58 results about "Ethyl aminobenzoate" patented technology

The invention relates to the technical field of fine chemistry industry, in particular to a method for preparing N-(4-ethoxycarbonylphenyl)-N'-methyl-N'-phenylformamidine, comprising the following two condensation reaction processes: in the first condensation reaction process, parathesin is mixed with trialkyl ortho-formate according to the mass ratio of 1:1-1:10 for the condensation reaction at the temperature of 100-200 DEG C and reduced pressure distilling is carried out to obtain intermediate; in the second condensation reaction process, the condensation reaction is carried out on the intermediate generated in the first condensation reaction process and N-methylaniline according to the mass ratio of 1:1-1:5 at the temperature of 100-200 DEG C and simple reduced pressure distilling is carried out on reaction liquid to obtain the N-(4-ethoxycarbonylphenyl)-N'-methyl-N'-phenylformamidine. The method solves the problem of difficulty in large-scale industrial production in the prior art.

The invention relates to the technical field of photochemistry synthesis, in particular to a preparation method of photoresponse hydrogel. In the preparation method of the photoresponse hydrogel containing the azo monomers, acrylicester is used as a main component, the use level of the azo monomers is 1-5 percent of the weight of acrylicester, the use level of N,N methylene-bisacrylamide is 5-20 percent of the weight of acrylicester, the use level of Poly(ethylene glycol) diacrylate is 5-20 percent of the weight of acrylicester, and the use level of water is 200-400 percent of the weight of acrylicester. Visible light is adopted for irradiation in the reaction, camphorquinone and the 4-N,N-(dimethylamino)-benzoic acid ethyl ester having the same weight are adopted and account for 0.5-5 percent of the weight of acrylicester, the light intensity of a light source is controlled to be 30-300 mW, and the temperature for preparation is 80 DEG C below zero to 80 DEG C. The preparation method of the photoresponse hydrogel comprises the following steps of: injecting prepared mixture into a transparent and closed die, adjusting the temperature, and irradiating for 2-60 minutes by adopting visible light source.

The invention discloses a method for preparing N-(4-ethyoxylcarbonylphenyl)-N'-methyl-N'-phenyl carbonamidine. The method comprises the following steps of: (1) adding N-methylaniline, ethyl p-aminobenzoate and triethyl orthoformate into a reaction device, stirring and heating up to 80-90 DEG C; (2) adding propionic acid or glacial acetic acid used as a catalyst into the reaction device, meanwhile, evaporating out generated alcohol, and reacting for 1-3 hours at a temperature of 80-90 DEG C; (3) heating up to 100-110 DEG C, meanwhile, reducing the pressure to 1-20mmHg, continuously reacting until no alcohol is evaporated out; and (4) after the reaction ends, reducing the pressure and distilling to obtain the N-(4-ethyoxylcarbonylphenyl)-N'-methyl-N'-phenyl carbonamidine. The method has the advantages of simple process, moderate condition and high productivity and is suitable for large-scale industrial production.

The invention discloses modified wollastonite for a polyvinyl chloride (PVC) cable sheath material capable of resisting 105 DEG C and a preparation method of the modified wollastonite. The modified wollastonite is prepared from the following raw materials in parts by weight: 40 to 60 parts of wollastonite, 10 to 15 parts of polycaprolactone, 5 to 10 parts of aluminum dihydrogen tripolyphosphate, 3 to 6 parts of sperm oil, 1 to 2 parts of sorbitan oleate, 2 to 3 parts of polydiphenylsiloxane, 3 to 5 parts of zinc stannate, 5 to 10 parts of natural zeolite powder, 4 to 7 parts of nano tungsten carbide, 2 to 4 parts of dibromo triphenyl antimony, 1 to 2 parts of dibutyltin dilaurate, 5 to 10 parts of epoxy silkworm chrysalis butyl oleate, 2 to 4 parts of bisphenol A polyoxyethylene ether, 1.5 to 2.5 parts of ethyl p-aminobenzoate and 3.5 to 4.5 parts of auxiliaries. The modified wollastonite has good compatibility with a PVC base material, so that the filling performance of the modified wollastonite in PVC resin is improved so as to enhance a reinforcing effect. Thus, the tensile strength, the electric insulativity, the heat resistance and the like of the PVC cable material are obviously improved. As a result, the modified wollastonite has a wide application prospect.

