19 results about "Callicarpa nudiflora" patented technology

The invention provides a production process, a product and application of callicarpa nudiflora granules, and belongs to the technical field of traditional Chinese medicine preparations. The production process of the callicarpa nudiflora comprises the following steps: S1, decocting callicarpa nudiflora with water, filtering, concentrating filtrate to obtain thick paste, and drying the thick paste to obtain dry callicarpa nudiflora extract; s2, mixing the callicarpa nudiflora dry extract obtained in the step S1 with auxiliary materials, granulating, and drying to obtain callicarpa nudiflora granules; wherein in the step S1, the filtration comprises screen filtration and ceramic membrane filtration, and the filtrate concentration comprises membrane concentration and vacuum concentration. Compared with the prior art, the process has the advantages that the energy consumption is effectively reduced and the production cost is reduced on the basis of ensuring that the solid content, the effective component content and the product quality of the product are not influenced.

The invention relates to the technical field of natural medicinal chemistry, and particularly discloses a compound, a preparation method thereof and application of the compound in preparation of a medicine with an anti-inflammatory effect. The compound has a structure as shown in a formula I; researches show that the compound with the structure as shown in the formula I has a very excellent anti-inflammatory effect; the anti-inflammatory effect is obviously higher than that of a positive control drug dexamethasone; therefore, when being used as an active ingredient for preparing the medicine with the anti-inflammatory effect, the compound has an important application prospect. In addition, the callicarpa nudiflora stems and leaves are used as raw materials for the first time, and the compound with the structure shown in the formula I is prepared from the callicarpa nudiflora stems and leaves by adopting a multi-chromatography technology; a brand-new preparation method is provided for the compound with the structure as shown in the formula I.

The invention provides a functional feed additive for improving the quality of tilapia mossambica. The functional feed additive comprises the following raw materials: hydrolyzed fish meal, fermented soybean meal, insect protein powder, fish soluble, callicarpa nudiflora powder, fish oil, polysaccharide, an intestine regulating agent and vitamins. The preparation method of the hydrolyzed fish meal comprises the following steps: crushing fish, adding a Na2CO3 solution for rinsing, performing high-temperature and high-pressure squeezing for degreasing, adding a mixed enzyme solution for enzymolysis, performing enzyme deactivation for 2-3 times, performing centrifugal separation, concentrating, drying, crushing and sieving. Wherein the polysaccharide is fucoidin and trametes robiniophila polysaccharide, and the intestine regulating agent is lactobacillus rhamnosus powder and lactobacillus kefir powder. The feed additive is balanced in formula nutrition, improves the quality of tilapia mossambica, reduces intestinal diseases of tilapia mossambica, and has application value.

The invention provides a method for simultaneously detecting multiple components in a callicarpa nudiflora medicinal material. Specifically, the invention provides the detection method for the callicarpa nudiflora medicinal material based on an ultra-high performance liquid chromatography-tandem triple quadrupole mass spectrometer, the target components detected by the method comprise geniposidic acid, decaffeoyl verbascoside, caffeic acid, cistanche glycoside F, protocatechuic aldehyde, ferulic acid, luteoloside, verbascoside, isoverbascoside, 2-acetyl eugenol glycoside and luteolin. The method disclosed by the invention can be used for accurately, quickly and comprehensively detecting and evaluating the quality of the callicarpa nudiflora medicinal material.

The invention discloses a method for simultaneously determining various effective components in callicarpa nudiflora through UPLC-UV (Ultra Performance Liquid Chromatography-Ultraviolet). The method comprises the following steps: (1) preparing a reference substance solution; (2) preparing a test solution; and (3) carrying out UPLC-UV detection. The method is easy and convenient to operate, high in sensitivity, good in precision and good in reproducibility, and the quality stability and the clinical curative effect of the callicarpa nudiflora and the product can be guaranteed.

