The present invention relates a composition for use in increasing the
longevity and / or enhancing
healthy aging of a subject, particularly a human subject, and methods thereof. The composition comprises at least one of: isoscabertopin; 1,7-Bis (hydroxyphenyl)-4-hepten-3-one; eupafolin; isokuranetin, (E) - aldosecologanin, or any combination thereof, and increases expression of or activates a
transcription factor selected from the group consisting of: nuclear factor (erythroid-derived 2)-like 2 (NRF2), Forkhead box O3 (FOXO3) and Grainy head 1 (GRHL1). Non-therapeutic or therapeutic uses and methods are disclosed herein. The extending
longevity includes stimulating innate
immunity, resistance against
oxidative stress, inhibition of tumor
cell growth, treating or preventing age-related diseases and disorders, which include:
inflammation and inflammatory diseases, non-communicable diseases including: cardiovascular diseases, arthropathies,
cancer, neurodegenerative diseases, diabetes, frailty, decline of
physical fitness, decline of physical endurance or combinations thereof.