36 results about "Ethyl p-Aminobenzoate" patented technology

The invention relates to the technical field of fine chemistry industry, in particular to a method for preparing N-(4-ethoxycarbonylphenyl)-N'-methyl-N'-phenylformamidine, comprising the following two condensation reaction processes: in the first condensation reaction process, parathesin is mixed with trialkyl ortho-formate according to the mass ratio of 1:1-1:10 for the condensation reaction at the temperature of 100-200 DEG C and reduced pressure distilling is carried out to obtain intermediate; in the second condensation reaction process, the condensation reaction is carried out on the intermediate generated in the first condensation reaction process and N-methylaniline according to the mass ratio of 1:1-1:5 at the temperature of 100-200 DEG C and simple reduced pressure distilling is carried out on reaction liquid to obtain the N-(4-ethoxycarbonylphenyl)-N'-methyl-N'-phenylformamidine. The method solves the problem of difficulty in large-scale industrial production in the prior art.

The invention discloses a preparation method of N,(4-ethyoxyl carbonyl phenyl)-N'-methyl-N'-phenyl formamidine. According to the method, ethyl p-aminobenzoate, orthoformic acid trialkyl ester and N-methylaniline are adopted as original raw materials, activated aluminum oxide is adopted as a catalyst, and N,(4-ethyoxyl carbonyl phenyl)-N'-methyl-N'-phenyl formamidine is prepared through a one-step reaction. The method is simple in process, convenient to operate, free of contamination and high in product purity, and the adopted catalyst aluminum oxide can be recycled.

The invention discloses a preparation method of N,N'-bis (4-ethoxycarbonylphenyl)-N'-benzyl formamidine. The preparation method comprises the steps of carrying out condensation reaction on ethyl p-aminobenzoate and trialkyl ortho-formate to obtain N,N'-bis (4-ethoxycarbonylphenyl) formamidine; reacting benzyl chloride with the N,N'-bis (4-ethoxycarbonylphenyl) formamidine through N-alkylation reaction to obtain the N,N'-bis (4-ethoxycarbonylphenyl)-N'-benzyl formamidine, wherein the molar ratio of the ethyl p-aminobenzoate and the trialkyl ortho-formate is 1:0.3-1:0.7. According to the preparation method, two 4-ethoxycarbonylphenyls are grafted once, and only two reaction steps are required to obtain the N,N'-bis (4-ethoxycarbonylphenyl)-N'-benzyl formamidine, therefore, the synthetic route is greatly shortened, the total reaction yield can be up to more than 60%, and the preparation method is particularly suitable for industrial production.

The invention provides a high compatibility modifier for plastic processing. The high compatibility modifier for plastic processing comprises, by weight parts, 5-15 parts of nano calcium carbonate, 5-10 parts of chlorinated polyethylene, 5-10 parts of silicone acrylic emulsion, 2-5 parts of dimethicone copolyol, 0.5-2 parts of grafted polyether polyol, 3-10 parts of polyethylene glycol, 0-1 part of ethyl p-aminobenzoate, 0-1 part of heat stabilizer, 0-1 part of coupling agent and 0-0.5 part of surfactant. Through the reasonable raw material ratio, the made modifier has excellent dispersibilityand compatibility for plastic processing and improves plastic product quality stability. In addition, the high compatibility modifier also has excellent weather resistance, UV resistance and toughness, the comprehensive quality is obviously improved, the practical benefit is improved, and the high compatibility modifier is worth promoting.

The invention relates to a process for preparing benzocaine (ethyl p-aminobenzoate) through solvent-free hydrogenation, and belongs to the field of chemical engineering. The process comprises: (1) heating ethyl p-nitrobenzoate for more than 1 h at a temperature of more than 100 DEG C; (2) adding a catalyst and the ethyl p-nitrobenzoate treated in the step (1); and (3) in the absence of a solvent,introducing hydrogen until the reaction does not absorb hydrogen, and carrying out post-treatment to obtain the product.

The invention relates to the technical field of fine chemicals, in particular to a preparation method of ethyl p-aminobenzoate. A kind of preparation method of p-aminobenzoic acid ethyl ester of the present invention is characterized in that, comprises the following steps: (1) p-nitrobenzoic acid, ethanol, composite catalyst are dropped into reactor; (2) react 6- 8h, obtain ethyl p-aminobenzoate, intermediate p-aminobenzoic acid, and unreacted complete p-nitrobenzoic acid; (3) aftertreatment, obtain the finished product of p-aminobenzoic acid ethyl ester; the composite catalyst consists of sulfate , Inorganic reducing agent, diatomaceous earth, amine accelerator composition.