The invention provides an external traditional Chinese medicine composition for promoting healing of chronic refractory wounds as well as a preparation method and application of the external traditional Chinese medicine composition. The composition is prepared from water-soluble lignin extracted from callicarpa nudiflora stems and callicarpa nudiflora leaf water extract in a weight ratio of (1-3): (1-3). The preparation method comprises the following steps: extracting water-soluble lignin from callicarpa nudiflora stems; effective components are extracted from the callicarpa nudiflora leaves through water decoction; and finally, mixing the two with pharmaceutical auxiliary materials to prepare external preparations such as gel and the like. The composition disclosed by the invention gives full play to the anti-oxidation and repair promotion capabilities of the water-soluble lignin and the traditional effects of clearing away heat and toxic materials and astringing to stop bleeding of the callicarpa nudiflora, and has a multi-target synergistic effect. Animal experiments show that the composition can obviously accelerate the healing of chronic refractory wounds, the curative effect is definite, the preparation process is stable, the safety is high, and a new effective medicine is provided for solving the problem of chronic wound healing.

The present invention provides a silage additive, functional silage, and a preparation method and application, which belong to the technical field of animal husbandry feed. The present invention provides a silage additive, comprising: Morinda officinalis, Achyranthes bidentata, Callicarpa nudiflora and Blumea balsamifera. The Chinese herbal medicines of Morinda officinalis, Achyranthes bidentata, Callicarpa nudiflora and Blumea balsamifera described in the present invention are rich in bioactive ingredients, have antibacterial and antimicrobial effects, antioxidant effects, etc., and as silage additives, can significantly improve the quality of silage fermentation, increase the lactic acid content of silage, reduce the content of acetic acid, propionic acid and butyric acid in silage, reduce the pH value, and improve the microbial community structure of silage. In addition, the Morinda officinalis described in the present invention has the effects of promoting kidney yang and treating infertility, and Achyranthes bidentata has the effects of promoting blood circulation, unblocking menstruation, and nourishing the liver and kidneys. The silage prepared by fermenting silage raw materials using the silage additive containing Morinda officinalis and Achyranthes bidentata provided by the present invention can significantly improve the production performance and reproductive performance of animals, thereby improving the efficiency of the breeding industry.

The present invention provides SSR molecular markers for Callicarpa nudiflora, core primer pairs, kits, and applications thereof, belonging to the field of molecular biology technology. The present invention develops and screens 14 pairs of SSR molecular marker primers with excellent amplification effects and high polymorphism from the transcriptome sequence of Callicarpa nudiflora. These SSR molecular marker primers can be used to evaluate the genetic diversity of Callicarpa nudiflora germplasm resources, perform cluster analysis, construct SSR fingerprints, and perform molecular-assisted breeding. These markers are of great significance for subsequent Callicarpa nudiflora germplasm resource management, breeding, genetic conservation, and genetic diversity analysis between and within populations.

The application provides a feed additive suitable for Danzhou chicken and a preparation method thereof, which comprises a Callicarpa nudiflora complex, a wine lees fermentation extract and an eleocharis tuberose peel; the wine lees fermentation extract is obtained by fermenting wheat flour and egg white powder with sweet wine lees, and then performing enzymatic dissolution with protease and glucanase, and then concentrating and drying; the feed additive suitable for Danzhou chicken is prepared from the Callicarpa nudiflora complex, the wine lees fermentation extract and the eleocharis tuberose peel; the feeding test proves that the Callicarpa nudiflora complex, the wine lees fermentation extract and the eleocharis tuberose peel have a good promoting effect on the production performance of Danzhou chicken, effectively improve the feed conversion rate, and reduce the mortality rate; and the inhibition rates of the Callicarpa nudiflora complex, the wine lees fermentation extract and the eleocharis tuberose peel on six kinds of bacteria, including Salmonella enteritidis, Salmonella typhi, Staphylococcus aureus, Escherichia coli, Listeria monocytogenes and Proteus mirabilis, are all above 90%.