A photopolymerization initiator comprising (A) an α-diketone compound such as camphorquinone, (B1) an aliphatic amine compound such as triethanolamine or N-methyldiethanolamine, (B2) an aromatic amine compound such as ethyl p-dimethylaminobenzoate or N,N-dimethyl p-toluidine, and (C) a triazine compound substituted with a trihalomethyl group, such as 2,4,6-tris(trichloromethyl)-s-triazine or 2-phenyl-4,6-bis(trichloromethyl)-s-triazine. The photopolymerization initiator remains stable against the environmental light such as the indoor illumination light from a fluorescent lamp or the dental light illuminating the interior of the oral cavity, is excellently handled, is quickly cured by the irradiation with an intense light emitted from a light irradiator for polymerization, provides a cured body having excellent properties, can be stably preserved even at high temperatures, and is very useful as a dental composite resin.

The invention relates to a method for preparing a candesartan ring compound, which comprises the following steps: 1) preparing 3-animo-2-ethyl ethoxy formacyl amino benzoate; 2) preparing 2-ethyoxylbenzimidazole-4-ethyl indole carboxylate; and 3) preparing candesartan ring compound, namely 2-ethyoxyl-1-1[[(2-cyanobiphenyl-4-yl) mthyl] benzimidazole]-7-carboxylate. In the invention, a benzimidazole ring is constructed, tetraethyl orthocarbonate is avoided, and intramolecular dehydration construction is realized; and finally alkylation is accomplished, canobromobiphenyl is introduced; and thus, the minimum consumption of canobromobiphenyl is realized and the cost of the candesartan ring compound is minimized.

The invention discloses a making method of p-dimethyl ethyl benzoate, which comprises the following steps: preblending ethyl benzoate and carbinol; adding cavaform to do catalytic hydrogenation; filtering; distilling; condensing; crystallizing; drying; obtaining the product.

The present invention relates to a preparation method of ethyl-4-dimethylaminobenzoate intermediate benzocaine (ethyl-4-aminobenzoate). The specific steps are as follows: adding 4- nitrobenzoic acid, absolute ethyl alcohol, a solid catalyst and a water carrying agent into a reaction vessel with a water separator, wherein the reaction vessel is equipped with the water separator, a reflux condenser and a thermometer; heating, refluxing to separate water, and reacting to no stratification; filtering the reaction solution while hot, adding the reaction solution into a hydrogenation reactor, conducting a hydrogenation reaction by directly using Pd / C until hydrogen-absorption of the system stops, and then insulating for 1 h; filtering, cooling, and precipitating a white solid product of benzocaine with content of more than 99.5%. The method is a pure green route, not only avoids production of a lot of waste acid in the esterification process, but also recycles the solvent and catalyst. The method has the advantages of simple method, mild conditions, continuous two-step reaction, and good prospects in the industry.

The invention discloses a surface light-curing odor-free paint for wood and a construction technology of the paint. The surface light-curing odor-free paint for wood is low in environment pollution, rapid in curing speed, energy-saving, capable of a and less in irritation to human body; and through adoption of the paint, the cured product has good performance and a substrate hardly gets yellow after film formation. In addition, the invention also provides the construction technology of the surface light-curing odor-free paint for wood. The surface light-curing odor-free paint for wood comprises the following components by weight percent: 25-45% of bisphenol-A epoxy acrylate, 8-10% of urethane acrylate, 35-45% of trimethylopropane triacrylate, 1-5% of 4-phenyl-benzophenone, 1-5% of dimethylaminobenzoate, 8-12% of filler and 0.1-1% of additives, wherein the additives include defoaming agent, dispersing agent and flatting agent. The invention can be widely applied to the production manufacturing field of flat plate coating.

