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A kind of external plaster for treating joint pain and arthritis and preparation method thereof

A technology for joint pain and joint, which is applied in the field of topical plaster for treating joint pain and joint inflammation and its preparation field, can solve the problems of short drug effect time, difficulty in achieving air permeability, poor air permeability and the like, and achieves simple preparation method and good sustained release effect, effect of good breathability

Active Publication Date: 2021-05-18
杭州仁德药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Existing plasters usually use natural rubber matrix. A serious disadvantage of natural rubber-based plasters is their extremely poor air permeability. , but in order to improve the air permeability of plaster paste, the effect of such improvement is extremely limited, and it is difficult to achieve good air permeability requirements
In addition, there is another shortcoming, which is also the problem of the existing natural rubber matrix plaster, that is, its drug effect time is short, and it does not have the characteristics of long-acting onset, which also causes patients to frequently replace the plaster when using it. , which brings great inconvenience to patients, especially for plasters that need to be applied on special parts, and the replacement brings great inconvenience; existing sustained-release drugs only exist in oral and other drugs, for There are almost no sustained-release treatment methods for external-use drugs, which can achieve a feasible and effective drug sustained-release treatment method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] An external plaster for treating joint pain and arthritis, prepared from the following raw materials in parts by weight:

[0037]250 parts of pepper, 25 parts of menthol, 25 parts of borneol, 200 parts of rubber, 80 parts of lanolin, 240 parts of zinc oxide, 240 parts of rosin, 70 parts of beeswax, 7 parts of coating agent, 500 parts of gasoline; Acetyl chitin;

[0038] Wherein, zinc oxide is a mixture of zinc oxide powder and zinc oxide fiber, wherein the weight percentage of zinc oxide fiber is 45%; the length of zinc oxide fiber is 50 μm, the aspect ratio is 5, and the particle size of zinc oxide powder is 200 mesh;

[0039] Zinc oxide is processed through the following steps before use:

[0040] Add zinc oxide to water twice the weight of zinc oxide, then add carboxymethyl cellulose with 20% weight of zinc oxide, and stir magnetically at a speed of 41rpm for 10 minutes, then magnetically stir at a speed of 11rpm for 1 minute, then vacuum The liquid is removed by f...

Embodiment 2

[0051] An external plaster for treating joint pain and arthritis, prepared from the following raw materials in parts by weight:

[0052] 250 parts of pepper, 30 parts of menthol, 30 parts of borneol, 250 parts of rubber, 90 parts of lanolin, 250 parts of zinc oxide, 255 parts of rosin, 80 parts of beeswax, 9 parts of coating agent, 560 parts of gasoline; Acetyl chitin and dimethylaminoethyl methacrylate-methacrylate copolymer are composed at a weight ratio of 5:4;

[0053] Wherein, zinc oxide is a mixture of zinc oxide powder and zinc oxide fiber, wherein the weight percentage of zinc oxide fiber is 50%; the length of zinc oxide fiber is 200 μm, the aspect ratio is 7, and the particle size of zinc oxide powder is 300 mesh;

[0054] Zinc oxide is processed through the following steps before use:

[0055] Add zinc oxide to water that is 4 times the weight of zinc oxide, then add carboxymethyl cellulose with 30% weight of zinc oxide, and magnetically stir at a speed of 45rpm for...

Embodiment 3

[0066] An external plaster for treating joint pain and arthritis, prepared from the following raw materials in parts by weight:

[0067] 250 parts of pepper, 30 parts of menthol, 30 parts of borneol, 250 parts of rubber, 90 parts of lanolin, 250 parts of zinc oxide, 255 parts of rosin, 80 parts of beeswax, 9 parts of coating agent, 560 parts of gasoline; Acetyl chitin and dimethylaminoethyl methacrylate-methacrylate copolymer are composed at a weight ratio of 5:12;

[0068] Wherein, zinc oxide is a mixture of zinc oxide powder and zinc oxide fiber, wherein the weight percentage of zinc oxide fiber is 50%; the length of zinc oxide fiber is 200 μm, the aspect ratio is 7, and the particle size of zinc oxide powder is 300 mesh;

[0069] Zinc oxide is processed through the following steps before use:

[0070] Add zinc oxide to water that is 4 times the weight of zinc oxide, then add carboxymethyl cellulose with 30% weight of zinc oxide, and magnetically stir at a speed of 45rpm fo...

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Abstract

The invention belongs to the technical field of plaster and its preparation. The invention discloses an external plaster for treating joint pain and arthritis and a preparation method thereof. The plaster is composed of capsicum, menthol, borneol, rubber, lanolin, zinc oxide, rosin, beeswax, coating agent and gasoline and other raw materials, and its preparation method consists of steps such as material preparation, pharmacy, rubber mixing, coating, beating, glue coating, drying and post-treatment. (1) The external plaster used for the treatment of joint pain and arthritis in the present invention has the functions of dispelling wind and cold, relaxing tendons and activating collaterals, reducing swelling and relieving pain, etc., and can be used for joint pain, backache, sprain, bruise and chronic arthritis and the treatment of diseases such as non-ulcerated chilblains; at the same time, it has good air permeability, has a good sustained-release effect, and the drug has a long onset time; the preparation method of the external plaster for treating joint pain and arthritis in the present invention is simple, Easy to implement on existing equipment.

Description

technical field [0001] The invention relates to the technical field of plaster and its preparation, in particular to an external plaster for treating joint pain and arthritis and a preparation method thereof. Background technique [0002] Existing plasters usually use natural rubber matrix. A serious disadvantage of natural rubber-based plasters is their extremely poor air permeability. , but due to improving the air permeability of plaster paste, such improvement has extremely limited effect, and it is difficult to realize the requirement of good air permeability. In addition, there is another shortcoming, which is also the problem of the existing natural rubber matrix plaster, that is, its drug effect time is short, and it does not have the characteristics of long-acting onset, which also causes patients to frequently replace the plaster when using it. , which brings great inconvenience to patients, especially for plasters that need to be applied on special parts, and the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K36/81A61K47/36A61K47/44A61K47/32A61K47/02A61P29/00A61P19/02A61K31/045
CPCA61K9/0002A61K9/7076A61K31/045A61K36/81A61K47/02A61K47/32A61K47/36A61K2300/00
Inventor 俞帮和徐明蒋志刚汪海涛
Owner 杭州仁德药业股份有限公司
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