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33results about How to "Improve liver damage" patented technology
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Bifidobacterium adolescentis CCFM1061, fermented food thereof and preparation method of microbial agent
ActiveCN110331118AReduce absorptionImprove liver damageMilk preparationBacteriaBifidobacterium adolescentisPerfluorooctanoic acid
The invention discloses Bifidobacterium adolescentis CCFM1061, a fermented food thereof and a preparation method of a microbial agent. The Bifidobacterium adolescentis CCFM1061 can remarkably improveliver injury of patients with non-alcoholic fatty liver disease, reduce serum ALT level, and reduce liver adiposis, liver balloon-like lesion and liver lobular inflammation; can obviously relieve theincrease of contents of serum total cholesterol, blood glucose, liver triglyceride and low-density protein cholesterol caused by high-fat diet in patients with non-alcoholic fatty liver disease; meanwhile, can obviously improve the anti-oxidation capacity of the liver of a NAFLD patient; can obviously improve the expression of Nrf2 gene of fatty liver cells; and can improve the fasting blood glucose of a type II diabetic mouse. In addition, the Bifidobacterium adolescentis CCFM1061 has strong adsorption capability to perfluorooctanoic acid, reduces the absorption of the perfluorooctanoic acidin vivo, and has the capability of relieving PFOA toxicity.
Owner:JIANGNAN UNIV
Wine-relieving and liver-protecting composition containing probiotics and preparation method and application thereof
PendingCN110122878AHas hangover effectTo promote metabolismConfectionerySweetmeatsAlcoholLactobacillus rhamnosus
The invention belongs to the technical field of food and health care, in particular, relates to a wine-relieving and liver-protecting composition containing probiotics and a preparation method thereof, and is mainly used for alleviating drunkenness and protecting liver. The wine-relieving and liver-protecting composition includes the following components in parts by weight: taraxerone, lactobacillus rhamnosus GG, inulin, fructooligosaccharide and the like. The taraxerone and the lactobacillus rhamnosus are jointly used for the first time, so the wine-relieving and liver-protecting compositioncan alleviate alcohol-induced liver injury, has better wine-relieving and liver-protecting effects, fully accelerates alcohol metabolism and alleviates ethyl alcohol damage to organs caused by products of the metabolic process. The wine-relieving and liver-protecting composition is made into pressed candies or granules, is convenient to process, economical in cost, easy to marketize and easy to use by consumers, and has a quite broad market application prospect.
Owner:山东圣奥生物科技有限公司
Potentilla viscosa Donn extract and application thereof
PendingCN107823286ASignificantly effective in treating diabetesImprove fatty liverMetabolism disorderDigestive systemHigh dosesTherapeutic effect
The invention discloses a Potentilla viscosa Donn extract and application thereof. The extract is a water extract of Potentilla viscosa Donn, a 30-100% ethanol extract product or a 30-100% methanol extract. The extract has a remarkable effect of improving high-fat diet induced fatty liver and liver injury and has an obvious effect of reducing blood sugar. It shows that the extract has a remarkableeffect of treating diabetes. There is no report related to therapeutic effect of Potentilla viscosa Donn on fatty liver and diabetes at present. Experimental data show that the high-dose Potentilla viscosa Donn extract group has better hypoglycemic effect than a metformin group and the product shows a good application prospect.
Owner:YANBIAN UNIV
Drug composition for treating chronic liver disease and its application
ActiveUS20120053135A1Improving liver fibrosis liverImproving liver liver injuryBiocideOrganic active ingredientsAstragalosideDisease
A drug composition for treating chronic liver diseases, consists of: Astragalus Astragalosides and Glycyrrhiza Acid by weight ratio of 3˜6:1. By testing and validating with classic animal model, the results confirmed that the drug composition of the present invention can significantly reduce the collagen content of rat liver, and reduce liver fibrosis and liver injury, wherein the effect is better than the effect of each component alone. The drug composition of the two components or ingredients can improve the anti-hepatic fibrosis, effectively prevent liver fibrosis and promote the development of liver fibrosis reversal, and thus can be used for the treatment and prevention of various chronic hepatitis, liver fibrosis, cirrhosis and other illnesses.
