37 results about "Functional medicine" patented technology

The invention discloses upgraded and improved multifunctional medicine grinding equipment which comprises a machine shell, a grinding assembly, a storage assembly and a control assembly. The machine shell comprises a machine shell front body and a machine shell rear body. The grinding assembly comprises a mortar and a pestle, round filtering holes are formed in the lower bottom surface of the mortar, and stirring convex pieces are further arranged on the lower bottom surface of the mortar; the storage assembly comprises a cushion frame and a support, and a drawing box is arranged in the cushion frame. The support comprises a frame plate and a supporting ring, the supporting ring is a hollow ring body arranged on the outer wall of the mortar, and the supporting ring is slidably connected to the side, away from the machine shell rear body, of the frame plate; the control assembly comprises a power plug, a controller, an input panel, a motor, a control rod, an upper transmission part, a middle transmission part and a lower transmission part, the upper transmission part drives the grinding pestle to do lifting motion, the middle transmission part drives the grinding pestle to do circular motion, and the lower transmission part drives the stirring convex pieces to rotate. Medicine splashing can be prevented; the angle can be adjusted, and coarse particles can be finely ground; meanwhile, medicine pouring is convenient, and extra manual intervention is not needed.

The invention discloses lotus leaf homogeneous polysaccharide LLP3-1 as well as a separation and purification method and application thereof, and belongs to the technical field of plant polysaccharide. The lotus leaf homogeneous polysaccharide LLP3-1 is composed of rhamnose, arabinose, galactose and galacturonic acid, the molar percentage of monosaccharide is 21.95: 25.33: 21.10: 31.62, the lotus leaf homogeneous polysaccharide LLP3-1 is acidic pectin polysaccharide with RG-I as a main structural domain and with part of side chains, the main chain is mainly composed of galacturonic acid and rhamnose, and the side chains are mainly composed of arabinose and galactose. The lotus leaf homogeneous polysaccharide LLP3-1 has the beneficial effects that the lotus leaf homogeneous polysaccharide LLP3-1 can obviously improve the symptoms of ulcerative colitis; the compound can be widely applied to preparation of medicines for treating ulcerative colitis, medicines for inhibiting proinflammatory factor secretion, antioxidation medicines, medicines for improving intestinal barrier integrity and functions, medicines for promoting short-chain fatty acid generation and medicines for improving intestinal flora disorder of ulcerative colitis.

The utility model relates to a multifunctional medicine box which comprises a shell and a chassis, a medicine temporary storage channel is arranged in the shell, a recognition camera is arranged at a medicine outlet, a medicine taking opening is formed in the side wall of the shell, and the chassis is rotationally connected to the bottom of the shell; the medicine storage mechanism comprises a rotating disc assembly and a plurality of medicine bins circumferentially arranged on the circumferential side of the rotating disc assembly, the bottoms of the medicine bins are slidably connected to the base plate through sliding rails, and the rotating disc assembly is used for pushing the designated medicine bins to the medicine taking openings in a reciprocating mode through the sliding rails; according to the multifunctional medicine chest, through cooperation of the recognition camera and the grabbing mechanism, medicine can be accurately put into the designated medicine bin, the medicine bins arranged in the circumferential direction can store various kinds of medicine, the designated medicine is pushed outwards through the medicine taking opening through the rotary disc assembly, medicine output is smooth, and the medicine is not prone to being squeezed and blocked in the medicine chest.

The invention discloses a lactobacillus delbrueckii subsp. Bulgaricus CCFM1520 for transforming curcumin to produce tetrahydrocurcumin to relieve nervous anxiety, and belongs to the technical field of microorganisms. The lactobacillus delbrueckii subsp. Bulgaricus CCFM1520 screened by the invention has the capability of converting curcumin, and can utilize curcumin and generate tetrahydrocurcumin. The invention further provides a synbiotic preparation prepared from the lactobacillus gasseri CCFM1481 and curcumin, the synbiotic preparation can be used as an anti-fatigue functional medicine, the individual behavioral memory level can be improved, the imbalance of body neurotransmitters (DA, 5-HT and NE) can be slowed down, the expression of body neuroprotection related genes (BDNF, TrkB, DRD1 and TH) can be improved, and the synbiotic preparation has a huge application prospect.