The invention relates to the technical field of fine chemistry industry, in particular to a method for preparing N-(4-ethoxycarbonylphenyl)-N'-methyl-N'-phenylformamidine, comprising the following two condensation reaction processes: in the first condensation reaction process, parathesin is mixed with trialkyl ortho-formate according to the mass ratio of 1:1-1:10 for the condensation reaction at the temperature of 100-200 DEG C and reduced pressure distilling is carried out to obtain intermediate; in the second condensation reaction process, the condensation reaction is carried out on the intermediate generated in the first condensation reaction process and N-methylaniline according to the mass ratio of 1:1-1:5 at the temperature of 100-200 DEG C and simple reduced pressure distilling is carried out on reaction liquid to obtain the N-(4-ethoxycarbonylphenyl)-N'-methyl-N'-phenylformamidine. The method solves the problem of difficulty in large-scale industrial production in the prior art.

The invention discloses an N, N'-(4-ethyoxyl carbonyl phenyl)-N'-benzyl formamidine preparation method, and belongs to the technical field of benzyl formamidine compound preparation, wherein N, N'-(4-ethyoxyl carbonyl phenyl)-N'-benzyl formamidine is mainly used for an ultraviolet light absorber. According to the N, N'-(4-ethyoxyl carbonyl phenyl)-N'-benzyl formamidine preparation method, ethyl p-aminobenzoate is used as the raw material, and the ethyl p-aminobenzoate is subjected to a synthetic route including formylation, condensation and N-alkylation to prepare the N, N'-(4-ethyoxyl carbonyl phenyl)-N'-benzyl formamidine product. The N, N'-(4-ethyoxyl carbonyl phenyl)-N'-benzyl formamidine preparation method has the remarkable advantages that the time for the overall reaction process is shortened, the total yield is increased, the cost is reduced because filtrate in an aftertreatment process of the formylation reaction and the condensation reaction can be recycled and reused, the yield of final products can be stabilized between 65% and 70%, and the preparation method is beneficial to industrial production.

The invention discloses an environment-friendly preparation process of an N-(4-ethoxy carbonyl phenyl)-N'-methyl-N'-phenyl formamidine intermediate. The process comprises the steps of making p-nitrobenzoic acid and ethyl alcohol be subjected to an esterification reaction under the catalysis of concentrated sulphuric acid, conducting aftertreatment and catalytic hydrogenation on materials generated after the esterification reaction, and obtaining ethyl p-aminobenzoate; an aftertreatment procedure comprises the steps of removing ethyl alcohol in the materials generated after the esterification reaction through evaporation, then leaving remaining materials standing still for layering, and conducting neutralization treatment on materials on the lower layer. According to the environment-friendly preparation process, the concentrated sulfuric acid is separated out before neutralization treatment is conducted on the materials obtained after the esterification reaction, a great amount of high salinity waste water cannot be generated, environment pollution is reduced, and the yield of the esterification reaction can be raised.

Provided is an anesthetic agent which can exhibit an anesthetic effect rapidly when adhered on mucosal membranes, the skin or the like by means of application or the like in local anesthesia, particularly surface anesthesia. Prepared are: a fast-acting surface anesthetic agent containing lidocaine and ethyl paraaminobenzoate at a specific ratio; and a super fast-acting surface anesthetic agent containing lidocaine, ethyl paraaminobenzoate and adrenaline at a specific ratio.

The invention relates to a preparation method of a permanently charged hydrazine-based saccharide marker, and belongs to the technical field of organic synthesis and bioinformation, wherein benzocaine is subjected to a series of synthesis to prepare the permanently charged hydrazine-based saccharide marker. According to the present invention, the reaction conditions (5% acetic acid, 80 DEG C and 3 h) of the prepared permanently charged hydrazine-based saccharide marker are mild so as to remarkably improve the sensitivity; and after the reaction, the detection can be performed directly with high performance liquid chromatography and mass spectrometry (ESI-MS, MALDI-ToF-MS) without further purification, and the sensitivity is good.

The invention relates to the technical field of fine chemistry industry, in particular to a method for preparing N, N'-di(4-ethoxycarbonylphenyl)-N'-phenylformamidine. Parathesin and benzyl chloride are taken as raw materials. The method comprises a formylation reaction process, an N alkylation reaction process and a condensation reaction process; wherein, in the N alkylation reaction process, 4-formamido ethyl benzoate generated in the formylation reaction process is added into dipolar aprotic solvent, and then inorganic weak base and the benzyl chloride are added, the temperature rises and is preserved and the reaction lasts for 20-25 hours; then the temperature is lowered to the room temperature and suction filtration and washing are carried out on the separated pale yellow solid to obtain pale yellow intermediate; the intermediate and the parathesin are added into halogenated hydrocarbon and then dehydrant is added; after heatingup and reflux for 15-17 hours, the temperature is cooled to the room temperature; NaOH aqueous solution is added to steam out the halogenated hydrocarbon under normal pressure and then separate out offwhite solid; suction filtration, washing by water and drying are carried out on the solid and the white solid of N, N'-di(4-ethoxycarbonylphenyl)-N'-phenylformamidine is obtained by recrystallization and cooling the solid to the room temperature after washing.