Identification of genetic markers of biological age and metabolism

a technology applied in the field of identification of genetic markers of biological age and metabolism, can solve the problems of complex organismal senescence, lack of biological age molecular markers, and difficulty in elucidating mechanisms and testing interventions
US20080254464A1Inactive Publication Date: 2008-10-16WEINDRUCH RICHARD H +2
1 Cites 15 Cited by

Patent Information

Authority / Receiving Office
US Β· United States
Patent Type
Applications(United States)
Current Assignee / Owner
WEINDRUCH RICHARD H
Publication Date
2008-10-16
Estimated Expiration
Not applicable Β· inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
Patent Text Reader

Abstract

A method of measuring the biological age of a multicellular organism is disclosed. In one embodiment this method comprises the steps of obtaining a sample of nucleic acid isolated from the organism's organ, tissue or cell and determining the expression pattern of a panel of sequences within the nucleic acid that have been predetermined by either increase or decrease in response to biological aging of the organ, tissue or cell. A method of obtaining biomarkers of aging is also disclosed. This method comprises the step of comparing a gene expression profile of a young multicellular organism subject's organ, tissue or cells; a gene expression profile from a chronologically aged subject's organ, tissue or cell; and a gene expression profile from a chronologically aged but biologically younger subject's organ, tissue or cell and identifying gene expression alterations that are observed when comparing the young subjects and the chronologically aged subjects and are not observed or reduced in magnitude when comparing the young subjects and the chronologically aged but biologically younger subjects.
Need to check novelty before this filing date? Find Prior Art

Description

CROSS-REFERENCE TO RELATED APPLICATION

[0001] This application claims priority to provisional application 60 / 148,540, filed Aug. 12, 1999, U.S. provisional application 60 / 178,232, filed Jan. 26, 2000 and 60 / 211,923 filed Jun. 16, 2000. These provisional applications are incorporated by reference as if fully set forth herein.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT

[0002] This invention was made with United States government support awarded by the following agencies: NIH Grant No: AG 11915. The United States has certain rights in this invention.BACKGROUND OF THE INVENTION

[0003] A common feature of most multicellular organisms is the progressive and irreversible physiological decline that characterizes senescence. Although genetic and environmental factors can influence the aging process, the molecular basis of senescence remains unknown. Postulated mechanisms include cumulative damage to DNA leading to genomic instability, epigenetic alterations that lead to altere...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More