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Drug composition, and preparation method and application thereof

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, antibacterial drugs, etc., can solve the problems of long course of otitis in dogs and cats, easy dependence, and difficult treatment, etc., to achieve the goal of large-scale production, damage Small and easy to operate

Inactive Publication Date: 2019-03-12
湖北中博绿亚生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are many factors that cause otitis in dogs and cats, and mites, bacteria, fungi and parasitic infections are all important causes of otitis externa in dogs and cats; among them, bacteria mainly include Staphylococcus aureus, Escherichia coli, Proteus, etc.; fungi mainly include equine Lasceriella, yeast, etc.; mites are mainly itchy ear mites, and a variety of predisposing factors often lead to a longer course of otitis in dogs and cats, and it is difficult to treat
[0004] For the inflammation of the ear canal in dogs and cats, most domestic glucocorticoids are used for treatment, such as hydrocortisone acetate, fluocinonide, dexamethasone, prednisone acetate, triamcinolone acetate, etc. There are many phenomena of abuse of corticosteroid preparations. Although their efficacy is good, they are prone to dependence, and long-term use is prone to skin atrophy

Method used

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preparation example Construction

[0036] The present invention also provides a preparation method of the above-mentioned pharmaceutical composition, which comprises the following steps: dissolving dyclonine hydrochloride, terbinafine hydrochloride and matrine in an aqueous solution of glycerin, stirring until completely dissolved, and then adjusting the pH value to 4-7; preferably, use hydrochloric acid aqueous solution to adjust the pH value; more preferably, use pure water to adjust the pH value.

[0037] The preparation method of the pharmaceutical composition provided by the embodiment of the present invention has the advantages of simple process and convenient operation. It only needs to dissolve the raw materials in a solvent and mix them uniformly and adjust to a suitable pH value. It does not require high temperature and high pressure environment and toxic and explosive raw materials. , and will not produce industrial waste water, suitable for large-scale production preparation.

[0038] The present in...

Embodiment 1

[0041] The embodiment of the present invention provides a pharmaceutical composition, which is prepared by the following preparation method:

[0042] Weigh 0.2 g of dyclonine hydrochloride, 0.5 g of terbinafine hydrochloride, and 0.1 g of matrine and dissolve them in 90 ml of an aqueous solution of glycerin with a volume concentration of 30%, stir for 15 min until they are all dissolved, add purified water and measure Adjust the pH value to 4.0 with an aqueous solution of hydrochloric acid with a concentration of 10%, add purified water to 100ml, stir for 15min and mix well.

Embodiment 2

[0044] The embodiment of the present invention provides a pharmaceutical composition, which is prepared by the following preparation method:

[0045]Weigh 0.5 g of dyclonine hydrochloride, 1 g of terbinafine hydrochloride, and 0.5 g of matrine and dissolve them in 90 ml of aqueous solution of glycerol with a volume concentration of 40%, stir for 15 min until they are all dissolved, add purified water and measure the mass concentration Adjust the pH value to 6.0 with 10% hydrochloric acid aqueous solution, add purified water to 100ml and stir for 15min to mix evenly.

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Abstract

The invention discloses a drug composition, and a preparation method and application thereof, and relates to the field of veterinary drugs. The drug composition comprises a solvent, wherein the solvent is prepared from the following components: 0.02 to 0.2 g / L of dyclonine hydrochloride, 0.05 to 0.2 g / L of terbinafine hydrochloride, and 0.01 to 0.1 g / L of matrine, and the solvent is an aqueous solution of glycerol. When used for treating auditory meatus inflammation of dogs and cats, the drug composition has the advantages of high efficacy, short treatment period and small damage. Furthermore,the invention relates to the preparation method of the drug composition and application of the drug composition in preparation of a drug for treating the auditory meatus inflammation of the dogs andcats.

Description

technical field [0001] The invention relates to the field of veterinary medicines, and in particular to a pharmaceutical composition, its preparation method and its application. Background technique [0002] Ear canal inflammation refers to acute or chronic inflammation of the epithelium of the external auditory canal, sometimes accompanied by auricular disease or otitis media, the main symptoms are ear itching, erythema of the auricle and ear canal, excessive secretions in the ear with peculiar smell, and in severe cases, it may be purulent and inflamed. Smelly, and even hyperplasia occlusion of the ear canal. Inflammation of the ear canal in dogs and cats can lead to loss of appetite in sick dogs or cats, frequent shaking of the head and ear rubbing, resulting in serious consequences such as ear shell scratches, abrasions, bleeding or hematoma, epithelial ulceration, and even hearing loss. [0003] There are many factors that cause otitis in dogs and cats, and mites, bact...

Claims

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Application Information

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IPC IPC(8): A61K31/4453A61K31/137A61K31/4375A61P27/02A61P33/14A61P31/04A61P31/10
CPCA61K31/137A61K31/4375A61K31/4453A61P27/02A61P31/04A61P31/10A61P33/14A61K2300/00
Inventor 王昌库伍中杰朱波
Owner 湖北中博绿亚生物技术有限公司
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