The application discloses a polypeptide with ACE domain selective inhibition and application in blood pressure reduction, the polypeptide has high selective inhibition to the C domain of ACE and weak inhibition to the N domain, can effectively control blood pressure while avoiding bradykinin accumulation, thus having low side effects, easy absorption and other characteristics, can be developed into a functional medicine with blood pressure reduction effect, and food or health care product for helping to maintain a healthy blood pressure level, not only solves the problems of poor selectivity and large side effects of existing ACE inhibitors, but also provides a new technical approach for developing safe and effective blood pressure reduction functional products.

This invention relates to the application of 5-(tetradecoxy)-2-furoic acid (TOFA) in the preparation of drugs that inhibit osteoclast differentiation and function. Using a RANKL-induced mouse bone marrow macrophage osteoclast differentiation model, experiments demonstrated that TOFA can effectively inhibit osteoclast differentiation and function by inhibiting ROS and downregulating the expression of key osteoclast differentiation and function proteins such as Nfatc1, Src, and Ctsk. Furthermore, TOFA at concentrations of 40 μM and below showed no significant cytotoxicity, proving that TOFA can serve as a candidate compound for developing drugs that inhibit osteoclast differentiation and function, and for treating diseases caused by excessive activation of osteoclasts, thus possessing significant clinical application value. Additionally, by constructing a mouse ovariectomized osteoporosis model, the preventive and therapeutic effects of TOFA on estrogen-deficiency-induced osteoporosis were demonstrated.

The invention belongs to the field of biological medicine, and particularly relates to a dendritic multi-targeting antibody coupling carrier, an antibody coupling medicine as well as a preparation method and application of the dendritic multi-targeting antibody coupling carrier and the antibody coupling medicine. The dendritic multi-targeting antibody coupling carrier is composed of a targeting module and a drug coupling module, wherein the targeting module has multispecificity and a multivalent binding receptor function; the drug coupling module can realize fixed-point coupling and high drug loading capacity of drugs. The fusion proteins of the two modules can be specifically bound by a spy reaction through spontaneously formed covalent bonds. According to the present invention, the dendritic multi-targeting antibody coupling carrier is further utilized to construct the antibody coupling drug, such that the targeting property of the drug is improved, the relative drug loading capacity of the drug is improved, and the tumor treatment effect of the antibody coupling drug is finally improved.

The invention discloses lactobacillus gasseri CCFM1481 for converting curcumin to produce tetrahydrocurcumin and enhance an anti-fatigue effect, and belongs to the technical field of microorganisms. The lactobacillus gasseri CCFM1481 obtained through screening has the capacity of converting curcumin, curcumin can be utilized, tetrahydrocurcumin can be generated, and the conversion rate is 89.83%. The invention further provides a synbiotic preparation prepared from the lactobacillus gasseri CCFM1481 and curcumin, and the synbiotic preparation can be used as an anti-fatigue functional medicine and has a good application prospect and an industrialization foundation.

The utility model belongs to the technical field of medical auxiliary instrument, concretely relates to a percutaneous electric medicine synergic treatment device, including host computer and with the electric medicine treatment unit of host computer electric connection, the electric medicine treatment unit includes annular adhesive member, ring electrode, drug loading disc and medicine gel piece, annular adhesive member, ring electrode and drug loading disc coaxial arrangement, ring electrode is fixed between drug loading disc side surface and annular adhesive member inboard, the thickness of drug loading disc is less than the thickness of ring electrode, and the inboard of ring electrode and the surface of drug loading disc form the recessed cavity for accommodating medicine gel piece, and when medicine gel piece sets up in recessed cavity, medicine gel piece side surface and ring electrode inboard are pasted. The utility model can improve medicine transdermal absorption rate on the basis of guaranteeing electric stimulation itself effect, thereby more effectively realizes electric stimulation and medicine synergic effect, to improve synergic curative effect, realizes the flexible replacement use of different function medicine gel piece, satisfies the individualized treatment demand.

