35 results about "Healthy aging" patented technology

The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, infections of the skin, peripheral vascular disease, stroke, and the like.

The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, infections of the skin, peripheral vascular disease, stroke, and the like.

The invention discloses an endogenous metabolic small molecular marker for indicating a healthy aging key pathway and application. The number of the endogenous metabolic small molecules is 155. The key pathway is totally 30. The invention provides a new endogenous small molecule marker for indicating the key pathways for blood health and aging for the first time, and the change of the small molecules can be measured to comprehensively evaluate the change of pathways related to health and aging in a human body, thereby providing support for subsequent intervention and response.

The invention discloses novel application of forsythin belonging to active components of natural medicinal plants, and particularly relates to application of forsythin as the only active ingredient to preparation of a medicine for improving a cognitive function and treating Alzheimer's diseases. Animal and cell research results indicate that the forsythin has the exact function of improving the cognitive function and can remarkably improve the spatial learning and memory ability of animals in an aging and Alzheimer's disease model, the level of a center monoamine neurotransmitter of an old-aged animal is increased, the genetic expression of presenilin 2 in a rat brain of an Alzheimer's disease model is reduced, and the survival rate of neuroblastoma cells induced by beta-amyloid protein is increased. The forsythin is matched with relevant auxiliary materials, a health care product or a medicine for purposefully improving the cognitive function and treating the Alzheimer's diseases can be prepared by a conventional preparation method, and the health care product and the medicine can be used for delaying and improving relevant diseases of cognitive hypofunction such as the course of the Alzheimer's diseases, enhancing the healthy quality and the life quality of old people and realizing a healthy aging social value.

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, the treatment of ischemic injury, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, diabetic cardiomyopathy, infections of the skin, peripheral vascular disease, stroke, asthma, and the like.

The invention discloses a serum protein marker for indicating healthy aging key pathways and application. The number of the serum protein markers is 193, and the key pathways comprise 12 up-regulationpathways and 4 down-regulation pathways. The invention provides a novel serum protein marker for indicating a blood health aging key pathway for the first time. By measuring changes of the serum protein markers, changes of channels related to healthy aging in a human body can be comprehensively evaluated, the risk of non-healthy aging of elderly individuals is further evaluated, and theoretical support is provided for subsequent intervention and response.

The present invention relates to method for calculating biological age of a subject and across multiple subjects by performing polygenic DNA methylation on biomarkers which comprise measuring the methylation status of 13 CG sites positioned in a putative antisense region to ElovL2 gene, ElovL2 AS1 region. Further, the present invention provides a computer-implemented method for providing recommendations for lifestyle changes in form of a self-learning “ecosystem” for lifestyle management of biological aging using a novel measurement of the DNA methylation clock as a continuous dynamic outcome. The present invention also relates to combination of DNA methylation biomarkers for calculating biological age, a kit for determining the biological age. Further, the present invention discloses the use of the disclosed methods for calculating biological age in a method of assessing the effect of the effect of a biological intervention and in a method of screening for an anti-ageing agent.

The invention relates to a method for predicting healthy aging through relative abundance of intestinal flora, and belongs to the technical field of elderly medicine. The composition characteristics of the taxonomy level of the intestinal flora of the elderly are studied through a high-throughput sequencing method, and the obviously different intestinal flora in the 100-year old, the elderly and the young adults is analyzed and used as a detection index for predicting healthy aging. Six kinds of intestinal microorganisms are used for predicting healthy aging. According to the method, the intestinal microorganisms for predicting healthy aging are screened out according to the abundance of the differential intestinal flora of the 100-year old, the elderly and the young adults, and new indexes and basis are provided for health aging detection of the whole people.

The invention discloses a fall-preventing bathing enclosure frame for healthy aging life. The fall-preventing bathing enclosure frame for healthy aging life comprises a bathing enclosure frame body, wherein an installing and fixing plate is integrally formed on the surface of the bathing enclosure frame body, a lifting groove is formed in a side plate of the bathing enclosure frame body, a connecting slide plate is slidingly connected in the lifting groove, an adjusting frame is welded to the surface of the connecting slide plate, enclosure rods are slidingly connected in the adjusting frame,an adjusting screw is rotatably connected to the surface of the connecting slide plate and penetrates through the adjusting frame and the outer walls of the enclosure rods simultaneously, a lap jointgroove opening is formed in the surface of each enclosure rod, a telescoping cross rod is in lap joint with the inside of the lap joint groove opening, and a backrest groove is formed in the surface of the bathing enclosure frame body. Two enclosure rods are arranged on the bathing enclosure frame body, the separating distance between the two enclosure rods is adjusted through the adjusting screw,and the enclosure structure is formed jointly through matching of the telescoping cross rod, so that convenience is brought to an old user for holding during standing, and fall is prevented.

The invention discloses a healthy aging diagnosis marker and application thereof. The marker is prepared from one or more of alpha-N-phenylacetyl-L-glutamine, 4-methylphenol, N6-methyladenosine, N1-methyl-2-pyridone-5-carboxamide, 3-phenyllactic acid, 5-hydroxyindoleacetic acid, dopamine, 4-hydroxyphenylpyruvic acid, propionylglycine, 4-aminohippuric acid, indoxyl sulfate, 3,4-dihydroxybutyric acid, O-acetylserine, N2,N2-dimethyl guanosine, N-ticagrelor glycine, threitol, methoxyacetic acid, indole-3-pyruvic acid, L-histidine, homoarginine and arachidonic acid. The marker has the characteristics of high accuracy and high sensitivity, and can be directly used as an index for healthy aging.

Methods are provided for determining if a subject is likely to develop an age-related disease based on miRNA signatures. Related methods of treatment are also provided.