61results about How to "Achieve slow release" patented technology

The invention provides poly (gamma-propargyl-L-glutamate)-polyamino acid segmented copolymer. The poly (gamma-propargyl-L-glutamate)-polyamino acid segmented copolymer is presented as the formula (I). Small molecules containing primary amino radical serve as an initiator, and the poly (gamma-propargyl-L-glutamate)-polyamino acid segmented copolymer is obtained through the gradual ring cleavage reaction of gamma- propargyl-L-glutamate-N-carboxylic acid anhydride and amino acid-N- carboxylic acid anhydride. The side chain of the segmented copolymer is propargyl which is easy to modify, has high reactivity and is beneficial to functional small molecules which are subjected to bonded azide and have biological activity or environmental responsiveness, and the bonding process cannot lead to the breakage of amino acid backbones and is not affected by the amount and steric hindrance of functional small molecules. The segmented copolymer has good biocompatibility after being functionalized and can be applied in fields such as targeted drug delivery, organizational projects and protein separation and detection.

The invention discloses an efficient compound fertilizer which is prepared from the following raw materials in parts by weight: 70-80 parts of sheep manure, 45-50 parts of waste residues of beer, 23-26 parts of pear saw dust, 30-34 parts of potatoes, 30-34 parts of urea, 20-23 parts of monopotassium phosphate, 12-17 parts of diammonium phosphate, 10-14 parts of potassium chloride, 10-12 parts of potassium sulfate, 1-2 parts of sodium sulfite, 4-6 parts of sodium humate, 4-6 parts of a coating agent, 3-4 parts of an EM bactericide, and a proper amount of water. The fertilizer disclosed by the invention is prepared from organic matters including the sheep manure, the waste residues of beer, the pear saw dust, the potatoes and the like which are added with nitrogen, phosphorus and potassium, micro-elements, mid-elements and a sustained-release material, so that the fertility of the soil is improved and the aim of slowly releasing fertilizer nutrients is achieved, the utilization rate of the fertilizer is increased as well, and the environmental pollution is reduced. The prepared fertilizer has the characteristics of water retention, fertilizer retention, long fertilizer action time and good air permeability; meanwhile, the soil can be improved, nutrient balance of the soil is guaranteed, and sustainable development of the agriculture is promoted.

The invention discloses a preparation method of an icariin controlled release chitosan/hydroxyapatite composite scaffold material. The method comprises the following steps: (1) preparing a raw material solution; and (2) stirring and mixing a chitosan solution with hydroxyapatite slurry evenly to obtain mixed slurry, dropwise adding a succinic acid icariin solution at the amount of keeping the final concentration of succinic acid icariin in the mixed slurry at 1*10<-5> to 1*10<-2> mol/L, adding a cross-linking agent, adjusting the pH to be 5.0-6.5, further stirring and reacting for 10-120 minutes, centrifuging reaction liquid and removing bubbles after reaction is ended, injecting into a mold, and standing for 10-240 minutes to obtain a gel product; freezing, drying, washing, and freezing and drying again. The composite scaffold material disclosed by the invention is capable of improving the bone repair performance of the scaffold material through proliferation and differentiation of slowly released Ica regulating cells.

The invention relates to a controlled-release compound fertilizer, which consists of the following components in parts by weight: 10-30 parts of a phosphogypsum-fly ash slow-release compound, 20-40 parts of a slow-release nitrogen fertilizer containing a urease inhibitor and a digesting bacteria inhibitor, 15-30 parts of a mixed potassium fertilizer and 2-4 parts of a trace element compound. In the invention, the phosphogypsum-fly ash slow-release compound is adopted, so that slow release of fertilizer nutrients is realized, the utilization ratio of the fertilizer is increased, pollution is eliminated, the environment is protected, resources are saved, and production cost is lowered; and the stable digesting bacteria inhibitor is used, so that the nitration and denitrification reaction rates are effectively lowered, leaching loss of the nitrogen fertilizer and release of the nitrogen fertilizer in the form of NO and NO2 gas are reduced, and the utilization ratio of the fertilizer is increased.

The invention discloses a yeast microcapsule of globe artichoke polyphenol and a preparation method of the yeast microcapsule. A yeast microcapsule product is prepared from freeze-dried powder of globe artichoke serving as a core material and yeast cells serving as an embedding wall material through water bath constant-temperature oscillation, centrifuging and freeze-drying, wherein the freeze-dried powder of globe artichoke is obtained through extraction, purification and freeze-drying. Yeast cells are rich in nutrition self, and due to microencapsulation of the yeast cells, the antioxidant activity of polyphenol is maintained, and furthermore nutrient substances of yeast are supplied, so that the yeast microcapsule has the characteristics of slow medicine release, high bioavailability, relatively simple preparation process and is suitable for industrial large-scale production, and meanwhile ideas and directions are provided for further application of polyphenol.

