60 results about "Geniposidic acid" patented technology

The invention discloses a method for extracting active sites of iridoid, and extracting monomer geniposidic acid (GPA), geniposide(GP) and aucubin(AU) from eucommia, wherein raw materials are extracted by taking the eucommia(husk, leaf or seed) as materials and utilizing the conventional leaching method, the ultrasonic extraction method or the microwave extraction method, and an extracting solution is preliminarily purified by methods such as the solvent extraction and the adsorption separation of special adsorbents, etc., and thus the active sites of the iridoid(the total content of the iridoid is no less than 50 percent) is obtained, and GPA, GP and AU undergo the separation, low temperature condensation, refrigeration and drying by using the preparation high pass filter technique and taking an alcohol-water solution as the mobile phase to obtain monomers of GPA, GP and AU, contents of which are all no less than 90 percent. The preparation method disclosed by the invention utilizes novel process of the extraction and separation, and can simultaneously prepare a plurality of monomer products of the eucommia, and provides scientific foundations for the comprehensive development and utilization of the eucommia; moreover, the whole process does not use solvents harmful to human bodies, thereby realizing the green preparation.

The present invention relates to a drug-loaded biodegradable stent and methods for treating vulnerable plaques of a patient comprising a plurality of layers or zones, each layer or zone comprising its own specific biodegradation rate and its specific drug loading characteristics. In one embodiment, the layers and zones are configured and arranged, in combination, radially, circumferentially and longitudinally.

The invention discloses a folium cortex eucommiae extract which is a water extract or an ethanol extract of folium cortex eucommiae. The folium cortex eucommiae extract contains no less than 9% of chlorogenic acid, no less than 1% of geniposidic acid and no less than 1% of aucubin. Furthermore, the invention also provides a preparation method and an application of the folium cortex eucommiae extract. The folium cortex eucommiae extract, as a traditional Chinese medicine extract, is low in side effect, capable of being used for a long term, free from toxic and side effects to organisms, safe and effective, capable of improving the life quality of patients and having a significant curative effect on psoriasis; and therefore, the folium cortex eucommiae extract has a broad application prospect in treating psoriasis.

The invention discloses a fructus gardeniae standard substance and a fructus gardeniae analog extracted from traditional Chinese medicine fructus and the preparation methods thereof. The fructus gardeniae analog consists essentially of fructus gardeniae, iso-fructus-gardeniae, dehydroxy fructus gardeniae (geniposide), geniposidic gentiobiose glycoside, wild fructus gardeniae, gardeniae ketoside; scandoside formate, deacetylasperuloside, geniposidic acid, 10-O-acetyl geniposidic glocoside, 6-para-cormaroyl geniposidic gentiobioside glycoside etc. The fructus gardeniae standard substance and the fructus gardeniae analog can be prepared by any of the methods such as solvent extraction, macroporous absorption resin, supercritical fluid extraction, column chromatography, fluid-fluid countercurrent chromatography, or any combination of the methods. The purity of the prepared fructus gardeniae standard substance is 98-100 percent (w / w), and the total percentage contents of iridoid components in the fructus gardeniae analog are 5-100 percent (w / w), wherein, the content of fructus gardeniae account for 5-100 percent (w / w) of the total iridoid contents.

The present invention discloses a multi-component content determining method of a eucommia ulmoides herb. The method is used for simultaneous determining the contents of aucubin, geniposidic acid, chlorogenic acid, geniposide, pinores inoldiglucoside,and pinores inolmonoglucoside in a a eucommia ulmoides herb, wherein a UPLC method is used, Waters BET C18 (2.1*150 mm, 1.7 [mu]m) is adopted as a chromatographic column, a 0.1% formic acid acetonitrile solution-0.1% formic acid aqueous solution is adopted to carry out gradient elution, the detection wavelength is 205 nm, the flow rate is 0.25 mL / min, and the column temperature is 45 DEG C. According to the method of the present invention, the six effective components in the eucommia ulmoides can be well separated, the adding recovery rate of the method is 96.92-101.01%, RSD is less than 3%, and the method can provide the basis for the quality control of the eucommia ulmoides.

