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Method for constructing evaluation model for biological age of Chinese population based on clinical markers, and evaluation method

An evaluation model and evaluation method technology, applied in the field of biological age evaluation, can solve the problems that cannot accurately reflect the degree of aging of individuals, differences in disease susceptibility, etc., and achieve the effect of reducing the risk of disease and having great application potential

Pending Publication Date: 2020-10-23
ZHEJIANG UNIV
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Problems solved by technology

However, there are still differences in susceptibility to these diseases among individuals of the same chronological age. One of the reasons may be that chronological age cannot accurately reflect the degree of aging of an individual

Method used

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  • Method for constructing evaluation model for biological age of Chinese population based on clinical markers, and evaluation method
  • Method for constructing evaluation model for biological age of Chinese population based on clinical markers, and evaluation method
  • Method for constructing evaluation model for biological age of Chinese population based on clinical markers, and evaluation method

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Embodiment Construction

[0037] Below in conjunction with embodiment and accompanying drawing, the present invention will be further described:

[0038] The concrete content of embodiment:

[0039] 1. Comprehensively consider biological and statistical standards, select clinical routine markers, and use the KDM algorithm to construct biological age evaluation indicators in the CHNS (2009) cohort of 20-79-year-old people.

[0040] The markers we selected came from the 2009 China Health and Nutrition Survey (China Health and Nutrition Survey, CHNS) data. CHNS is a national-level prospective cohort study of all age groups (starting from 0 years old) in China. Its purpose is to explore how socioeconomic and demographic transitions affect the nutritional and health status of the entire population across time and space. The CHNS was launched in 1989 and was subsequently repeated in 1991, 1993, 1997, 2000, 2004, 2006, 2009, 2011 and 2015. CHNS adopted a multi-stage cluster sampling method to recruit respon...

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Abstract

The invention discloses a method for constructing an evaluation model for the biological age of a Chinese population based on clinical markers. The method comprises the following steps: (1) selectingclinical routine markers representing different pathophysiological systems or functions; (2) constructing a biological age evaluation model by utilizing the selected markers based on a KDM algorithm;(3) evaluating the obtained biological age evaluation model, and if the effect of the model is poor, returning to the steps (1) and (2) and carrying out the next round of model construction operation,or if the effect meets requirements, outputting the constructed biological age evaluation model. The method can be applied to early identification and prevention of aging of people in China and intervention effect evaluation of senile diseases, and has practicability and huge application potential.

Description

technical field [0001] The present invention is suitable for the technical field of biological age evaluation, and in particular relates to a method and evaluation method for constructing a biological age evaluation model based on clinical conventional markers, and is applicable to Chinese population. Background technique [0002] Promoting healthy aging objectively requires reducing the burden of diseases (such as hypertension and diabetes) in the elderly. Chronological age is undoubtedly the greatest risk factor for these chronic diseases and death. However, there are still differences in susceptibility to these diseases among individuals of the same chronological age. One of the reasons may be that chronological age cannot accurately reflect the aging degree of an individual. Correspondingly, Biological Age can evaluate aging more accurately, and then help identify high-risk individuals, especially in early life (such as middle-aged and young adults), and on the other ha...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/30
CPCG16H50/30
Inventor 刘足云
Owner ZHEJIANG UNIV
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