The invention discloses a sustained-release soluble microneedle, a preparation method and application. The microneedle comprises a base body, a needle body and a carrier which is distributed in the needle body and coated with a drug to be sustained-released, wherein the carrier comprises a degradable high polymer material or inorganic nanoparticles modified by a polymer. The method comprises the following steps of: preparing the carrier coated with the drug to be sustained-released by adopting one of an emulsion method, a dialysis method, a solvent evaporation method, a spray drying method anda polyelectrolyte protection method, wherein the carrier comprises the degradable high polymer material or the inorganic nanoparticles; and dissolving or dispersing the carrier coated with the drug to be sustained-released into a matrix solution, casting the matrix solution into a mold by utilizing a vacuumizing method, drying and demolding to obtain the sustained-release soluble microneedle. According to the sustained-release soluble microneedle, the degradable high polymer material or the inorganic nanoparticles modified by the polymer are used as the carrier of the drug, so that the release speed of the drug is slowed down.

The invention discloses an insect sex pheromone micro-capsule based on a multiwalled carbon nanotube. The micro-capsule is composed of a capsule wall and a core material. The multiwalled carbon nanotube is used for making the capsule wall, and the core material comprises insect sex pheromones (Z,E)-9,12-tetradecadienyl acetate or (Z,E)-9,11-tetradecadienyl acetate. The multiwalled carbon nanotube has a special seamless hollow nanoscale coaxial cylinder structure and has a larger specific area and higher loading capacity. The multiwalled carbon nanotube is used for making the capsule wall, the loading capacity of the insect sex pheromones can be larger, slow release of the insect sex pheromones in the micro-capsule can be achieved, the lasting, efficient and stable pest trapping and killing effect is achieved, and storage stability is improved. Meanwhile, the dosage of an organic solvent is small in the preparation process of the micro-capsule, environmental pollution caused in the use process can be avoided, and the micro-capsule is an efficient and environment-friendly material.

The invention belongs to the field of medicinal preparations, and relates to aqueous dispersion preparation of a camptothecin analogue-phospholipid complex and a method for preparing the same. The aqueous dispersion of the camptothecin analogue-phospholipid complex substantially consists of camptothecin analogue, phospholipid and water for injection of therapeutic effective dose, and each milliliter of aqueous dispersion comprises the following components: 0.001 to 5 mg of camptothecin analogue, 0.001 to 500 mg of phospholipid, 0 to 500 mg of additive and the balance of the water for injection. The aqueous dispersion of the camptothecin analogue-phospholipid complex provided by the invention has the advantages of active structure of a lactone ring of camptothecin, high medicament-loading rate, wide clinical application range, little toxic or side effect, long-circulation modification and freeze drying storage, good stability of the preparations, high medicament-to-phospholipid ratio, industrialized production and the like.

The invention disclose a lignin-containing organic-inorganic compound fertilizer prepared by an ammonia-acid method as well as the ammonia-acid production method. According to the invention, the organic-inorganic compound fertilizer is prepared by using the following components in parts by weight through an ammonia-acid process: 20-30 parts of lignin, 50-60 parts of nitrogen-phosphorus-potassium fertilizer, 0.2-0.5 parts of compound inoculant, 3-5 part of concentrated sulfuric acid, 2.5-3.5 parts of liquid ammonia and 5-15 parts of binding agent; and the raw materials also include 2-4 parts of chelated trace element fertilizer. The organic-inorganic compound fertilizer prepared by the ammonia-acid method uses the lignin as the source of organic material, has a large amount of organic active materials and a large amount of nitrogen, phosphorus and potassium elements, and can satisfy the growth needs of the farm corps completely.

The present invention discloses anti-aging yoghurt containing modified starch and a preparation method thereof. The anti-aging yoghurt containing the modified starch comprises the following raw materials in parts by weight: 40-100 parts of bovine colostrum, 10-30 parts of fish collagen peptide powder, 1-5 parts of a thickener, 2-6 parts of concentrated fruit juice, 0.5-1.5 parts of tea polyphenol nanoparticles, 0.1-1 part of a sweetener and 0.1-1 part of probiotics. The thickener is composed of sodium alginate and modified starch according to a mass ratio of 1:(4-6). The anti-aging yoghurt containing the modified starch is rich in nutrients, delicate in mouthfeel, smooth and refreshing, has effects of regulating balance of human body intestinal micro-ecology, improving intestinal functions, lowering blood lipids and lowering blood pressure, enhancing human body immunity and delaying aging, and is simple and easy to implement in the preparation method, strong in operability, low in cost and suitable for factory production applications.

