57 results about "Biological age" patented technology

A method of age management, by consulting with a patient, performing comprehensive testing on the patient, determining the physiological, functional, and biological age of the patient, and recommending and performing treatments based on the physiological, functional, and biological age of the patient. The performing comprehensive testing is further defined as performing a test of standard plus functional medicine testing, complete hormonal panel, infectious disease panel, tumor markers panel, and combinations thereof.

Provided are methods of diagnosis, prognosis, and monitoring of aging using biomarkers that have been discovered to be linked to biological aging process. Methods for increasing neural cell regeneration and cognitive function are also provided. The methods are, at least in part, based on a discovery that altered expression patterns of certain biological markers are associated with biological aging processes. These markers comprise at least Eotaxin/CCL11, 2-microglobulin, MCP-1 and Hap-toglobulin, increased expression of which has been shown to be associated with increase in biological aging process.

The invention belongs to the technical field of building materials, and particularly relates to polyurethane sealing glue. The polyurethane sealing glue is characterized in that the polyurethane sealing glue consists of component A and component B, and the ratio of the component A to the component B in portion by weight is 1:1-10, wherein the component A is polyurethane prepolymer; and the component B comprises the following compositions in portion by weight: 16 to 30 portions of polyether polyol, 2 to 15 portions of plasticizer, 40 to 70 portions of filler, 0.1 to 2 portions of catalyst, and 0.1 to 2 portions of thixotropic agent. The polyurethane sealing glue has the advantages of good abrasion resistance, low-temperature flexibility, wide performance adjustable range, large mechanical strength, good adhesive property, good elasticity, good rebound resilience, good weather resisting property, good oil resistivity and biological ageing resistance, is suitable for dynamic joint, and does not contain volatile solvent and other small molecular substances; the service life of the polyurethane sealing glue can reach 15 to 20 years; and the solid content of the polyurethane sealing glue is 100 percent.

The present invention is a method for analyzing the biological age of a subject. The method analyzes the biological age as it relates to a number of factors indicating levels of health, energy production and metabolism. The method may also be used to calculate a subject's biological age and treat the factors associated with biological age.

A method of measuring the biological age of a multicellular organism is disclosed. In one embodiment this method comprises the steps of obtaining a sample of nucleic acid isolated from the organism's organ, tissue or cell and determining the expression pattern of a panel of sequences within the nucleic acid that have been predetermined by either increase or decrease in response to biological aging of the organ, tissue or cell. A method of obtaining biomarkers of aging is also disclosed. This method comprises the step of comparing a gene expression profile of a young multicellular organism subject's organ, tissue or cells; a gene expression profile from a chronologically aged subject's organ, tissue or cell; and a gene expression profile from a chronologically aged but biologically younger subject's organ, tissue or cell and identifying gene expression alterations that are observed when comparing the young subjects and the chronologically aged subjects and are not observed or reduced in magnitude when comparing the young subjects and the chronologically aged but biologically younger subjects.

The invention provides a method for obtaining biological age of an individual child based on an oral microbial community. The method comprises the steps of obtaining a sample containing oral microorganisms of the individual child; extracting DNAs of the oral microorganisms; and transforming DNA information into microbial community information, performing regressive analysis on the oral microbial community information and age by utilizing a random forest algorithm, building a regressive model, and obtaining the age of the individual child in Chinese population. According to the scheme provided by the method, the biological age of the individual child in the Chinese population can be accurately obtained; oral saliva or dental plaque samples can be non-invasively, simply and quickly obtained; and the age of the individual child is detected for a long term, so that a physiological health state of a host can be quickly judged, a clue can be provided for health monitoring, and early diagnosis speed of diseases can be increased.

Systems and methods are provided for using earphones with biometric sensors to track a user's biological age over time. In one embodiment, the system includes earphones, including: speakers; a processor; and a heartrate sensor electrically coupled to the processor. In this embodiment, the system also includes a memory coupled to a processor and having instructions stored that, when executed by the processor: receive one or more user determinable biological age parameters including an actual age of the user; determine one or more system measurable biological age parameters based on signals generated by the heartrate sensor; calculate a biological age factor as a function of the user determinable biological age parameters and the system measurable biological age parameters; calculate the user's biological age as a function of the biological age factor and the user's actual age; and display on a display the user's biological age.

