120 results about "4-Aminobenzoic acid" patented technology

This invention defines a novel method for treatment of several neurological diseases and pathophysiologically related symptomology, said diseases including peripheral neuropathies, secondary symptomology of diabetes, Alzheimer's disease, Parkinson's disease, alcoholic polyneuropathy and age-onset symptomology, as well as analogous veterinary disease states. An opportunity exists for pharmacological intervention in some neurological diseases by use of water soluble, small molecular weight primary amine agents and chemical derivatives thereof. Examples of such primary pharmacological agents include 4-aminobenzoic acid and derivatives thereof. The present invention also includes: (1) oral use of optional non-absorbable polyamine polymeric co-agents such as chitosan, (2) oral use of optional known antioxidant co-agents and nutritional factors related thereto, and (3) use of the primary agents and co-agents noted above in optional combination with medicaments recognized as effective for treatment of the diseases addressed herein or symptoms thereof.

A series of S-triazolyl α-mercaptoacetanilides having N-(α-mercaptoacetyl) p amino benzoic acid derivatives.

are provided, where Q is CO₂H, or a salt or ester thereof, or a C(O)N-linked amino acid. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.

The invention relates to the field of synthesis of high polymer materials, particularly a preparation method of poly-p-aminobenzoylamonoundecylamine, which comprises the following steps: (1) salification: uniformly stirring 20 parts by weight of aminoundecanoic acid, 14 parts by weight of p-aminobenzoic acid, 150 parts by weight of distilled water and 0.2 part by weight of catalyst, reacting at 120 DEG C for 3 hours, carrying out vacuum filtration, washing, and carrying out vacuum drying to obtain PA11T salt; (2) feeding: stirring uniformly the PA11T salt, distilled water or organic solvent with the same weight as the PA11T salt, and a blocking agent accounting for 0.6-1.2% (w/w) of the PA11T salt to obtain a mixture; and (3) reaction synthesis: heating the mixture to 270-290 DEG C in a protective gas atmosphere, pressurizing to 2.5-3 MPa, keeping the temperature and pressure for 2 hours, reducing to atmospheric pressure within 2 hours while heating to 310-330 DEG C, keeping the temperature for 2 hours, vacuumizing to -0.095 MPa, keeping the temperature and pressure for 1 hour, and discharging, thereby obtaining the PA11T.

A preparation method of a novel nanoscale fire retardant comprises the following steps: first, performing reduction on oxidized graphene; then, grafting para aminobenzoic acid on graphene to functionalize reduced graphene oxide; finally, grafting phosphonitrilic chloride trimer to further enhance the stability, and grafting chlorine element and phosphorus element on graphene, that is, combining a graphene flame retardant, a phosphorus flame retardant and a halogen flame retardant to prepare the nanoscale flame retardant. Base materials into which the novel nanoscale flame retardant can be added comprise natural rubber, EPDM (Ethylene Propylene Diene Monomer), butadiene styrene rubber and polypropene plastics. Compared with a traditional intumescent flame retardant and a traditional halogen flame retardant, the novel nanoscale flame retardant prepared by the preparation method can effectively solve the problems that the traditional flame retardant is poor in dispersity in material base bodies, weak in surface migration resisting capability, large in addition amount, poor in compatibility, un-ideal in flame-retardant effect, weak in carbon forming capability and the like, so that the flame retardant property of the composite and the compatibility between the flame retardant and the material base body are greatly improved.

The invention relates to a dinuclear europium complex luminescent material and a preparation and application of the dinuclear europium complex luminescent material. The structural general formula of the dinuclear europium complex luminescent material is Eu2L16L22(CH3OH)2, wherein L1 is a p-aminobenzoic acid benzoyl thioureas derivatives; and L2 is one of 1,10-phenanthroline, 2,2-dipyridyl or 2-thenoyltrifluoroacetone. The dinuclear europium complex is a luminescent material with good thermal stability and high luminous efficiency; the molecular structure of the dinuclear europium complex is regular, and after a second auxiliary ligand is added in the dinuclear europium complex luminescent material, the fluorescence intensity and the quantum yield of the dinuclear europium complex luminescent material are improved quite obviously. The preparation method has the advantages of simplicity and convenience in process, simple used equipment, simple and easily obtained raw materials and low production cost.

