24 results about "Healthy aging" patented technology

The invention relates to a comprehensive management system and method for elderly loneliness based on a mobile phone APP, and the system employs a three-level architecture of a host client-a control client-a data server, and achieves the intelligent and precise intervention. The host client integrates a multi-mode data acquisition function, an aging-suitable interaction interface function, a video / game intervention function and an emergency response function, and supports the elderly to autonomously complete mental health monitoring intervention. The control client is responsible for data cleaning, quality control and standardized management and provides reliable input for AI analysis. And the data server generates a personalized intervention scheme by relying on an AI model in combination with manual auditing, and dynamically optimizes a strategy. According to the system, wearable monitoring, CBT (Cathode Based Therapy) and an intelligent algorithm are combined, the goals of reducing the loneliness score of the old people and improving the social interaction frequency are expected to be achieved in future trial points, and the application prospects of the system in the aspects of accurate evaluation, risk early warning and intervention are embodied. By reducing medical resource consumption and enhancing intergenerational linkage, a replicable scheme is provided for healthy aging.

The invention discloses application of a composition containing lycium barbarum polysaccharide. The lycium barbarum polysaccharide is used for achieving the effects of resisting aging and removing lipofuscin, particularly, the specific lycium barbarum polysaccharide LBP1C can more remarkably reduce the level of transcription factors GATA4, activate key transcription regulatory factors of autophagy, reduce aging-related secretion phenotypes and inhibit accumulation of lipofuscin, and the lycium barbarum polysaccharide LBP1C has the effects of delaying aging, whitening skin and promoting healthy aging.

The present disclosure relates to compositions, nutraceutical compositions, and dietary supplements that improve gut health, enhance energy, improve focus and energy, reduce cravings, improve stress management, improve overall health, promote healthy aging, replenish nutrients, support immune health, promote healthy skin, promote hair and nail growth, and enhance recovery after physical activity. The compositions comprise one or more of each of seaweeds, enzymes, and protein; two or more of each of adaptogens, botanicals, extracts, fibers, microalgae, micronutrients, minerals, vitamins, and whole fruit or vegetable powders; and three or more probiotics.

A high-oxygen adaptive anti-aging oxygen-enhanced adaptive functional beverage formulated using advanced liposomal encapsulation, plant-based microencapsulation, and microbubble oxygenation technologies to enhance bioavailability, stability, and oxygen delivery. The oxygen-enhanced adaptive functional beverage improves cellular metabolism, mitochondrial function, and oxygen utilization, leading to increased energy levels, cognitive function, and oxidative stress resistance. By promoting efficient oxygen absorption and retention, the oxygen-enhanced adaptive functional beverage supports healthy aging, athletic performance, and high-altitude adaptation. The oxygen-enhanced adaptive functional beverage incorporates bioactive compounds, antioxidants, and essential nutrients, ensuring prolonged effectiveness and enhanced physiological benefits.

The invention provides a community old people rehabilitation service platform system construction method based on the Internet and the cloud computing technology, and can establish an Internet + rehabilitation platform and a community old people rehabilitation service ecosphere based on the mobile Internet and the cloud computing technology. Patients are divided into multiple rehabilitation types according to demand information distribution intervals existing in community rehabilitation demands of old people, then a targeted rehabilitation scheme is generated based on the rehabilitation demands and individual characteristics of the old people, and dynamic adjustment is performed according to rehabilitation progress conditions of the old people. On-line virtual community communication between community rehabilitation elderly people and between the elderly people and medical care groups is constructed through the platform, and companion support and professional guidance are enhanced. Intelligent matching between the requirements of the old and rehabilitation services is achieved, the life quality and happiness of the old are improved through more effective rehabilitation services, and then healthy aging and development of work of healthy China are boosted. Belongs to the elderly rehabilitation service field.

