19 results about "Eyes irritation" patented technology

The present application relates to an ophthalmic preparation and use thereof. Specifically, the present application relates to an ophthalmic preparation of pilocarpine and use thereof for treating eye diseases. The ophthalmic preparation of pilocarpine provided by the present application has the beneficial effects of good stability and less eye irritation.

The utility model relates to a lacrimal passage flushing auxiliary eyelid fixing tool which comprises an annular flexible eyeshade, and fixing structures used for fixing the annular flexible eyeshade to the eye socket position of a patient are installed at the two ends of the annular flexible eyeshade. Sliding sleeves are fixedly arranged on the upper side wall and the lower side wall of the annular flexible eyeshade in a penetrating mode, and pull rods are slidably connected into the sliding sleeves. When the eyeshade is used, the annular flexible eyeshade is worn at the eye socket position of a patient through the cloth belt, then the pull rod is pressed into the annular flexible eyeshade to extrude the spring to contract until the shifting plate installed on the metal reed moves to be aligned with the eyelids of the patient, then the screw is rotated to adjust the position of the metal reed so that the shifting plate can be attached to the eyelids of the patient, and the pull rod can be loosened. At the moment, the spring can push the pull rod to slide reversely under the action of elastic force, upper and lower eyelids of the patient are opened through the shifting plate, and the problem that operation of medical staff is affected due to frequent blinking of the patient caused by eye stimulation during lacrimal passage flushing of the patient is solved as much as possible.

The present invention relates to an eye drop composition comprising imatinib. The present invention relates to an eye drop composition and a method for preparing same, in which the eye drop composition is prepared at a pH level suitable as an eye drop while an appropriate amount of an imatinib derivative is dissolved even within a relatively high pH range, compared to conventional compositions prepared under pH conditions (< pH 5.5) unsuitable for eye drop, in order to dissolve imatinib, and has improved phase stability, long-term stability, bioavailability, and eye irritation.

The invention relates to the technical field of pharmaceutics, in particular to a monoclonal antibody preparation for inhibiting fibrosis after an eye operation and application. The anti-periostin humanized monoclonal antibody injection preparation provided by the invention is prepared from the following components: an anti-periostin humanized monoclonal antibody, a buffering agent, amino acid, polysorbate and trehalose. The preparation is stable in property. The biological activity is good, and the stimulation to eyeballs can be reduced.

The invention relates to the technical field of traditional Chinese medicines, in particular to a hydrogel eye patch for treating xerophthalmia as well as a preparation method and application thereof, and discloses a traditional Chinese medicine composition which comprises the following components in parts by weight: 6-15 parts of ginseng, 6-15 parts of fructus alpiniae oxyphyllae, 6-15 parts of bidens bipinnata, 6-15 parts of chrysanthemum, 6-15 parts of corydalis tuber, 6-15 parts of asparagus cochinchinensis, 6-15 parts of fructus aurantii and 3-9 parts of mint. The hydrogel eye pad prepared from the traditional Chinese medicine composition can improve cornea fluorescent staining, prolong tear film rupture time and increase tear secretion, clinical symptoms of xerophthalmia patients are effectively relieved, eye irritation is small when the eye pad is used, and patient compliance is improved.

The invention discloses eye drops containing polyvinyl alcohol and a preparation method of the eye drops. The eye drops are prepared from the following components in percentage by mass: 1.2 to 1.6 percent of polyvinyl alcohol, 0.3 to 0.8 percent of a thickening agent, 0.3 to 0.8 percent of a surfactant, 0.1 to 0.6 percent of a dispersing agent, 1.0 to 5.0 percent of a cosolvent and the balance of water for injection. The preparation method comprises the following steps: premixing the polyvinyl alcohol and the cosolvent; mixing the dispersing agent with 40-60% of water for injection, and then adding the surfactant; mixing the thickening agent with 20-30% of water for injection; and combining the mixtures in sequence, finally adding an isotonic agent to adjust the pH and osmotic pressure, supplementing the balance of water for injection, and carrying out multi-stage sterilization and filtration to obtain a finished product. The preparation can be completed at the temperature of 30-59 DEG C without a high-temperature condition, the dissolving time is less than 60 minutes, and the product is good in stability, free of eye irritation and suitable for industrial production.

