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Eucommia ulmoides extract composition and preparation method and application thereof

An extract and composition technology, applied in the field of eucommia extract composition and its preparation, can solve the problems of complicated preparation methods, affecting the utilization rate of active ingredients, and cannot be ruled out, so as to promote drug efficacy, improve drug utilization rate, and promote The effect of extraction

Inactive Publication Date: 2021-09-21
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although all have a certain effect on the treatment of essential hypertension, there are many kinds of drugs in the above technologies, the preparation methods are complicated, and the influence of other impurities cannot be ruled out. On the other hand, it may also affect the utilization rate of active ingredients and increase the cost of pharmaceuticals

Method used

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  • Eucommia ulmoides extract composition and preparation method and application thereof

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Effect test

Embodiment 1

[0049] A composition of Eucommia ulmoides extract, in parts by weight, comprising the following components: 5 parts of geniposidic acid, 3 parts of chlorogenic acid, 6 parts of aucubin, pinoresinol diglucoside and dehydrodi 3 parts of the mixture of coniferyl alcohol diglucoside.

[0050] The preparation method of the eucommia extract composition comprises the following steps:

[0051] (1) Take ulmoides and pulverize them, add 6 times of distilled water, add 1.5wt% sodium acetate and polysorbate 80 with a mass ratio of 2:1, extract at 70°C for 50min, boil for 1.5h, filter, and prepare Obtain water extract and filter residue;

[0052] (2) Add the filter residue to 4 times of 55wt% ethanol aqueous solution, extract for 1.5h, and filter to obtain the alcohol extract;

[0053](3) After the water extract is adsorbed with HZ-820 macroporous resin, first use 2.5BV distilled water to elute and remove impurities, and the elution rate is 2BV / h to prepare distilled water to elute A for...

Embodiment 2

[0060] A composition of Eucommia ulmoides extract, in parts by weight, comprising the following components: 8 parts of geniposide, 6 parts of chlorogenic acid, 8 parts of aucubin, pinoresinol diglucoside and dehydrodi 7 parts of the mixture of coniferyl alcohol diglucoside.

[0061] The preparation method of the eucommia extract composition comprises the following steps:

[0062] (1) Take ulmoides and pulverize them, add 5 times distilled water, add 1wt% sodium acetate and polysorbate 80 with a mass ratio of 1:1, extract at 80°C for 30min, boil for 1h, filter to obtain water extract and filter residue;

[0063] (2) Add the filter residue to 5 times of 45wt% ethanol aqueous solution, extract for 1 hour, and filter to obtain an alcohol extract;

[0064] (3) After the water extract is adsorbed with HZ-820 macroporous resin, first use 3BV distilled water to elute and remove impurities, and the elution rate is 1BV / h to prepare distilled water to elute A for use; then use 3BV mass...

Embodiment 3

[0071] A composition of Eucommia ulmoides extract, in parts by weight, comprising the following components: 1 part of geniposide, 1 part of chlorogenic acid, 5 parts of aucubin, pinoresinol diglucoside and dehydrodi 1 part of the mixture of coniferyl alcohol diglucoside.

[0072] The preparation method of the eucommia extract composition comprises the following steps:

[0073] (1) Take ulmoides and pulverize them, add 8 times distilled water, add 2wt% sodium acetate and polysorbate 80 with a mass ratio of 3:1, extract at 60°C for 60 minutes, boil and extract for 2 hours, filter to obtain water extract and filter residue;

[0074] (2) adding the filter residue to 5 times of 75wt% ethanol aqueous solution, extracting for 2 hours, and filtering to obtain an alcohol extract;

[0075] (3) After the water extract is adsorbed with HZ-820 macroporous resin, first use 2BV distilled water to elute and remove impurities, and the elution rate is 4BV / h to prepare distilled water to elute...

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Abstract

The invention belongs to the technical field of medicine preparation, and particularly relates to a eucommia ulmoides extract composition and a preparation method and application thereof. The composition comprises the following components: geniposidic acid, chlorogenic acid, aucubin, and a mixture of pinoresinol diglucoside and dehydrodiconiferyl alcohol diglucoside. The extract composition can effectively treat primary hypertension or kidney deficiency syndrome, has no toxic or side effect, is small in dosage, and can effectively reduce the medication cost.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to an extract composition of Eucommia ulmoides and its preparation method and application. Background technique [0002] Hypertension refers to an increase in systemic arterial blood pressure (systolic blood pressure and / or diastolic blood pressure) as the main feature (systolic blood pressure ≥ 140 mm Hg, diastolic blood pressure ≥ 90 mm Hg), which may be accompanied by heart, brain, kidney and other organ functions Or clinical syndrome of organic damage. When the exact cause of high blood pressure cannot be found, it is called essential hypertension. [0003] There are many methods for treating essential hypertension in the prior art. For example, Chinese patent application CN103127421A discloses a traditional Chinese medicine composition for treating essential hypertension. , Motherwort, Millet Spatholobus, Chinese Yam, Eucommia. [0004] Chinese paten...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/216A61K47/12A61K47/26A61K36/46A61P9/12A61P1/14A61P13/12
CPCA61K31/7048A61K31/216A61K47/12A61K47/26A61K36/46A61P9/12A61P1/14A61P13/12A61K2300/00
Inventor 陈梁李小锋刘厚权毛金娣林飞英张梅红胡吉忠夏淑英
Owner JIANGXI POZIN PHARMA
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