The invention relates to a resin adhesive material with good hydrophobic performance, a preparation method and an application of the material in filling treatment of tooth hard tissue defects of mouth rehabilitation and belongs to the technical field of stomatological materials. The material is composed of a main component, a diluent and a photoinitiator, wherein the main component is a mixture of isocyanate terminated polyether triol and polyurethane dimethacrylate and accounts for 50-70%; the diluent comprises methyl methacrylate and butyl acrylate which respectively account for 10-20% and 19-27%; and the photoinitiator is a mixed initiation system composed of ethyl-4-dimethylamino ethyl benzoate and camphorquinone and accounts for 1-3%. The material provided by the invention does not contain hydroxyl, carboxyl, phosphate groups and sulfonic groups which are prone to absorb water and swell, has good hydrophobic performance, can effectively prevent infiltration and absorption of water molecules, and meanwhile further has good tensile strength; and the material effectively prevents micro-leakages after repair, so that occurrence of restoration breakage and secondary caries which are common clinically is greatly reduced.

The invention relates to an important intermediate 7-ACCA of cephalosporin cefaclor, comprising the following steps of: 1) preparation of 3-amino-2-ethoxyformyl anesthesin; 2) preparation of 2-ethoxybenzimidazole-4-carboxylic acid ethyl ester; 3) preparation of candesartan cyclic compound. According to the invention, the benzimidazole ring is constructed, tetraehtyl orthocarbonate is avoided, andintramolecular dehydration is accomplished; and alkylation is accomplished in the final stage and cyanobromobiphenyl is introduced to minimize the consumption of cyanobromobiphenyl as well as the cost of the candesartan cyclic compound.

The invention relates to technology of relieving stress response of fish, in particular to a method for relieving stress response in the manual operations of juvenile fish of sebastes schlegeli hilgendorf. The method is characterized by firstly stopping feeding the juvenile fish of sebastes schlegeli hilgendorf for a day to ensure the food in the intestines and stomach of the fish to be emptied; computing the dose of the required isotopic ethyl aminobenzoate alkane sulfonate (MS-222) according to the concentration of 90-110mg / L and dissolving the isotopic ethyl aminobenzoate alkane sulfonate into seawater and stirring to fully dissolve the isotopic ethyl aminobenzoate alkane sulfonate; and then spooning the juvenile fish of sebastes schlegeli hilgendorf into the MS-222 seawater solution, carrying out various test operations when the fish lies at the bottom of a water tank three minutes later and moving the juvenile fish of sebastes schlegeli hilgendorf into common seawater after the operations are completed. The optimum range of the concentration of the seawater solution is 100mg / L. Obviously, the method brings great convenience for such manual operations as transportation, individual marking, immunization injection, physiological experiment and the like, is characterized in that the juvenile fish does not contract diseases, and is fast and safe.

The invention relates to a method for synthesizing an ultraviolet photoinitiator of p-dimethylamin benzoic ether compounds of ethyl p-dimethylaminobenzoate (EDB), isoamyl p-dimethylaminobenzoate (IADB) and isooctyl p-dimethylaminobenzoate (EHA, trade name thereof is 507) and a production process thereof. The method comprises the following steps of: performing nitro reduction reaction and nitrogenmethylation reaction by using nitrobenzonitrile as a raw material to obtain p-dimethylamino cyanophenyl; reacting the cyanophenyl with a Vilsmeier reagent to generate an intermediate; and performing hydrolyzation in an alkyl alcohol / water / hydrogen chloride (HCl) system to obtain the corresponding p-dimethylamin benzoic ether compounds, wherein the purity of the product is over 98 percent and the total yield is over 80 percent. The synthesizing method has the characteristics of mild reaction condition, simple operation, environmental friendliness, easy recovery and application of solvent and suitability for industrial production.