The invention relates to the field of pharmaceutical preparations, in particular to an ophthalmic composition containing cyclosporine. The ophthalmic composition comprises a first component and a second component, wherein the first component is ciclosporin or a pharmaceutically acceptable salt or a pharmaceutically acceptable derivative thereof; and a second component, wherein the second component is selected from at least one of alkyl glycoside and polyethylene glycol-15-hydroxystearate. The cyclosporine composition disclosed by the invention is good in stability, and repeated administration results show that the composition is free from eye irritation, so that the safety and the patient compliance are greatly improved. Meanwhile, the preparation process of the cyclosporine composition is simple, batch production can be realized through a conventional ophthalmic preparation production line, and the cyclosporine composition is beneficial to popularization and application in actual production.

The invention relates to the field of contact lens care, in particular to a hydrogen peroxide care solution suitable for a platinum alloy neutralization ring. The care solution is prepared from the following components in parts by weight: 20 to 50 parts of hydrogen peroxide, 7.6 to 11.3 parts of borate buffer agent, 0.1 to 0.5 part of chelating agent, 6 to 12 parts of nano inclusion solution, 20 to 40 parts of solubilizer, 0.01 to 0.05 part of antioxidant, 5 to 10 parts of regulator and 1000 parts of distilled water. The hydrogen peroxide care solution provided by the invention is suitable for a platinum alloy neutralization ring, and a hydrogen peroxide stabilizing system, a dibazol slow-release system and other auxiliaries are added into the hydrogen peroxide care solution. The care solution can prolong the life of a platinum ring, and the corrosion rate of platinum alloy is reduced by more than 50%; the production of strong acid neutralization products is avoided, and the eye irritation is reduced; in addition, the antibacterial broad-spectrum property is also realized.

The invention relates to a high-stability and low-irritation composition for eye diseases as well as a preparation method and application of the high-stability and low-irritation composition. The composition comprises the following components in percentage by weight: 0.01%-0.2% of cyclosporin, 0.5%-10% of an oil phase, 0.05%-0.5% of cationic lipid, 0.1%-3.0% of an emulsifier, 0.1%-5.0% of a stability enhancer, 0.3%-3.0% of an osmotic pressure regulator and the balance of water. The innovation points are as follows: 1, the cyclosporin is embedded into an oil phase by adopting the oil-in-water nano emulsion, so that hydrolysis is avoided; meanwhile, trehalose or sodium mannose phosphate is added to inhibit drug degradation. 2, net positive charges are given to the emulsion through stearylamine or oleylamine, electrostatic adsorption with ocular surface anionic mucosa is enhanced, and the dwell time of a tear film is prolonged; and 3, poloxamer 188 is used for replacing a traditional preservative and is combined with natural anti-inflammatory components, so that the risk of corneal epithelium injury is reduced. Experiments show that the six-month drug retention rate of the composition in an acceleration test at 40 DEG C is greater than 95%, the irritation score of rabbit eyes is less than or equal to level 1, and the effective rate of treating xerophthalmia is increased by 25% compared with that of commercially available cyclosporin emulsion.

A cell-based device and method are disclosed for in vitro testing of compositions or compounds for irritation potential. Both the device and method comprise a) a confluent layer of corneal epithelial cells supported on a chemically patterned hydrogel, where the cells are aligned with the chemical pattern, b) a collector to receive effluent fluid, and optionally c) a detector. The device and method can also comprise an extracellular matrix (ECM) assembled by corneal keratocytes supported on the chemically patterned hydrogel. The cell-based device and method provide simple replacements for the in vivo Draize rabbit eye irritation test.

