Purpose of walnut shell flavone extract in preparation of medicine for treating hyperlipidemia

A technology of hyperlipidemia and shell flavonoids, which is applied in the field of medicine to achieve the effects of reducing serum and liver lipid levels, treating and preventing hyperlipidemia, and improving liver damage

Inactive Publication Date: 2018-03-27
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, for the walnut shell flavonoid extract with complex components, it is currently limited to knowing that it has a protective effect on acute myocardial ischemia and certain activities such as strengthening the heart and improving myocardial blood supply. Research reports on the role of treatment and prevention of nutritional hyperlipidemia

Method used

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  • Purpose of walnut shell flavone extract in preparation of medicine for treating hyperlipidemia
  • Purpose of walnut shell flavone extract in preparation of medicine for treating hyperlipidemia
  • Purpose of walnut shell flavone extract in preparation of medicine for treating hyperlipidemia

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preparation example Construction

[0016] The preparation concrete operation of described walnut shell flavone extract is as follows:

[0017] Wash the walnut shells, dry them, and crush them through 80-100 mesh sieves. Use 55-65% ethanol aqueous solution with a liquid-to-material ratio of 30-35:1 at a temperature of 75-80°C for 1-2 hours per hour. Reflux extraction for 2 to 3 times, combine the filtrate and recover ethanol, then freeze-dry or spray-dry to obtain flavonoid extract from walnut shell

[0018] Use of walnut shell flavone extract of the present invention in the preparation of medicines for treating hyperlipidemia, said hyperlipidemia refers to the increase of total cholesterol, triglyceride, low-density lipoprotein cholesterol content in serum and liver and A reduction in high-density lipoprotein cholesterol levels.

[0019] The hyperlipidemia also includes liver damage caused by hyperlipidemia.

[0020] The liver damage refers to elevated levels of aspartate aminotransferase and alanine aminotra...

experiment example

[0027] 1 Materials and methods

[0028] 1.1 Materials and reagents

[0029] Walnut shells were purchased from Yangbi County, Dali, Yunnan, China, and flavonoid extracts from walnut shells were self-made by the laboratory.

[0030] TG assay kit, TC assay kit, HDL-C assay kit, LDL-C assay kit (Sinobio Biotechnology Co., Ltd.); AST kit, ALT kit, SOD kit, MDA kit , GSH-Px kit (Nanjing Jiancheng Biotechnology Co., Ltd.); food-grade cholesterol (Henan Xingyuan Chemical Products Co., Ltd.); pig bile salt (Beijing Suolaibao Technology Co., Ltd.); sodium cholate, propyl sulfoxide Pyrimidine, Tween-80 (Guangdong South China Pharmaceutical Group Co., Ltd.); Egg yolk powder (purchase egg homemade), sucrose, lard (market purchase); Normal saline (Kunming Nanjiang Pharmaceutical Co., Ltd.); 70% ethanol (Kunming Ming Gen Disinfection Products Co., Ltd.).

[0031] 1.2 Experimental animals and feed

[0032] Experimental animals: 30 SPF male SD rats, body weight (150±10) g, provided by Huna...

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Abstract

The invention discloses a purpose of a walnut shell flavone extract in preparation of a medicine for treating hyperlipidemia. The walnut shell flavone extract is an ethanol extract of walnut shell, and general flavone content in the extract is no less than 3%. According to the invention, hyperlipidemia means that total cholesterol, triglyceride, and low-density lipoprotein cholesterol content in serum and liver are increased, and high-density lipoprotein cholesterol content is reduced. The experiment result shows that the walnut shell flavone extract can obviously inhibit body weight increaseof rats with high-fat diet, Lee's index and fat index can be reduced, a lipid level in serum and liver is obviously reduced, such as reduction of TC, TG and LDL-C as well as increase of HDL-C, the walnut shell flavone extract has obvious protection effect and is capable of improving liver damage and liver fatty degeneration, and has effects for preventing and treating hyperlipidemia.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to the use of walnut shell flavonoid extracts in the preparation of medicines for treating hyperlipidemia. Background technique [0002] Hyperlipidemia refers to high total cholesterol (TC) and / or triglycerides (TG) or low high-density lipoprotein cholesterol (HDL-C) in the blood. Hyperlipidemia is also commonly referred to as hyperlipoproteinemia disease. Hyperlipidemia is a risk factor for stroke, myocardial infarction, coronary heart disease, heart failure, hypertension, diabetes, fatty liver and obesity. If hyperlipidemia is not adjusted and treated, it will induce atherosclerosis and liver cirrhosis , coronary heart disease, myocardial infarction and other cardiovascular and cerebrovascular diseases that seriously threaten human health. At present, most people take weight-loss drugs and lipid-lowering drugs to control obesity and improve dyslipidemia. However, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/52A61K45/06A61P3/06A61P1/16A61K131/00
CPCA61K36/52A61K45/06A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 赵声兰罗燕刘竞元陈朝银杨映宁
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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