This invention relates to a nutritional composition comprising a combination of β-lactoglobulin and lactoferrin. β-Lactoglobulin is a major whey protein with excellent emulsifying and gelling properties, while lactoferrin is known for its antimicrobial and immune-modulating effects. The combination of these proteins provides enhanced health benefits such as improved immune support and gut health. A key feature of this invention is the ability of β-lactoglobulin to prevent or reduce the coagulation of lactoferrin during heating, maintaining its functional integrity and efficacy. Additionally, methods for recombinantly producing lactoferrin and β-lactoglobulin, and specific formulations for targeted demographics such as children, infants, and the elderly, and formulations for healthy ageing, for improvement of women's health and / or as a sports nutrition composition are disclosed.

A digital method of therapeutic brain stimulation is provided. The method comprises presenting to a user in a UI a group of trials by sequentially displaying symbols against a background. The symbols are randomly displayed one at a time against one several contexts in the background to stimulate the user's parietal or frontal lobes or motor cortex. A user response is received for each display of a symbol indicating whether the symbol is the same or different from an immediately prior symbol for the same context, wherein each trial has a maximum allowed response time for the user input after which any response is counted as a false alarm. A user score is generated for the group of trials, wherein the score compares correct identification and incorrect false alarm responses for the group of trials against a user score of a previous group of trials.

A method for calculating the biological age of a subject and across multiple subjects by performing multi-gene DNA methylation on biomarkers is provided, the method comprising measuring the methylation status of 13 CG sites located in the putative antisense region of the ElovL2 gene, namely the ElovL2 AS1 region. Further, a computer-implemented method for providing recommendations for lifestyle changes in the form of a self-learning "ecosystem" is provided, the self-learning "ecosystem" using new measurements of the DNA methylation clock as continuous dynamic results for lifestyle management of biological aging. Also provided is a combination of DNA methylation biomarkers for calculating biological age and a kit for determining the biological age. Further, disclosed is the use of a disclosed method for calculating biological age in a method for evaluating the effect of biological interventions and a method for screening anti-aging agents.

The present invention relates a composition for use in increasing the longevity and / or enhancing healthy aging of a subject, particularly a human subject, and methods thereof. The composition comprises at least one of: isoscabertopin; 1,7-Bis (hydroxyphenyl)-4-hepten-3-one; eupafolin; isokuranetin, (E) - aldosecologanin, or any combination thereof, and increases expression of or activates a transcription factor selected from the group consisting of: nuclear factor (erythroid-derived 2)-like 2 (NRF2), Forkhead box O3 (FOXO3) and Grainy head 1 (GRHL1). Non-therapeutic or therapeutic uses and methods are disclosed herein. The extending longevity includes stimulating innate immunity, resistance against oxidative stress, inhibition of tumor cell growth, treating or preventing age-related diseases and disorders, which include: inflammation and inflammatory diseases, non-communicable diseases including: cardiovascular diseases, arthropathies, cancer, neurodegenerative diseases, diabetes, frailty, decline of physical fitness, decline of physical endurance or combinations thereof.

The invention belongs to the technical field of medical-care combination services, and particularly relates to a community home medical-care combination service evaluation system based on health aging, which comprises a multi-source data acquisition subsystem, a health data acquisition unit, a data processing subsystem, a data processing subsystem, a data processing subsystem and a data processing subsystem, wherein the health data acquisition unit is used for collecting physiological parameters such as heart rate, blood pressure and blood sugar of old people in real time through wearable equipment, household medical detection instruments and the like; medical data such as a disease diagnosis report and a treatment record are acquired; the method can comprehensively and accurately collect and analyze related data of community home medical and nursing combined services, provides a solid foundation for scientific evaluation, fully considers the multi-dimensional requirements of health aging, makes the evaluation result more scientific and targeted, can quickly and effectively solve the problems existing in the services, and improves the service quality. The service quality and the life quality of the old people are improved, the benign development of community home medical and nursing combined service is promoted, the utilization efficiency of social resources is improved, the social nursing burden is relieved, and remarkable social benefits and economic benefits are achieved.