The invention relates to a preparation method of dimethyl ethyl aminobenzoate midbody nitrobenzoic acid ethyl ester. The preparation method includes the following steps that 1, nitrobenzoic acid and ethyl alcohol are added to a dissolution kettle, and the mixture obtained after dissolution is pumped into a fixed-bed reactor through a metering pump, wherein the fixed-bed reactor is pre-filled with an HY type solid acid catalyst, and the temperature of the fixed-bed reactor is controlled; 2, after the content of the material obtained after a fixed-bed reaction reaches the index, the material is pumped into a desolvation kettle, after desolvation, alkali washing and washing, cooling and dispersing, centrifuging and drying are conducted, and the product is obtained. The target product is obtained through the preparation method in which ultra-high solid acid serves as the catalyst and the fixed-bed reactor is used for continuous esterification, the problem that a large amount of waste acid and high-salinity wastewater is generated in existing industrial production is solved, and the emission of wastewater is greatly reduced.

The invention discloses a synthetic method of ethyl p-aminobenzoate, comprising the following steps: using alcohol to dissolve para amino benzoic acid, preparing a para amino benzoic acid solution with the mass fraction of 5-30 %, adding thionyl chloride dropwisely in the para amino benzoic acid solution at the temperature of 0-50 DEG C for esterification reaction for 4-10 hours, after adding dropwisely, heating until reflux; after the reaction ends, cooling the reaction materials, after the solid substance is dissolved out, carrying out filtering, using water to dissolve the solid substance, adding weak base to neutralize the pH to 7-8, after the solid substance is dissolved out, carrying out filtering again, and then washing and drying to obtain the product of ethyl p-aminobenzoate. The method adopts para amino benzoic acid as raw material, uses thionyl chloride as desiccant for esterification reaction to prepare ethyl p-aminobenzoate, the advantages of rapid reaction speed, high yield, and high product purity are achieved, and the method has a good application prospect in industry.

The invention discloses a preparation method of a 4-ethyl aminobenzoate powder. The preparation method includes the steps of: 1) catalytically hydrogenating 4-nitrobenzoic acid to prepare 4-aminobenzoic acid; 2) esterifying the 4-aminobenzoic acid with ethanol to prepare a 4-ethyl aminobenzoate crude product; 3) performing ethanol recrystallization, in the presence of alkyl sulfonate, to the 4-ethyl aminobenzoate crude product to prepare the 4-ethyl aminobenzoate powder. In the method, a less amount of alkyl sulfonates, such as sodium dodecyl sulfate, is added during the ethanol recrystallization step, so that the crystallization process of the product is controlled well. The 4-ethyl aminobenzoate powder has small granularity and uniform granularity distribution, is high in quality, and can satisfy the high demand on granularity in the fields of medicines, materials and cosmetics.

The invention discloses a locomotive fluoroplastic cable material and a preparation method thereof. The locomotive fluoroplastic cable material is prepared from the following raw materials in parts by weight: 57-81 parts of FEP resin, 22-36 parts of ethylene-octylene copolymer, 8-14 parts of propylene carbonate, 17-23 parts of hydrated magnesium silicate ultrafine powder, 14-18 parts of lithium feldspar powder, 10-15 parts of aluminum dihydrogen tripolyphosphate, 12-17 parts of tri-ethylene glycol BNDB, 7-11 parts of ethyl 4-dimethylaminobenzoate, 13-19 parts of a composite flame retardant, 1.5-2.5 parts of di-n-octyltin moleate polymer, 2-3 parts of PGFE, 5-8 parts of liquid paraffin, 2-3 parts of 1,4-bis(methoxymethyl)-benzene and 1-2 parts of 2-2 stearate pentaerythritol phosphate. The prepared cable material is excellent in overall performance, has the excellent performances of higher mechanical strength, excellent electrical insulating property, fire resistance, heat resistance, abrasive resistance, chemical corrosion resistance, heat stability, gaining resistance, and the like, and is wide in application prospect.

The invention relates to a preparation method for p-dimethylamino methyl benzoate, p-dimethylamino ethyl benzoate (EBD), p-dimethylamino isoamyl benzoate (DMBI) and p-dimethylamino benzoic di-iso-octyl sebacate (EHA) compounds of an ultraviolet initiating agent. P-dimethylamino benzaldehyde serving as a raw material reacts with alkyl alcohol and hydrogen peroxide under catalysis of ferric perchlorate to obtain corresponding p-dimethylamino benzoate compounds; the purity of a product is higher than or equal to 99 percent. The preparation method disclosed by the invention has the advantages that the raw materials are low in cost and readily available; the reaction conditions are mild and are easy to operate; the purity is high, the yield is high, the amount of three wastes is small; the preparation method is suitable for industrial production.

