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Burn and scald ointment and preparation method thereof

An ointment, burn and scald technology, applied in ointment delivery, anti-inflammatory agents, pharmaceutical formulations, etc., can solve the problems of large wound irritation, inability to apply medicine on time, and strong local pain of the patient, so as to relieve pain and improve medication compliance sexual effect

Inactive Publication Date: 2017-05-03
CHANGZHOU SUNLIGHT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Clinical practice shows that after the above two ointments are applied, the wound surface is greatly stimulated, and the patient's local pain is strong. For severe burns, the pain is aggravated. The patient's medication compliance is poor, and often cannot be applied on time, resulting in poor wound care and difficult healing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1）

[0019] The formula of the burn ointment of the present embodiment is as follows: 20 g of silver sulfadiazine, 10 g of zinc sulfadiazine, 10 g of ethyl p-aminobenzoate with D90≤50 μm, 90 g of cetyl alcohol, 60 g of liquid paraffin, 140 g of white petrolatum, dodecane 10g of sodium hydroxysulfate, 1.5g of ethylparaben, 50g of glycerin, 9g of laurocaprolactone, and 599.5g of purified water.

[0020] The preparation method of this burn and scald ointment has the following steps:

[0021] ① According to the recipe, put cetyl alcohol, liquid paraffin and white petrolatum into a glass beaker, heat in a water bath until melted and keep the temperature at 70-80°C, and set aside.

[0022] ② According to the recipe, put sodium lauryl sulfate, ethyl paraben, glycerin and purified water into a glass beaker, heat in a water bath until dissolved and keep the temperature at 70-80°C, and set aside.

[0023] ③ Slowly add the melted material in step ① to the dissolved material in step ②, stir e...

experiment example ）

[0033] 100 burn patients (superficial II degree) were randomly divided into 5 groups, the wound surface was cleaned with sterilized normal saline, and then the affected area was wrapped with gauze made from the ointment of Example 1 and Comparative Examples 1-4 respectively, and the patients were observed The pain situation after 60 minutes, the results are shown in Table 1.

[0034] Table 1

[0035] components Example 1 Comparative example 1 Comparative example 2 Comparative example 3 Comparative example 4 increased pain 0 2 1 4 10 no change in pain 1 7 10 8 4 pain relief 4 7 4 6 6 pain gone 15 4 5 2 0

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PUM

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Abstract

The invention discloses a burn and scald ointment and a preparation method thereof. The burn and scald ointment is prepared from the following components in parts by weight: 20 parts of sulfadiazine silver, 10 parts of sulfadiazine zinc, 10 parts of ethyl p-aminobenzoate with D90 less than or equal to 50 microns, 90 parts of hexadecanol, 60 parts of liquid paraffin, 140 parts of albolene, 10 parts of lauryl sodium sulfate, 1.5 parts of ethylparaben, 50 parts of glycerin, 9 parts of laurocapram, and 599.5 parts of purified water. According to the burn and scald ointment and the preparation method thereof, micronized ethyl p-aminobenzoate (D90 is less than or equal to 50 microns) is adopted, and a weight ratio of sulfadiazine silver, sulfadiazine zinc and ethyl p-aminobenzoate is controlled to be 2 : 1 : 1, so that ethyl p-aminobenzoate can be in close contact with a wound for quickly taking a pain-relieving effect, the pain of the wound surface of a patient is relieved, and the medication compliance of the patient is improved.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a burn and scald ointment and a preparation method thereof. Background technique [0002] Burns and scalds are common wounds for human beings in daily life. Burns and scalds are the first damage to the human epidermis. Burns and scalds are the main way to cause systemic infection. Therefore, controlling the infection of burns and scalds will promote Wound healing is the key to curing patients with burns and scalds, and it is also the basic requirement for external use of burns and scalds. [0003] Sulfadiazine silver salt has been used in the clinical treatment of burns and scalds since the 1970s, and has played a good role in controlling the bacterial infection of burn and scald wounds, especially the infection of Pseudomonas aeruginosa and Escherichia coli. The sulfadiazine zinc salt developed later, in addition to preventing infection, also pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/38A61K31/635A61K9/06A61P17/02A61P29/00A61K33/30A61K31/245
CPCA61K9/0014A61K9/06A61K31/245A61K31/635A61K33/30A61K33/38A61K2300/00
Inventor 胡锦平胡国宜丁盛何继文奚小金
Owner CHANGZHOU SUNLIGHT PHARMA
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