The invention discloses a Plantain seed extract and application thereof. The Plantain seed extract is acquired by reflux extraction of Plantain seed with 2-6 volume times of 60-90vol% ethanol aqueous solution 2-6 times. The Plantain seed extract contains acteoside, isoacteoside, geniposidic acid, ferulic acid, and Cheqiansu A and Cheqiansu B. In-vivo experiments show that the Plantain seed extract provided by the invention can promote glucose consumption and has lower toxicity to cells; and simultaneously in-vitro experiments show that the Plantain seed extract can significantly increase serum insulin level and reduce fasting blood-glucose level, presents good medicinal value in treatment of diabetes; therefore, the Plantain seed extract can be used in the preparation of pharmaceutical medicaments for treating diabetes singly or together with a pharmaceutically acceptable composition composed of a drug carrier.

The invention discloses a quality control method of a traditional Chinese medicine compound preparation for treating osteoporosis. The quality control method comprises the following steps: (1) by taking eucommia ulmoides as a contrast medicinal material and taking pinoresinol diglucoside and geniposidic acid as comparison products, carrying out qualitative identification on eucommia ulmoides in the traditional Chinese medicine compound preparation by adopting a thin-layer chromatography; (2) by taking radix achyranthis bidentatae as a contrast medicinal material and taking beta-ecdysterone as a comparison product, carrying out qualitative identification on radix achyranthis bidentatae in the traditional Chinese medicine compound preparation by adopting the thin-layer chromatography; (3) by taking wolfberry fruits as contrast medicinal materials, carrying out qualitative identification on the wolfberry fruits in the traditional Chinese medicine compound preparation by adopting the thin-layer chromatography; and (4) determining the content of three active components (or index components) including epimedium glucoside, gentiopicroside and loganin acid in the traditional Chinese medicine compound preparation by adopting a high performance liquid chromatography. According to the quality control method, the quality of the traditional Chinese medicine compound preparation can be controlled very well, and the stability of a product production process is monitored; and the quality of the traditional Chinese medicine compound preparation is stable, uniform and controllable.

Disclosed are a eucommia leaf extract, and preparation method and use thereof. The extract is a liquid of the eucommia leaf or an ethyl alcohol extract, and has chlorogenic acid of a content not less than 9%, geniposidic acid of a content not less than 1% and aucubin of a content not less than 1%. The extract has a good effect on psoriasis.

The invention discloses eucommia ulmoides fine powder and a preparation method thereof. The eucommia ulmoides fine powder comprises the following components: larger than or equal to 15 percent of total sugar, larger than or equal to 5 percent of chlorogenic acid, larger than or equal to 15 percent of total flavone, larger than or equal to 1.8 percent of geniposidic acid, larger than or equal to 0.8 percent of aucubin, less than or equal to 6.0 percent of water and trace elements such as B, Ca, Cu, Mg, Mn, P, Se, Zn, Na, K and Fe. According to the preparation method, the eucommia ulmoides fine powder is efficiently extracted from eucommia ulmoides leaves and eucommia ulmoides bark and a membrane technology is introduced for separation, concentration, decoloration and the like, so that the labor and time are reduced, the product quality and yield can also be improved, the temperature of the extraction process is low, and the damage of high temperature heating on effective components is avoided. In addition, the phenomenon that the eucommia ulmoides fine powder is insoluble in water the second time is avoided. The eucommia ulmoides fine powder belongs to a natural health food preparation, is safe and non-toxic, and is suitable for the industries such as medicine, health care products and food antioxidants. Eucommia ulmoides gum can be continuously extracted out from extractive residue after extraction of the eucommia ulmoides fine powder, and the economic benefit of high-value using of eucommia ulmoides is effectively improved.

The invention belongs to the field of extraction of traditional Chinese medicine, and particularly relates to a cortex eucommiae extract composition for treating renal fibrosis and application of thecortex eucommiae extract composition. The cortex eucommiae extract composition is prepared from the components of aucubin, a mixed extract of geniposide and geniposidic acid, quercetin and chlorogenicacid through the steps of extraction, separation, purification and the like, and the cortex eucommiae extract composition can be further prepared into a preparation. A preparation method is simple and efficient, and the prepared cortex eucommiae extract composition has the good effect of treating renal fibrosis.

The invention aims to disclose a processing method of dry noodles, in which eucommea leaves are capable of being effectively utilized and reducing eucommea rubber, and the dry noodles are low in cost and rich in active substances such as geniposidic acid, and aucubin and nutrient substances such as amino acid, and glucose; the dry noodles can be widely applied to the diet for preventing and treating the high blood pressure. The eucommea leaves are extracted by using an ethanol solution and acid water to obtain an eucommea ethanol extract and an eucommea water extract, then, dry flour is dissolved by using water to form a flour emulsion, and finally, the dry eucommea noodles are obtained through the steps of embedding, vacuum degassing, curing, tabletting and the like. The dry eucommea noodles produced by the invention contain part of chlorogenic acid which is beneficial to the antivirus and diuresis of human bodies and is also beneficial to the storage of the dry noodles; the ultrasonic treatment is adopted so as to be beneficial to the rapid permeability of effective ingredients in the eucommea leaves into a reticular structure of starch and relatively beneficial to the reservation of the effective ingredients; an eucommea leaf extract is added into the flour, so that the influence of the eucommea rubber in eucommea barks to the dry noodles can be completely eliminated.

