36 results about "Healthy aging" patented technology

The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, infections of the skin, peripheral vascular disease, stroke, and the like.

The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, infections of the skin, peripheral vascular disease, stroke, and the like.

The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, infections of the skin, peripheral vascular disease, stroke, and the like.

The invention discloses a circRNA small molecular marker indicating key pathways of healthy aging and application. The key pathways of healthy aging include 8 key pathways in 3 categories. The circRNAsmall molecular marker includes 40 circRNA and nucleotide sequences of the 40 circRNA are shown as SEQ ID NO.1-40, the circRNA small molecular marker can be directly applied to indicate the changesof the healthy aging-related pathway changes in the current state of ordinary aging people, and the health aging state is evaluated from the mechanism.

The present invention is directed to the use of (a composition comprising) hydroxytyrosol as anti-aging agent. The composition, to which the present invention is also directed, does essentially not comprise resveratrol and is administered orally to animals. The present invention is further directed to anti-aging methods. “Anti-aging” meaning in the context of the present invention: retarding the aging processes in said animals, improving age-related physiological deficits in said animals and / or promoting a healthy aging in said animals.

The invention discloses an endogenous metabolic small molecular marker for indicating a healthy aging key pathway and application. The number of the endogenous metabolic small molecules is 155. The key pathway is totally 30. The invention provides a new endogenous small molecule marker for indicating the key pathways for blood health and aging for the first time, and the change of the small molecules can be measured to comprehensively evaluate the change of pathways related to health and aging in a human body, thereby providing support for subsequent intervention and response.

The invention discloses novel application of forsythin belonging to active components of natural medicinal plants, and particularly relates to application of forsythin as the only active ingredient to preparation of a medicine for improving a cognitive function and treating Alzheimer's diseases. Animal and cell research results indicate that the forsythin has the exact function of improving the cognitive function and can remarkably improve the spatial learning and memory ability of animals in an aging and Alzheimer's disease model, the level of a center monoamine neurotransmitter of an old-aged animal is increased, the genetic expression of presenilin 2 in a rat brain of an Alzheimer's disease model is reduced, and the survival rate of neuroblastoma cells induced by beta-amyloid protein is increased. The forsythin is matched with relevant auxiliary materials, a health care product or a medicine for purposefully improving the cognitive function and treating the Alzheimer's diseases can be prepared by a conventional preparation method, and the health care product and the medicine can be used for delaying and improving relevant diseases of cognitive hypofunction such as the course of the Alzheimer's diseases, enhancing the healthy quality and the life quality of old people and realizing a healthy aging social value.

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, the treatment of ischemic injury, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, diabetic cardiomyopathy, infections of the skin, peripheral vascular disease, stroke, asthma, and the like.

The invention provides methods and compositions relating to identification and use of genetic information from the FOXO3A gene that can be used for determining and increasing an individual's likelihood of longevity and of retaining physical and cognitive function during aging, and for determining and decreasing an individual's likelihood of developing a cardiovascular-, metabolic- or age-related disease, including coronary artery (heart) disease, stroke, cancer, chronic pulmonary disease, diabetes, Parkinson's disease and dementia.

The invention discloses a serum protein marker for indicating healthy aging key pathways and application. The number of the serum protein markers is 193, and the key pathways comprise 12 up-regulationpathways and 4 down-regulation pathways. The invention provides a novel serum protein marker for indicating a blood health aging key pathway for the first time. By measuring changes of the serum protein markers, changes of channels related to healthy aging in a human body can be comprehensively evaluated, the risk of non-healthy aging of elderly individuals is further evaluated, and theoretical support is provided for subsequent intervention and response.

The present invention relates to method for calculating biological age of a subject and across multiple subjects by performing polygenic DNA methylation on biomarkers which comprise measuring the methylation status of 13 CG sites positioned in a putative antisense region to ElovL2 gene, ElovL2 AS1 region. Further, the present invention provides a computer-implemented method for providing recommendations for lifestyle changes in form of a self-learning “ecosystem” for lifestyle management of biological aging using a novel measurement of the DNA methylation clock as a continuous dynamic outcome. The present invention also relates to combination of DNA methylation biomarkers for calculating biological age, a kit for determining the biological age. Further, the present invention discloses the use of the disclosed methods for calculating biological age in a method of assessing the effect of the effect of a biological intervention and in a method of screening for an anti-ageing agent.

The invention relates to a method for predicting healthy aging through relative abundance of intestinal flora, and belongs to the technical field of elderly medicine. The composition characteristics of the taxonomy level of the intestinal flora of the elderly are studied through a high-throughput sequencing method, and the obviously different intestinal flora in the 100-year old, the elderly and the young adults is analyzed and used as a detection index for predicting healthy aging. Six kinds of intestinal microorganisms are used for predicting healthy aging. According to the method, the intestinal microorganisms for predicting healthy aging are screened out according to the abundance of the differential intestinal flora of the 100-year old, the elderly and the young adults, and new indexes and basis are provided for health aging detection of the whole people.

