The invention discloses a compound essential oil having functions of refreshing spirit, restoring consciousness and resisting fatigue, and a wet tissue containing the same. The compound essential oil is prepared by the following raw materials in parts by weight: 20-50 parts of peppermint camphor, 0.5-2 parts of Ylang Ylang flower oil, 15-25 parts of lavender oil, 3-10 parts of rosemary leaf oil, 20-30 parts of sweet orange oil, 15-25 parts of eucalyptol, 20-40 parts of lemon leaf oil, 0.1-0.2 part of peppermint oil, 20-50 parts of clove oil and 30-55 parts of spearmint oil. The invention adopts pure natural plant ingredients, utilizes the characteristics of various aromatic plant active ingredients, such as strong seepage force, high dissolubility and the like, functions in virtue of skins, channels and collaterals, and acupuncture points for seepage and absorption, has obvious curing effect, is suitable for curing various apocamnosis such as eyestrain, brain fatigue, physical fatigue, dizziness, lassitude, sleepiness, strength lacking and the like, has extremely good effect in refreshing spirit, restoring consciousness, relaxing nervus, eliminating dysthesia, stabilizing sentiment and strengthening stamina.