The invention relates to a production technology of a special water dropper for preventing a root system from being invaded by subsurface drop irrigation, comprising the following steps: (1) evenly mixing high pressure polyethylene, N-di-propyl-4-trifluoromet, antioxidant aging agent and biological aging inhibitor to obtain a mixture; (2) successfully heating, plasticizing, extruding, shaping, cooling, granulating and drying the mixture, and preparing into root-removal anti-aging master batch; and (3) after the root-removal anti-aging master batch obtained in step (2) is evenly mixed with injection-class low pressure polyethylene and master batch, heating, plasticizing, closing mould, injecting, pressurizing, cooling and shaping to obtain the finished product. The method of the invention can ensure that a functional auxiliary material with small content is evenly and integrally mixed, and plasticizing dispersing evenness in the injection process of the finished product is obviously improved; and meanwhile, the method can effectively improve the heat resistance, the aging resistance and the corrosion resistance of the finished product.

The invention discloses a kit for telomere length detection. The kit includes a telomere gene primer sequence and a reference gene primer sequence. The invention also discloses a biological age evaluation method, which comprises the following steps: (1) establishing a Chinese population telomere length detection calibration T/S database; (2) fitting algorithm according to the above telomere lengthcalibration T/S value-age model distribution diagram, and establishing a telomere length-biological age algorithm model system. With the application of the kit and by using the calibration T/S ratioas the telomere length evaluation standard, accurate detection and dynamic evaluation analysis of telomere length can be realized. With the application of the kit, scientific evaluation of biologicalage can be realized through a biological age database and a calculation model system. With the application of the kit for telomere length detection, the effect is stable, raw materials are cheap and easily-available, and experiment operation is simple and feasible.

The invention relates to a preparation method of developing polyurethane, which pertains to the technical field of high polymer material. The preparation method comprises the steps that: firstly, polymers, diatomic alcohol and diisocyanate are mixed; the mixture of the diatomic alcohol and the diisocyanate is stirred and reacts under the protection of nitrogen gas to obtain a prepolymer; after the temperature thereof is raised, the prepolymer is added with a chain extender and stirred for reaction; and the polymers are cured. As the chain extender contains developing atoms and developing groups are connected with the polyurethane by the effect of chemical bonds, the developing polyurethane prepared by the preparation method has long lasting development effect, good stability, biocompatibility and anticoagulant performance, arouses no inflammation in human bodies, is biological aging resistant and animalcule resistant, has good physical properties, can be sterilized by usual methods, is easy to be processed and takes advantages over non-developing polyurethane when being applied to heart valves, conduits and vascular stents. The preparation method is flexible, effective, simple and easy to be realized.

The present invention provides an improved method for using the measurement of total urinary 17 KS-S, referred to herein as the urinary Anabolic/Catabolic Index (ACI), as part of a biomarker for biological age.

The present invention is a method for analyzing biological age of a subject. The method analyzes the biological age as it relates to a number of factors indicating levels of health, energy production and metabolism. The method may also be used to calculate a subject's biological age and treat the factors associated with biological age.

The invention discloses a biological age step-by-step predication method based on a support vector machine, and relates to the biological age step-by-step predication method based on the support vector machine. The invention aims to solve the problems that a conventional biological age predication method is low in predication efficiency, low in accuracy, high in cost, and complex. According to the technical scheme, the biological age step-by-step predication method comprises: step I, preparing a biological age data set; step II, distinguishing a biological sample with known ages from a biological sample with unknown ages; step III, carrying out inter-group classifying; step IV, generating a corresponding support vector machine model; step V, establishing an optimal support vector machine model; step VI, establishing an optical characteristic sub set; step VII, obtaining the group type of an age group corresponding to the biological sample with known ages in the test set; step VIII, carrying out inter-group classifying; step IX, generating an inter-group classified support vector machine model; and step X, obtaining the exact age of a test set sample in certain age group. The biological age step-by-step predication method is applied to the biological age predication field.

