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Novel method for synthesizing cefoperazone sodium compound

A technology for cefoperazone sodium and compound is applied in the new field of synthesizing cefoperazone sodium compound, which can solve the problems of long synthesis steps, high synthesis difficulty and low purity, and achieve the effects of low cost, simple operation and high purity

Active Publication Date: 2012-03-14
哈药集团股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The above-mentioned prior art has the disadvantages of long synthesis steps, high synthesis difficulty, low yield, and low purity. In order to overcome the above-mentioned shortcoming of the prior art

Method used

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Embodiment 2

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Abstract

The invention relates to a novel preparation method for (6R,7R)-3-[[(1-methyl-1H-tetrazole-5 radial)sulphur]methyl]-7-[(R)-2-(4-ethyl-2,3-dioxo-1-piperazine carbon amido)-2-p-hydroxyl phenyl-acetamido]-8-keto-5-thia-1-polyaza[4.2.0]octane-2-alkene-2-sodiumformate(cefoperazone sodium) shown as a formula (I). The formula (I) is shown in the specifications. The invention aims to provide a novel method for synthesizing a cefoperazone sodium compound. The method has the advantages of synthesis of TZA from 7-ACA (Acetic Acid) and 1-methyl-5-sulfydryl tetrazole, mild reaction condition, easiness for operating, one-step use of recyclable dimethyl carbonate serving as an environmentally-friendly solvent, great saving in the cost, high yields of products prepared in each step, good quality, low cost, high product purity and suitability for industrial production.

Description

technical field The invention relates to the technical field of medicine, in particular to a method for synthesizing cefoperazone sodium compound. Background technique Cefoperazone sodium (cefoperazone sodium), its chemical name is: (6R, 7R)-3-[[(1-methyl-1H-tetrazol-5yl)sulfur]methyl]-7-[(R)-2- (4-Ethyl-2,3-dioxo-1-piperazinecarbonylamino)-2-p-hydroxyphenyl-acetylamino]-8-oxo-5-thia-1-azabicyclo[ 4.2.0] Oct-2-ene-2-carboxylic acid sodium salt. It belongs to the third-generation cephalosporin antibiotics. It has the advantages of broad antibacterial spectrum and strong antibacterial effect. It is widely used in clinical practice, such as cefoperazone sodium for injection, and the compound preparation made with sulbactam is cefoperazone sodium and sulbactam sodium for injection. Its structural formula is: Cefoperazone sodium is an oral third-generation cephalosporin with a broad antibacterial spectrum. After entering the body, it is hydrolyzed into cefoperazone by n...

Claims

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Application Information

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IPC IPC(8): C07D501/36C07D501/04
Inventor 吴志军王喜军杨新春孙翠玲
Owner 哈药集团股份有限公司
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