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Electroactive polymer with water solubility and biological degradability, preparation method thereof and application thereof

An electroactive polymer and biodegradable technology, applied in the field of medical devices, can solve the problems of easy induction of chronic inflammation, failure to meet the requirements of water solubility, poor solubility, etc., and achieve the effect of simple process and promotion of tissue regeneration and repair

Inactive Publication Date: 2009-11-04
THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Common conductive polymers, such as polypyrrole, polythiophene, polyaniline, polyacetylene, etc., have poor solubility in most common solvents, especially water, and have no biodegradability.
Most organic solvents are highly toxic, and leakage of even very low concentrations of toxic reagents into body fluids can cause disastrous consequences, so these systems have potential safety hazards when used as tissue engineering scaffolds
The non-degradable nature of the material prevents it from being cleared by the kidneys and can only remain in the body for a long time
The long-term retention of the material in the body can easily induce chronic inflammation, and there is a risk of surgical removal.
In order to solve the degradation problem of conductive polymers, Rivers, Hu and Huang successfully introduced low molecular weight oligomers such as aniline, pyrrole and thiophene into degradable polymers, allowing the materials to retain a certain degree of conductive activity and achieve biodegradation. purpose, but none of them can meet the requirements of water solubility under physiological conditions

Method used

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  • Electroactive polymer with water solubility and biological degradability, preparation method thereof and application thereof
  • Electroactive polymer with water solubility and biological degradability, preparation method thereof and application thereof
  • Electroactive polymer with water solubility and biological degradability, preparation method thereof and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1. Sample

[0040] The water-soluble and biodegradable electroactive polymer provided in this example is prepared by the following method: sodium periodate is used to oxidize sodium alginate to prepare polyaldehyde-based sodium alginate MASA, and the method of oxidative coupling is adopted Prepare the intrinsic state benzene / amine-terminated aniline tetramer, and obtain the fully reduced benzene / amine-terminated aniline tetramer TA-NH after reducing the intrinsic state benzene / amine-terminated aniline tetramer 2 , through the all-reduced benzene / amine capping aniline tetramer TA-NH 2 The terminal amino groups on the polyaldehyde sodium alginate MASA react with the aldehyde groups on the polyaldehyde sodium alginate MASA, and the fully reduced benzene / amine-terminated aniline tetramer TA is introduced into the polyaldehyde sodium alginate MASA to obtain aniline oligomer-modified polyaldehyde Base sodium alginate TA-MASA, its structural formula is as follows:

[0041] A...

Embodiment 2

[0078] The water-soluble and biodegradable electroactive polymer provided in this example is prepared by the following method: sodium periodate is used to oxidize sodium alginate to prepare polyaldehyde-based sodium alginate MASA, and the method of oxidative coupling is adopted Prepare the intrinsic state benzene / amine-terminated aniline oligomer, and obtain the fully reduced benzene / amine-terminated aniline tetramer TA-NH after reducing the intrinsic state benzene / amine-terminated aniline oligomer 2 , the fully reduced benzene / amine-terminated aniline octamer OcA-NH was prepared by adding aniline tetramer to phenylhydrazine containing ferric chloride 2 , capping the aniline octamer OcA-NH via the all-reduced benzene / amine 2The terminal amino group on the polyaldehyde group reacts with the aldehyde group on the polyaldehyde sodium alginate MASA, and the fully reduced benzene / amine-terminated aniline octamer OcA is introduced into the polyaldehyde sodium alginate MASA to obtain...

Embodiment 3

[0092] The water-soluble and biodegradable electroactive polymer provided in this example is prepared by the following method: sodium periodate is used to oxidize sodium alginate to prepare polyaldehyde-based sodium alginate MASA, and the method of oxidative coupling is adopted Prepare the intrinsic state benzene / amine-terminated aniline oligomer, and obtain the fully reduced benzene / amine-terminated aniline oligomer OA-NH after reducing the intrinsic state benzene / amine-terminated aniline oligomer 2 , capping the aniline oligomer OA-NH via the fully reduced benzene / amine 2 The terminal amino group on the polyaldehyde group reacts with the aldehyde group on the polyaldehyde sodium alginate MASA, and the fully reduced benzene / amine-terminated aniline oligomer OA is introduced into the polyaldehyde sodium alginate MASA to obtain the polyaldehyde modified by the aniline oligomer Base sodium alginate OA-MASA, its structural formula is as follows:

[0093] Among them, the structur...

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Abstract

The invention discloses an electroactive polymer with water solubility and biological degradability, which is prepared by a method comprising the following steps: preparing sodium polyaldehyde alginate by oxidizing sodium alginate with sodium periodate; preparing eigenstate phenyl / amino end-capped aniline oligomer by an oxidative coupling method; reducing the eigenstate phenyl / amino end-capped aniline oligomer to obtain fully reducedphenyl / amino end-capped aniline oligomer; and introducing the fully reducedphenyl / amino end-capped aniline oligomer into the sodium polyaldehyde alginate by the reaction of terminal amino in the fully reducedphenyl / amino end-capped aniline oligomer and the aldehyde in the sodium polyaldehyde alginate to obtain the aniline oligomer modified sodium polyaldehyde alginate. The invention also discloses a preparation method and application of the polymer. The polymer has the advantages of biocompatibility, water solubility, electroactive, degradability and the like; the preparation method of the electroactive polymer is simple in process and easy to control; and the electroactive polymer can be used in the field of injectable tissue engineering bracket materials or manufacturing of biological medicinal devices requiring electroactive.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a water-soluble and biodegradable electroactive polymer and its preparation method and application. Background technique [0002] In recent years, the potential of conducting polymers such as polypyrrole, polyaniline, and polythiophene as scaffolds for tissue engineering has been extensively explored. Studies have shown that conductive polymers such as polypyrrole and polyaniline have good biocompatibility, can transmit electrical signals, and can promote cell adhesion, proliferation, and differentiation, especially cells that respond to electrical stimulation. Schmidt et al. cultured PC12 nerve cells on polypyrrole scaffolds, and the results proved that electrical stimulation can accelerate the nerve cell differentiation induced by nerve growth factor. They then introduced functional peptide molecules to the surface of chlorine-doped polypyrrole, which was s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/04A61L27/26A61L27/58A61L27/20A61L27/18
Inventor 王琴梅汪乾滕伟
Owner THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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