8 results about "Callicarpa nudiflora" patented technology

The invention discloses a method for simultaneously determining various effective components in callicarpa nudiflora through UPLC-UV (Ultra Performance Liquid Chromatography-Ultraviolet). The method comprises the following steps: (1) preparing a reference substance solution; (2) preparing a test solution; and (3) carrying out UPLC-UV detection. The method is easy and convenient to operate, high in sensitivity, good in precision and good in reproducibility, and the quality stability and the clinical curative effect of the callicarpa nudiflora and the product can be guaranteed.

The invention provides an external traditional Chinese medicine composition for promoting healing of chronic refractory wounds as well as a preparation method and application of the external traditional Chinese medicine composition. The composition is prepared from water-soluble lignin extracted from callicarpa nudiflora stems and callicarpa nudiflora leaf water extract in a weight ratio of (1-3): (1-3). The preparation method comprises the following steps: extracting water-soluble lignin from callicarpa nudiflora stems; effective components are extracted from the callicarpa nudiflora leaves through water decoction; and finally, mixing the two with pharmaceutical auxiliary materials to prepare external preparations such as gel and the like. The composition disclosed by the invention gives full play to the anti-oxidation and repair promotion capabilities of the water-soluble lignin and the traditional effects of clearing away heat and toxic materials and astringing to stop bleeding of the callicarpa nudiflora, and has a multi-target synergistic effect. Animal experiments show that the composition can obviously accelerate the healing of chronic refractory wounds, the curative effect is definite, the preparation process is stable, the safety is high, and a new effective medicine is provided for solving the problem of chronic wound healing.

The invention discloses callicarpa nudiflora-derived extracellular vesicle-loaded inulin gel as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The gel comprises callicarpa nudiflora derived extracellular vesicles (EVLP), an inulin gel matrix and zinc ions. The preparation method is characterized in that inulin gel with colon targeting is prepared through a heating-cooling method, EVLP is encapsulated, and zinc ions are loaded. Through oral administration, the medicine is accurately released at an inflammation part by utilizing colon targeting property of the inulin gel, and multiple effects of resisting inflammation and oxidation of EVLP, regulating intestinal flora by inulin and enhancing inflammation resistance and repairing a barrier by zinc ions are synergistically exerted. The gel improves drug targeting, prolongs local residence time, and can treat ulcerative colitis with high efficiency and low side effect.

This invention provides an apremilast-loaded hydrogel of *Callicarpa nudiflora* vesicles, its preparation method, and its application, relating to the field of pharmaceutical formulation technology. This invention utilizes *Callicarpa nudiflora* vesicles to encapsulate apremilast and then reconstitute it into a hydrogel, preparing a drug that can be directly applied to the affected skin of psoriasis patients via local transdermal administration. The hydrogel achieves synergistic treatment of psoriasis through apremilast and *Callicarpa nudiflora* vesicles, improving efficacy.

The invention belongs to the technical field of medicines for burns and scalds, and particularly relates to a spray for burns and scalds and a preparation method thereof, the spray for burns and scalds comprises pollen typhae, herba cepbalanoplosis segeti, callicarpa nudiflora, humifuse euphorbia herb, verbena, herba seu stipulae, lalang grass rhizome, a natural astringent, azone, bisabolol and a plant extract. The preparation method comprises the following steps: removing impurities from the herba cepbalanoplosis segeti, callicarpa nudiflora, humifuse euphorbia herb, verbena officinalis, herba seu stigmae draconis and lalang grass rhizome, cleaning, drying and crushing, cleaning and drying the pollen typhae, and soaking the pollen typhae in alcohol; filtering to obtain a liquid medicine, adding borneol into the liquid medicine, then adding glycerol, azone, a plant extract, bisabolol and a natural astringent, and diluting the alcohol concentration in the liquid medicine with sterile distilled water; the spray for burns and scalds provided by the invention can timely treat wound surfaces and quickly stop bleeding, and has the characteristics of safety, no irritation, economy, convenience, natural healing, no scars and the like.

The invention provides application of combination of callicarpa nudiflora particles and lactobacillus reuteri in preparation of a medicine for treating ulcerative colitis, and belongs to the technical field of traditional Chinese medicines. The invention finds that the combined use of callicarpa nudiflora particles and lactobacillus reuteri has a synergistic effect on improvement of enteritis symptoms of mice, the disease activity index of the mice is reduced, the colon shortening degree is relieved, the score of pathological sections is reduced, and the bile acid metabolic disorder and immune cell imbalance tend to be normal, so that the treatment purpose is achieved.

This invention discloses a β-glucan-based medical aesthetic essence with barrier repair function, belonging to the field of cosmetic technology. The invention first encapsulates fibronectin with β-glucan, then uses a heat-sensitive membrane for secondary encapsulation, allowing for sustained release of active ingredients through heat application and increasing transepidermal absorption. β-glucan, fibronectin, and *Callicarpa nudiflora* extract work synergistically for triple anti-inflammatory repair, reducing transepidermal water loss and providing long-term repair effects.

The invention belongs to the field of medicines, and particularly relates to a diterpenoid compound for inhibiting NLRP3 inflammasome and application of the diterpenoid compound. A new compound separated from callicarpa nudiflora is identified to belong to diterpenoids. Cell experiments show that the compound can significantly inhibit the expression in LPS-induced human monocyte line THP-1 derived macrophage NLRP3 inflammasome, and also has a significant inhibition effect on the expression of IL-1beta and IL-18 at the same time. The results show that the compound has remarkable anti-inflammatory activity, provides a candidate compound for research and development of anti-inflammatory drugs, and particularly has important potential application value in treatment of skin wound inflammatory diseases such as skin wound healing, diseases accompanied with inflammation or pathological processes.