The invention belongs to the technical field of biology and medicine, and particularly relates to a tumor targeted photo-thermal chemotherapy drug delivery system and a preparation method and application thereof. According to the tumor targeted photo-thermal chemotherapy drug delivery system provided by the invention, a core carrier adopts a black phosphorus nanosheet (BPNS) and ferroferric oxide (Fe3O4) composite structure, BPNS generates heat under irradiation of near-infrared light to realize photo-thermal therapy, and Fe3O4 endows a magnetic targeting function; the medicine part is a ferroptosis inducer RSL3, glutathione (GSH) is reduced and reactive oxygen species (ROS) is increased through an inhibition system Xc-, and tumor cell ferroptosis is induced; the targeting modification layer is liver cancer cell membrane protein (Pro), and liver cancer cell surface receptors are specifically recognized through a homologous targeting mechanism, so that the enrichment efficiency of drugs in tumor tissues is improved. The system can significantly improve the treatment effect and reduce the toxicity to normal tissues, and provides a new solution for liver cancer treatment.

The multifunctional medicine divider comprises a device shell, a medicine containing box and a box cover, a water storage cavity is formed in the device shell, a connecting ring is fixedly connected to the upper end of the device shell, a first thread is arranged on the outer side of the connecting ring in a surrounding mode, and a connecting cavity connected with the first thread in a matched mode is formed in the lower end of the medicine containing box; a medicine storage cavity is formed in the upper end of the medicine containing box, partition plates are fixedly connected into the medicine storage cavity, the partition plates are distributed in a crossed mode to divide the medicine storage cavity into a plurality of medicine storage areas, a rotating column is arranged on the medicine containing box and located in the middle of the medicine storage areas, a medicine dividing plate is rotationally connected to the rotating column, and a second thread is arranged on the outer side of the medicine containing box. The box cover is in threaded connection with the second thread. The medicine dispenser is reasonable in overall structural design, integrates partition storage, regular prompt, convenient medicine taking and good packaging performance, and has good practicability and popularization value.

The present invention discloses a hydrogel composite, a preparation method and an application, belonging to the technical field of hydrogels; the hydrogel composite provided by the present invention comprises the following raw materials: a hydrogel matrix, sodium glycerophosphate pentahydrate and a functional drug; the hydrogel matrix comprises chitosan, hydroxybutyl chitosan and methacrylated gelatin; the functional drug comprises cannabidiol, tobramycin and acetylsalicylic acid; the hydrogel composite provided by the present invention has excellent mechanical properties and water vapor permeability, and also has excellent sustained release properties and wound healing ability, and can be widely applied to the preparation of drugs for treating wounds. Moreover, the preparation method of the hydrogel composite provided by the present invention is simple to operate and is beneficial to practical application.

This utility model relates to the field of medical packaging technology and provides a multifunctional drug container interface, including a capsule and a sealing plug. One end of the capsule has an integrally formed base post, and the base post has wings on two opposite sides for welding to an infusion bag or for holding. The capsule has an interior cavity for storing drugs, with open ends. One open end has a sealing diaphragm that can be ruptured by squeezing the capsule. The sealing plug is located at the other open end. When oral or intravenous administration is required, a steel or plastic needle can be inserted into the cavity through the sealing plug. The interface provided by this utility model can be used for welding to infusion bags as an infusion accessory, and also as a container for oral medications, making the interface versatile and reducing packaging material waste.

