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Mosquito-repelling and itching-relieving cream

A technology for repelling mosquitoes and relieving itching, which can be applied to plant raw materials, cosmetics, organic active ingredients, etc., and can solve problems such as human harm

Inactive Publication Date: 2012-05-09
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Most of the above products contain pyrethrum, pyrethroids and other raw materials that are toxic and irritating to humans. After direct contact with the human body, they are harmful to the human body.

Method used

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  • Mosquito-repelling and itching-relieving cream

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 Therapeutic effect of mosquito repellent and antipruritic cream on mouse mosquito bite reaction

[0019] 1 Materials and methods

[0020] 1.1 Animals: white mice, provided by the Experimental Animal Center of the Academy of Military Medical Sciences, two genders, weighing 28-35g. Aedes albopictus, wild, bred and reared by our laboratory.

[0021] 1.2 Experimental method:

[0022] The artificially propagated mature Aedes albopictus was placed in a nylon wire mesh cage with a size of 20×20×20 cm. Only water was supplied in the cage and food was provided. Remove the hair from the abdomen of the mice, and fix them in pairs on the outer wall of the cage. The hair-removed part of the abdomen is close to the cage wall for mosquitoes to bite. It was removed after one hour, and Evans blue was injected into the tail vein. 10 rats were the experimental group, which were coated with 0.1ml of mosquito repellent and antipruritic cream, and the other 10 rats were the con...

Embodiment 2

[0028] Example 2 Observation on Mosquito Repellent Effect of Antipruritic Mosquito Repellent Cream Laboratory

[0029] 1. Materials and methods

[0030] 1.1 Materials Mosquito repellent and antipruritic cream, self-made by our unit (4g / tube)

[0031] 1.2 Experimental animals Male SD rats were provided by the Experimental Animal Center of Academy of Military Medical Sciences.

[0032] 1.3 The test insect, Aedes albopictus, was a non-blood-sucking female adult 4-5 days after eclosion was bred in this laboratory.

[0033] 1.4 Method

[0034] 1.4.1 Test conditions The test temperature is (26±1)°C; the relative humidity is 65%±5%.

[0035] 1.4.2 Aggression test Put 100 test insects in a 20cm×20cm×20cm mosquito cage, cut off the 2cm×2cm hair on the abdomen of the rat to expose the epidermis. After fixing the rat, put it into the mosquito cage for 5 minutes, if more than 20 test insects come to land, the attack power is qualified, and the rat and the mosquito in the cage can be u...

Embodiment 3

[0040] Example 3 Toxicological Test of Mosquito Repellent and Antipruritic Cream

[0041] 1. Materials and methods

[0042] 1.1 Materials Mosquito repellent and antipruritic cream, self-made by our unit (4g / tube)

[0043] 1.2 Experimental animals White mice were provided by the Experimental Animal Center of the Academy of Military Medical Sciences.

[0044] 1.3 Method

[0045] The skin irritation was measured by mouse ear-shell reaction weighing method, and the experimental design was self-control. That is, one side of the ear shell of the mouse was coated with medicine, once a day, 0.1ml each time, for 10 consecutive days; the opposite ear of the same mouse was used as the control group and no medicine was applied. On the 11th day, take bilateral ear shells with a diameter of 8mm, weigh them, and observe the effect.

[0046] 2. Results

[0047] Results of mouse ear shell irritation test

[0048]

[0049] The results of the experiment showed that the mosquito repellen...

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Abstract

The invention relates to a mosquito-repelling and itching-relieving cream and discloses a mosquito-repelling and itching-relieving cream which is prepared from natural herbaceous plant extracts, antistine hydrochloride and dyclonine hydrochloride and has the effects of repelling mosquitos and relieving itching. The prescription of the mosquito-repelling and itching-relieving cream comprises the following main ingredients: a combination of any medicines, such as 1-25 percent of antistine hydrochloride, 0.2-15 percent of dyclonine hydrochloride and 6-8 percent of menthol, 3-5 percent of eucalyptus oil, as well as 3-5 percent of camphor and 0.2-0.6 percent of clove basil oil, and 60-80 percent of matrix. The matrix consists of the following components: 10 percent of anhydrous lanolin, 60 percent of albolene and 30 percent of cera alba. The mosquito-repelling and itching-relieving cream is an external preparation prepared from the pure natural herbaceous plant extracts, the antistine hydrochloride and the dyclonine hydrochloride, has the functions of repelling mosquitos and relieving items, refreshing spirit and restoring consciousness and protecting the skin from mosquito bite, has no any toxic and side effects to the body and is safe and reliable to use.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a medicament prepared from natural herbal plant extracts, antacin hydrochloride and dyclonine hydrochloride, belonging to an external cream for repelling mosquitoes and relieving itching. Background technique [0002] Mosquitoes bring a lot of harassment and harm to humans in summer and autumn. Mosquitoes are the vectors of many infectious diseases, such as yellow fever, malaria, Japanese encephalitis, and dengue fever. In addition to transmitting diseases, mosquitoes can also not be ignored for their blood-sucking and harassment effects on people. According to the statistics of the World Health Organization, there are 300-500 million malaria cases and 3-5 million deaths in the world every year, and tens of millions of dengue fever cases every year. In my country, 30,000 to 50,000 malaria cases are reported every year. There have been uninterrupted reports of malaria...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/61A61K9/06A61K47/44A61K8/97A61P17/04A61Q17/02A61K31/045A61K31/125A61K31/417A61K31/4453
Inventor 刘屏穆丽华舒锦荣郭代红胡园魏宇宁裴保香
Owner GENERAL HOSPITAL OF PLA
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