Owner:SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
Application of clostridium butyrate in preparation for prevention and treatment or adjuvant therapy of hyperglycemia
ActiveCN105769928AChange compositionRecovery functionMetabolism disorderDigestive systemAcute hyperglycaemiaGlucagon-like peptide-1
The invention discloses an application of clostridium butyrate in a preparation for prevention and treatment or adjuvant therapy of hyperglycemia and belongs to the technical field of prevention and treatment of diabetes. According to the application, during the prevention and treatment or adjuvant therapy of the hyperglycemia, butyric acid is produced in an intestinal tract, meanwhile, florae of the intestinal tract are changed, signals are sent to an ileum, a liver, a pancreatic gland and a brain by a portal vein blood sugar sensor, the ileum is promoted to secrete (GLP-1) glucagon-like peptide-1, the gluconeogenesis of the liver is lowered, pancreatic beta cells are protected, the secretion of insulin of the pancreatic gland is promoted, and thus, the action of reducing blood sugar is exerted. The clostridium butyrate is a medicine which has been proven by clinical drug trials and can be directly taken orally.
Owner:QINGDAO EASTSEA PHARMA
Lactobacillus plantarum for efficiently lowering in-vivo cholesterol level and application of lactobacillus plantarum
The invention discloses lactobacillus plantarum H6 for efficiently lowering an in-vivo cholesterol level. The lactobacillus plantarum H6 is collected in General Microorganisms Center of China Committee for Culture Collection of Microorganisms and has a collection number of CGMCC No. 18205. The lactobacillus plantarum H6 can be used for effectively improving alteration of intestinal florae and liver injury induced by high-cholesterol diets.
Owner:THANKCOME BIOLOGICAL SCI & TECH CO LTD
Bifidobacterium adolescentis ccfm1061, its fermented food and preparation method of bacterial agent
ActiveCN110331118BReduce absorptionImprove liver damageMilk preparationBacteriaBiotechnologyLiver steatosis
Owner:JIANGNAN UNIV
Curcumin composition capable of relieving hangover and protecting liver
InactiveCN106266026AImprove liver damageRelieves symptoms of dry mouthDigestive systemAntinoxious agentsDoellingeriaTongue symptoms
The invention discloses a curcumin composition capable of relieving a hangover and protecting the liver. The curcumin composition is mainly prepared from, by weight, 8-10 parts of curcumin, 20-25 parts of osmanthus flower essence, 6-8 parts of photinia glabra fruit, 3-5 parts of scabrous doellingeria rhizomes and roots, 2-3 parts of herb of pellionia repens and 0.02-0.05 part of neohesperidin dihydrochalcone. The obtained composition has the effects of removing toxicity, soothing the liver, invigorating the spleen and promoting body fluid secretion, not only can be used for relieving the hangover and protecting the liver, but also can obviously relive the parched mouth and scorched tongue symptoms occurring after drinking and has a good market prospect.
Owner:福建拓天生物科技有限公司
Composition for preventing and treating alcoholic liver injury
PendingCN109985206ALow toxicityReduce pathological damageDigestive systemFood ingredient functionsRhizomeGastroenterology
The invention relates to a composition for preventing and treating alcoholic liver injury, and the composition comprises kudzuvine root flowers, hyacinth bean flowers, semen hoveniae, largetrifoliolious bugbane rhizome, turmeric and kudzuvine root.
Owner:孟凤仙 +1
Preparation method of mulberry leaf alkaloids and application of prepared mulberry leaf alkaloids
ActiveCN109223865AInhibit apoptosisReduce apoptosisDigestive systemPlant ingredientsBiotechnologyLiver tissue
The invention provides a preparation method of mulberry leaf alkaloids and application of the prepared mulberry leaf alkaloids, and relates to the technical field of alkaloid extraction. The preparation method comprises the following steps: 1) mixing mulberry leaves and ethanol aqueous solution accord to a material-liquid ratio of 1g: (15-26) mL to obtain a mixture; 2) mixing that mulberry leavesand ethanol aqueous solution according to a material-liquid ratio of (15-26) mL to obtain a mixture; 2) filtering the mixture obtained in the step 1) by ultrasonic wave to obtain filtrate; The power of the ultrasonic wave is 720-900W; 3) concentrating the filtrate obtained in the step 2) to obtain a concentrated solution; 4) purifying that concentrated solution obtain in the step 3) through a column to obtain mulberry leaf alkaloid. The mulberry leaf alkaloid prepared by the method of the invention has a purity of more than 60%, and can be used for preparing medicine for treating liver function damage, improving liver tissue inflammatory reaction and inhibiting liver cell apoptosis.