This invention relates to the fields of biomedicine and food nutrition, specifically to the application of purple sweet potato anthocyanins in the preparation of products for preventing or improving intestinal aging. This invention demonstrates that purple sweet potato anthocyanins can significantly improve the degenerative changes and barrier fragility of the colon caused by natural aging, restore colonic crypt morphology and epithelial ultrastructure, and upregulate the expression of tight junction proteins and mucus barrier-related indicators. Furthermore, purple sweet potato anthocyanins can effectively enhance crypt proliferation activity and promote the differentiation of intestinal stem cells into secretory lineages (such as goblet cells and enteroendocrine cells). Its mechanism of action does not rely on direct anti-inflammatory pathways, but rather on remodeling intestinal flora metabolism (such as increasing short-chain fatty acids) and activating intestinal cell autophagy via the PI3K-Akt signaling pathway, thereby supporting the continuous renewal and maintenance of the intestinal barrier. This invention provides a new approach for the development and application of food-derived polyphenols targeting the gut to promote healthy aging.

The invention belongs to the technical field of health assessment, and discloses a personalized biological age construction method based on deep learning and causal inference, and the method comprises the steps: 1, constructing a multi-dimensional biological age evaluation index system; 2, collecting and preprocessing data; step 3, screening senescence biomarkers; 4, constructing a multi-level and multi-mode biological age model; 5, performing causal inference optimization risk assessment; and step 6, carrying out multi-dimensional comprehensive evaluation by adopting a layered weighted TOPSIS method by means of the multi-dimensional biological age evaluation index system and the multi-level and multi-mode biological age model. According to the method, the multi-level healthy aging biological age suitable for basic-level use is selected, the individual data collection requirement of the elderly is judged according to the predicted biological age, and the feedback guidance is performed to accurately predict the biological age.

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, the treatment of ischemic injury, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, cardiomyopathy, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, diabetic cardiomyopathy, infections of the skin, peripheral vascular disease, stroke, galactosemia, asthma, PMM2-CDG and the like.

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, the treatment of ischemic injury, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, cardiomyopathy, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, diabetic cardiomyopathy, infections of the skin, peripheral vascular disease, stroke, galactosemia, asthma, PMM2-CDG and the like.

The invention relates to the technical field of biological medicine, and discloses application of cell wall component peptidoglycan in activating lysosome and delaying healthy aging. The invention finds that the peptidoglycan, which is a bacterial cell wall component, can improve lysosome activity. Experiments prove that the peptidoglycan serving as the bacterial cell wall component can improve lysosome activity so as to delay animal aging, so that the peptidoglycan serving as the bacterial cell wall component can be used for preparing lysosome activators or medicines for delaying healthy aging.

The invention relates to the technical field of intestinal probiotics, in particular to a plant lactobacillus fruit lobed sourced-6282m and an application of the plant lactobacillus fruit lobed sourced-6282m. The lactobacillus plantarum fruit logen 6282m is preserved in the China Center for Type Culture Collection on December 8, 2025, the preservation number of the lactobacillus plantarum fruit logen 6282m is CCTCC (China Center for Type Culture Collection) NO: M 20252810, and the lactobacillus plantarum fruit logen 6282m is named as lactobacillus plantarum fruit logen 6282m. The invention also provides a culture, a fermentation broth, a bacterial suspension, a bacterial agent and bacterial powder of the strain. The invention aims to screen and identify the lactic acid bacteria strain with hypoxia tolerance and oxidation resistance from the traditional fermented food of the Tibet Plateau, and provides a strain resource for developing a novel probiotic product for relieving physiological fatigue, enhancing environmental adaptability and promoting healthy aging.

The invention provides methods and compositions relating to identification and use of genetic information from the FOXO3A gene that can be used for determining and increasing an individual's likelihood of longevity and of retaining physical and cognitive function during aging, and for determining and decreasing an individual's likelihood of developing a cardiovascular-, metabolic- or age-related disease, including coronary artery (heart) disease, stroke, cancer, chronic pulmonary disease, diabetes, Parkinson's disease and dementia.

