compared with the control group, the density of protozoa after treatment, the time of protozoa turning negative, the number of red blood cells and the change of body temperature were used for evaluation.

[0014] result:

[0015] 1. Erythrocyte infection rate: The results of Plasmodium erythrocyte infection rate before and after treatment are shown in Figure 2:

[0016] 120mg / kg / d and 240...

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Abstract

The invention relates to application of indinavir in preparing medicament or medicinal composition for treating malaria. The application comprises establishing monkey model with malaria infection, treating with Indinavir dripfeed administeration, detecting infection rate of plasmodium red blood cell through blood smear, comparing with negative control group, getting indicator such as parasite density, parasite clearance time, red-cell count and temperature, detecting therapeutic action and effective therapeutic dose of Indinavir to monkey malaria infection. Effective dose of indinavir for treating human malaria is no less than 20mg / kg / d according to equivalent dose converting equation of different genus animals. The invention provides new target spot and research direction for exploiting antiperiodic, and settles foundation for discussing combined application of indinavir and other antiperiodic.

Description

[technical field] [0001] The present invention relates to a new application of protease inhibitor. Specifically, the present invention relates to the application of indinavir (Indinavir) in the preparation of medicine or pharmaceutical composition for treating malaria. [Background technique] [0002] Malaria is currently the main parasitic disease in developing countries, causing serious harm. However, at present, Plasmodium has developed resistance to most traditional antimalarial drugs, and the cross-resistance of similar drugs has made this problem more serious, and has become the main cause of morbidity and death after malaria infection. The selective pressure of drugs and the movement of parasite populations make Plasmodium parasites resistant to any drug, which directly leads to the demand for new drugs for the prevention and treatment of malaria. Therefore, the development of new antimalarial drugs has received renewed attention. [0003] Protease inhibitors are a c...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61P33/06
CPCY02A50/30
Inventor 陈小平秦莉彭南政阮志燕刘广杰陆靖高宁张海翔
Owner GUANGZHOU INST OF BIOMEDICINE & HEALTH CHINESE ACAD OF SCI
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