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Cortex eucommiae extract composition for treating renal fibrosis and application of cortex eucommiae extract composition

A technology of renal fibrosis and composition, which is applied in the field of eucommia extract composition for treating renal fibrosis, can solve the problems that the extraction of active ingredients needs to be further optimized, and the effective ingredients cannot be extracted well, so as to improve the treatment of renal fibrosis. The effect of improving the application value and enhancing the stability

Pending Publication Date: 2019-12-06
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limitations of the preparation method, the active ingredients cannot be extracted well, and the effect in the treatment of renal fibrosis needs to be improved, and the extraction of the active ingredients needs to be further optimized

Method used

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  • Cortex eucommiae extract composition for treating renal fibrosis and application of cortex eucommiae extract composition
  • Cortex eucommiae extract composition for treating renal fibrosis and application of cortex eucommiae extract composition
  • Cortex eucommiae extract composition for treating renal fibrosis and application of cortex eucommiae extract composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The Eucommia ulmoides extract composition for treating renal fibrosis described in this example, in parts by weight, the composition includes:

[0036] 50 parts aucubin, 35 parts mixed extract of geniposide and genipodic acid, 3 parts quercetin, 10 parts chlorogenic acid.

[0037] The preparation method of the eucommia extract composition for treating renal fibrosis comprises the following steps:

[0038] (1) Take Eucommia ulmoides and grind it to 30 mesh, add it to water, enzymolyze the mixture of cellulase and polymethylgalacturonase with a mass ratio of 1:2, and filter to obtain the enzymatic hydrolyzate and filter residue 1;

[0039] (2) Take filter residue 1 and wash it with petroleum ether, place it in ethanol, heat to 65°C, filter to obtain alcohol solution, add 1 times the volume of distilled water to the alcohol solution and cool to 2°C, recrystallize to obtain quercetin crystal;

[0040] (3) Adsorb the enzymolysis solution through XDA-1 type macroporous resi...

Embodiment 2

[0044] The Eucommia ulmoides extract composition for treating renal fibrosis described in this example, in parts by weight, the composition includes:

[0045] 70 parts aucubin, 50 parts mixed extract of geniposide and genipodic acid, 2 parts quercetin, 5 parts chlorogenic acid.

[0046] The preparation method of the eucommia extract composition for treating renal fibrosis comprises the following steps:

[0047] (1) Take Eucommia ulmoides and crush it to 20 meshes, add water, enzymolyze the mixture of cellulase and polymethylgalacturonase with a mass ratio of 1:1, and filter to obtain enzymolysis solution and filter residue 1;

[0048] (2) Take filter residue 1 and wash it with petroleum ether, place it in ethanol, heat to 60°C, filter to obtain alcohol solution, add 1 times the volume of distilled water to the alcohol solution and cool to 1°C, recrystallize to obtain quercetin crystal;

[0049] (3) Adsorb the enzymolysis solution through XDA-1 type macroporous resin, HZ-820 ty...

Embodiment 3

[0053] The Eucommia ulmoides extract composition for treating renal fibrosis described in this example, in parts by weight, the composition includes: a mixture of 30 parts of aucubin, 66 parts of geniposide and geniposidic acid Extract, 1 part quercetin, 15 parts chlorogenic acid.

[0054] The preparation method of the eucommia extract composition for treating renal fibrosis comprises the following steps:

[0055] (1) Take Eucommia ulmoides and crush it to 40 mesh, add it to water, enzymolyze the mixture of cellulase and polymethylgalacturonase with a mass ratio of 1:3, and filter to obtain the enzymatic hydrolyzate and filter residue 1;

[0056] (2) Take filter residue 1 and wash it with petroleum ether, place it in ethanol, heat to 70°C, filter to obtain alcohol solution, add 2 times the volume of distilled water to the alcohol solution and cool to 5°C, recrystallize to obtain quercetin crystal;

[0057] (3) Adsorb the enzymolysis solution through XDA-1 type macroporous re...

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Abstract

The invention belongs to the field of extraction of traditional Chinese medicine, and particularly relates to a cortex eucommiae extract composition for treating renal fibrosis and application of thecortex eucommiae extract composition. The cortex eucommiae extract composition is prepared from the components of aucubin, a mixed extract of geniposide and geniposidic acid, quercetin and chlorogenicacid through the steps of extraction, separation, purification and the like, and the cortex eucommiae extract composition can be further prepared into a preparation. A preparation method is simple and efficient, and the prepared cortex eucommiae extract composition has the good effect of treating renal fibrosis.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine extraction, and in particular relates to an extract composition of Eucommia ulmoides for treating renal fibrosis and its application. Background technique [0002] Renal fibrosis is a pathophysiological change, which is a gradual process in which the function of the kidney changes from healthy to damaged, then damaged, and finally lost. The kidney is stimulated by various pathogenic factors such as trauma, infection, inflammation, blood circulation disorder, and immune response, and its intrinsic cells are damaged. In the later stage of development, a large amount of collagen deposits and accumulates, causing the renal parenchyma to gradually harden and form scars, until the kidney is damaged. Complete loss of organ function. The process of intrinsic cell fibrosis and sclerosis in the kidney is also the process of renal fibrosis. Renal fibrosis is characterized by abnormal deposition ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/216A61K31/352A61P13/12A61K36/46
CPCA61K31/7048A61K31/216A61K31/352A61P13/12A61K36/46A61K2300/00
Inventor 李小锋刘厚权胡吉忠夏淑英张金良周朝忠毛金娣陈梁
Owner JIANGXI POZIN PHARMA
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