Natural extract for inhibiting hepatitis B virus and its main active ingredients

A hepatitis B virus, natural extract technology, applied in the direction of organic active ingredients, antiviral agents, plant/algae/fungus/moss components, etc., can solve drug-resistant mutant viruses, hepatitis recurrence, resistant mutant virus strains, etc. problem, to achieve the effect of anti-inflammatory response and improving liver damage

Inactive Publication Date: 2007-09-05
WUHAN INST OF VIROLOGY CHINESE ACADEMY OF SCI
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  • Abstract
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Problems solved by technology

[0003] The drugs currently used for treatment are mainly interferon and lamivudine nucleoside analogues, but the results of the treatment are not so ideal. In addition to the side effects of interferon, it only has a therapeutic effect on patients with specific symptoms; As a reverse transcriptase inhibitor, although it can effectively inhibit the replication of hepatitis B virus, as the course of treatment progresses, resistant mutant virus strains will appear and lead to recurrence of hepatitis
Although some new nucleoside analogs such as adefovir have shown good anti-hepatitis B virus effects, as the course of treatment progresses, drug-resistant mutant viruses will still appear and lead to recurrence of hepatitis

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  • Natural extract for inhibiting hepatitis B virus and its main active ingredients
  • Natural extract for inhibiting hepatitis B virus and its main active ingredients
  • Natural extract for inhibiting hepatitis B virus and its main active ingredients

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Embodiment Construction

[0015] The natural extract for inhibiting hepatitis B virus and its main active ingredient provided by the invention are the natural extract extracted from green tea. Wherein: the main component of the extract is tea polyphenol; the main component of the tea polyphenol is EGCG, namely epigallocatechin gallate.

[0016] When the tea polyphenols in the above natural extracts are applied at a concentration of 10-40 mg / ml, they can effectively inhibit the expression of antigenic proteins, DNA replication, the formation of replication intermediates and the formation of covalently closed DNA of hepatitis B virus.

[0017] The above-mentioned active ingredient EGCG, when its monomer concentration is 6.25-50 μM, can effectively inhibit the expression of antigen protein, DNA replication, the formation of replication intermediates and the formation of covalently closed DNA of hepatitis B virus.

[0018] The invention provides the natural extract for inhibiting hepatitis B virus and its ...

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Abstract

A natural extract for suppressing the hepatitis B virus (HBV) is prepared from green tea through extracting. It features that its main active component is the polyphenols of tea (PPT) containing EGCG as its active component.

Description

technical field [0001] The present invention relates to a natural extract and its main active ingredients which have the function of preventing and treating hepatitis B virus, in particular to a kind of anti-hepatitis B containing tea polyphenols whose main component is epigallocatechin gallate (EGCG). Natural extract of hepatitis virus. Background technique [0002] Chronic hepatitis B virus infection is one of the main problems that endanger the health of people all over the world. There are more than 400 million people in the world who have been chronic hepatitis B infection. Although extensive vaccination programs have been implemented, WHO data shows that there are still 5 % of chronic infections. Many data show that hepatitis B virus plays an important role in the occurrence and development of liver cirrhosis and hepatocellular carcinoma. [0003] The drugs currently used for treatment are mainly interferon and lamivudine nucleoside analogues, but the results of the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61K31/352A61P1/16A61P31/20
Inventor 王华林许君邓菲胡志红
Owner WUHAN INST OF VIROLOGY CHINESE ACADEMY OF SCI
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