The invention relates to a synthesis and preparation method and an application of selenous acidized beta-lactoglobulin. Beta-lactoglobulin and SeO2 are taken as raw materials, selenous acid groups are introduced into beta-lactoglobulin with an oxidation-reduction method, and a novel organic selenium source is prepared. The preparationmethodcomprises the following steps: preparation of selenous acid; preparation ofa beta-lactoglobulinliquid containing selenous acid; introduction of selenous acid radical; filterationand centrifugation; freeze drying; and obtaining of a pure product selenous acidized beta-lactoglobulin. The obtained selenous acidized beta-lactoglobulin has high nutritive value, stable properties, and anticancer and anti-aging effects, and is an excellent organic selenium source. The method not only has greattheoretical significance on development of organic selenized protein, but also has great social practical significance on healthy aging.

The invention discloses a healthy aging serum protein marker and application thereof. The marker comprises 19 proteins. According to the invention, the protein markers for health aging are extracted from the serum protein level for the first time, and have the characteristics of high accuracy and high sensitivity (AUC is greater than 0.800, and the highest sensitivity is 0.878). The method can bedirectly used as an evaluation index of health aging.

The invention discloses a fall-preventing bathing enclosure frame for healthy aging life. The fall-preventing bathing enclosure frame for healthy aging life comprises a bathing enclosure frame body, wherein an installing and fixing plate is integrally formed on the surface of the bathing enclosure frame body, a lifting groove is formed in a side plate of the bathing enclosure frame body, a connecting slide plate is slidingly connected in the lifting groove, an adjusting frame is welded to the surface of the connecting slide plate, enclosure rods are slidingly connected in the adjusting frame,an adjusting screw is rotatably connected to the surface of the connecting slide plate and penetrates through the adjusting frame and the outer walls of the enclosure rods simultaneously, a lap jointgroove opening is formed in the surface of each enclosure rod, a telescoping cross rod is in lap joint with the inside of the lap joint groove opening, and a backrest groove is formed in the surface of the bathing enclosure frame body. Two enclosure rods are arranged on the bathing enclosure frame body, the separating distance between the two enclosure rods is adjusted through the adjusting screw,and the enclosure structure is formed jointly through matching of the telescoping cross rod, so that convenience is brought to an old user for holding during standing, and fall is prevented.

The invention provides methods and compositions relating to identification and use of genetic information from the FOXO3A gene that can be used for determining and increasing an individual's likelihood of longevity and of retaining physical and cognitive function during aging, and for determining and decreasing an individual's likelihood of developing a cardiovascular-, metabolic- or age-related disease, including coronary artery (heart) disease, stroke, cancer, chronic pulmonary disease, diabetes, Parkinson's disease and dementia.

The invention relates to the field of medicinal chemistry, in particular to application of a tangerine seed extract in a medicine for treating healthy aging, and the tangerine seed extract is a tangerine seed ethanol extract. It is reported that the tangerine seed extract serves as a potential candidate drug for promoting longevity, the tangerine seed extract prolongs the life of caenorhabditis elegans by activating the autophagy effect, health is promoted, and the tangerine seed extract has a quite large treatment effect on senescence and senescence-related diseases; the clinical application of the tangerine seed extract in senescence and senescence-related diseases can be better promoted.

Synergistic herbal compositions comprising combination of a first ingredient selected from the extract(s), fraction(s), active compound(s) and phytochemicals or mixtures thereof derived from the plant parts of Punica granatum and a second ingredient selected from the extract(s), fraction(s), active compound(s) and phytochemicals or mixtures thereof derived from the plant parts of Theobroma cacao for improving testosterone levels. The invention further provides the method of obtaining at least one health benefit related to enhanced anabolic and androgenic activities in the body selected from improving testosterone levels, energy levels, sustained energy, vigor, stamina, healthy aging, cellular longevity, muscle mass, muscle strength sexual function (libido and erectile function) and psychological well-being (mood and focus); and reducing stress in humans and alleviating the symptoms associated with the low levels of testosterone in humans such as loss of libido, loss of erectile function, abdominal obesity, decreased muscle mass and strength, fatigue, mood swing, decreased bone density, decreased motivation, and decreased memory and concentration.

The present invention relates to chitosan nitrate for use as nitric oxide donor, in particular for use in the prevention or treatment of a condition related to NO deficiency in mammals, preferably humans. Suitable conditions to be treated with chitosan nitrate include disorders related to the skin, conditions related to sexual dysfunction, conditions wherein there is a need for pain treatment, conditions being a disorder related to the eyes, nose and sinus, conditions being a disorder related to the airways, conditions related to a gastro-intestinal disorder, and conditions being a metabolic disorder. These conditions were successfully treated or reduced by the application of chitosan nitrate according to the present invention. The invention also concerns a non-therapeutic or cosmetic method for skin protection and / or for healthy aging.