The utility model discloses a pharmacy multifunctional medicine shelf partition relates to pharmacy equipment field, including fixed axle, soft partition and accomodation axle, and fixed axle fixed connection is in soft partition one side, and the other side fixed connection of soft partition is in accomodation axle inside, and soft partition is magnetic material, and whole can be bent, and fixed axle includes axle body main part, first sucking disc, second sucking disc and third sucking disc, and first sucking disc and second sucking disc fixed connection are in axle body main part outside, and third sucking disc fixed connection is in axle body main part bottom end, the utility model provides a pharmacy multifunctional medicine shelf partition, and the soft partition of the device is the writing board with magnetism, can be convenient for pharmacist to write medicine expiration date and other related information on it, and is designed as erasable, and the fixed axle and accomodation axle of the device can utilize built -in sucking disc structure and be adsorbed and fixed in the arbitrary place of medicine shelf, and can be moved at will according to demand simultaneously, and can accomodate and save space at any time when not using.

The invention relates to a multifunctional medicine balloon which comprises a balloon body, a catheter and a connecting handle, the balloon body comprises a balloon body and thrombectomy control rails, the middle of the balloon body is sunken in the radial direction, and the thrombectomy control rails are connected with shoulders at the two ends of the balloon body and arranged on the periphery of the balloon body in parallel in the radial direction. According to the invention, expansion is carried out at a blood vessel stenosis part, an effective hemodynamic effect can be provided for the part, and the restenosis rate of an embolism part is reduced; the sunken part of the balloon body increases the surface area of the balloon and carries medicine together with the thrombectomy control track, so that the medicine loading capacity is improved; meanwhile, the thrombus extraction control track can increase assistance for blood vessel expansion and support and is matched with the sunken part of the capsule body to crush and capture thrombus in the blood vessel; by means of the sawtooth-shaped butt-joint net, thrombus debris remaining in the blood vessel is collected, the thrombus debris is prevented from flowing into a smaller blood vessel at the far end of the blood vessel to cause secondary blockage, the multiple effects of blood vessel expansion, thrombus extraction and hyperplasia resistance are achieved, and the operation efficiency and success rate are improved.

1. Name of the product in this design: Medicine Box. 2. Purpose of this design: For use in a multi-functional medicine box. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

This invention provides the application of *Pleurotus oosporum* polysaccharide in the preparation of drugs and health foods that regulate intestinal barrier function or protect against intestinal damage-related diseases. Its protective effect against a mouse model of intestinal damage induced by sodium dextran sulfate was investigated. Results showed that *Pleurotus oosporum* polysaccharide significantly improved symptoms such as weight loss, loose stools, and colonic atrophy caused by intestinal damage in mice, reduced the disease activity index, inhibited colonic epithelial destruction, inflammatory cell infiltration, and goblet cell necrosis, and enhanced intestinal mucosal barrier function. As a fungus, *Pleurotus oosporum* has high safety and is a potential source of active ingredients against intestinal damage, showing promising development prospects in intestinal barrier protection.

The utility model relates to the technical field of medicine bottles, in particular to a novel multifunctional medicine bottle. Comprising an outer barrel and inner barrels, a containing cavity used for installing the inner barrels is preset in the outer barrel, a partition plate is vertically arranged in the middle of the containing cavity and divides the interior of the containing cavity into two cavities at equal intervals, the two cavities correspondingly contain the two inner barrels respectively, and the function of containing one or more inner barrels is achieved. According to the novel multifunctional medicine bottle, the front end and the rear end of the containing cavity are divided into two parts at equal intervals through the partition plate to form the two cavities, the two inner barrels can be correspondingly contained through the design of the two cavities, and due to the design, a user can carry the medicine bottle conveniently, meanwhile, the phenomenon of omission is avoided, and application and popularization are facilitated.

1. The name of the design product: multi-functional medicine storage box. 2. The use of the design product: medicine storage box. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best shows the design points: perspective view 1.

The invention discloses a polypeptide with an ACE structural domain selective inhibition effect and application in blood pressure lowering, the polypeptide has a high-selectivity inhibition effect on a C structural domain of ACE and a weak inhibition effect on an N structural domain of ACE, and can effectively control blood pressure and avoid accumulation of bradykinin, so that the polypeptide has the characteristics of low side effect, easiness in absorption and the like; the ACE inhibitor disclosed by the invention can be developed into a functional medicine with a blood pressure reducing effect and a food or a health-care product beneficial to maintaining the blood pressure health level, so that not only are the problems of poor selectivity and large side effect generally existing in the conventional ACE inhibitor solved, but also a new technical approach is provided for developing a safe and effective blood pressure reducing functional product.

