Folium cortex eucommiae extract as well as preparation method and application thereof

A technique for Eucommia ulmoides leaves and extracts, which is applied in the field of Eucommia ulmoides leaf extracts and their preparation, and achieves the effects of less side effects, significant curative effect, and broad application prospects.

Inactive Publication Date: 2015-04-29
SICHUAN JIUZHANG BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There is no report on the treatment of psoriasis with Eucommia leaf extract

Method used

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  • Folium cortex eucommiae extract as well as preparation method and application thereof
  • Folium cortex eucommiae extract as well as preparation method and application thereof
  • Folium cortex eucommiae extract as well as preparation method and application thereof

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Experimental program
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Embodiment 1

[0037] The preparation of embodiment 1 Eucommia ulmoides leaf extract of the present invention

[0038]Leaves of Eucommia ulmoides were extracted twice at 70°C with 60% ethanol, each time with 15 times the volume, and each time for 1 hour, the extracts were combined and concentrated to recover ethanol, and the concentrated solution was saturated with D-101 macroporous adsorption resin. Sequentially elute with 10%, 30%, 70% and 90% ethanol at gradient concentrations of ethanol, collect the eluate, combine the 10% and 30% eluate, concentrate and dry to obtain extract sample 1 (content: chlorogenic acid=11.27 %, genipinic acid=1.87%, aucubin=1.17%); combined 70% and 90% eluents, concentrated and dried to obtain extract sample 2 (content: chlorogenic acid=32.37%, genipin Nucleic acid = 2.24%, aucubin = 2.07%)

Embodiment 2

[0039] Embodiment 2 The preparation of Eucommia ulmoides leaf extract of the present invention

[0040] Leaves of Eucommia ulmoides were extracted twice at 60°C with 30% ethanol, each time with 12 times the volume, and each time for 2 hours, the extracts were combined and concentrated to recover ethanol, and the concentrated solution was saturated with HPD-100 macroporous adsorption resin. Sequentially eluted with 10%, 30%, 70% and 90% ethanol at gradient concentrations of ethanol, collected the eluate, combined 70% and 90% eluate, concentrated and dried to obtain extract sample 1 (content: chlorogenic acid=11.24 %, genipinic acid=9.38%, aucubin=9.56%); 30% eluate was concentrated and dried to obtain extract sample 2 (content: chlorogenic acid=38.55%, geniporin=1.18% , aucubin=1.36%)

Embodiment 3

[0041] Embodiment 3 Preparation of Eucommia leaf extract of the present invention

[0042] Extract Eucommia leaves with 20 times of water at 80°C once for 1.5 hours each time. After the extract is saturated and adsorbed with XAD-16 macroporous adsorption resin, it is eluted with 20% and 60% ethanol gradient concentration ethanol successively, and the collected and washed Dehydration, 20% eluate was concentrated and dried to obtain extract sample 1 (content: chlorogenic acid=23.04%, geniposide=1.29%, aucubin=3.54%); 60% eluate was concentrated and dried Obtained extract sample 2 (content: chlorogenic acid=10.21%, geniposide=1.03%, aucubin=1.24%)

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Abstract

The invention discloses a folium cortex eucommiae extract which is a water extract or an ethanol extract of folium cortex eucommiae. The folium cortex eucommiae extract contains no less than 9% of chlorogenic acid, no less than 1% of geniposidic acid and no less than 1% of aucubin. Furthermore, the invention also provides a preparation method and an application of the folium cortex eucommiae extract. The folium cortex eucommiae extract, as a traditional Chinese medicine extract, is low in side effect, capable of being used for a long term, free from toxic and side effects to organisms, safe and effective, capable of improving the life quality of patients and having a significant curative effect on psoriasis; and therefore, the folium cortex eucommiae extract has a broad application prospect in treating psoriasis.

Description

technical field [0001] The present invention relates to eucommia leaf extract and its preparation method and use. Background technique [0002] Psoriasis, commonly known as "psoriasis", is a common and recurring chronic inflammatory skin disease characterized by mica-like scales, erythema, and spotting. The incidence rate in my country is about 0.123%. In recent years, the incidence of psoriasis is on the rise. It has obvious seasonality in the early stage, and it is severe in winter and light in summer. It can occur in both men, women, and children. The etiology is currently unknown, and there is still no effective treatment. [0003] Psoriasis is currently divided into 4 types, psoriasis vulgaris, arthropathic psoriasis, erythrodermic psoriasis and pustular psoriasis, of which psoriasis vulgaris accounts for more than 99%. Psoriasis vulgaris is common psoriasis, while the other three types are called specific psoriasis. According to the summarization of the experience of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/46A61P17/06A61K127/00
Inventor 张洁黄望张亮黄骏
Owner SICHUAN JIUZHANG BIO TECH CO LTD
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