An electrolyte for a lithium secondary battery, which includes a lithium salt, a nonaqueous organic solvent and at least one additive selected from the group consisting of vitamin G (vitamin B₂, riboflavin), vitamin B₃ (niacinamide), vitamin B₄ (adenine), vitamin B₅ (pantothenic acid), vitamin H (vitamin B₇, biotin), vitamin M (vitamin B₉, folic acid), vitamin B_X (4-aminobenzoic acid), vitamin D₂ (ergocalciferol), vitamin D₃ (cholecalciferol), vitamin K₁ (phylloquinone), ascorbyl palmitate, and sodium ascorbate.

The invention relates to the field of environmental protection, and particularly discloses copper-based metal organic framework material immobilized laccase as well as a preparation method and application thereof. The preparation method comprises the following steps of dissolving copper acetate and laccase in water to prepare a solution A; dissolving a p-aminobenzoic acid solution into an acetic acid buffer solution to prepare a solution B, then mixing the two solutions, and performing stirring for 4 hours or above; and centrifugally collecting solid, performing washing with water, and performing freeze-drying to obtain the copper-based metal organic framework material immobilized laccase. According to the method, the copper-based MOF (Cu-PABA) immobilized laccase is adopted for the firsttime, a coprecipitation method is used for one-step synthesis, the method is faster and more environmentally friendly, the stability of the laccase is greatly improved, and the laccase can be recycledfor eight times or above after bisphenol A is degraded. After the laccase is immobilized, 41.7% of the activity can be retained. The copper-based metal organic framework material immobilized laccaseprovided by the invention has good bisphenol A removal capability, and the bisphenol A removal rate in 12 hours can reach about 80% in the presence of ABTS.

The invention relates to a chiral azobenzene polymer and a production method of the chiral azobenzene polymer. The chiral azobenzene polymer is a polyurethane material with a chiral group and an azobenzene group on a side chain. The production method of the chiral azobenzene polymer takes S-2-methyl-1-butanol as a chiral source, the S-2-methyl-1-butanol and 4-aminobenzoic acid react to obtain 4-aminobenzoic acid-S-2-methyl butyl ester, the polyurethane is prepared through condensation polymerization of diisocyanate and N,N-dihydroxyethylaniline, and finally the 4-aminobenzoic acid-S-2-methyl butyl ester and the polyurethane are subjected to a diazo coupling reaction to obtain the corresponding chiral azobenzene polymer. The main chain structure of the chiral azobenzene polymer is changed by changing the structure of the diisocyanate, and the molecular weight of the chiral azobenzene polymer is regulated by controlling the reaction time of condensation polymerization and the reactant ratio of the diazo coupling reaction. The surface of the chiral azobenzene polymer realizes holographic optical storage of information under the radiation of interference laser of 450-550 nm, and a formed holographic pattern can be erased and rewritten.

The invention relates to a series of whitening agents containing p-aminophenyl formic acid radical hyamine fluorescence as well as synthesis and applications thereof; the series of whitening agent are mainly applied to paper making, dope, printing ink and weaving. The invention adopts the following synthetic steps of: a, using cyanuric chloride to react with p-aminophenyl formic acid for 2.5h under the temperature of 0 to 5 DEG C, controlling the pH between 1.8 to 2.1 and synthesizing a primary condensation product; b, using the primary condensation product to react with 4, 4'-Diaminostilbene-2, 2'-disulfonic acid for 2.0h under the temperature of 40 to 45 DEG C, controlling the pH between 3.5 to 4.5 and synthesizing a secondary condensation product; c, using the secondary condensation product to react with a series of tertiary amine compounds for 3.0h under the temperature of 78 to 85 DEG C, controlling the pH between 7.8 to 8.3 and synthesizing a series of p-aminophenyl formic acid radical hyamine triazine-DSD acid fluorescence whitening agents. The application result shows that; the whitening agents not only can be used under neutral conditions and alkaline conditions, but also has higher dying rate under acidic conditions and better whitening effect.