The utility model discloses a multifunctional medicine cutting device which comprises a medicine storage device, a cover body covers the medicine storage device, a medicine outlet channel is formed in the center of the cover body, a medicine cutting assembly is arranged on the cover body, the medicine cutting assembly comprises an annular base and a blade, a composite cover is arranged on the upper end face of the cover body, a sliding groove is formed in the composite cover, and a sliding block is connected into the sliding groove in a sliding mode. According to the tablet cutting device, by rotating the composite cover, a user can easily guide tablets to a preset cutting position, after the tablets smoothly slide into the tablet storage space of the tablet groove, the tablet groove is aligned with the blade in the corresponding shape by loosening the sliding block, and the tablets can be cut conveniently. And then, the tablet pressing block is used for applying proper downward pressure, so that the tablets can be uniformly and accurately cut into required parts (such as four parts or three parts), and the cutting precision and consistency are ensured.

The invention discloses biophysical and biochemical double-gradient bionic hydrogel, preparation and application of the biophysical and biochemical double-gradient bionic hydrogel in promoting osteochondral regeneration, and belongs to the field of biomedical materials. The hydrogel is composed of a double structure of hydrogel and a functional drug nanocapsule, and the hydrogel has a concentration gradual change in the overall structure so as to form a soft-hard gradual change biophysical mechanical gradient; the functional drug nanocapsule has a biochemical gradient with gradually changed concentration from high concentration to low concentration; the biophysical mechanical gradient change direction of the hydrogel is the same as or different from the biochemical gradient change direction of the functional drug nanocapsule. The low electric field aligns the charged matrix network and the biochemically packaged nanoparticles to the electrode, and double gradients are formed on the network structure and spatial biochemical distribution. By adjusting the used monomer and cross-linking agent, the release rate and the surface charge of the biodegradable polymer nanoparticles can be accurately controlled, and the programmable biochemical gradient can be realized in the hydrogel. The application prospect of realizing clinical transformation is realized.

This invention provides a functional medicine proactive health management method and system for large-scale model fine-tuning engineering. The method includes the following steps: S101, pre-training a general large-scale model using functional medicine literature and clinical guidelines; S102, fine-tuning the general large-scale model using medical tasks to form a medical-specific large-scale model; S103, integrating LSTM and Transformer temporal algorithms, and introducing autoencoder model reconstruction error as an anomaly scoring indicator; S104, integrating reinforcement learning and generative adversarial networks to output personalized health intervention suggestions based on user health risks; S105, collecting user health behavior data in real time through IoT wearable devices and portable detection instruments, preprocessing the health behavior data to generate a structured health dataset, and inputting it into the medical-specific large-scale model for user health assessment and management. This invention achieves a closed-loop process from data collection, accurate assessment, dynamic early warning to personalized intervention, meeting the needs of functional medicine proactive health management.

1. Name of the product in this design: Multifunctional medicine rubbing machine. 2. Purpose of this design: A multi-functional medicine-rubbing machine. 3. The key design features of this product are its overall shape. 4. The image or photograph that best illustrates the design's key features: the front view.

The invention belongs to the technical field of biology, and particularly relates to a biomarker for potential treatment needing Qingshu granules and application of the biomarker. The biomarkers comprise a series of differentially expressed genes (such as Egr3, Gpr88 and Adora2a) and proteins (such as GAD67, ER beta and the like), the markers are highly associated with occurrence and development of hypertension, especially pathological mechanisms of estrogen deficiency related hypertension, so that the biomarkers are applied to preparation of novel antihypertensive drugs, hypertension is reduced through a multi-channel synergistic effect, and the antihypertensive effect is achieved. Comprising the following steps: regulating hypothalamic functions, recovering estrogen level, improving neurotransmitter balance, inhibiting oxidative stress and inflammatory response and the like; the Qingshu granules disclosed by the invention can be used as a corresponding functional medicine. The key effects of the Egr3 and the GAD67 in a central nervous system, especially in function connection of an emotion regulation brain region, are defined for the first time.