The invention discloses callicarpa nudiflora-derived extracellular vesicle-loaded inulin gel as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The gel comprises callicarpa nudiflora derived extracellular vesicles (EVLP), an inulin gel matrix and zinc ions. The preparation method is characterized in that inulin gel with colon targeting is prepared through a heating-cooling method, EVLP is encapsulated, and zinc ions are loaded. Through oral administration, the medicine is accurately released at an inflammation part by utilizing colon targeting property of the inulin gel, and multiple effects of resisting inflammation and oxidation of EVLP, regulating intestinal flora by inulin and enhancing inflammation resistance and repairing a barrier by zinc ions are synergistically exerted. The gel improves drug targeting, prolongs local residence time, and can treat ulcerative colitis with high efficiency and low side effect.

This invention provides an apremilast-loaded hydrogel of *Callicarpa nudiflora* vesicles, its preparation method, and its application, relating to the field of pharmaceutical formulation technology. This invention utilizes *Callicarpa nudiflora* vesicles to encapsulate apremilast and then reconstitute it into a hydrogel, preparing a drug that can be directly applied to the affected skin of psoriasis patients via local transdermal administration. The hydrogel achieves synergistic treatment of psoriasis through apremilast and *Callicarpa nudiflora* vesicles, improving efficacy.

The invention belongs to the technical field of medicines for burns and scalds, and particularly relates to a spray for burns and scalds and a preparation method thereof, the spray for burns and scalds comprises pollen typhae, herba cepbalanoplosis segeti, callicarpa nudiflora, humifuse euphorbia herb, verbena, herba seu stipulae, lalang grass rhizome, a natural astringent, azone, bisabolol and a plant extract. The preparation method comprises the following steps: removing impurities from the herba cepbalanoplosis segeti, callicarpa nudiflora, humifuse euphorbia herb, verbena officinalis, herba seu stigmae draconis and lalang grass rhizome, cleaning, drying and crushing, cleaning and drying the pollen typhae, and soaking the pollen typhae in alcohol; filtering to obtain a liquid medicine, adding borneol into the liquid medicine, then adding glycerol, azone, a plant extract, bisabolol and a natural astringent, and diluting the alcohol concentration in the liquid medicine with sterile distilled water; the spray for burns and scalds provided by the invention can timely treat wound surfaces and quickly stop bleeding, and has the characteristics of safety, no irritation, economy, convenience, natural healing, no scars and the like.

The invention provides application of combination of callicarpa nudiflora particles and lactobacillus reuteri in preparation of a medicine for treating ulcerative colitis, and belongs to the technical field of traditional Chinese medicines. The invention finds that the combined use of callicarpa nudiflora particles and lactobacillus reuteri has a synergistic effect on improvement of enteritis symptoms of mice, the disease activity index of the mice is reduced, the colon shortening degree is relieved, the score of pathological sections is reduced, and the bile acid metabolic disorder and immune cell imbalance tend to be normal, so that the treatment purpose is achieved.

The invention relates to the technical field of biological prevention and control of invasive plants, in particular to a preparation and method for inhibiting growth of mikania micrantha, and the method comprises the following steps: obtaining freeze-dried powder of a callicarpa nudiflora leaf extract; preparing a water-soluble reagent of freeze-dried powder of the callicarpa nudiflora leaf extract; the water-soluble reagent is sprayed and applied to mikania micrantha plants. The callicarpa nudiflora leaf extract freeze-dried powder is relatively simple in preparation process, relatively low in cost, easy to store, capable of effectively inhibiting growth of mikania micrantha, free of the problem of drug resistance like chemical agents, environmentally friendly, free of damage to soil and ecological systems and capable of meeting the requirement of sustainable development; the callicarpa nudiflora leaf extract reagent is sprayed in January to February and April to May every year, staged precise prevention and control of the seed germination stage and the stem node adventitious root growth stage of the mikania micrantha can be achieved, and the reproduction rate of the mikania micrantha is reduced more efficiently.

This invention discloses a β-glucan-based medical aesthetic essence with barrier repair function, belonging to the field of cosmetic technology. The invention first encapsulates fibronectin with β-glucan, then uses a heat-sensitive membrane for secondary encapsulation, allowing for sustained release of active ingredients through heat application and increasing transepidermal absorption. β-glucan, fibronectin, and *Callicarpa nudiflora* extract work synergistically for triple anti-inflammatory repair, reducing transepidermal water loss and providing long-term repair effects.