Using NMR / MS-based metabolomics and targeted lipidomics approaches, the inventors studied the metabolic phenotypes of aging and longevity in a cohort including centenarians, older adults, and young adults. The present inventors identified biomarkers of reduced risk of developing age-related chronic inflammatory disorders, proposing a method of using PC-040:1 as a biomarker to diagnose a lifestyle that allows delaying and / or avoiding age-related chronic inflammatory disorders.

The invention discloses a healthy aging diagnosis marker and application thereof. The marker is prepared from one or more of alpha-N-phenylacetyl-L-glutamine, 4-methylphenol, N6-methyladenosine, N1-methyl-2-pyridone-5-carboxamide, 3-phenyllactic acid, 5-hydroxyindoleacetic acid, dopamine, 4-hydroxyphenylpyruvic acid, propionylglycine, 4-aminohippuric acid, indoxyl sulfate, 3,4-dihydroxybutyric acid, O-acetylserine, N2,N2-dimethyl guanosine, N-ticagrelor glycine, threitol, methoxyacetic acid, indole-3-pyruvic acid, L-histidine, homoarginine and arachidonic acid. The marker has the characteristics of high accuracy and high sensitivity, and can be directly used as an index for healthy aging.

In one aspect, the invention provides a method for predicting a subject's risk of unhealthy aging, said method comprising: (a) determining two or more lipids in a sample from said subject Levels of biomarkers, wherein the biomarkers are selected from two or more of the following group: (i) triacylglycerol (TAG), from TAG (46:5) to TAG (54:3); (ii) ether phosphatidylcholine (PC‑O), from PC‑O (28:0) to PC‑O (38:6); (iii) sphingomyelin (SM), from SM (33:1) to SM (50:1); (iv) phosphatidylcholine (PC), from PC (32:1) to PC (40:5); (v) phosphatidylinositol (PI), from PI (36:1 ) to PI (38:3); (vi) phosphatidylethanolamine (PE), from PE (36:2) to PE (38:4); and (b) the level of the biomarker in the sample compared to a reference value; wherein the level of the biomarker in the sample, compared to the reference value, is indicative of the subject's risk of unhealthy aging.

The invention discloses an old people function impairment assessment system. The system comprises an information acquisition part; acquiring personal life functions, family life functions and social activity functions of the old people by using contents of the old people function impairment assessment scale; the information analysis and statistics module is used for scoring the collected information and counting a total score; functional impairment assessment entries of the old people functional impairment assessment system are suitable for the old people in China, the operability is high, the system evaluates the functional conditions of the old people, identifies functional impairment of the old people and intervenes as soon as possible, and the system is suitable for the old people in China. Therefore, the occurrence and development of disability are delayed, the functional ability of the old people is maintained, the life quality of the old people is improved, and healthy aging is realized.

Using NMR / MS-based metabolomics and targeted lipidomics approaches, the inventors studied the metabolic phenotypes of aging and longevity in a cohort including centenarians, older adults, and young adults. The present inventors have identified biomarkers for reducing the risk of developing age-related chronic inflammatory disorders, proposing the use of 9-oxo-HODE as a biomarker to diagnose a lifestyle that allows delaying and / or avoiding age-related chronic inflammatory disorders Methods.

The present invention relates to compositions and methods related to scavenging particulates. The present invention provides scavenging particles, methods for treating a subject suffering from cancer, an autoimmune disease, a neurodegenerative disease, methods for promoting healthy aging in a subject, methods for treating a metabolic disorder in a subject, and methods for increasing muscle mass in a subject. The present disclosure provides, among other things, compositions that bind to and inhibit the biological activity of soluble biomolecules and pharmaceutical compositions thereof. Compositions may include a plurality of particles that specifically bind to a target, such as a soluble biomolecule or biomolecule on the surface of a pathogen, to inhibit the target (or pathogen) from interacting with other molecules or cells. The disclosure also provides certain applications (e.g., therapeutic applications) where the compositions are useful.

Using NMR / MS-based metabolomics and targeted lipidomics approaches, the inventors studied the metabolic phenotypes of aging and longevity in a cohort including centenarians, older adults, and young adults. The present inventors have identified biomarkers for the reduced risk of developing age-related chronic inflammatory conditions, proposing that the use of phenylacetylglutamine (PAG) as a biomarker diagnosis allows delaying and / or avoiding the life of aging-related chronic inflammatory conditions. way of in vitro methods.

Methods are provided for determining if a subject is likely to develop an age-related disease based on miRNA signatures. Related methods of treatment are also provided.

The present invention relates to novel compounds and pharmaceutical compositions thereof, and the use of compounds and compositions of the present invention to promote healthy aging of the skin, to treat skin disorders, to treat cardiovascular disorders, to treat renal disorders, to treat angiogenic disorders such as cancer, to treat tissue Injuries such as non-cardiac tissue injuries, methods of treating developing myocardial infarction and treating various other conditions such as complications due to diabetes. Other conditions may include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, skin infection, peripheral vascular disease, stroke, and the like.