The invention belongs to the technical field of pomegranate planting and particularly provides a cutting seedling-raising matrix for pomegranates. The cutting seedling-raising matrix is prepared from perlite, river sand, rotten leaf soil, fresh cow dung, compound fermentation bacteria, rice bran, soybean meal, fresh wax gourd peel, pepper leaves, fresh semen pharbitidis extract, litchi kernel extract, lignan, geniposidic acid and anaphalis xylorhiza alkali. The cutting seedling-raising matrix is comprehensive and sufficient in nutrition, good in permeability, strong in biological activity, good in slow-release property and long in acting time, does not need fertilization in a whole seedling-raising period, only needs watering, is simple to use, makes cuttings root quickly, makes stems and leaves grow healthily and strongly, improves the disease resistance ability of the cuttings, reduces plant diseases and insect pests and improves the seedling-raising quality of cuttings, and a rejuvenation period after transplantation is shortened. The cutting seedling-raising matrix makes the cutting rooting time shortened to be 13.6-14.1 days, the rooting rate is up to 97.8%-98.1%, and the survival rate is up to 96.3%-96.7%.

The invention discloses a method for preparing eucommia ulmoides extract by using a natural eutectic solvent. The method comprises the following steps that: eucommia ulmoides powder is added into the natural eutectic solvent according to a material-liquid ratio of (1: 1)-(1: 100g / mL), and ultrasonic-assisted extraction is performed for 10-90 minutes at 20-80 DEG C and 50-500W, wherein the natural eutectic solvent is composed of a hydrogen bond donor, a hydrogen bond acceptor and distilled water according to the mass ratio of 1: (1-30): (1-50), wherein the hydrogen bond donor comprises L-lactic acid, sorbitol, urea, DL-malic acid, D-fructose, glucose and citric acid, and the hydrogen bond acceptor comprises choline chloride, betaine and citric acid; centrifugation is performed, supernatant is taken, and the supernatant is further concentrated and dried, so that the eucommia ulmoides extract is obtained. The method is safe, economical and recoverable; various active ingredients such as aucubin, geniposidic acid, chlorogenic acid and rutin in eucommia ulmoides can be extracted; and compared with that of a water extract, the content of the active ingredients in the natural eutectic solvent extract is remarkably increased, the extraction efficiency is high, and the components of the natural eutectic solvent can also be used as functional components in functional food and cosmetics; and the step of removing an extraction solvent in a traditional process is omitted. The method is more economical and efficient.

The invention discloses a method for simultaneously measuring the content of multiple active ingredients in eucommia ulmoides. The method adopts high performance liquid chromatography for analysis; the chromatographic condition is taking octadecylsilane bonded silica as a filler; the mobile-phase gradient elution process is: the mobile phase A is methanol, and the mobile phase B is an aqueous solution of phosphoric acid with mass concentration of 0.1%; the content of the mobile phase B is increased from 30% to 70% by mass according to the first-order linear gradient in 0.01-30.00min, reduced to 30% in 30.00-30.01min and kept at 30% in 30.01-40.00min; the flow rate is 0.8ml / min; the column temperature is 30 DEG C; the sample injection volume is 5mul; the detection wavelength detection process is: the 254nm wavelength is selected in 0.01-7.00min, the 277nm wavelength is selected in 7.00-12.50min, and the 254nm wavelength is selected in 12.50-40.00min; and multiple active ingredients include geniposidic acid, chlorogenic acid, pinoresinol diglucoside and rutin. According to the invention, the method is verified by linear relation survey, stability test, precision test, reproducibility test and sample injection recycling test, and the analysis method is proved to be accurate and reliable.