Owner:SOUTHWEST UNIV
Natural extract for inhibiting hepatitis B virus and its main active ingredients
InactiveCN101028382AAntioxidantAntibacterialOrganic active ingredientsDigestive systemAntigenDrug Substitution
A natural extract for suppressing the hepatitis B virus (HBV) is prepared from green tea through extracting. It features that its main active component is the polyphenols of tea (PPT) containing EGCG as its active component.
Owner:WUHAN INST OF VIROLOGY CHINESE ACADEMY OF SCI
Application of Clostridium butyricum in prevention or auxiliary treatment of hyperglycemia preparations
ActiveCN105769928BChange compositionRecovery functionBacteriaUnknown materialsPancreatic hormoneAdjuvant therapy
The invention discloses an application of clostridium butyrate in a preparation for prevention and treatment or adjuvant therapy of hyperglycemia and belongs to the technical field of prevention and treatment of diabetes. According to the application, during the prevention and treatment or adjuvant therapy of the hyperglycemia, butyric acid is produced in an intestinal tract, meanwhile, florae of the intestinal tract are changed, signals are sent to an ileum, a liver, a pancreatic gland and a brain by a portal vein blood sugar sensor, the ileum is promoted to secrete (GLP-1) glucagon-like peptide-1, the gluconeogenesis of the liver is lowered, pancreatic beta cells are protected, the secretion of insulin of the pancreatic gland is promoted, and thus, the action of reducing blood sugar is exerted. The clostridium butyrate is a medicine which has been proven by clinical drug trials and can be directly taken orally.
Owner:QINGDAO EASTSEA PHARMA
Application of alantolactone and derivatives thereof in preventing and treating fatty liver damage
ActiveCN107468683AAlleviate lipid metabolism disordersInhibit accumulation of lipid dropletsOrganic active ingredientsDigestive systemDyslipidemiaLiver function
The invention discloses a new medical application of alantolactone and derivatives thereof, and particularly relates to an application of alantolactone and derivatives thereof in preventing and treating fatty liver damage. The alantolactone and derivatives thereof can relieve the lipid metabolism disorder of liver cells, inhibit oxLDL-induced TG and TC levels in liver cells and lipid droplet accumulation in cells, prevent and treat liver damage caused by alcoholic fatty liver diseases, effectively improve the liver function, effectively relieve dyslipidemia, and prevent and treat liver damage caused by non-alcoholic fatty liver diseases. Compared with various existing lipid-lowering drugs, the alantolactone and derivatives thereof have the advantages of being small in toxic and side effect and good in treatment effect, and have the potential of being developed into natural low-toxicity lipid-lowering drugs with clinical application value.
Owner:NORTHEAST NORMAL UNIVERSITY
Small hairpin RNA (Ribonucleic Acid) recombination oncolytic adenovirus carrying target mitotic phase phosphoprotein 1 gene
InactiveCN104195117AInhibitionInhibitory activityGenetic material ingredientsViruses/bacteriophagesOncolytic adenovirusKinesin
The invention belongs to the field of biopharmacy and relates to a small hairpin RNA (Ribonucleic Acid) recombination oncolytic adenovirus carrying a target human kinesin (mitotic phase phosphoprotein 1) gene and a preparation method of the recombination oncolytic adenovirus. The invention provides a brand-new liver cancer drug target, namely mitotic phase phosphoprotein 1 which has a broad spectrum that the traditional gene therapy target p53 gene does not have; the invention further provides the preparation method of the small hairpin RNA recombination oncolytic adenovirus for expressing the mitotic phase phosphoprotein 1; and at the same time, the invention provides an application of the recombination oncolytic adenovirus in preparing a cancer treatment drug.
Owner:WUHAN BAIAOJING BIOLOGICAL PHARMA CO LTD
Purpose of walnut shell flavone extract in preparation of medicine for treating hyperlipidemia
InactiveCN107837297ACurb weight gainLower levelMetabolism disorderDigestive systemLow density lipoprotein cholesterolWeight gain
The invention discloses a purpose of a walnut shell flavone extract in preparation of a medicine for treating hyperlipidemia. The walnut shell flavone extract is an ethanol extract of walnut shell, and general flavone content in the extract is no less than 3%. According to the invention, hyperlipidemia means that total cholesterol, triglyceride, and low-density lipoprotein cholesterol content in serum and liver are increased, and high-density lipoprotein cholesterol content is reduced. The experiment result shows that the walnut shell flavone extract can obviously inhibit body weight increaseof rats with high-fat diet, Lee's index and fat index can be reduced, a lipid level in serum and liver is obviously reduced, such as reduction of TC, TG and LDL-C as well as increase of HDL-C, the walnut shell flavone extract has obvious protection effect and is capable of improving liver damage and liver fatty degeneration, and has effects for preventing and treating hyperlipidemia.