This invention relates to the field of elderly care monitoring technology, specifically disclosing a method and system for monitoring the behavior of healthy elderly people. The invention determines the corresponding elderly care monitoring levels for multiple monitoring devices through monitoring level analysis; sets up daily monitoring to determine daily monitoring levels; marks multiple devices at different daily levels for daily behavior monitoring; upgrades monitoring levels when abnormal behavior is detected; and determines whether the behavior remains abnormal. If abnormal behavior persists, full-level monitoring is initiated, along with an anomaly alarm. This invention can determine the corresponding elderly care monitoring levels for multiple monitoring devices, set up daily monitoring according to the needs of the target elderly person, upgrade monitoring levels when abnormal behavior is detected during daily monitoring, and initiate full-level monitoring if abnormal behavior persists. This allows for both monitoring adjustments based on the needs of different elderly people and timely proactive monitoring adjustments, effectively ensuring the safety of the elderly.

The invention discloses a kit for detecting intestinal flora and predicting healthy aging and application of the kit. The kit contains a reagent for detecting intestinal bacteria Alistipes bacteria, Akkermansia bacteria and Klebsiella bacteria, and the reagent contains a forward primer and a reverse primer for detecting DNA of the Alistipes bacteria, the Akkermansia bacteria and the Klebsiella bacteria. The method is clear in screening targeting, rapid and accurate in detection and simple and convenient to operate, can be converted into a health evaluation tool, assists in judging the healthy aging state, provides support for long-life prediction and anti-aging intervention research and development, assists in promoting healthy aging, and is wide in application prospect.

To provide novel compounds and pharmaceutical compositions thereof for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, the treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, the treatment of ischemic injury, and the treatment of various other disorders, such as complications arising from diabetes, with the compounds and compositions of the invention.SOLUTION: For example, the compound in the figure is demonstrated.SELECTED DRAWING: None

The present invention relates to the use of a NOP receptor antagonist in the promotion of elderly health. Specifically, the invention provides an application of an NOP receptor antagonist in preparation of a medicine or a preparation, and the medicine or the preparation is used for promoting the health of old people; the cognitive ability is improved, and the athletic ability is improved. Experiments prove that the NOP receptor antagonist disclosed by the invention has an obvious improvement effect on motor function degeneration and cognitive function degeneration in the aging process of mammals, and prolongs the life of the mammals, so that the health of the old is safely and efficiently promoted.

This invention discloses a longevity biomarker based on serum metabolomics and its application, belonging to the field of biomedical technology. The longevity biomarker disclosed in this invention, based on serum metabolomics, includes mandelic acid, glutethimide, fenmetrazine, hydroxyheptanoic acid, norfloxacin, N-acetylserotonin, 3,4-methylenedioxyphenylamine, palmitoleic acid, cinconidine, gulonose, 5-aminopentanal, 12,13-dihydroxy-9Z-octadecenoic acid, anserine, (3Z)-phytochrome bile, phytocyanin, and L-selenomethylselenocysteine. This invention provides new biomarkers for diagnosing healthy aging and predicting human lifespan, and can be used to prepare products that predict the likelihood of longevity, showing promising applications in the field of anti-aging and health.

This invention relates to microbiome markers for healthy aging. There is provided, inter alia, a method of predicting or determining healthy aging in an individual, the method comprising: (a) determining the presence or an amount of at least one microorganism in a sample representing the individual's gut microbiome, wherein the at least one microorganism is selected from Table 1A, wherein an enrichment of said microorganisms is indicative of healthy aging; and / or (b) determining the presence or an amount of at least one microorganism in a sample representing the individual's gut microbiome, wherein the at least one microorganism is selected from Table 1 B, wherein a depletion of said microorganisms is indicative of healthy aging.

The utility model discloses a multi-functional bedside cabinet for health care for the aged, which comprises a cabinet body, a placing assembly, an extension assembly and an extension assembly, the placing assembly is arranged above the cabinet body, the extension assembly is arranged below the placing assembly, the extension assembly is arranged on one side of the cabinet body, and the extension assembly is arranged on the other side of the cabinet body through an extension plate. One end of the extension plate is rotationally and fixedly connected with the extension rod, the other end of the extension plate is rotationally connected with the placement assembly, and a groove allowing the fixing rod to lock the extension rod is formed in the fixing groove. The height of the bed is matched by extending the placement assembly through the extension rod, so that the adjustment of the placement assembly is realized, when an old person lies in bed, an external dining plate does not need to be added, the bedside table is changed into the dining plate, the use function of the bedside table is increased, and the problem of single function is solved by the device.