A method of creating a biological aging clock for a subject can include: (a) receiving a transcriptome signature derived from a tissue or organ of the subject; (b) creating input vectors based on the transcriptome signature; (c) inputting the input vectors into a machine learning platform; (d) generating a predicted biological aging clock of the tissue or organ based on the input vectors by the machine learning platform, wherein the biological aging clock is specific to the tissue or organ; and (e) preparing a report that includes the biological aging clock that identifies a predicted biological age of the tissue or organ.

The invention provides a human biological age measuring-calculating device and system, and relates to the technical field of biological age measurement and calculation. The device comprises a controller, and a detector, an identity information collector and an information logging unit connected with the controller, and the controller is also connected with a calculation server and a database server. The detector detects the first reference biological age of a user, the identity information collector collects identity information of the user, and the information logging unit logs in private information of the user. The controller obtains the historical biological age of the user from the database server, and carry out calculation on the basis of the first reference biological age, the historical biological age and the private information to obtain the biological age of the user. A calculation model used to calculate the biological age can be updated via the calculation server. The biological age calculated by the device can reflect the aging condition of the user comprehensively and accurately.

The invention discloses a preparation method of polyester fiber compounding type silicon dioxide aerogel cold insulation felt. The method comprises the following steps of (1) preparing a silicon dioxide aerogel solution, wherein the silicon dioxide aerogel solution is prepared from the following raw materials of a silicon source precursor, a solvent, a hydrolysis catalyst and a modifying agent; (2) compounding and shaping polyester fiber felt aerogel; (3) maturing the compounded and shaped polyester fiber felt aerogel; (4) aging the matured polyester fiber felt aerogel; (5) performing secondary maturing on the aged polyester fiber felt aerogel; (6) performing surface modification on the polyester fiber felt aerogel subjected to secondary maturing; (7) drying and detecting the polyester fiber felt aerogel subjected to surface modification. The prepared polyester fiber compounding type silicon dioxide aerogel cold insulation felt disclosed by the invention has the advantages that the heat isolation/cold insulation performance is excellent; the adjustable range is wide; the applicability is high; the biological aging resistance is realized; the anti-condensation and hydrophobic performance are good; the construction is convenient. The preparation method avoids a solvent replacement step; the operation is simple and easy; the process is controllable; the production continuity is realized.

The invention discloses a method for preparing curdlan gum-kojic acid derivatives, and belongs to the field of antioxidants. The method has the advantages that kojic acid is led onto curdlan gum to prepare the curdlan gum-kojic acid derivatives, accordingly, the curdlan gum is soluble in water and also can have the antibacterial properties and the oxidation resistance of the kojic acid, biologicalaging can be delayed, biological aging symptoms can be improved, and effects of moisturizing skin and enhancing skin barrier can be realized.

The present invention relates to method for calculating biological age of a subject and across multiple subjects by performing polygenic DNA methylation on biomarkers which comprise measuring the methylation status of 13 CG sites positioned in a putative antisense region to ElovL2 gene, ElovL2 AS1 region. Further, the present invention provides a computer-implemented method for providing recommendations for lifestyle changes in form of a self-learning “ecosystem” for lifestyle management of biological aging using a novel measurement of the DNA methylation clock as a continuous dynamic outcome. The present invention also relates to combination of DNA methylation biomarkers for calculating biological age, a kit for determining the biological age. Further, the present invention discloses the use of the disclosed methods for calculating biological age in a method of assessing the effect of the effect of a biological intervention and in a method of screening for an anti-ageing agent.

The invention relates to a method for measuring a remaining life of a person by using a biological age and a survival probability and, more specifically, to a method for measuring a survival probability by using a biological age measured through a biological age measurement algorithm to which a health medical examination result is reflected and a method for measuring a remaining life by using thebiological age and the survival probability measured by the method. According to the invention, a remaining life can be predicted more accurately than a remaining life method which does not consider an existing biological age.