The invention discloses a photosensitive resin solution and a photosensitive dry film of a circuit board and preparation methods. The photosensitive resin solution of the circuit board comprises the following raw material ingredients: a methyl methacrylate monomer, a styrene monomer, a methacrylic acid monomer, butyl acrylate, azodiisobutyronitrile, ethyl 4-dimethylaminobenzoate, tetraethyl Michler ketone, ethoxylated trimethylolpropane triacrylate, polypropylene glycol acrylate, polyethylene glycol diacrylatebisphenol A polyoxyethylene ether dimethacrylate, crystal violet, basic green, a polymerization inhibitor, butanone and methanol. The photosensitive dry film prepared from the photosensitive resin solution is excellent in photodecomposability, photo-crosslinking and photopolymerization, can generate a high resolution of an exposure developed image, and is high in photosensitive speed and good in adhesion.

The invention discloses a rapid detection method for three common anesthetics in aquatic products, and belongs to the technical field of detection. According to the method, a single quadrupole gas chromatograph-mass spectrometer (GC-MS) is used for screening, quantification and confirmation, a Thermo TG 1701 MS capillary column is used as an analytical column, and the method for determining the content of three anesthetics, namely eugenol (Eugenol, CAS: 97-53-0), isoeugenol (Isoeugenol, CAS: 97-57-1) and 3-aminobenzoic acid ethyl ester methyl sulfonate (MS-222, CAS: 886-86-2), in the aquatic product is established in a positive ion selected ion monitoring mode (SIM). According to the method, the detection limit of eugenol and isoeugenol is 25.0 [mu] g / kg, and the detection limit of 3-aminobenzoic acid ethyl ester methyl sulfonate is 50.0 [mu] g / kg. Compared with a traditional instrument analysis method, the detection method is simpler and quicker, has higher linear correlation, and has the characteristics of high sensitivity, matrix interference resistance, high accuracy and high stability.

The invention relates to a bromofluoro polysubstituted benzaldehyde derivative and a preparation method. The preparation method comprises the following steps: obtaining 2,6-difluoro-4-cyano phenylamine under nitrogen protection by using 2,6-difluoro-4-bromaniline and N,N-dimethyl formamide and cuprous cyanide as raw materials to react; carrying out a reaction on 2,6-difloro-4-bromaniline and sodium hydroxide, adjusting the pH value and carrying out decompressed evaporation to obtain 3,5-difluoro-4-aminobenzoic acid; carrying out a reaction on 3,5-difluoro-4-aminobenzoic acid and absolute ethylalcohol and concentrated sulfuric acid to obtain 3,5-difloro-4-ethyl aminobenzoate and carrying out a reaction with 40% hydrobromic acid and cuprous bromide to obtain 3,5-difluoro-4-ethyl bromobenzoate; adding sodium borohydride and carrying out a reaction to obtain 3,5-difloro-4-bromobenzyl alcohol; and carrying out a reaction on 3,5-difloro-4-bromobenzyl alcohol with MnO2 in chloroform to obtain a final product bromofluoro polysubstituted benzaldehyde.

Aniline copolymers and the synthesis thereof for use as antimicrobial (antibacterial, antifungal or antiviral material) material of for the manufacture of antimicrobial objects, suitable for use in the health, food, packaging, water, paint, wood, textile, poultry, glass, paper, rubber, ceramic, seafood, sports, plastic and agricultural industries. The copolymer may be for example (A): where for example R3=H5—CO2H, —CO2Me, or —CO2Et. R is typically H or a C1-C6 alkyl, x is an integer between 1 and 0 and m indicates the degree of polymerisation. Preferred copolymers are copolymers of aniline with 3-aminobenzoic acid, 2-aminobenzoic acid and ethyl 3-aminobenzoate.

