Piracetam eutectic and preparation method thereof

Abstract

The invention relates to the field of pharmaceutical materials, and discloses a piracetam eutectic, which is synthesized by using piracetam and gentilic acid, wherein the molecular formula is C6H10N2O2 C7H6O4, and the molecular weight is 296; the eutectic structure is that O atoms of phenolic hydroxyl groups adjacent to gentilic acid and carboxyl are used as hydrogen bond acceptors, and N atoms onpiracetam amino groups are used as hydrogen bond donors to form intermolecular double bonds; double bond O atoms on the gentilic acid carboxyl are used as hydrogen bond acceptors, and the O atoms onthe adjacent phenolic hydroxyl groups are used as hydrogen bond donors to form an intramolecular hydrogen bond so as to jointly form a basic unit of the eutectic; the crystal is c2 / c and monoclinic, and the cell parameters are shown in the description, wherein alpha=gamma=90 degrees, beta=101.09 degrees, Z=8. Compared with the original piracetam, the dissolution rate and stability of the medicineeutectic are greatly improved.

Description

Technical field [0001] The invention belongs to the field of pharmaceutical materials, and specifically relates to a piracetam co-crystal and a preparation method thereof. Background technique [0002] When researching and developing drugs, the solid form of the active ingredient of the drug will be selected according to the nature of the drug and the requirements of the formulation. The solid form of the drug affects the physical and chemical properties of the drug to a certain extent, such as stability, solubility and bioavailability And so on, and then affect the efficacy of the drug. Different forms of drugs have different particle properties, which will affect the filtration, washing, drying, crushing, mixing, tableting, dissolving, recrystallization and freeze-drying operations in the industrial production of drugs, which also has certain influence on the drug production process and quality control. Impact. [0003] According to the Cambridge Structural Database (CSD), abou...

AI Technical Summary

Problems solved by technology

[0006] Piracetam currently has five known crystal forms. During the production and use process, these crystal forms often undergo crystal transformation under the influence of external factors, resulting in low stability of the drug, which will affect the stability of the drug. Quality has an impact, therefore, the study of piracetam co-crystals can improve the physicochemical properties of the drug

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