The invention provides an application of fructus psoraleae polysaccharide in preparation of a medicine or health food for regulating an intestinal barrier function. Specifically, the fructus psoraleae polysaccharide acts on an intestinal tract. In the intestinal tract action process, the fructus psoraleae polysaccharide effectively improves damaged intestinal tract barrier repair; the number of CD4 + and CD8 + T cells in intestinal tracts is increased, and the immune barrier of the intestinal tracts is improved; according to the present invention, the expression of tight junction proteins Claudin-1, Occludin and ZO-1 can be promoted, the intestinal mechanical barrier can be repaired and enhanced, and the polypeptide can be used for preventing, relieving or treating intestinal barrier damage, has excellent performance in the regulation of the intestinal barrier function, and has good application prospects.

1. The name of the design product: multi-functional medicine transport case. 2. The use of the design product: for medicine transport. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view. 5. The right view is the same as the left view, and the right view is omitted.

The invention relates to the technical field of monoclonal antibody drugs, in particular to a boron-containing modified bevacizumab drug as well as a preparation method, a nano-carrier and application thereof. According to the technical scheme, the medicine is formed by covalent coupling of bevacizumab and a boron-containing compound through a disulfide bond. According to the invention, boron atoms are introduced into bevacizumab molecules through chemical modification, and a dual-function drug with anti-angiogenesis and boron neutron capture therapy radiosensitization functions is constructed, so that bevacizumab has anti-angiogenesis activity of anti-vascular endothelial growth factors and a boron source function of a capture therapy radiosensitizer at the same time; the design breaks through the limitation of a traditional single-function medicine, the concentration of the medicine in the brain tumor and the radiotherapy curative effect are improved through double-function cooperation, and a brand new strategy is provided for brain glioma treatment.

The invention discloses a green tea extract, hydrolyzed keratin and vitamin C composition for delaying senescence of cats and dogs, and belongs to the technical field of pet anti-aging food preparation. The composition of the three components can promote the proliferation of cat mammary gland cells and dog mammary gland cells, and obviously improve the cell proliferation capacity decline caused by actinomycin D; meanwhile, the expression level of senescence-related proteins (such as p16, p21, p53 and the like) can be down-regulated, and the up-regulation trend of the senescence-related proteins in a senescence-induced state can be reversed. In addition, the composition has a remarkable protection effect on oxidative damage of cat mammary gland cells and dog mammary gland cells, and is regulated and controlled by a Hippo signal channel. Animal experiment results show that the composition can improve the athletic ability and oxidative stress level of aged mice and delay the aging process of the aged mice. The technical scheme provided by the invention is high in safety and remarkable in biological activity, and has a wide application prospect in the fields of pet anti-aging nutrition intervention and functional medicine development.

The invention discloses application of dandelion polysaccharide in preparation of a medicine for improving the barrier function of inflammatory bowel disease, and relates to the field of traditional Chinese medicine. 107 action targets of dandelion for improving dextran sodium sulfate to influence ulcerative colitis are determined through a network pharmacology strategy; molecular docking results prove that dandelion has good binding force with potential molecular targets. Then, an in-vivo exposure experiment is carried out, and it is verified that the dandelion polysaccharide can effectively improve UC mouse symptoms. Meanwhile, glycogen in the tissue is detected through an alcian blue-periodate-Schiff staining experiment, and it is verified that the dandelion polysaccharide can effectively improve intestinal barrier damage caused by the inflammatory bowel disease. The invention provides application of dandelion polysaccharide in drugs, food or health care products for preventing and treating intestinal barrier damage caused by inflammatory bowel diseases.