Composition for preventing and treating alcoholic liver injury

A technology for alcoholic liver injury and a composition, applied in the field of compositions for preventing and treating alcoholic liver injury, can solve problems such as restricting the treatment of severe alcoholic liver injury, and achieve the effects of reducing liver pathological damage, improving liver injury, and reducing toxicity

Pending Publication Date: 2019-07-09
孟凤仙 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] 3. Drug treatment: ① Corticosteroids: reduce inflammatory responses by down-regulating pre-transcriptional inflammatory cytokines TNF-α and IL-8, etc., and are currently the main drugs for the treatment of severe alcoholic hepatitis, but they have no effect on early alcoholic liver injury exact curative effect
Currently, liver transplantation is the only possible cure for severe alcoholic liver injury, however, the shortage of liver donors severely restricts the treatment of severe alcoholic liver injury;

Method used

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  • Composition for preventing and treating alcoholic liver injury
  • Composition for preventing and treating alcoholic liver injury
  • Composition for preventing and treating alcoholic liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1: Effects of Drugs on the Alcoholic Chronic Liver Injury Model in Rats

[0031] Experimental materials and methods

[0032] 1. Test animals

[0033] Male Wister rats, SPF grade, weighing 140±10g, were provided by the Institute of Experimental Animals, Chinese Academy of Medical Sciences, license number: scxk11-00-0006.

[0034] 2. Test drug:

[0035] Drugs: Provided by the Preparation Room of the School of Pharmacy, Beijing University of Traditional Chinese Medicine, each gram (g) of brown powder corresponds to 5.7g of crude drug. The ratio of crude drugs is as follows: 30g of kudzu root flower, 30g of white hyacinth bean flower, 10g of Hovenia dulcis, 15g of cohosh, 15g of turmeric, and 15g of kudzu root. Storage conditions: Store in airtight storage at room temperature.

[0036] Dosage design: The clinical dosage for humans is 115g crude drug / 60kg, which is about 2.0g crude drug / kg; in the experiment, the doses of crude drug / kg, 10g crude drug / kg, and 5g c...

Embodiment 2

[0092] Example 2: The protective effect of drugs on alcohol-induced acute liver injury in mice

[0093] 1. The test drug: provided by the preparation room of the School of Pharmacy, Beijing University of Traditional Chinese Medicine, each gram (g) of brown powder corresponds to 5.7g of crude drug. The ratio of crude drugs is as follows: 30g of kudzu root flower, 30g of white hyacinth bean flower, 10g of Hovenia dulcis, 15g of cohosh, 15g of turmeric, and 15g of kudzu root. Storage conditions: Store in airtight storage at room temperature.

[0094] 2. Experimental animals: male ICR mice, SPF grade, weighing 19±10g, provided by Beijing Weitong Lihua Experimental Animal Technology Research Institute, license number: scxkjing-2002-0003.

[0095] 3. Dosage design: The clinical dosage for humans is 115g crude drug / 60kg, that is, about 2.0g crude drug / kg; in the experiment, the doses for mice are 40g crude drug / kg, 20g crude drug / kg, and 10g, based on the equivalent dose conversion ...

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PUM

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Abstract

The invention relates to a composition for preventing and treating alcoholic liver injury, and the composition comprises kudzuvine root flowers, hyacinth bean flowers, semen hoveniae, largetrifoliolious bugbane rhizome, turmeric and kudzuvine root.

Description

technical field [0001] The invention relates to a composition for preventing and treating alcoholic liver injury, the composition comprises kudzu root flower, white hyacinth bean flower, mandarin orange, cohosh, turmeric and kudzu root. Background technique [0002] Alcoholic liver injury refers to liver damage caused by excessive alcohol consumption. Fat accumulation, inflammation, and scarring occur in the liver. It is one of the clinical diseases that cannot be ignored. In recent years, diseases caused by alcohol abuse and alcohol dependence have become increasingly serious public health problems in the world today. Among non-viral liver diseases, the incidence of alcoholic liver injury occupies the first place. In Western countries, alcoholic fatty liver is the main cause of liver cirrhosis and one of the ten most common causes of death. In my country, the incidence of alcoholic liver injury is also increasing, becoming the second leading cause of liver damage in my co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P1/16A23L33/00
CPCA23V2002/00A61K36/48A61K36/488A61K36/71A61K36/72A61K36/9066A23L33/00A61P1/16A61K2300/00A23V2200/30A23V2200/334
Inventor 孟凤仙崔晓兰
Owner 孟凤仙
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