Owner:YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE +2
Traditional Chinese medicine for protecting liver and gallbladder and preparing method thereof
InactiveCN103816306AReduce denaturationReduce necrosisDigestive systemAntiviralsSalvia miltiorrhizaBile Juice
The invention discloses a traditional Chinese medicine for protecting liver and gallbladder and a preparing method thereof. The traditional Chinese medicine includes the following raw materials matched in parts by weight: 37-72 parts of abrus cantoniensis hance, 20-45 parts of artemisisa capillaris, 24-43 parts of dandelions, 27-46 parts of glossy privet fruits, 16-31 parts of salvia miltiorrhiza, 11-28 parts of cistanche salsa, 19-41 parts of fruits of Chinese wolfberry, 1.3-2.7 parts of panax quinquefolium, 2.1-4 parts of crocus sativus, 1.45-2.78 parts of pseudo-ginseng. The traditional Chinese medicine for protecting liver and gallbladder can effectively protect liver subjected to liver injury caused by CCl4, besides, has the functions of preventing hepatocirrhosis, promoting hepatic cell regeneration, reducing cholesterol and facilitating bile secretion and excretion, and the preparing method is simple and feasible.
Owner:大连圣弘生物科技有限公司
Pharmaceutical composition used for treating fatty liver and containing glucosamine
ActiveCN105616430ALower liver indexImprove liver damageOrganic active ingredientsDigestive systemDrugPolyene
The invention belongs to the field of medicines and particularly relates to a pharmaceutical composition used for treating fatty liver and containing glucosamine. The pharmaceutical composition used for treating fatty liver and containing glucosamine comprises glucosamine and polyene phosphatidyl choline, and further comprises betahistine or pharmaceutical salt of betahistine. Experiments discover that the pharmaceutical composition provided by the invention can remarkably reduce a liver index of a rat suffering from the fatty liver as well as an ALT value and an AST value in blood plasma, has a remarkable fat-reducing effect, and has a remarkable treatment effect for the fatty liver. Moreover, the pharmaceutical composition can remarkably enhance the free radical scavenging capability of the body of the rat suffering from the fatty liver, reduce the lipid peroxidation degree of the body and improve the detoxification capability of the body, thereby better facilitating the rehabilitation of the fatty liver.
Owner:GUANGDONG PHARMA UNIV
Composition with effects of resisting oxidation, improving liver damage and improving immunity
InactiveCN105475999AImprove antioxidant capacityImprove protectionHydrocarbon active ingredientsHydroxy compound active ingredientsVitamin CLycopene
The invention belongs to the field of nutrition and health and relates to a composition with effects of resisting oxidation, improving liver damage and improving immunity. The composition comprises vitamin C, wall-broken ganoderma lucidum spore powder, taurine, zinc gluconate, cysteine, resveratrol, lycopene, grape seed extract, corn oligopeptides, vitamin B1, vitamin B2, vitamin B6 and vitamin B12. Through scientific compatibility of the Chinese traditional medicinals and edible raw materials, vitamins, mineral matters, plant extract products and amino acid polypeptide, antioxidation is used as a function base so that liver damage is relieved and immunity is improved.
Owner:杭州海王生物工程有限公司
Application of pterostilbene in preparation of medicine for preventing and/or treating diabetic complications
PendingCN113197883AImprove depression-like behaviorFunction increaseNervous disorderMetabolism disorderDyslipidemiaLiver functions
The invention discloses application of pterostilbene in preparation of a medicine for preventing and / or treating diabetic complications. Through extensive and deep research, behavioral experiments and detection of blood fat, liver functions and kidney functions, it is unexpectedly found for the first time that the pterostilbene can improve depression-like behaviors and cognitive impairment induced by diabetes mellitus; the TC and LDL-C content increase caused by the type 2 diabetes mellitus can be effectively reduced, so that the dyslipidemia of mice with the type 2 diabetes mellitus is improved; in addition, ALT and AST levels of liver tissues can be reduced, liver injury caused by type 2 diabetes mellitus is improved, and pterostilbeneis used for preventing or treating non-alcoholic fatty liver disease induced by type 2 diabetes mellitus; the levels of urea nitrogen and creatinine can be reduced, and diabetes complicated with renal function decline is improved; the pterostilbene provides a new natural medicine choice for preventing or treating diabetic complications.