The invention discloses stable isotope labeled 3-ethyl aminobenzoate-D5 and a preparation method thereof. The method comprises the steps as follows: ethanol-D6 is used as an isotope labeled precursorand subjected to a bimolecular esterification reaction with 3-aminobenzoic acid to obtain the stable isotope labeled 3-ethyl aminobenzoate-D5; the ethanol-D6 is DOCD2CD3. The blank of deficiency of the stable isotope labeled 3-ethyl aminobenzoate-D5 is filled up, the prepared stable isotope labeled 3-ethyl aminobenzoate-D5 has stable isotope labeling position and has isotopic abundance of 99.0% atom D or above, and the demand of residual isotope dilution-gas chromatography-mass spectrometry detection in the field of food safety can be fully met.

The invention discloses a preparation method of an ultraviolet light absorber UV-1. The ultraviolet light absorber UV-1 is prepared by condensation of ethyl p-aminobenzoate and N-methylformanilide inthe presence of thionyl chloride or trifluoromethanesulfonic anhydride. The condensation reaction comprises the following steps: performing a reaction at room temperature for 12-24 hours, heating thereactants to 45-60 DEG C, and performing a reaction for 5-10 hours. The molar ratio of the ethyl p-aminobenzoate to the N-methylformanilide is (1:0.5)-(1:1.5). The molar ratio of thionyl chloride or trifluoromethanesulfonic anhydride to N-methylformamide is 1:1-10:1. According to the method, trimethyl orthoformate / triethyl orthoformate can be prevented from being used as a main raw material, so that the cost for preparing the UV-1 is greatly reduced; thionyl chloride / trifluoromethanesulfonic anhydride is used as a reaction reagent of ethyl p-aminobenzoate and N-methylformyl aniline, so that the method is not only environment-friendly, but also can obtain higher reaction yield and product purity.

The invention discloses an external ultraviolet curing coating for an automobile, belonging to a coating of the automobile. The external ultraviolet curing coating for the automobile disclosed by the invention comprises the following components by weight percent: 10-45% of epoxy acrylic ester, 5-20% of water-based polyester acrylate, 1-3% of diphenyl ketone, 1-10% of ethyl 4-dimethylaminobenzoate, 1-10% of a thinner, 5-8% of calcium carbonate, 2-10% of silicon dioxide, 1-10% of a defoamer and 2-12% of organic silicon resin. By adopting the external ultraviolet curing coating, the defects of the prior art are overcome, the external ultraviolet curing coating can be well fused with an automobile housing after being irradiated by an ultraviolet light, the durability and the abrasion resistance are improved, an outer film of an automobile is smooth, and the abrasion resistance and the decay resistance of the automobile housing are improved.

The present invention relates to a composition comprising a combination of a (halogenoacetamido)benzoate, a flavonol and a terpene, and, as example, relates to a composition comprising the combination of ethyl 3-(2-chloroacetamido)benzoate, dihydroquercetin and bisabolol.Said composition is for use in the treatment of leishmaniasis, especially cutaneous or mucosal leishmaniasis, the composition being applied topically for concomitantly treating both parasitic infection and skin inflammation of the infected area induced by leishmaniasis.

The invention discloses a UV coating material for coating aldehyde-free impregnated thermosetting resins paper, and belongs to the field of coating material preparation. The UV coating material is prepared from the following components by mass: 100 to 120 parts of polycarbonate, 80 to 100 parts of isocyanate, 20 to 40 parts of nano cellulose, 10 to 15 parts of a photoinitiator, 10-15 parts of a UV curing agent, and 20 to 30 parts of a solvent. According to the invention, polycarbonate with low polymerization degree is adopted as a base material, and the material has good physicochemical properties and belongs to an environment-friendly material; isocyanate and the polycarbonate with low polymerization degree are compounded for use, so that the UV coating material belongs to an environment-friendly UV material; and peroxide of cumene hydroperoxide or tert-butyl hydroperoxide is adopted as a photoinitiator and is combined with a UV curing agent of 4-dimethylamino-ethyl benzoate for use, so that the curing effect is good, and the photoinitiator can be rapidly cured to form a net-shaped polymer surface layer under the irradiation of ultraviolet light during use.