The invention discloses 2,2'-(1,4-phenylene)bi(benzimidazole-5-carboxylic acid) which has the following structural formula and a preparation method thereof. The preparation method comprises the steps of: dissolving 3,4-diaminobenzoic acid in an aprotic polar solvent, heating by using an oil bath to a certain temperature, dropwise adding an aprotic polar solvent solution of terephthalaldehyde, stirring for a certain time after the adding; adding an oxidant in a reaction system, and continuously stirring for reacting for a certain time; and pouring reaction liquid into alcohol, filtering, and drying to obtain a light brown solid (2,2'-(1,4-phenylene)bi(benzimidazole-5-carboxylic acid)). The aprotic polar solvent is selected from one or more of tetrahydrofuran, acetonitrile, N-methylpyrrolidone, N,N-dimethylformamide and dimethylsulfoxide; and the oxidant is selected from one or more of cerous nitrate, hydrogen peroxide, ferric trichloride, copper acetate, iodobenzene diacetate, air, oxygen, benzoquinone, dichloro dicyane benzoquinone and 3-nitryl-4-aminobenzoic acid.

The invention belongs to the technical field of fluorescent probes, and provides a fluorescent probe for quantitatively detecting acidic or basic amino acids on basis of a carbon quantum dot fluorescence quenching or enhancement method and a preparation method for the fluorescent probe. The preparation method comprises the following steps: with o-phenylenediamine and p-aminobenzoic acid as substrates, synthesizing carbon quantum dots (C-dots) through a hydrothermal method, and performing rotary evaporation, centrifuging and freeze-drying so as to obtain the fluorescent probe--C-dots solid powder. C-dots are sensitive to pH; when the pH is acidic, fluorescence of the C-dots is weakened; and when the pH is alkaline, the fluorescence of the C-dots is enhanced. Thus, the C-dots are used for amino acid category detection. When acidic amino acid is added, the fluorescence of the C-dots is gradually weakened; when basic amino acid is added, the fluorescence of the C-dots is gradually enhanced; and the C-dots can be used for acidic and basic amino acid detection. The method provided by the invention has the advantages of simple operation, good selectivity, high sensitivity, rapid detection, no need of expensive instruments and equipment, and low detection cost, and can be used for qualitative distinguishing detection of acidic and alkaline amino acids.

The invention relates to the technical field of hydrogel composite materials, and discloses a hydrogel material with a shape memory function and preparation and application thereof. The hydrogel material is a rare earth complex formed by CNF/CMC/Tb/Ab, and the rare earth complex is connected with a cellulose network skeleton formed by CNF and CMC in a covalent bond mode, wherein Ab is sodium p-aminobenzoate, Tb is rare earth terbium ions, CMC is carboxymethyl cellulose, and CNF is cellulose nanofibers. Cellulose nanofibers are combined with carboxymethyl cellulose through hydrogen bonds to form a cellulose network framework, rare earth terbium ions are coordinated with carboxyl functional groups in the carboxymethyl cellulose so that the rare earth terbium ions are stably connected with the cellulose network framework in a covalent bond mode, and then sodium p-aminobenzoate is further coordinated with the rare earth terbium ions, green fluorescent material with excellent luminescence is formed, meanwhile, the material has an excellent shape memory function and can be used as a novel shape memory fluorescent material.

The invention discloses a compound crystal, and a preparation method and application thereof, belonging to the technical field of chemical medicines. The compound crystal is a eutectic crystal of favipiravir and p-aminobenzoic acid, the unit cell of the eutectic crystal belongs to a monoclinic system and a P21/c space group, and the unit cell parameters are as follows: alpha = gamma = 90 degrees and beta = 92.578 (3) degrees. The equivalent solubility of the favipiravir in the compound crystal provided by the invention is reduced by about 50%, so that the dissolution rate of the favipiravir is favorably reduced, the onset time of the favipiravir is prolonged, and the toxic and side effects of the favipiravir are reduced.

