Piracetam eutectic and preparation method thereof

A technology of piracetam and crystals, which is applied in the field of pharmaceutical materials, can solve the problems of drug quality impact and low drug stability, and achieve the effects of delaying dissolution rate, facilitating sustained release and absorption, and facilitating production quality control

Inactive Publication Date: 2019-05-24
YUNNAN OPEN UNIV
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  • Description
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Problems solved by technology

[0006] Piracetam currently has five known crystal forms. During the production and use process, these crystal forms often undergo crystal transformation under the influence of external factors, resulti

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  • Piracetam eutectic and preparation method thereof
  • Piracetam eutectic and preparation method thereof
  • Piracetam eutectic and preparation method thereof

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Embodiment Construction

[0026] The present invention will be further explained below in conjunction with specific embodiments. It should be understood that these embodiments are only used to illustrate the present invention and not to limit the scope of the present invention. In addition, it should be understood that after reading the teachings of the present invention, those skilled in the art can make various modifications or changes to the present invention, and these equivalent forms also fall within the scope defined by the appended claims of this application.

[0027] A co-crystal of piracetam, using piracetam and gentisic acid as the components of the co-crystal to make piracetam-gentisic acid co-crystal, its molecular formula is C 6 H 10 N 2 O 2 ·C 7 H 6 O 4 , The molecular weight is 296, and its crystal structure is that the O atom of the phenolic hydroxyl group adjacent to the carboxyl group of gentisic acid acts as the hydrogen bond acceptor, and the N atom on the piracetam amino group acts as...

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Abstract

The invention relates to the field of pharmaceutical materials, and discloses a piracetam eutectic, which is synthesized by using piracetam and gentilic acid, wherein the molecular formula is C6H10N2O2 C7H6O4, and the molecular weight is 296; the eutectic structure is that O atoms of phenolic hydroxyl groups adjacent to gentilic acid and carboxyl are used as hydrogen bond acceptors, and N atoms onpiracetam amino groups are used as hydrogen bond donors to form intermolecular double bonds; double bond O atoms on the gentilic acid carboxyl are used as hydrogen bond acceptors, and the O atoms onthe adjacent phenolic hydroxyl groups are used as hydrogen bond donors to form an intramolecular hydrogen bond so as to jointly form a basic unit of the eutectic; the crystal is c2/c and monoclinic, and the cell parameters are shown in the description, wherein alpha=gamma=90 degrees, beta=101.09 degrees, Z=8. Compared with the original piracetam, the dissolution rate and stability of the medicineeutectic are greatly improved.

Description

Technical field [0001] The invention belongs to the field of pharmaceutical materials, and specifically relates to a piracetam co-crystal and a preparation method thereof. Background technique [0002] When researching and developing drugs, the solid form of the active ingredient of the drug will be selected according to the nature of the drug and the requirements of the formulation. The solid form of the drug affects the physical and chemical properties of the drug to a certain extent, such as stability, solubility and bioavailability And so on, and then affect the efficacy of the drug. Different forms of drugs have different particle properties, which will affect the filtration, washing, drying, crushing, mixing, tableting, dissolving, recrystallization and freeze-drying operations in the industrial production of drugs, which also has certain influence on the drug production process and quality control. Impact. [0003] According to the Cambridge Structural Database (CSD), abou...

Claims

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Application Information

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IPC IPC(8): C07D207/27C07C51/43C07C65/03
Inventor 陈晓春朱丽
Owner YUNNAN OPEN UNIV
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