Owner:GUANGDONG PHARMA UNIV
Preparation method and application of euphorbia lathylris lathyrane type macrocyclic diterpene compounds
ActiveCN113384567AExcellent agonistic activityImprove liver damageOrganic compound preparationOrganic chemistry methodsAgonistPharmaceutical Substances
The invention discloses a preparation method and application of euphorbia lathylris lathyrane type macrocyclic diterpene compounds. The euphorbia lathylris lathyrane type macrocyclic diterpene compounds are used for preparing anti-cholestasis drugs for the first time. Cell experiment results show that the euphorbia lathylris lathyrane type macrocyclic diterpene compounds have good pregnane X receptor agonistic activity and anti-cholestasis activity, and are expected to be developed into novel pregnane X receptor agonists and anti-cholestasis drugs.
Owner:GUANGZHOU ZHONGDA NANSHA TECH INNOVATION IND PARK
Use of inulin and its derivatives in the preparation of drugs for the prevention and treatment of fatty liver damage
ActiveCN107468683BAlleviate lipid metabolism disordersInhibit accumulation of lipid dropletsOrganic active ingredientsDigestive systemLiver functionsDyslipidemia
Owner:NORTHEAST NORMAL UNIVERSITY
Method of treating nash using a long-acting mutant human fibroblast growth factor
PendingUS20190367574A1Decrease in levelImprove inflammationPeptide/protein ingredientsDigestive systemNon alcoholicFibroblast growth factor
The invention relates to a method of treatment comprising administering a long-acting mutant human fibroblast growth factor to a subject in need thereof. The said long-acting mutant human fibroblast growth factor is mPEG-CH2—NαH-mFGF21, wherein mFGF21 consists of SEQ ID NO:1, and the said new use consists of a method of treating non-alcoholic steatohepatitis.
Owner:TASLY BIOPHARMACEUTICALS CO LTD
Application of lactobacillus reuteri and metabolite thereof in preparation of medicine for treating liver cancer
PendingCN114558039AGrowth inhibitionSmall side effectsAntibody ingredientsUnknown materialsMetaboliteSide effect
The invention provides application of lactobacillus reuteri and metabolites thereof in preparation of a medicine for treating liver cancer, and belongs to the technical field of biological medicine, when the lactobacillus reuteri is used for treating the liver cancer, the content of acetate is increased, liver injury is improved, and tumor progression of mice with the liver cancer is delayed. When the metabolite of the lactobacillus reuteri is used for treating the liver cancer, the growth of the liver cancer can be effectively inhibited, and especially when the metabolite of the lactobacillus reuteri and an immune checkpoint inhibitor are combined for treating the liver cancer, the aim of synergistically treating the liver cancer can also be achieved. The invention provides a new thought and a more economic therapeutic drug for liver cancer treatment, and lactobacillus reuteri and acetate are taken as endogenous substances of a human body, so that the therapeutic drug has small toxic and side effects and high safety, and a theoretical basis is provided for development of new drugs.
Owner:JIANGSU CANCER HOSPITAL
Preparation method and application of a class of continuon-type macrocyclic diterpenoids
ActiveCN113384567BExcellent agonistic activityImprove liver damageOrganic compound preparationOrganic chemistry methodsAlkaneCombinatorial chemistry
Owner:GUANGZHOU ZHONGDA NANSHA TECH INNOVATION IND PARK
A liver-protecting and analgesic traditional Chinese medicine composition and preparation method thereof
ActiveCN103705775BGood liver protectionReduce necrosisAntipyreticAnalgesicsMedicinal herbsLygodium japonicum
The invention relates to a traditional Chinese medicine composition for achieving liver-protection and pain-easing effects and a preparation method of the traditional Chinese medicine composition. The preparation method comprises the steps of taking eight medicinal materials including Desmodium styracifolium, corn stigma, pyrrosia lingua, Abrus cantoniensis Hance, Poria cocos, plantain herb, Lygodium japonicum Sw and lalang grass rhizome, wherein the Desmodium styracifolium, the pyrrosia lingua and the Abrus cantoniensis Hance are extracted by an alkaline aqueous solution, and the lalang grass rhizome, the Poria cocos, the plantain herb, the corn stigma and the Lygodium japonicum Sw are extracted by water; and finally mixing fluid extracts obtained by the two extraction methods. The animal pharmacological experiments and clinical test results prove that the traditional Chinese medicine composition has excellent liver-protection and pain-easing effects superior to the prior art when being used for treating lithiasis in urinary system.