A supercapacitor electrode material and preparation method thereof are related in the invention. The method includes adding and stirring an aqueous solution of NaOH and a dioxane solution of melaminechloride in p-aminobenzoic acid, heating and refluxing, naturally cooling to room temperature, pumping and filtering, washing with water, adjusting pH value, vacuum drying to obtain ligand, mixing cobalt acetate hexahydrate and ligand, putting the ligand into a reaction kettle, mixing ethanol and N, N-dimethylformamide as solvent, temperature-controlled reaction 36-60 hour, that obtained product is filter by suction, washed with ethanol and dried in vacuum to obtain the electrode material of the supercapacitor. As compare with that prior art, the mesoporous nano-structure Co with high nitrogencontent is prepared by the preparation method of the invention; MOFs are ideal electrode materials for supercapacitors because of their excellent capacitive properties and cyclic stability.

The invention provides a covalent organic framework-based composite photocatalyst for degrading organic pollutants in water and a preparation method of the photocatalyst. The method comprises the following steps: performing ice bath on a covalent organic framework crystalline triazine-based organic framework (CTF-1) solution and a 4-aminobenzoic acid solution, performing stirring, performing washing, and performing vacuum drying to prepare a benzoic acid functionalized CTF-1, wherein the benzoic acid functionalized CTF-1 is labeled as CFB; and performing ball milling to compound the CFB with phosphotungstic acid (H3PW12O40) according to different ratios to obtain H3PW12O40/CFB, that is, the covalent organic framework-based composite photocatalyst used for degrading the organic pollutants in the water. According to the method provided by the invention, the covalent organic framework CTF-1 is subjected to benzoic acid functional modification, and the phosphotungstic acid is immobilized into the CTF-1, so that monodispersion of the phosphotungstic acid at the molecular level is realized, the photocatalytic activity is effectively improved, and the degradation efficiency on the organicmatter is obviously improved; and the photocatalyst has good stability in the water, long service life, a relatively-simple process, raw materials easy to obtain and a low price, and can be used forindustrial application and promotion.

The invention belongs to the technical field of fluorescence imaging, and provides application of carbon quantum dots in targeted cell nucleolus wash-free imaging. A preparation method comprises the following steps: by taking m-phenylenediamine and p-aminobenzoic acid as a carbon source and a nitrogen source, preparing brown-yellow carbon quantum dots (N-CDs) by a one-step hydrothermal method, andremoving an ethanol solvent by rotary evaporation to obtain a brown viscous material; dissolving the obtained brown viscous material in secondary water, centrifuging to remove insoluble substances, dialyzing to remove unreacted reaction precursor small molecules, and freeze-drying to obtain brown N-CDs solid powder, namely the carbon quantum dots for targeted cell nuclei wash-free imaging. High-resolution cell imaging images of HeLa and PC12 are obtained by laser confocal imaging, which shows that N-CDs can successfully target cell nucleolus for no-clean imaging, and the reagent is an excellent cell nucleolus imaging reagent. The preparation method is simple, can target cell nuclei without modification, has low requirements on instruments and equipment, is simple and convenient to operate, does not need to wash nuclei for imaging, saves time and can avoid cell damage.

The invention relates to the technical field of photocatalysis, in particular to application of a sea urchin-shaped cobalt-based photocatalyst to synthesis of benzoazacycle by converting CO2. A complex is of a sea urchin-shaped microsphere structure, which is composed of an organic ligand L and cobalt nitrate hexahydrate and is formed by arranging a plurality of nano needle-shaped complex crystals. The main body of the organic ligand L is p-aminobenzoic acid; the application comprises the following steps: introducing CO2 into a solution containing o-phenylenediamine compounds, carrying out carbonylation reaction and cyclization with o-phenylenediamine compounds under the action of the urchin-shaped cobalt-based catalyst to generate the benzoazacycle compounds. The sea urchin-shaped microsphere structure cobalt-based catalyst formed by the obtained nano needle-shaped complex crystal has a very large specific surface area and high photocatalytic efficiency; when the photocatalyst is adopted to catalyze and activate CO2, the reaction for synthesizing the benzoazacycle by converting CO2 can be carried out at room temperature, so that the energy consumption is greatly reduced, and the cost is reduced.

