The invention discloses a synthetic method of ethyl p-aminobenzoate, comprising the following steps: using
alcohol to dissolve para amino
benzoic acid, preparing a para amino
benzoic acid solution with the
mass fraction of 5-30 %, adding
thionyl chloride dropwisely in the para amino
benzoic acid solution at the temperature of 0-50 DEG C for
esterification reaction for 4-10 hours, after adding dropwisely, heating until
reflux; after the reaction ends, cooling the reaction materials, after the
solid substance is dissolved out, carrying out filtering, using water to dissolve the
solid substance, adding
weak base to neutralize the pH to 7-8, after the
solid substance is dissolved out, carrying out filtering again, and then washing and
drying to obtain the product of ethyl p-aminobenzoate. The method adopts para amino benzoic acid as
raw material, uses
thionyl chloride as
desiccant for
esterification reaction to prepare ethyl p-aminobenzoate, the advantages of rapid
reaction speed, high yield, and high product purity are achieved, and the method has a good application prospect in industry.