Owner:GUANGXI WUZHOU PHARMA GRP
A kind of Lactobacillus plantarum efficiently lowering the cholesterol level in the body and its application
ActiveCN110616173BAvoid absorptionEasy dischargeBacteriaMetabolism disorderBiotechnologyMicroorganism
The invention discloses a plant lactobacillus Lactobacillus plantarum H6 that can efficiently reduce the cholesterol level in the body, which is preserved in the General Microorganism Center of China Microbiological Culture Collection Management Committee, and the preservation number is CGMCC No.18205. The bacteria can effectively improve the intestinal flora imbalance and liver damage caused by high cholesterol diet.
Owner:THANKCOME BIOLOGICAL SCI & TECH CO LTD
Capsule for improving liver damage and body fatigue and preparation method thereof
ActiveCN109663123BRemarkably stable formulaFormulation ScienceDigestive systemAntinoxious agentsFormularyTaurine
Owner:GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
Traditional Chinese medicine composition for achieving liver-protection and pain-easing effects and preparation method thereof
ActiveCN103705775AGood liver protectionReduce necrosisAntipyreticDigestive systemLygodium japonicumClinical tests
The invention relates to a traditional Chinese medicine composition for achieving liver-protection and pain-easing effects and a preparation method of the traditional Chinese medicine composition. The preparation method comprises the steps of taking eight medicinal materials including Desmodium styracifolium, corn stigma, pyrrosia lingua, Abrus cantoniensis Hance, Poria cocos, plantain herb, Lygodium japonicum Sw and lalang grass rhizome, wherein the Desmodium styracifolium, the pyrrosia lingua and the Abrus cantoniensis Hance are extracted by an alkaline aqueous solution, and the lalang grass rhizome, the Poria cocos, the plantain herb, the corn stigma and the Lygodium japonicum Sw are extracted by water; and finally mixing fluid extracts obtained by the two extraction methods. The animal pharmacological experiments and clinical test results prove that the traditional Chinese medicine composition has excellent liver-protection and pain-easing effects superior to the prior art when being used for treating lithiasis in urinary system.
Owner:GUANGXI WUZHOU PHARMA GRP
Drug composition for treating chronic liver disease and its application
ActiveUS8846626B2Improve liver damageEffectively treating chronic liver diseasesBiocideOrganic active ingredientsAstragalosideDisease
Owner:SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
Application of Demethylzeylasteral (T-96) in preparation of drugs for preventing or treating hepatic fibrosis
InactiveCN113244244ADose dependentHave expression levelOrganic active ingredientsDigestive systemLiver functionsSide effect
The invention discloses application of Demethylzeylasteral (T-96) in preparation of drugs for preventing or treating hepatic fibrosis, and belongs to the technical field of biological medicines. In-vivo and in-vitro experiments prove that the Demethylzeylasteral (T-96) can inhibit activation of hepatic stellate cells, reduce collagen deposition in livers of hepatic fibrosis mice, inhibit fibroplasia, improve liver functions and down-regulate expression of hepatic fibrosis related proteins, which indicates that the Demethylzeylasteral (T-96) has an anti-hepatic fibrosis effect. In addition, transcriptome sequencing and experimental results show that the Demethylzeylasteral (T-96) can inhibit activation of the hepatic stellate cells by regulating expression of proteins such as AGAP2 and the like so as to improve hepatic fibrosis, and the Demethylzeylasteral (T-96) has the advantages of small toxic and side effects, wide raw material sources, low production cost and the like. Therefore, the Demethylzeylasteral (T-96) can be used for preparing drugs and pharmaceutical compositions for preventing / treating hepatic fibrosis, and has good development and application values.
Owner:CHINA PHARM UNIV
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