The invention discloses a synthetic method of ethyl p-aminobenzoate, comprising the following steps: using alcohol to dissolve para amino benzoic acid, preparing a para amino benzoic acid solution with the mass fraction of 5-30 %, adding thionyl chloride dropwisely in the para amino benzoic acid solution at the temperature of 0-50 DEG C for esterification reaction for 4-10 hours, after adding dropwisely, heating until reflux; after the reaction ends, cooling the reaction materials, after the solid substance is dissolved out, carrying out filtering, using water to dissolve the solid substance, adding weak base to neutralize the pH to 7-8, after the solid substance is dissolved out, carrying out filtering again, and then washing and drying to obtain the product of ethyl p-aminobenzoate. The method adopts para amino benzoic acid as raw material, uses thionyl chloride as desiccant for esterification reaction to prepare ethyl p-aminobenzoate, the advantages of rapid reaction speed, high yield, and high product purity are achieved, and the method has a good application prospect in industry.

The invention belongs to the technical field of organic chemical synthesis and specifically discloses a water-phase synthetic method of probenecid. The water-phase synthetic method comprises the following steps: firstly, preparing diazotization reaction liquor by reacting aminobenzoic acid, hydrochloric acid and sodium nitrite; secondly, feeding liquid-state sulfur dioxide into diluted hydrochloric acid aqueous liquor to obtain a sulfonyl chlorinazation reagent; thirdly, enabling the two reaction liquor to generate sulfonyl chlorinazation reaction to obtain p-carboxyl benzene sulfonyl chloride; and finally, preparing a probenecid pure product by reacting the p-carboxyl benzene sulfonyl chloride with dipropyl amine through acidifying. The synthetic process adopts a water-phase synthetic technology, changes a reaction path, reduces production of byproducts, and avoids use of an organic solvent and a virulent agent; and product yield is ideal (91%, in terms of para aminobenzoic acid), and purity is high (98%). The novel synthetic process is developed for being beneficial to enlarged implementation of industrialization.

The invention discloses a photoresist cleaning composition. The cleaning composition comprises DL-1-phenethylalcohol or benzenemethanol, polypropylene oxide triol, polyoxy ethylene nonyl phenyl ether and an organic solvent. The cleaning composition also comprises a corrosion inhibitor 4-aminobenzoic acid methyl ester, catechol and an osmotic agent JFC-2. The composition has a good cleaning capability for the photoresist, and simultaneously the composition does not erode the chip base material; the composition is very suitable for industrial production as well as large scale popularization and application.

The invention relates to the technical field of organic synthetic chemistry, and particularly relates to a method for preparing a 4-aminobenzoic acid from a 4-nitrobenzoic acid by catalytic hydrogenation. 4-aminobenzoic acid is prepared from a sodium salt water solution of 4-nitrobenzoic acid by low-temperature hydrogenation catalytic reduction and acidification under the catalysis of a noble metal catalyst; the selectivity of 4-nitrobenzoic acid can be up to 100%; the yield of 4-aminobenzoic acid can be up to over 96%; the product is white or off-white power; the purity is more than 99% (high performance liquid chromatography (HPLC)). The method has the advantages of short route, fewer three wastes, low energy consumption, high yield and excellent quality. A water solution is prepared from the 4-nitrobenzoic acid and sodium hydroxide; the water solution of the sodium salt is obtained by hydrogenation reduction under the catalysis of a Pd/C catalyst, and then acidified to obtain the 4-aminobenzoic acid. The selectivity of the 4-nitrobenzoic acid can be up to 100%, the yield of 4-aminobenzoic acid can be up to over 96%, the product is white or off-white power, and the purity is more than 99% (HPLC).

