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Method for preparing curdlan gum-kojic acid derivatives

A technology of kojic acid derivatives and kojic acid, which is applied in the field of antioxidants, can solve the problems of unsatisfactory modification effect of kojic acid, mild conditions, and reduced function, and achieve easy control of reaction conditions, short reaction time, and low production cost Effect

Inactive Publication Date: 2019-02-19
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, since kojic acid has an unstable structure of dilute alcohol, it will oxidize and deteriorate when left for a long time, resulting in the reduction or even loss of its function. Therefore, it is necessary to modify the curve to achieve a stable structure of kojic acid derivatives
[0005] At present, the modification of kojic acid mostly uses natural polysaccharides such as chitosan, but the reaction between chitosan and kojic acid is carried out in an organic solvent, the conditions are not mild, and the modification effect on kojic acid is not ideal.

Method used

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  • Method for preparing curdlan gum-kojic acid derivatives
  • Method for preparing curdlan gum-kojic acid derivatives
  • Method for preparing curdlan gum-kojic acid derivatives

Examples

Experimental program
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Effect test

Embodiment 1

[0035] Preparation method: (1) Mix 5g of kojic acid and 25ml of dichloromethane solvent, add 4ml of thionyl chloride dropwise while stirring at room temperature, and react for 0.5h; (2) Use petroleum After washing with ether for 2-3 times, filter to obtain kojic acid chloride, and dry it to obtain white or pink kojic acid powder; (3) Take 0.5 g curdlan gum and disperse it in 30 mL of water, then add 0.5 g of NaOH solid, stirred at room temperature for 3 hours to obtain curdlan gum-NaoH aqueous solution; (4) pour curdlan gum-NaoH aqueous solution into a three-necked flask and preheat to 60°C, and add 0.5 g of chlorinated Kojic acid solid, react for 2h; (5) Precipitate the yellow solid curdlan gum-kojic acid derivative from the solution with absolute ethanol, and then dry the extracted yellow solid curdlan gum-kojic acid derivative, then .

[0036] attached by figure 1 It can be seen that figure 1 Center at 3320.80cm -1 The broad peak at is the stretching vibration absorptio...

Embodiment 2

[0041] Preparation method: (1) Mix 5g of kojic acid and 25ml of dichloromethane solvent, add 10ml of thionyl chloride dropwise while stirring at room temperature, and react for 1h; (2) Dilute the product obtained in step (1) with petroleum ether After washing 2-3 times, filter to obtain kojic acid chlorinated, and dry it to obtain white or pink kojic acid chlorinated powder; (3) Take 0.5g of curdlan gum and disperse it in 30mL of water, then add 1g of kojic acid NaOH solid, stirred at room temperature for 1 hour to obtain curdlan gum-NaoH aqueous solution A; (4) Pour solution A into a three-necked flask and preheat to 30°C, add 3 g of kojic acid chlorinated solid under constant stirring, and react for 5 hours; (5) Precipitate a yellow solid curdlan-kojic acid derivative from the solution with absolute ethanol, and then dry the extracted yellow solid curdlan-kojic acid derivative. The degree of substitution of the obtained curdlan-kojic acid derivative was 101%.

Embodiment 3

[0043]Preparation method: (1) Mix 5g of kojic acid and 25ml of dichloromethane solvent, add 12ml of thionyl chloride dropwise while stirring at room temperature, and react for 1h; (2) Add petroleum ether to the product obtained in step (1) After washing 2-3 times, filter to obtain kojic acid chloride, and dry it to obtain white or pink kojic acid powder; (3) Take 0.5g of curdlan gum and disperse it in 30mL of water, then add 4g of kojic acid NaOH solid, stirred at room temperature for 24 hours to obtain curdlan gum-NaOH aqueous solution A; (4) Pour the A solution into a three-necked flask and preheat it to 70°C, add 5 g of kojic acid chlorinated solid under constant stirring, and react for 10 hours; (5) Precipitating the yellow solid curdlan-kojic acid derivative with a 2:1 mixture of absolute ethanol and acetone, and then drying the extracted yellow solid curdlan-kojic acid derivative, That's it. The degree of substitution of the obtained curdlan-kojic acid derivative was 18...

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Abstract

The invention discloses a method for preparing curdlan gum-kojic acid derivatives, and belongs to the field of antioxidants. The method has the advantages that kojic acid is led onto curdlan gum to prepare the curdlan gum-kojic acid derivatives, accordingly, the curdlan gum is soluble in water and also can have the antibacterial properties and the oxidation resistance of the kojic acid, biologicalaging can be delayed, biological aging symptoms can be improved, and effects of moisturizing skin and enhancing skin barrier can be realized.

Description

technical field [0001] The invention relates to a preparation method of curdlan gum-kojic acid derivatives, belonging to the field of antioxidants. Background technique [0002] With the improvement of people's living standards, the concepts of health and green are more and more accepted by the public. The development of highly efficient, safe, broad-spectrum, and stable natural antioxidants has attracted more and more attention from researchers. The market demand for natural antioxidants is also bound to grow. [0003] Curdlan gum is a neutral water-insoluble microbial exopolysaccharide with thermal gelation properties and can be widely used in the food processing industry. Because of its insoluble characteristics in water, its application is limited, but its molecular structure contains multiple active -OH, which is an ideal site for structural modification, and other groups can be introduced through chemical modification to enhance its application range. [0004] Koji...

Claims

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Application Information

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IPC IPC(8): C08B37/02
Inventor 陈美玲
Owner JIANGNAN UNIV
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