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Application of pterostilbene in preparation of medicine for preventing and/or treating diabetic complications

A technology of diabetes and pterostilbene, which is applied in the field of biomedicine to achieve the effects of improving renal function decline, liver damage, and dyslipidemia

Pending Publication Date: 2021-08-03
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no relevant reports at home and abroad about the effect of pterostilbene on diabetic complications, and further studies are needed.

Method used

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  • Application of pterostilbene in preparation of medicine for preventing and/or treating diabetic complications
  • Application of pterostilbene in preparation of medicine for preventing and/or treating diabetic complications
  • Application of pterostilbene in preparation of medicine for preventing and/or treating diabetic complications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Example 1 Behavior Experiment

[0057] (1) Field experiment (OFT): The experimental device is a square box having a size of 27.31 cm × 27.31 cm × 27.31cm, and the mouse head is placed in the housing box, and then records the mice within 6 minutes. Free exploration, observed indicators have mice stationary time and mice enter the central area. The experimental environment requires quiet and uninterrupted, once each test, 1 mice each test, and wipe the box with 75% ethanol after test to ensure no mice.

[0058] (2) Suspension Experiment (TST): The suspension test device is a 50cm high white open box. The paper tape was fixed with a paper tape at the end of the tail portion of the mouse, and mice hang in the top of the device. Use the automatic camera and computer record experiment, time total 6min. After the experiment, replay the recording, starting 2 minutes as the adaption period, not counting the statistical range, and the immovable time of mice within 4 minutes is the te...

Embodiment 2

[0074] Example 2 Effect of rosewood on gum metabolism in diabetic mice

[0075] (1) Experimental method

[0076] After the end of the experiment, he was immediately tentative with a cardiophagus, and hepatin sodium was added. After 30 min, the collected blood was collected, centrifuged at 4000 rpm / min, and collected in the EP tube, and the refrigerator was stored in the -80 ° C.

[0077] Take the blood and detect fasting blood glucose (FBG) and fructose amine (FRU) using a fully automated biochemical instrument.

[0078] (2) Experimental results

[0079] Sugar metabolism results Image 6 As shown, the blood glucose in the model group in the model group increased significantly in the normal group. Image 6 -A, P Image 6 -B, P <0.01). The above results indicate that the rosewood can improve the metabolism of diabetic mice, lower blood sugar, and lower dose of rosteen 茋 lower blood sugar effect.

Embodiment 3

[0080] Example 3 Effect of rosewood on fat metabolism in diabetic mice

[0081] (1) Experimental method

[0082] Take the blood, use a fully automated biochemical to detect triglycerides (Tg), total cholesterol (Tc), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C).

[0083] (2) Experimental results

[0084] Lipid metabolism Figure 7 As shown, compared with normal groups, the content of the model group was significantly increased (P 0.05). It indicated that the rosewood can improve the blood lipids of type 2 diabetes mice.

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Abstract

The invention discloses application of pterostilbene in preparation of a medicine for preventing and / or treating diabetic complications. Through extensive and deep research, behavioral experiments and detection of blood fat, liver functions and kidney functions, it is unexpectedly found for the first time that the pterostilbene can improve depression-like behaviors and cognitive impairment induced by diabetes mellitus; the TC and LDL-C content increase caused by the type 2 diabetes mellitus can be effectively reduced, so that the dyslipidemia of mice with the type 2 diabetes mellitus is improved; in addition, ALT and AST levels of liver tissues can be reduced, liver injury caused by type 2 diabetes mellitus is improved, and pterostilbeneis used for preventing or treating non-alcoholic fatty liver disease induced by type 2 diabetes mellitus; the levels of urea nitrogen and creatinine can be reduced, and diabetes complicated with renal function decline is improved; the pterostilbene provides a new natural medicine choice for preventing or treating diabetic complications.

Description

Technical field [0001] The invention belongs to the field of biomedical technology. More specifically, it involves the application of a drug in the preparation of prevention and / or treatment of diabetic complications. Background technique [0002] Diabetes is due to the absolute or relatively insufficient body insulin, or a series of metabolic disorder syndrome with high blood sugar caused by insulin resistance. The most typical clinical symptoms of diabetes are more than drinking, eating, multi urine, body weight loss, etc., commonly known as more than one less. Long-term blood glucose increases to damage large blood vessels, microvascular, and seriously endanger the heart, brain, kidney, nerves, eyes, and sufficient. Diabetes complications are common chronic diseases that are converted from diabetic lesions, including diabetic cardiovascular disease, diabetic nephropathy, diabetes, diabetes liver injury. It seriously threatens human health, has become the main cause of blindn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/09A61P3/10A61P25/24A61P25/28A61P3/06A61P1/16A61P13/12
CPCA61K31/09A61P3/10A61P25/24A61P25/28A61P3/06A61P1/16A61P13/12
Inventor 汤丹王淑美张志同邓思敏庄国栋梁清峰黄广枭
Owner GUANGDONG PHARMA UNIV
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