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Natamycin-grafted oxidized alginic acid fiber membrane and preparation method thereof

A technology for oxidizing alginic acid and catacinamycin, which is applied in the field of medical materials and can solve the problem of low degradation rate

Active Publication Date: 2021-07-06
THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the degradation rate of alginate itself is very low. In order to improve the degradation performance of alginic acid, alginic acid is oxidized to convert the hydroxyl groups of some uronic acid units of alginic acid into aldehyde groups, so as to improve the degradation performance of alginic acid; The reactivity of the aldehyde group is relatively high, and it can be coupled with biologically active substances such as active proteins, polypeptides, and specific amino acid sequences, and can improve the interaction between materials and cells. Therefore, it is necessary to seek to design a grafted natamycin oxidation The alginate fiber film and its preparation method, using the oxidized alginate fiber prepared by oxidizing the alginate fiber to graft natamycin, effectively improving the utilization rate of natamycin and reducing the eye irritation and discomfort of natamycin sense, improve the therapeutic effect of fungal keratitis

Method used

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  • Natamycin-grafted oxidized alginic acid fiber membrane and preparation method thereof
  • Natamycin-grafted oxidized alginic acid fiber membrane and preparation method thereof
  • Natamycin-grafted oxidized alginic acid fiber membrane and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0023] This example relates to an oxidized alginate fiber membrane grafted with natamycin, which is prepared by soaking the oxidized alginate fiber in an aqueous solution of natamycin, and reacting the oxidized alginate fiber with natamycin in a Schiff base, specifically The preparation process is as follows:

[0024] (1) Preparation of oxidized alginic acid fiber: take alginic acid fiber, rinse it with sterilized double distilled water, remove impurities on the surface of the fiber, then dry it at 45°C to constant weight, and then put it into Soak in sodium periodate aqueous solution, stir and react at 40°C for 0.5-1.5 hours at a constant temperature in the dark, to generate oxidized alginic acid (OCA) fibers;

[0025] (2) Soak the oxidized alginic acid fiber in a glycerol aqueous solution with a molar concentration of 0.1mol / L for half an hour to remove unreacted sodium periodate, then rinse it with sterilized double distilled water for 3 times, and put it in an oven Dry at...

Embodiment 2

[0029] This example relates to an oxidized alginate fiber membrane grafted with natamycin, which is prepared by soaking the oxidized alginate fiber in an aqueous solution of natamycin, and reacting the oxidized alginate fiber with natamycin in a Schiff base, specifically The preparation process is as follows:

[0030] (1) Preparation of oxidized alginic acid fiber: take alginic acid fiber, rinse with sterilized double distilled water to remove impurities on the surface of the fiber, then dry at 45°C to constant weight, and then add high iodine with a mass concentration of 1g / L Soak in sodium nitrite aqueous solution, stir and react at 40°C for 1 hour at a constant temperature in the dark, to generate oxidized alginic acid (OCA) fibers;

[0031] (2) Soak the oxidized alginic acid fiber in a glycerol aqueous solution with a molar concentration of 0.1mol / L for half an hour to remove unreacted sodium periodate, then rinse it with sterilized double distilled water for 3 times, and ...

Embodiment 3

[0035] This example relates to an oxidized alginate fiber film grafted with natamycin, which is prepared by soaking the oxidized alginate fiber in an aqueous solution of natamycin, and the oxidized alginate fiber undergoes a Schiff base reaction with natamycin, specifically The preparation process is as follows:

[0036](1) Preparation of oxidized alginic acid fiber: take the woven alginic acid fiber, rinse it with sterilized double distilled water to remove impurities on the surface of the fiber, then dry it at 45°C to constant weight, and then put it into the Soak in L of sodium periodate aqueous solution, stir and react at 40°C for 0.5 hours at a constant temperature in the dark to avoid light, and generate oxidized alginic acid (OCA) fibers;

[0037] (2) Soak the oxidized alginic acid fiber in a glycerol aqueous solution with a molar concentration of 0.1mol / L for half an hour to remove unreacted sodium periodate, then rinse it with sterilized double distilled water for 3 t...

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Abstract

The invention relates to the technical field of medical materials, and relates to a natamycin-grafted oxidized alginic acid fiber membrane and a preparation method thereof. The preparation method comprises specific preparation process as follows: preparing oxidized alginic acid fiber: reacting sodium periodate with alginic acid fiber to obtain the oxidized alginic acid fiber; putting the oxidized alginic acid fiber into a glycerol aqueous solution to be soaked, conducting rinsing and drying, and putting the oxidized alginic acid fiber into a dry and sterile centrifugal tube to be stored; and soaking the oxidized alginic acid fiber with a natamycin aqueous solution, oscillating and incubating the oxidized alginic acid fiber at 50 DEG C in a dark place for 36 hours, then washing the oxidized alginic acid fiber twice with an ethanol aqueous solution and deionized water, and drying to obtain the oxidized alginic acid fiber membrane. The surface of the oxidized alginic acid fiber membrane is grafted with natamycin, so that the eye irritation and discomfort caused by the natamycin can be reduced, the half-life period of the medicine is prolonged, the utilization rate of the medicine is increased, and the treatment effect of the fungal keratitis is improved; and the preparation process is simple, the cost is low, and the product is easy to preserve and has wide market prospects.

Description

Technical field: [0001] The invention relates to the technical field of medical materials, and relates to an oxidized alginate fiber membrane grafted with natamycin and a preparation method thereof. Natamycin is grafted on the surface of the oxidized alginate fiber membrane, which can reduce natamycin eye damage. Reduce external irritation and discomfort, prolong the half-life of the drug, improve the utilization rate of the drug, and improve the therapeutic effect of fungal keratitis. [0002] technical background: [0003] Fungal keratitis (Fungal keratitis, FK) is a corneal disease caused by pathogenic fungal infection. my country, as a developing country with industry and agriculture as its main industry, is a high-incidence area of ​​fungal keratitis. Corneal trauma, especially plant trauma during production activities provides opportunities for the occurrence of fungal keratitis. With the continuous expansion of the population and the abuse of antibiotics and hormones, ...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K31/7048A61K47/61A61P27/02A61P31/10
CPCA61K31/7048A61K47/6953A61K47/61A61K9/0048A61P31/10A61P27/02
Inventor 赵桂秋李翠李道浩彭旭东林静尹敏胡丽婷刘桂波
Owner THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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