The invention relates to the technical field of rice planting, and discloses a rice planting compound fertilizer capable of improving soil, the rice planting compound fertilizer comprises the following raw materials in parts by mass: 20-30 parts of a massive element fertilizer, 15-20 parts of a medium element fertilizer, 10-15 parts of a trace element fertilizer, 3-8 parts of biological bacteria,1-5 parts of a water-retaining sustained-release agent, 1-5 parts of a plant growth conditioner, 1-5 parts of a chelating agent and 12-49 parts of a filler; and the filler comprises bentonite, dregs,shrimp shell powder, medical stone powder, diatomite, light burned magnesium powder and rice husk ash. The invention also discloses a preparation method of the rice planting compound fertilizer capable of improving soil. According to the invention, the combination of a soil conditioner and the fertilizers can provide comprehensive and balanced nutrition required by rice, the fertilizer effect is rapid and lasting, the labor amount of farmers is reduced, time and labor are saved, heavy metals can be effectively prevented from being absorbed by crops, and the effect of treating the heavy metalsis achieved.

The invention relates to a functional fertilizer synergic composition which comprises a fertilizer synergist, a water retaining slow release agent and an organic matter, wherein the fertilizer synergist is potassium polyaspartate, the weight-average molecular weight of which is 8000-15000. Meanwhile, the invention also provides a preparation method of the functional fertilizer synergic composition. The functional fertilizer synergic composition is different from an existing fertilizer synergist which is single in function, and can realize slow release of the powder fertilizer, so that the utilization ratio of the fertilizer by crops is improved, and the usage of the fertilizer is reduced; and in addition, the composition can be used for surface treatment of the powdery fertilizer, can effectively prevent agglomeration of the powder fertilizer, improves the soil structure, and has a certain water-retaining and drought-resisting effect. As the environment-friendly functional fertilizer synergic composition, the functional fertilizer synergic composition has a wide application prospect.

The invention provides a slow-release pesticide fertilizer containing imidacloprid and pyrazosulfuron-ethyl for rice. The slow-release pesticide fertilizer comprises the following raw materials in parts by mass: 0.6 to 1.2% of imidacloprid, 0.05 to 0.1% of tetrachlorantraniliprole, 1%-3% of mefenacet; 0.2 to 0.4% of pyrazosulfuron-ethyl, 40%-50% of a nitrogen-phosphorus-potassium compound fertilizer, 10%-15% of medical stone powder, 15%-20% of modified sawdust, 5%-10% of ethyl cellulose, 5%-10% of cassava starch, 5%-10% of acetate starch, 0.1%-0.2% of a dispersing agent, 0.1%-0.3% of an emulsifying agent and 1%-3% of water. The invention also provides a preparation method of the pesticide fertilizer. The pesticide fertilizer has the characteristics of insect killing, weeding and nutrient supply for rice, and also has the function of releasing nutrients in stages and the like.

The invention discloses a thermoplastic elastomer used in an automobile engine, having temperature resistance grade of 150 DEG C and having oxygen resistance and oil resistance and a preparation method thereof. The thermoplastic elastomer is composed of the following raw materials in parts by mass: 50-75 parts of acrylate rubber, 25-50 parts of polyamide, 10-20 parts of carbon black, 2-4 parts ofa softening plasticizer, 5-30 parts of a surface modified loaded anti-aging agent, 1-2 parts of a processing aid and 2-4 parts of a vulcanizing agent. The invention also discloses the preparation method of the thermoplastic elastomer used in the automobile engine, having temperature resistance grade of 150 DEG C and having oxygen resistance and oil resistance. A polyacrylate rubber/polyamide TPV material is prepared by a dynamic vulcanization method; the problem that a traditional anti-aging agent is easy to extract is solved by using the loaded type anti-aging agent in the material; meanwhile, the anti-aging agent is slowly released, and the TPV material which can be used in the automobile engine and has long-term high temperature resistance, oil resistance and thermo-oxidative aging resistance is obtained.

The invention discloses a preparation method for azithromycin micro-emulsion eye drops. The preparation method comprises the following steps: under the condition of 40-50 DEG C of the temperature, slowly dropwise adding an oil phase using midchain oil as a matrix into a water phase in which azithromycin, an organic acid and buffer salt thereof are dissolved, adding an emulgator, and uniformly stirring to obtain the azithromycin micro-emulsion eye drops. The preparation method is capable of, under the heating condition, using the midchain oil as the oil phase matrix which is dropwise added into water solution in which the azithromycin and the organic acid and the buffer salt thereof are dissolved, embedding the acidized azithromycin dissolved in the water, and remarkably improving the bioavailability of the eye drops. In addition, O/W microemulsion is formed by a self-emulsifying method under the situation without adding an organic solvent, the permeability of cell membranes is greatly increased, the storage stability of the eye drops is improved, the slow release of the azithromycin in the eyes is realized, the untoward effect of the larger eye irritation by drugs is relieved, the eye drops has the good biocompatibility, the drug loss is reduced, the vision is not affected, the administration frequency is reduced, and the patient adaptability is improved.