The invention discloses a preparation method of a 4-ethyl aminobenzoate powder. The preparation method includes the steps of: 1) catalytically hydrogenating 4-nitrobenzoic acid to prepare 4-aminobenzoic acid; 2) esterifying the 4-aminobenzoic acid with ethanol to prepare a 4-ethyl aminobenzoate crude product; 3) performing ethanol recrystallization, in the presence of alkyl sulfonate, to the 4-ethyl aminobenzoate crude product to prepare the 4-ethyl aminobenzoate powder. In the method, a less amount of alkyl sulfonates, such as sodium dodecyl sulfate, is added during the ethanol recrystallization step, so that the crystallization process of the product is controlled well. The 4-ethyl aminobenzoate powder has small granularity and uniform granularity distribution, is high in quality, and can satisfy the high demand on granularity in the fields of medicines, materials and cosmetics.

The invention discloses a method for producing 3-methyl-4-aminobenzoic acid through a catalytic hydrogenation method. According to the method, 3-methyl-4-nitrobenzoic acid is dissolved in an aqueous solution, the obtained solution is added in a hydrogenation kettle, a catalyst is added, hydrogen is led in, a hydrogenation reaction is carried out, and acidification, crystallization, and drying are carried out to obtain 3-methyl-4-aminobenzoic acid. The raw material conversion rate is 100%, and the obtained product is white powder, has the chromatogram purity no less than 99%, and has the yield no less than 95%.

The invention discloses a printing ink printing method. One to two white printing ink layers are printed on the edge of a glass substrate of a touch screen, each white printing ink layer is of a frame-shaped structure, a black printing ink layer is further printed on each white printing ink layer and is of a frame-shaped structure, the inner edge of each black printing ink layer is located on theinner side of the inner edge of the corresponding white printing ink layer, and a black frame of the touch screen is formed by areas between the inner edges of the black printing ink layers and the inner edges of the white printing ink layers. The method is characterized in that components of each white printing ink layer comprise epoxy resin, titanium dioxide, a solvent, a dispersion agent, a defoaming agent, a flatting agent, an additive and modified nano-zinc oxide; and the additive is a mixture of 4-aminobenzoic acid, maleic acid, p-toluenesulfonic acid and sebacic acid. According to the method, the total thickness of the printing ink layers is greatly reduced, the risk that bubbles are generated in the capacitance screen attachment process is reduced, and therefore the yield is increased.

The invention relates to the technical field of photocatalysis, in particular to a sea urchin-shaped cobalt-based photocatalyst, which comprises a complex composed of an organic ligand L and cobalt nitrate hexahydrate, the complex is of a sea urchin-shaped microsphere structure formed by arranging a plurality of nanoneedle-shaped complex crystals, and the main body of the organic ligand L is p-aminobenzoic acid; the preparation method comprises the following steps: (1) mixing and stirring an organic ligand L and cobalt nitrate hexahydrate to form a mixed solution; (2) heating, cooling and filtering the mixed solution to obtain a mixed solid; and (3) washing the mixed solid with an organic solvent, and carrying out vacuum drying to obtain the urchin-shaped cobalt-based photocatalyst. The sea urchin-shaped microsphere structure cobalt-based catalyst formed by the obtained nano needle-shaped complex crystal has a very large specific surface area and high photocatalytic efficiency; the method has the advantages of few reaction components, simple steps, low preparation difficulty and no noble metal component, and greatly reduced cost.

The invention discloses a method for preparing p-aminobenzoic acid by reducing p-nitrobenzoic acid by utilizing ammonium thiosulfate. The method comprises the following steps: putting p-nitrobenzoic acid into a mixed solution of an organic solvent and water and stirring p-nitrobenzoic acid until p-nitrobenzoic acid is totally dissolved; adding ammonium thiosulfate and carrying out reflux reaction after heating and stirring; naturally cooling the reactant to the room temperature after reaction is stopped, precipitating a solid and leaching and drying the precipitated solid, thus obtaining the final product, namely p-aminobenzoic acid. The method is lower in production cost, is convenient and safe to operate, is environment-friendly, is simple in equipment and is suitable for continuous production.