A non-contact optical measuring ruler for eyes comprises a light source, a convex lens is arranged on one side of the light source, a first shading plate is arranged between one side of the convex lens and the light source, a strip-shaped measuring hole and a positioning light slit are arranged horizontally on the shading plate, a strip-shaped shading sheet is arranged on the first shading plate, the shading sheet is arranged on the measuring hole and relatively movably cooperates with the first shading plate, a measuring light slit is arranged on the shading sheet, a second shading plate is arranged on the other side of the convex lens, two splitting holes are arranged longitudinally on the second shading plate, and the positions of the two splitting holes and the measuring hole and the positioning light slit are arranged perpendicular to each other. The present invention adopts the optical imaging principle to project optical measurement marks on the measured object to complete the comparison measurement of the same plane, and its purpose is to complete the measurement of the eye structure in a non-contact state, reduce the stimulation to the eye of the examinee, and eliminate the risk of damaging the eye structure and causing eye infection caused by contact measurement.

The invention belongs to but not limited to the technical field of biological extraction, and discloses a high-activity eggshell membrane composite enzymatic hydrolysis extraction process and an extract, the process adopts a composite enzyme system of alkaline protease and papain for directional hydrolysis, and is combined with low-temperature ultrafiltration purification and freeze drying technologies, the total amount of amino acid in the obtained extract is greater than or equal to 79g / 100g, and the total amount of amino acid in the extract is greater than or equal to 79g / 100g. The sodium hyaluronate content is greater than or equal to 4.4 g / 100g, the collagen content is greater than or equal to 6.8%, the water solubility is greater than or equal to 95%, no skin and eye irritation is caused, the method can be widely applied to the fields of food health care, cosmetics, pet food and the like, the technical problems of loss of active ingredients and poor water solubility of a traditional process are solved, and the method is stable and controllable and suitable for industrial production. Through detection, the total amount of amino acid in the extract reaches 79.3 g / 100g, the content of sodium hyaluronate is 4.4 g / 100g, the content of collagen is 6.8%, and the extract is free of skin and eye irritation, can meet the application requirements in the fields of food health care, cosmetics and the like, is mature and controllable in process and is suitable for industrial large-scale production.

The disclosure relates to formulations and methods for the in chemico testing of toxins based on a discovery that measuring a reduction in enzyme activity can be used to predict in vivo toxicity, including for example, a skin corrosion, skin irritation, eye corrosion, eye irritation, lung toxicity, liver toxicity, nervous system toxicity, developmental toxicity, acute toxicity etc. Disclosed methods are rapid, easy to perform and shelf-stable approaches for identification of toxic chemicals and materials.

The present invention provides a detection method and a detection system for an active disinfection and sterilization device without chemical consumables that can coexist with humans. The detection method includes: Step A, placing the active disinfection and sterilization device in a test chamber, and after starting the device and running for a first period of time, performing: Step A1, measuring the concentration of by-products on the disinfection and sterilization factor output channel of the active disinfection and sterilization device; Step A2, collecting the disinfection and sterilization factors output by the active disinfection and sterilization device to obtain a liquid of disinfection and sterilization factors, and performing an acute inhalation toxicity test and / or a skin irritation test and / or an acute eye irritation test on the liquid of disinfection and sterilization factors. Testing in a clean and airtight test chamber can reduce the interference of the external environment and improve the test accuracy; this detection method not only detects the concentration of by-products, but also detects the harm of the disinfection and sterilization factors output by the active disinfection and sterilization device that directly acts on the human body, and can comprehensively and accurately evaluate the advantages and disadvantages of the human-machine coexistence of the active disinfection and sterilization device without chemical consumables, making the active disinfection and sterilization device safer and more reliable.