The invention discloses an aspirin and rivaroxaban compound preparation and a preparation method thereof. The compound preparation is prepared by filling aspirin micro-tablets and rivaroxaban micro-tablets into capsules, wherein aspirin is released in an enteric manner, rivaroxaban is released in a slow-release manner, and aspirin and rivaroxaban are used for treating thrombolysis and preventing thrombosis and other related diseases; the aspirin micro-tablets are enteric-coated tablets, the specification is 25-100 micrograms/tablet, and each capsule is filled with 1-4 aspirin micro-tablets; and the specification of the rivaroxaban micro-tablets is 1.25-20 micrograms/tablet, and each capsule is filled with 1-8 rivaroxaban micro-tablets. According to the compound solid preparation, differentmedicines and different types of micro-tablets are filled into the same capsule to prepare the compound preparation, so that the compound preparation is convenient for patients to take, and the riskof missing taking is reduced. Moreover, the capsule is convenient to open, and the micro-tablet filled capsule has a more flexible administration mode.

The invention discloses novel production equipment and process for producing a water quality improver prepared from oyster shell powder, and belongs to the field of agriculture. The novel production equipment is characterized in that a shell body is located above a granulation mold to form a closed space, a compression roller assembly is located on the upper surface of the granulation mold and cando rotational motion around the central axis of the granulation mold, and granulation through holes are formed in the positions, corresponding to the compression roller assembly, of the granulation mold; and a grinding assembly is installed on the outer side of the circumference of the compression roller assembly below the shell body and can rotate in the axis direction of the compression rollerassembly, and a first feeding pipeline used for containing blocky oyster shells, a second feeding pipeline used for containing coal cinder and a third feeding pipeline used for containing bentonite are fixedly formed in the lower surface of the shell body. The novel production equipment has the beneficial effects that the oyster shell powder, the coal cinder and the bentonite are mixed and granulated to form oyster shell powder purification blocks with a certain size, the oyster shell powder purification blocks are placed at the bottom of a water body, the slow release of the oyster shell powder can be achieved, the purification effect is stable, and the oyster shell powder purification blocks can be fished out after being used for a period of time and are convenient to recycle.

The embodiment of the invention discloses a multifunctional soil compound fertilizer. The multifunctional soil compound fertilizer is prepared from the following components in parts by mass: 10 to 30parts of urea, 10 to 30 parts of monoammonium phosphate, 5 to 20 parts of potassium sulfate, 10 to 30 parts of humic acid, 0.2 to 4 parts of zinc sulfate, 0.2 to 5 parts of ferrous sulfate, 0.1 to 2 parts of boric acid, 0.2 to 5 parts of copper sulfate, 0.2 to 5 parts of manganese sulfate, 0.1 to 1 part of ammonium molybdate and 10 to 20 parts of biological bacteria. The multifunctional soil compound fertilizer fully utilizes oyster shells, river sand, light burnt magnesium, organic matters, the humic acid, the biological bacteria and various trace elements, so that balanced nutrition can be provided for crops; meanwhile, a sulfur coat is used to wrap various nutrients to realize slow release of the various nutrients, which improves the fertilizer utilization, reduces the fertilizer loss and increases the grain yield; and the multifunctional soil compound fertilizer can be widely applied to soil improvement and fertilization.

The invention provides slow controlled-release fertilizer used for corn. The fertilizer is prepared from a urea furfural condensation product, furfural residues, rice husk charcoal, compound fertilizer and vermiculite powder. According to the characteristics of large biomass of corn and high demand of nitrogen and potassium, the compound fertilizer is quick in fertilizer efficiency, and is combined with the vermiculite powder and the rice husk charcoal, the nitrogen and potassium content is increased, the dissolution rate of nitrogen and potassium is reduced, the slow action effect of the compound fertilizer is improved, the demand for nitrogen and potassium in a corn large bell mouth stage and later growth and development is provided, and the vermiculite powder can also improve the fertility; the furfural residues and the urea furfural condensation product are combined, the biomass content and the nitrogen release capacity of the urea furfural condensation product are improved, at thesame time, the content of organic matter in the furfural residues and the rice husk charcoal is high, soil physical properties are improved, and nitrogen, phosphorus and potassium elements can be released to promote corn growth; and the rice husk charcoal is combined with the vermiculite powder to improve soil fertility and improve soil, and the slow controlled-release fertilizer used for the corn can better achieve slow releasing of nitrogen and potassium, and the effective period is more than 70 days.