Compound crystal, preparation method and application

A compound and crystal technology, applied in the field of chemistry and medicine, can solve problems such as not providing crystal structure data
CN112624985AActive Publication Date: 2021-04-09BEIJING INSTITUTE OF PETROCHEMICAL TECHNOLOGY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BEIJING INSTITUTE OF PETROCHEMICAL TECHNOLOGY
Publication Date
2021-04-09

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Abstract

The invention discloses a compound crystal, and a preparation method and application thereof, belonging to the technical field of chemical medicines. The compound crystal is a eutectic crystal of favipiravir and p-aminobenzoic acid, the unit cell of the eutectic crystal belongs to a monoclinic system and a P21 / c space group, and the unit cell parameters are as follows: alpha = gamma = 90 degrees and beta = 92.578 (3) degrees. The equivalent solubility of the favipiravir in the compound crystal provided by the invention is reduced by about 50%, so that the dissolution rate of the favipiravir is favorably reduced, the onset time of the favipiravir is prolonged, and the toxic and side effects of the favipiravir are reduced.
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Description

technical field

[0001] The invention belongs to the technical field of chemistry and medicine, and in particular relates to a compound crystal, a preparation method and an application. Background technique

[0002] The chemical structural formulas of 6-fluoro-3-hydroxypyrazine-2-carboxamide (favipiravir, cas259793-96-9, Chinese name Favipiravir) and 4-aminobenzoic acid are shown in Formula 1 and Formula 2.

[0003]

[0004] 6-Fluoro-3-hydroxypyrazine-2-carboxamide is a pyrazine analog drug developed by Toyama Chemical Co., Ltd. in Japan, which was originally approved for the treatment of drug-resistant influenza. 6-fluoro-3-hydroxypyrazine-2-carboxamide can not only inhibit the replication of influenza A and type B, but also has great hope in the treatment of avian influenza. There are currently studies using Favipiravir for the treatment of other deadly viral infections, such as Ebola virus, Lassa virus and new coronavirus (COVID-19).

[0005] In WO12043700A1 and WO120...

Claims

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