The invention discloses a preparation method of eucommia ulmoides geniposidic acid composite nanoparticles, zein loaded geniposidic acid composite nanoparticles are prepared by using the unique self-assembly characteristic of zein, taking polysaccharide as a stabilizer and utilizing an anti-solvent coprecipitation method; the operation is simple, the condition is mild, the cost is lower, and the method is green and environment-friendly. According to the zein-loaded geniposidic acid composite nano-particles, geniposidic acid is embedded in the protein nano-particles, so that the stability of the protein nano-particles is effectively improved, the solubility of the protein nano-particles is improved, the prepared zein-loaded geniposidic acid composite nano-particles are uniform in particle size, high in embedding rate and relatively good in stability, the bioavailability of the natural active ingredient geniposidic acid is improved, and the bioavailability of the zein-loaded geniposidic acid composite nano-particles is improved. The problems that geniposidic acid is unstable and difficult to dissolve are solved.

The invention relates to the field of tattoo stickers, in particular to a water transfer printing tattoo sticker as well as a preparation method and a use method thereof. The water transfer printing tattoo sticker is sequentially provided with four layers of structures, wherein the first layer is water transfer printing paper, the second layer is SD glue, the third layer is an adhesive mixture containing genipin or geniposidic acid, and the fourth layer is a protective film. The water transfer printing tattoo sticker has the advantages that firstly, use is convenient as the tattoo sticker needs to be attached to a certain portion of the surface of a body only, bottom paper is taken out after 1 minute, and color can be developed after 2-10h; secondly, the water transfer printing tattoo sticker is nontoxic and harmless, since the genipin and the geniposidic acid, as natural compounds, are adopted as chromogenic substances, and a large number of experiments show the safety of the genipinand the geniposidic acid; thirdly, the water transfer printing tattoo sticker is painless and non-invasive; and fourthly, the color of a pattern is long in retention time, the pattern is relatively intuitive, does not fade with being kept for 30 days in winter and does not fade with being kept for 10 days or above in summer, and the water transfer printing tattoo sticker is more washable relativeto a common tattoo sticker.

The invention discloses a preparation method of a tattoo liquid and a paster set. The method includes preparation of the tattoo liquid and preparation of the paster set. The tattoo liquid is prepared by mixing genipin and / or geniposidic acid with a matrix in certain proportion. The paster set is self-adhesive PVC paster. The method specifically includes the steps of: (1) mixing the matrix with genipin or geniposidic acid to obtain a mixture of genipin and the matrix and a mixture of geniposidic acid and the matrix respectively, and subpackaging the two mixtures in pinhead equipped plastic hoses respectively; and (2) employing a paper cutter or engraving machine to make the paster, making various patterns according to requirements, wherein the engraved pattern layer is PVC with proper hardness and is a glue-containing adhesion layer, the back layer is glossy paper, and the two layers are bonded together, and placing the prepared paster in a specific packaging bag. The tattoo liquid and the paster set provided by the invention have the advantages of convenient use, no toxicity or harm, no pain or invasion, and long retention time.

The invention belongs to the technical field of medicine preparation, and particularly relates to a eucommia ulmoides extract composition and a preparation method and application thereof. The composition comprises the following components: geniposidic acid, chlorogenic acid, aucubin, and a mixture of pinoresinol diglucoside and dehydrodiconiferyl alcohol diglucoside. The extract composition can effectively treat primary hypertension or kidney deficiency syndrome, has no toxic or side effect, is small in dosage, and can effectively reduce the medication cost.

The invention discloses a degradable composite nanofiber three-dimensional material and application thereof in tissue repair, and belongs to the technical field of degradable materials. The compositenanofiber three-dimensional material is prepared from a dopamine graft, and the dopamine graft adopts geniposidic acid to graft dopamine. The dopamine graft is adopted to prepare the composite nanofiber three-dimensional material so that the total amount of cell DNA on the surface of the composite nanofiber three-dimensional material is increased by at least 42.86%, and the highest dissolution loss rate of the composite nanofiber three-dimensional material is only 11%. The composite nanofiber three-dimensional material can be used for tissue repair materials and is stable, porous, good in biocompatibility and low in dissolution loss rate.

The invention discloses a method of rapidly identifying three active ingredients of Eucommia ulmoides Oliv leaves and barks by using thin-layer chromatography. The method comprises the following stepsof: 1) respectively preparing aucubin, geniposidic acid and chlorogenic acid reference substance solutions, 2) respectively preparing to-be-detected sample solutions of Eucommia ulmoides Oliv leavesand barks, and 3) respectively sucking proper amounts of the reference substance solutions and the to-be-detected sample solutions by using a quantitative capillary tube, applying the solutions on a GF 254 silica gel plate, taking butyl acetate: methanol: formic acid as a mixed solvent as a developing solvent, observing through a 254 nm ultraviolet lamp, carrying out thin-layer chromatography identification by taking a 5.0% sulfuric acid-ethanol solution as a color developing agent, and observing the positions and the colors of spots appearing in the thin-layer chromatography silica gel plateof the sample solution. Results show that three active ingredients of Eucommia ulmoides Oliv leaves and barks in an obtained chromatogram show different spots. The identification method is high in specificity and convenient to operate, and can be used for rapidly and accurately identifying aucubin, geniposidic acid and chlorogenic acid in Eucommia ulmoides Oliv leaves and barks at the same time.

