Method for obtaining biological age of individual child based on oral microbial community

Abstract

The invention provides a method for obtaining biological age of an individual child based on an oral microbial community. The method comprises the steps of obtaining a sample containing oral microorganisms of the individual child; extracting DNAs of the oral microorganisms; and transforming DNA information into microbial community information, performing regressive analysis on the oral microbial community information and age by utilizing a random forest algorithm, building a regressive model, and obtaining the age of the individual child in Chinese population. According to the scheme provided by the method, the biological age of the individual child in the Chinese population can be accurately obtained; oral saliva or dental plaque samples can be non-invasively, simply and quickly obtained; and the age of the individual child is detected for a long term, so that a physiological health state of a host can be quickly judged, a clue can be provided for health monitoring, and early diagnosis speed of diseases can be increased.

Description

technical field [0001] The invention relates to the field of microbial detection models, in particular to a method for obtaining the biological age of children based on oral microbial communities. Background technique [0002] Human beings are not alone in the world. Each human body carries billions of microorganisms. Human beings and the symbiotic microorganisms in their bodies together form a "super organism". There are no microorganisms in the womb, and the first contact with microorganisms is the birth canal. After birth, more microbes migrate into the human body through drinking milk and contact with the external environment. The human microbial community has age characteristics. The microbial community in the human body is gradually established with age and continues to evolve with changes in physiological development throughout life. Those microorganisms that enter the human body after birth and have an important impact on human health are important carriers of acqu...

AI Technical Summary

Problems solved by technology

Evaluation methods mainly include atlas method and scoring method. Among them, the atlas method is simple and intuitive, but the appraiser still compares and interprets the whole X-ray film in actual operation, and there are still problems such as strong subjective interpretation and many bone maturation combinations; Although the scoring method is relatively objective, the classification of bone development grades is too detailed, and it is difficult to grasp the standards, which reduces the reliability of bone age evaluation. Moreover, the establishment of bone age standard atlas database and the research of computer image reading system need to be solved urgently

In addition, although X-rays are almost harmless to the human body, long-term follow-up of children's growth and development still requires protective measures during treatment, and the development of non-radiographic bone age development evaluation and methods is still in the early stage, such as the interpretation accuracy of ultrasound detection. Low, methodological problems still exist

In addition to bone age, the commonly used methods for determining biological age are tooth maturity and secondary sexual characteristic development. However, these methods usually rely on the subjective judgment of the appraiser, and the results are all range values. age, and the evaluation indicators are relatively heterogeneous among individuals

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