36 results about "Ethyl p-Aminobenzoate" patented technology

The invention relates to the technical field of fine chemistry industry, in particular to a method for preparing N-(4-ethoxycarbonylphenyl)-N'-methyl-N'-phenylformamidine, comprising the following two condensation reaction processes: in the first condensation reaction process, parathesin is mixed with trialkyl ortho-formate according to the mass ratio of 1:1-1:10 for the condensation reaction at the temperature of 100-200 DEG C and reduced pressure distilling is carried out to obtain intermediate; in the second condensation reaction process, the condensation reaction is carried out on the intermediate generated in the first condensation reaction process and N-methylaniline according to the mass ratio of 1:1-1:5 at the temperature of 100-200 DEG C and simple reduced pressure distilling is carried out on reaction liquid to obtain the N-(4-ethoxycarbonylphenyl)-N'-methyl-N'-phenylformamidine. The method solves the problem of difficulty in large-scale industrial production in the prior art.

The invention discloses an N, N'-(4-ethyoxyl carbonyl phenyl)-N'-benzyl formamidine preparation method, and belongs to the technical field of benzyl formamidine compound preparation, wherein N, N'-(4-ethyoxyl carbonyl phenyl)-N'-benzyl formamidine is mainly used for an ultraviolet light absorber. According to the N, N'-(4-ethyoxyl carbonyl phenyl)-N'-benzyl formamidine preparation method, ethyl p-aminobenzoate is used as the raw material, and the ethyl p-aminobenzoate is subjected to a synthetic route including formylation, condensation and N-alkylation to prepare the N, N'-(4-ethyoxyl carbonyl phenyl)-N'-benzyl formamidine product. The N, N'-(4-ethyoxyl carbonyl phenyl)-N'-benzyl formamidine preparation method has the remarkable advantages that the time for the overall reaction process is shortened, the total yield is increased, the cost is reduced because filtrate in an aftertreatment process of the formylation reaction and the condensation reaction can be recycled and reused, the yield of final products can be stabilized between 65% and 70%, and the preparation method is beneficial to industrial production.

The invention discloses an environment-friendly preparation process of an N-(4-ethoxy carbonyl phenyl)-N'-methyl-N'-phenyl formamidine intermediate. The process comprises the steps of making p-nitrobenzoic acid and ethyl alcohol be subjected to an esterification reaction under the catalysis of concentrated sulphuric acid, conducting aftertreatment and catalytic hydrogenation on materials generated after the esterification reaction, and obtaining ethyl p-aminobenzoate; an aftertreatment procedure comprises the steps of removing ethyl alcohol in the materials generated after the esterification reaction through evaporation, then leaving remaining materials standing still for layering, and conducting neutralization treatment on materials on the lower layer. According to the environment-friendly preparation process, the concentrated sulfuric acid is separated out before neutralization treatment is conducted on the materials obtained after the esterification reaction, a great amount of high salinity waste water cannot be generated, environment pollution is reduced, and the yield of the esterification reaction can be raised.

Provided is an anesthetic agent which can exhibit an anesthetic effect rapidly when adhered on mucosal membranes, the skin or the like by means of application or the like in local anesthesia, particularly surface anesthesia. Prepared are: a fast-acting surface anesthetic agent containing lidocaine and ethyl paraaminobenzoate at a specific ratio; and a super fast-acting surface anesthetic agent containing lidocaine, ethyl paraaminobenzoate and adrenaline at a specific ratio.

The invention relates to a preparation method of a permanently charged hydrazine-based saccharide marker, and belongs to the technical field of organic synthesis and bioinformation, wherein benzocaine is subjected to a series of synthesis to prepare the permanently charged hydrazine-based saccharide marker. According to the present invention, the reaction conditions (5% acetic acid, 80 DEG C and 3 h) of the prepared permanently charged hydrazine-based saccharide marker are mild so as to remarkably improve the sensitivity; and after the reaction, the detection can be performed directly with high performance liquid chromatography and mass spectrometry (ESI-MS, MALDI-ToF-MS) without further purification, and the sensitivity is good.