The invention relates to a gardenia extract, in particular to a gardenia extract for treating hyperbileacidemia. The gardenia extract comprises geniposide, genipin 1-beta-D-gentiobioside, 6''-p-coumaroyl genipin gentiobioside, scandoside methyl ester, geniposidic acid, gardenoside and gardenoside, and is prepared through ethanol extraction and macroporous resin purification. The gardenia extract is capable of significantly reducing the bile acid level in the blood of rats, has a good effect on the treatment of hyperbileacidemia, and can be applied to the preparation of drugs for treating hyperbileacidemia.

The invention provides a Magnesium-rich eucommia plantation method comprising the following steps: adding magnesium elements into an EM bacterial strain biology liquid; applying the liquid to a root area and blade faces of the eucommia in a fertilizer form, so the eucommia can fully absorb and gather magnesium elements in a growth process, thus improving medicinal value. Compared with the prior art, the magnesium amount of the eucommia obtained by the plantation method equals to more than 2 times of that contained in normal eucommia; in addition, active ingredients like aucubine, chlorogenic acid, geniposidic acid, geniposide and general flavone in the eucommia obtained by the plantation method can be greatly increased, thus improving medicinal efficacy of the eucommia.

The invention discloses a structural formula of an LQC-Y as well as synthesis and an application thereof. Pharmacological experiments verify that the compound has a remarkable anti-tumor effect, wherein the single day maximum dosage of an LQC-Y3 mouse is 6000mg / kg. No toxic reactions happen within 14 days of continuous observation, thus, the drug is very high in safety and can be used for preparing drugs for preventing and treating cancers such as liver cancer and lung cancer. The structural formula of LQC-Y is as shown in the specification, wherein R represents sterides such as cholic acid, deoxycholic acid, ursodesoxycholic acid, chenodeoxycholic acid and hyodeoxycholic acid; triterpenoids such as oleanolic acid, ursolic acid, pachymic acid, glycyrrhetinic acid and glycosides; parietic acid, rheum emodin and other anthraquinone mother nucleus mono-substituted or multi-substituted structures; baicalein, baicalin and other flavone analogue compounds; shikimic acid, mono-substituted shikimic acid or multi-substituted shikimic acid; geniposidic acid and other iridoid acid derivatives; and paeonol, curcumin and structural derivatives.

The invention belongs to the technical field of production of solid beverages, and particularly relates to a preparation method of a cortex eucommiae and radix puerariae solid beverage. The preparation method of the cortex eucommiae and radix puerariae solid beverage is characterized by comprising the following steps of crushing cortex eucommiae staminate flowers or eucommia ulmoides leaves, mixing the cortex eucommiae staminate flower powder or the eucommia ulmoides leaf powder with radix puerariae powder and water, and performing granulation and performing drying so as to obtain the solid beverage. The cortex eucommiae and radix puerariae solid beverage has the beneficial effects that the made cortex eucommiae and radix puerariae solid beverage has the efficacy of the cortex eucommiae staminate flowers, and also has the nourishing efficacy of the radix puerariae powder and Chinese yam powder and the effect of reducing pathogenic fire of honeysuckle flowers. Through collocation, the efficacy of the cortex eucommiae and radix puerariae solid beverage can be strengthened, the health-care function of the cortex eucommiae and radix puerariae solid beverage can be greatly increased, and through detection, the content of active components of chlorogenic acids, geniposidic acids and geniposide achieves about 5.5%.

The invention belongs to the technical field of preparation of novel compounds, and particularly relates to an amide pentaacetyl geniposide derivative as well as a preparation method and application thereof. The amide penta-acetyl geniposide derivative provided by the invention is prepared by the following steps: firstly, hydrolyzing lipid groups at C-4 sites of iridoid in geniposide to obtain geniposidic acid, then acetylating five hydroxyl groups at 2 ', 3', 4 ', 6' and 11 sites on sugar to obtain penta-acetyl geniposidic acid (2a), and finally reacting with RNH2 to obtain the penta-acetyl geniposide derivative. The geniposide derivative prepared by the invention has remarkable XOD inhibitory activity and kidney injury improvement activity, and can effectively reduce the accumulation of uric acid in the kidney. The inflammatory reaction is reduced, so that the level of inflammatory factors is reduced; renal fibrosis of a mouse with hyperuricemia can be reduced by inhibiting expression of an inflammatory factor TGF-beta.

