Chitosan/polycaprolactone composite nanofiber membrane material and application thereof

Abstract

The invention discloses a chitosan/polycaprolactone composite nanofiber membrane material. The chitosan/polycaprolactone composite nanofiber membrane material is prepared by the following steps that a6-15wt% polycaprolactone solution is prepared, and 1-4wt% mupirocin is added; a 5-12wt% chitosan solution is prepared, and 0.5-8wt% lidocaine hydrochloride is added; the solutions are put into a feeding device of electrospinning equipment, the feeding rate is 8-50[mu]L/min, the receiving distance is 10-20cm, and the rotating speed of a receiver is 100-250 rpm/min; a high-voltage power supply is turned on, a voltage of 15-25 kV is applied, and the solutions are sprayed onto the fiber receiver for forming; and drying is carried out to remove the solvent, so that a composite nanofiber membrane is obtained. The composite nanofiber membrane exhibits excellent hydrophilicity, swelling rate, absorption capacity, thermal stability, mechanical properties and effective blood clotting ability, and further exhibits excellent cell compatibility and antibacterial activity; different release curves of different functional drugs can be realized; and the wound healing process can be significantly enhanced, and a synergistic effect of wound healing is achieved.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a chitosan / polycaprolactone composite nanofiber membrane material and its application. Background technique [0002] The skin is the largest vital organ in the human body and plays a key role in sensory function, thermoregulation and protection from the external environment. Although the skin has the ability to regenerate itself, when the skin encounters acute wounds, large-area lesions, and chronic wounds, there will be problems such as infection and delayed wound healing process, so wounds need to be bandaged and other treatments. Today, ideal wound dressing fibrous membrane materials for dressing wounds are expected to possess properties such as biocompatibility, pain minimization, antimicrobial, coagulation, and hemostatic properties. In order to achieve the desired wound dressing, techniques such as freeze-drying, self-assembly, phase-separation, and electrospi...

AI Technical Summary

Problems solved by technology

It is expected that the composite nanofiber wound dressing prepared by electrospinning technology will be difficult to predict because of the interaction between various polymers, the problem of impurities, the possibility of multiple substances inducing immune responses, and the complexity of the process due to many parameters. Technical problems such as these have brought obstacles to the innovative research of composite wound dressings, limiting the application of such wound dressings

Therefore, so far, there is almost no ideal composite wound dressing that can meet the requirements of skin wound dressings clinically.

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