This invention relates to the field of traditional Chinese medicine antibacterial liquid technology, and particularly to a traditional Chinese medicine antibacterial liquid for nasal use, made from the following raw materials: Xanthium sibiricum, Centipeda minima, Magnolia biondii, Asarum heterotropoides, Acorus tatarinowii, Akebia trifoliata, Atractylodes lancea, Indigo naturalis, Mentha haplocalyx, and polyhexamethylene biguanide. This invention combines nine traditional Chinese medicines—Xanthium sibiricum, Centipeda minima, Magnolia biondii, Asarum heterotropoides, Acorus tatarinowii, Akebia trifoliata, Atractylodes lancea, Indigo naturalis, and Mentha haplocalyx—with polyhexamethylene biguanide. The traditional Chinese medicine components are an improvement on the ancient formula of Xanthium sibiricum powder, synergistically exerting the effects of clearing the lungs and nasal passages, dispelling wind and cold, and anti-inflammatory and anti-allergic properties. Polyhexamethylene biguanide provides broad-spectrum antibacterial efficacy. By changing the traditional oral dosage form to a nasal drop, the liquid acts directly on the nasal mucosa lesion site, avoiding the first-pass effect of the liver and the metabolic burden on the kidneys associated with oral medications, significantly improving drug safety. Skin irritation, eye irritation, and allergy tests all showed no irritation or sensitization.

The invention belongs to the technical field of medical cosmetology, and discloses a melting-eliminating high-content salicylic acid composition as well as a preparation method and application thereof. The composition comprises salicylic acid, polyethylene glycol-8 and PPG-14-polyglycerol-2-ether, the weight fraction ratio of the salicylic acid to the polyethylene glycol-8 to the PPG-14-polyglycerol-2-ether is 3: (4-6): (1-3), and the weight percentage of the salicylic acid in the composition is 25%-30%. According to the composition disclosed by the invention, polyethylene glycol-8 and PPG-14-polyglycerol-2-ether in a specific proportion are taken as cofluxing agents, a stable homogeneous system is formed after the cofluxing agents and salicylic acid are co-melted, no salicylic acid melting peak exists in DSC scanning, and the problems that salicylic acid is poor in solubility and easy to crystallize and separate out in a formula are solved. The composition has good mildness, is not added with an organic solvent, a pH regulator and other components, and is verified by rabbit acute eye irritation tests and multiple skin irritation tests to be non-irritant. The preparation process is simple and easy to operate, and industrial production is facilitated.

This eye drop contains (A) 0.02-0.15 w / w% (inclusive) of a 2-methacryloyloxyethyl phosphorylcholine-dimethylacrylamide-stearyl methacrylate copolymer in which the molar ratio of structural units represented by formula (1) is a: b: c = 100: 10-400: 2-50, (B) 0.000001-0.0001 w / w% (inclusive) of polyhexamethylene biguanide represented by formula (2) or a salt thereof, and (C) 0.02 to 2.0 w / w% (inclusive) of polyoxyethylene polyoxypropylene glycol, and the content of sodium chloride is 0.3 w / w% or less. According to the present invention, it is possible to provide an eye drop which imparts lubricity to the cornea surface, has sufficient storage efficacy, and has low eye irritation.

The disclosure relates to formulations and methods for the in chemico testing of toxins based on a discovery that measuring a reduction in enzyme activity can be used to predict in vivo toxicity, including for example, a skin corrosion, skin irritation, eye corrosion, eye irritation, lung toxicity, liver toxicity, nervous system toxicity, developmental toxicity, acute toxicity etc. Disclosed methods are rapid, easy to perform and shelf-stable approaches for identification of toxic chemicals and materials.

To provide a method for manufacturing a partial plating product that can improve the working environment of a person, and that can peel off a masking agent in a short time even if the peeling agent is safe for the human body after plating, and to provide a partial plating product. 【Solution means】An oil-based ink containing rosin resin and alcohols as main components is used as a masking agent to form a coating film layer 20 on a plating base material 10, and by volatilizing the alcohols from the coating film layer, a consolidated film 30 mainly composed of rosin resin is formed. Further, a plating layer 50 is formed on the portion of the plating base material where there is no consolidated film by plating treatment with an acidic bath that does not dissolve the consolidated film. Alcohols have less eye irritation and irritating odor than thinners, are safe for the human body, so the working environment can be improved, and a consolidated film can be formed in a short time. Also, the rosin resin forming the consolidated film can be easily peeled off with alcohols.