The invention belongs to the field of medicines, and particularly relates to a diterpenoid compound for inhibiting NLRP3 inflammasome and application of the diterpenoid compound. A new compound separated from callicarpa nudiflora is identified to belong to diterpenoids. Cell experiments show that the compound can significantly inhibit the expression in LPS-induced human monocyte line THP-1 derived macrophage NLRP3 inflammasome, and also has a significant inhibition effect on the expression of IL-1beta and IL-18 at the same time. The results show that the compound has remarkable anti-inflammatory activity, provides a candidate compound for research and development of anti-inflammatory drugs, and particularly has important potential application value in treatment of skin wound inflammatory diseases such as skin wound healing, diseases accompanied with inflammation or pathological processes.

The invention discloses a callicarpa nudiflora extract as well as a preparation method and application thereof, and relates to the technical field of traditional Chinese medicine extraction. The extract is prepared from cistanche glycoside D, rehmannia and cosmosiin. Compared with the prior art, the obtained callicarpa nudiflora extract has the advantages that the components are clear, the use safety is greatly improved, the synergistic anti-inflammatory effect is achieved, the anti-inflammatory effect is good, and the callicarpa nudiflora extract has a good application prospect.

The invention belongs to the technical field of skin care products, and particularly relates to an oil control composition as well as a preparation method and application thereof. The oil control composition is prepared by compounding a dracocephalum integrifolium extract and a callicarpa nudiflora extract. The dracocephalum chinense extract is extracted through a deep-eutectic solvent in cooperation with an ultrasonic-microwave process, and the callicarpa nudiflora extract is extracted through an enzymolysis-supercritical CO2 microencapsulation process. Oil control is realized through a double-target mechanism, including blocking of SREBP-1 nuclear translocation, down-regulation of PPAR gamma and the like, in cooperation with the two. The composition can be applied to oil-control cosmetics such as essence and emulsion, the process is efficient and stable, and a safe and multi-effect solution is provided for oily skin care.

The present invention provides a traditional Chinese medicine composition for hemorrhoids, its fumigation powder and application. A traditional Chinese medicine composition for hemorrhoids is composed of the following raw materials: Bauhinia championii (Benth.) Benth., Callicarpa nudiflora Hook. et Arn., Momordica cochinchinensis (Lour.) Spreng., Melicope pteleifolia (Champ. ex Benth.) T. G. Hartley. The mass ratio of Bauhinia championii (Benth.) Benth., Callicarpa nudiflora Hook. et Arn., Momordica cochinchinensis (Lour.) Spreng., Melicope pteleifolia (Champ. ex Benth.) T. G. Hartley is 25-35:25-35:25-35:25-35. The present invention adopts scientific formula with Bauhinia championii (Benth.) Benth., Callicarpa nudiflora Hook. et Arn., Momordica cochinchinensis (Lour.) Spreng., Melicope pteleifolia (Champ. ex Benth.) T. G. Hartley. Taking Bauhinia championii (Benth.) Benth. as the monarch drug to dispel wind and dampness, promote qi and activate blood circulation; taking Callicarpa nudiflora Hook. et Arn. as the minister drug to disperse stasis and stop bleeding, detoxify and reduce swelling; Momordica cochinchinensis (Lour.) Spreng. has the effects of dissipating binds and reducing swelling, attacking toxins and treating sores, serving as the assistant drug; Melicope pteleifolia (Champ. ex Benth.) T. G. Hartley clearing heat, detoxifying, dispelling wind and dampness serves as the messenger drug; the whole formula synergistically enhances the effect, has definite curative effect on the wound healing after operation of patients with mixed hemorrhoids, can significantly improve the relevant traditional Chinese medicine syndromes, reduce the pain of patients, also has a significant improvement on the anorectal function, shortens the cure time, so it is worthy of promotion in clinical practice.