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Chitosan/polycaprolactone composite nanofiber membrane material and application thereof

A composite nanofiber and polycaprolactone technology, applied in fiber processing, fiber chemical characteristics, single-component polyester rayon, etc., can solve the problem of unpredictable, composite wound dressings that cannot meet skin wound dressings, limitations Wound dressing and other issues

Inactive Publication Date: 2020-10-20
中国人民解放军陆军特色医学中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is expected that the composite nanofiber wound dressing prepared by electrospinning technology will be difficult to predict because of the interaction between various polymers, the problem of impurities, the possibility of multiple substances inducing immune responses, and the complexity of the process due to many parameters. Technical problems such as these have brought obstacles to the innovative research of composite wound dressings, limiting the application of such wound dressings
Therefore, so far, there is almost no ideal composite wound dressing that can meet the requirements of skin wound dressings clinically.

Method used

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  • Chitosan/polycaprolactone composite nanofiber membrane material and application thereof
  • Chitosan/polycaprolactone composite nanofiber membrane material and application thereof
  • Chitosan/polycaprolactone composite nanofiber membrane material and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 Preparation of CSLD-PCLM nanofiber membrane

[0039] A preparation process of CSLD-PCLM nanofiber membrane, comprising the following steps:

[0040] 1. Preparation of PCL polymer solution: add an appropriate amount of HFIP / DCM organic solvent at a volume ratio of 1:3 to prepare a 10wt% (ie, 100ml solution includes 10g PCL polymer) PCL solution, and magnetically stir overnight at room temperature to obtain a homogeneous solution. Subsequently, 2wt% mupirocin was added to the PCL solution and stirred for 24 hours.

[0041] 2. Preparation of CS polymer solution: 8 wt% CS was dissolved in 30% DCM and 70% TFA for 48 hours, then 1 wt% LID was dissolved in CS solution and stirred for 12 hours.

[0042] 3. Preparation of CSLD-PCLM nanofiber membrane: using double-spinneret electrospinning technology, specifically, the two polymer solutions prepared above were loaded into two syringe pumps (Longer Precision Pump, Baoding, China) respectively. ), the syringe pump con...

Embodiment 2

[0047] The variables of electrospinning are set to prepare CSLD-PCLM nanofiber membranes under different variables, and the specific preparation method is the same as that of Example 1. Table 1 shows the prepared CSLD-PCLM composite nanofibers under different electrospinning variables.

[0048]

[0049] Using SEM to observe the surface morphology of the composite nanofiber material prepared in embodiment 1 and embodiment 2a-2f, it is concluded that the PCL-M fiber and CS-LID fiber form are the best in the composite nanofiber prepared in embodiment 1, followed by the implementation Composite nanofibers of Examples 2a and 2b and Example 2d. When the present invention adjusts the above-mentioned electrospinning variables beyond the range of variables explored by the present invention, the composite nanofibers fail to form filaments, the filament formation rate is low, or the fiber morphology is different after filament formation.

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Abstract

The invention discloses a chitosan / polycaprolactone composite nanofiber membrane material. The chitosan / polycaprolactone composite nanofiber membrane material is prepared by the following steps that a6-15wt% polycaprolactone solution is prepared, and 1-4wt% mupirocin is added; a 5-12wt% chitosan solution is prepared, and 0.5-8wt% lidocaine hydrochloride is added; the solutions are put into a feeding device of electrospinning equipment, the feeding rate is 8-50[mu]L / min, the receiving distance is 10-20cm, and the rotating speed of a receiver is 100-250 rpm / min; a high-voltage power supply is turned on, a voltage of 15-25 kV is applied, and the solutions are sprayed onto the fiber receiver for forming; and drying is carried out to remove the solvent, so that a composite nanofiber membrane is obtained. The composite nanofiber membrane exhibits excellent hydrophilicity, swelling rate, absorption capacity, thermal stability, mechanical properties and effective blood clotting ability, and further exhibits excellent cell compatibility and antibacterial activity; different release curves of different functional drugs can be realized; and the wound healing process can be significantly enhanced, and a synergistic effect of wound healing is achieved.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a chitosan / polycaprolactone composite nanofiber membrane material and its application. Background technique [0002] The skin is the largest vital organ in the human body and plays a key role in sensory function, thermoregulation and protection from the external environment. Although the skin has the ability to regenerate itself, when the skin encounters acute wounds, large-area lesions, and chronic wounds, there will be problems such as infection and delayed wound healing process, so wounds need to be bandaged and other treatments. Today, ideal wound dressing fibrous membrane materials for dressing wounds are expected to possess properties such as biocompatibility, pain minimization, antimicrobial, coagulation, and hemostatic properties. In order to achieve the desired wound dressing, techniques such as freeze-drying, self-assembly, phase-separation, and electrospi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/728D01D5/00D01F6/92D01F9/00D01F1/10A61L15/26A61L15/28A61L15/42A61L15/44A61L15/46
CPCA61L15/26A61L15/28A61L15/42A61L15/44A61L15/46A61L2300/216A61L2300/232A61L2300/404A61L2300/406A61L2300/418A61L2300/602A61L2400/04A61L2400/12D01D5/0015D01F1/103D01F6/92D01F9/00D04H1/728C08L67/04C08L5/08
Inventor 张波李晓明刘苹
Owner 中国人民解放军陆军特色医学中心
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