The invention provides a sandstone thermal storage geothermal resource recycle utilization optimal well network layout method. The method comprises the steps that 1, a geothermal geological model anda geothermal numerical model are built; 2, the single well water yield is calculated according to an analytical method, correction is conducted by applying an internal geothermal water sampling well,and a water yield calculation formula suitable for a research area is established; 3, the research area geothermal utilization resource requirements are determined, and the optimal water sampling well, the rate of the recharge well number, the water sampling well number and the recharge well number are determined in combination with the recharge condition; 4, according to the fact that by means ofthe age limit, single well water sampling and recharge temperature field and pressure field numerical simulation are conducted, it is determined that temperatures and pressure of the water sampling well and the recharge well affect the radius; 5, the optimal well network layout is determined. According to the method, the problems that at present, in domestic geothermal development and utilization, recharge is not thorough, the thermal storage pressure is lowered, and the thermal storage temperature is lowered are solved, the optical well network layout is put forward, and the geothermal resource recycle utilization efficiency is improved.