The invention discloses a method for measuring the concentration of 7 blood inflow ingredients in an eucommia extract. The method comprises the following steps: firstly preparing a standard control solution by using geniposidic acid, protocatechuic acid, neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, pinoresinol diglucoside and terpineol monoglucoside; preparing an internal standard solution by using puerarin; then establishing an analysis method for simultaneous measuring the concentration of 7 ingredients in the eucommia extract in rat plasma by using an HPLC-ESI-MS / MS analysis; and the result shows that the measurement method disclosed by the invention has the advantages of wide linear range, high sensitivity and low limit of quantification, and can be used for accurately and reliably measuring the concentration of the 7 ingredients in the eucommia extract in the rat plasma extracted at 15 different time points after a spontaneously hypertensive rat is gavaged with the eucommia extract at the same time, and can be used for providing a technical support for the researches on the pharmacokinetic characteristics of the 7 ingredients in the eucommia extract.

The invention discloses a method for extracting geniposidic acid and verbascoside in semen plantaginis by an ASE (Accelerated Solvent Extraction) method. The method is shorter in extraction time and good in repeatability, and belongs to the field of extraction of the geniposidic acid and the verbascoside. The method comprises the following steps: crushing a semen plantaginis sample, enabling the crushed semen plantaginis sample to pass through a second sieve, taking 1g of the semen plantaginis sample powder and mixing the 1g of the semen plantaginis sample powder with 1g of diatomite; charging a mixture obtained in the first step into an ASE extraction pool in which a fiber filtration film is putted, and adding the diatomite to be parallel to a pool opening; extracting with methanol, and fixing the volume of an extracting solution to be 50ml by using the methanol. The method disclosed by the invention can replace a pharmacopoeia method for extracting the geniposidic acid and the verbascoside in the semen plantaginis and determining the contents.

The application of a compound with the activity of promoting collagen synthesis in anti-aging cosmetics belongs to the technical field of cosmetics, and the compound is aucubin or genipinic acid. The extraction method of the two compounds of aucubin and geniposidic acid of the present invention is simple, the purity of the extract is high, and these two compounds can be applied to cosmetics to make liquid, emulsion or cream , to promote the synthesis of skin collagen, delay and inhibit the effect of skin aging.

The invention belongs to the technical field of novel compound preparation, and particularly relates to an ester pentaacetyl geniposide derivative obtained through esterification reaction and a preparation method and application thereof. The amide penta-acetyl geniposide derivative provided by the invention is prepared by the following steps: firstly, hydrolyzing lipid groups at C-4 sites of iridoid in geniposide to obtain geniposidic acid, then acetylating five hydroxyl groups at 2 ', 3', 4 ', 6' and 11 sites on sugar to obtain penta-acetyl geniposidic acid (2a), and finally reacting with ROH to obtain the penta-acetyl geniposide derivative. The geniposide derivative prepared by the invention has remarkable XOD inhibitory activity and kidney injury improvement activity, and can effectively reduce the accumulation of uric acid in the kidney. The inflammatory reaction is reduced, so that the level of inflammatory factors is reduced; renal fibrosis of a mouse with hyperuricemia can be reduced by inhibiting expression of an inflammatory factor TGF-beta.

The invention discloses a method for extracting and preparing geniposidic acid from semen plantaginis, which belongs to the technical field of geniposidic acid extraction, and comprises the following steps: (1) bead milling treatment; (2) corona treatment; (3) electron beam assisted soaking treatment; and (4) Soxhlet reflux extraction. According to the method for extracting and preparing geniposidic acid from semen plantaginis provided by the invention, Soxhlet reflux extraction is performed on the basis of performing bead milling crushing, corona treatment and electron beam irradiation auxiliary soaking treatment on the semen plantaginis, so that the active surface area of the semen plantaginis raw material is increased, the microporous structure of the semen plantaginis raw material is improved, and the cell permeability is improved; and permeation and diffusion of the extracting agent are promoted, so that the dissolution rate of geniposidic acid is increased, and the yield of geniposidic acid is increased.