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Preparation method of intermediate for improving efficacy of lipid-lowering traditional Chinese medicine composition containing panax notoginseng

A composition and technology of notoginseng, applied in the field of production and processing of Chinese patent medicines, can solve problems such as quality control problems, low product quality standards and production control levels, and mixing uniformity of intermediate drug powders and extract concentrates, so as to prevent drug loss, beneficial to production quality control, and the effect of improving batch-to-batch uniformity

Active Publication Date: 2019-11-15
长春三德天晟科技有限公司 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] It can be seen from the current standards that there are the following main problems in the process of Tongmai Jiangzhi Tablets: ①The quality control problem in the steaming process of raw Sanqi; Low problem

Method used

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  • Preparation method of intermediate for improving efficacy of lipid-lowering traditional Chinese medicine composition containing panax notoginseng
  • Preparation method of intermediate for improving efficacy of lipid-lowering traditional Chinese medicine composition containing panax notoginseng
  • Preparation method of intermediate for improving efficacy of lipid-lowering traditional Chinese medicine composition containing panax notoginseng

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preparation example Construction

[0112] The invention provides an intermediate preparation method for improving the efficacy of a lipid-lowering traditional Chinese medicine composition containing Panax notoginseng. Improve the level of the element, and prevent the loss of the drug in the production process to change the formula ratio; optimize the mixing process of the intermediate powder, that is, the steamed powder of notoginseng and the prefabricated fine powder of Chuanxiong, Zanthoxylum bungeanum, and lotus leaf are mixed for the second time and then pulverized to improve the mixing uniformity of the powder. It is conducive to production quality control and improvement of standards; and secondary crushing can also increase the cell wall breaking effect of Rhizoma Chuanxiong and Zanthoxylum bungeanum, so that Rhizoma Chuanxiong and Zanthoxylum bungeanum can release more volatile matter, which is beneficial to absorption; Batch-to-batch uniformity and drug efficacy of lipid-lowering traditional Chinese med...

Embodiment 1

[0132] Embodiment 1: 500,000 pieces / batch feeding, and production verification.

[0133] (1) Take 320 kg of pen tube grass, 25.5 kg of Chuanxiong, 129 kg of lotus leaves, 21 kg of Panax notoginseng, and 6.3 kg of Zanthoxylum bungeanum, remove mildew, moths, counterfeit products, impurities and non-medicinal parts, pen tube grass, lotus leaves, Panax notoginseng is cleaned, drenched, cut into sections, lotus leaves shredded, notoginseng broken, and dried to obtain net materials of pen tube grass 312.5kg, Chuanxiong 25kg, lotus leaf 125kg, Sanqi 20.8kg, Zanthoxylum bungeanum 6.25kg, spare.

[0134] (2) Take 25kg of dried and clean Ligusticum chuanxiong, 20.8kg of Panax notoginseng, 6.25kg of Zanthoxylum bungeanum, and 20.8kg of lotus leaves, respectively crush them with a linkage crushing unit, pass through a No. 6 sieve, and fine powder 65-70kg for later use;

[0135] (3) Put the fine powder of notoginseng into 20 stainless steel trays and flatten it, flatten it with a stainle...

Embodiment 2

[0140] Embodiment 2: Feed 500,000 pieces / batch, and carry out production verification.

[0141](1) Take 320 kg of pen tube grass, 25.5 kg of Chuanxiong, 129 kg of lotus leaves, 21 kg of Panax notoginseng, and 6.3 kg of Zanthoxylum bungeanum, remove mildew, moths, counterfeit products, impurities and non-medicinal parts, pen tube grass, lotus leaves, Panax notoginseng is cleaned, drenched, cut into sections, lotus leaves shredded, notoginseng broken, and dried to obtain net materials of pen tube grass 312.5kg, Chuanxiong 25kg, lotus leaf 125kg, Sanqi 20.8kg, Zanthoxylum bungeanum 6.25kg, spare.

[0142] (2) Take 25kg of dried and clean Ligusticum chuanxiong, 20.8kg of Panax notoginseng, 6.25kg of Zanthoxylum bungeanum, and 20.8kg of lotus leaf, respectively pulverize with a linkage crushing unit, pass through a No. 6 sieve, and fine powder 60-65kg for later use;

[0143] (3) Put the Panax notoginseng fine powder into 20 stainless steel trays and spread it flat, flatten it with...

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Abstract

The invention discloses a preparation method of an intermediate for improving efficacy of a lipid-lowering traditional Chinese medicine composition containing panax notoginseng. The method includes the following steps: step 1: steaming the panax notoginseng powder for 0.3-0.5h at low temperature after compression, then steaming the material at high temperature for 0.8-1.2h, and stirring the material after natural cooling to obtain a pasty powder paste; step 2: drying the powder paste under reduced pressure to obtain irregular granulated panax notoginseng steamed powder, and step 3, uniformly mixing the Ligusticum wallichii, Chinese prickly ash, lotus leaf fine powder and irregular granulated notoginseng steamed powder, and sieving the material to obtain the intermediate powder. The invention provides the preparation method of the intermediate for improving efficacy of the lipid-lowering traditional Chinese medicine composition containing panax notoginseng, which ensures uniform and stable total saponin content among batches, and improves the yield of the medicinal powder.

Description

technical field [0001] The invention relates to the technical field of production and processing of Chinese patent medicines, in particular to a method for preparing an intermediate for improving the efficacy of a lipid-lowering Chinese medicine composition containing Panax notoginseng. Background technique [0002] Hyperlipidemia refers to high total cholesterol (TC) and / or triglyceride (TG) or low high-density lipoprotein cholesterol (HDL-C) in the blood, which is a kind of fat metabolism or abnormal operation in the human body that leads to plasma Or more than normal levels of lipids, also known as dyslipidemia, hyperlipoproteinemia. [0003] Hyperlipidemia is a systemic disease that can directly cause some diseases that seriously endanger human health, such as atherosclerosis, vascular endothelial plaque, coronary heart disease, pancreatitis, etc. [0004] Hyperlipidemia can be divided into two types: primary and secondary. Primary is congenital and genetic, or due to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/758A61K36/258A61P3/06
CPCA61K36/236A61K36/258A61K36/62A61K36/758A61K2236/10A61P3/06A61K2300/00
Inventor 闫立成武兵孟韬马吉胜侯宝郝昕唐纪琳魏琦岩郑月
Owner 长春三德天晟科技有限公司
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