Liver-nourishing medicinal and edible composition as well as preparation method and application thereof

Abstract

The invention discloses a liver-nourishing medicinal and edible composition as well as a preparation method and application thereof. The liver-nourishing medicinal and edible composition is prepared from the following raw materials in parts by weight: 750 to 850 parts of tortoise plastron, 360 to 440 parts of lotus seed, 700 to 800 parts of rhizoma polygonati, 2450 to 2550 parts of corbicula fluminea, 1450 to 1550 parts of wax gourd, 180 to 220 parts of garlic bulb, 25 to 35 parts of edible salt, 45 to 55 parts of bamboo ginger, 460 to 540 parts of rock candy and 230 to 270 parts of winter honey. In the liver-nourishing medicinal and edible composition, various medicinal and edible raw materials or food raw materials all contain active ingredients beneficial to liver nourishing, and a synergistic effect is generated after reasonable compatibility, so that the liver can be nourished healthily, quickly and effectively, and the liver-nourishing medicinal and edible composition can be taken continuously for a relatively long time.

Description

Technical Field

[0001] The invention belongs to the technical field of medicines, and in particular relates to a liver-nourishing medicinal and edible composition and a preparation method and application thereof. Background Art

[0002] The liver is the largest digestive gland in the human body, most of which is located in the right hypochondrium and the upper abdomen. It has the functions of metabolism, detoxification, excretion, coagulation, immunity, etc. Damage can easily cause liver diseases. The main functions of the liver include the following: 1. Producing bile: Bile helps the small intestine break down and absorb fat, cholesterol and some vitamins. It is composed of bile salts, cholesterol, bilirubin, electrolytes and water. 2. Absorption and metabolism of bilirubin: Bilirubin is formed by the decomposition of hemoglobin. The iron released by hemoglobin is stored in the liver or bone marrow for the production of the next generation of blood cells. 3. Support the coagulation process: Since bile is essential for the absorption of vitamin K, the production of coagulation factors II, VII, IX, and X depends on vitamin K. 4. Fat metabolism: The decomposition of fat depends on the bile produced by the liver. 5. Storing glycogen: The liver can store glycogen and generate glucose through gluconeogenesis to provide energy. 6. Storing vitamins and minerals: The liver stores vitamins A, D, E, K and B12. 7. Protein metabolism: Bile helps break down protein and digest it. 8. Filtering blood: The liver can filter and remove some compounds in the body (such as hormones such as estrogen and aldosterone) and compounds outside the body (such as alcohol and other drugs). 9. Immune function: The liver is part of the mononuclear phagocyte system, and the former contains a large number of Kupffer cells involved in immune activities. Therefore, liver care is essential for human health.

[0003] At present, the liver-nourishing drugs on the market mainly include chemical drugs, Chinese medicine preparations and health products. Although chemical drugs and Chinese medicine preparations take effect quickly, they are prone to cause significant side effects on the liver and kidneys, and patients with liver diseases have the characteristics of repeated and continuous medication. If they take chemical drugs and Chinese medicine preparations for a long time and continuously, it will have a greater impact on health. However, the drug-food combination produced from raw materials of the same origin as medicine and food basically has no side effects on the human body. In view of this, the market is in urgent need of a liver-nourishing drug-food combination with significant efficacy, little or no toxic side effects, stable, controllable, convenient and suitable for long-term use. Summary of the invention

[0004] In order to solve the above problems, the present invention proposes a liver-nourishing medicinal and edible composition, a preparation method and an application thereof. In the liver-nourishing medicinal and edible composition, various medicinal and edible ingredients or food materials contain active ingredients that are beneficial to liver maintenance, which produce a synergistic effect after reasonable compatibility, thereby being able to nourish the liver in a healthy, rapid and effective manner, and can be taken relatively for a long time and continuously.

[0005] To achieve the above object, the present invention adopts the following technical solutions:

[0006] A liver-nourishing edible and medicinal composition, comprising the following raw materials in parts by weight: 750-850 parts of tortoise shell, 360-440 parts of lotus seeds, 700-800 parts of polygonatum, 2450-2550 parts of river clams, 1450-1550 parts of wax gourd, 180-220 parts of garlic, 25-35 parts of edible salt, 45-55 parts of ginger, 460-540 parts of rock sugar and 230-270 parts of winter honey.

[0007] Preferably, the liver nourishing medicinal and edible composition is composed of the following raw materials in parts by weight: 800 parts of tortoise shell, 400 parts of lotus seeds, 750 parts of polygonatum, 2500 parts of clams, 1500 parts of wax gourd, 200 parts of garlic, 30 parts of edible salt, 50 parts of bamboo ginger, 500 parts of crystal sugar and 250 parts of winter honey.

[0008] Preferably, the wax gourd is a wax gourd with the rough outer skin removed and the dermis retained.

[0009] Preferably, the winter honey is honey produced by winter flowering plants; wherein the winter flowering plants include loquat and wild osmanthus.

[0010] In the liver-nourishing medicinal and edible composition of the present invention, various medicinal and edible ingredients or food materials contain active ingredients that are beneficial to liver maintenance, and after reasonable compatibility, a synergistic effect is produced, thereby being able to nourish the liver in a healthy, rapid and effective manner. Among them:

[0011] The tortoise shell, also known as tortoise shell, god house, tortoise shell, etc., is the shell of the tortoise of the family Testudinidae, mainly the plastron. The tortoise shell tastes salty and sweet, is slightly cold in nature, and enters the liver, kidney, and heart meridians. In traditional Chinese medicine, the tortoise shell has the following effects and functions: 1) Nourishing yin and suppressing yang: the tortoise shell can nourish yin and suppress yang, and is used to treat symptoms such as bone steaming and fatigue fever caused by kidney yin deficiency, night sweats and spermatorrhea, yin deficiency and yang hyperactivity, yin deficiency and fire excess, and internal wind movement. 2) Nourishing the kidney and strengthening bones: the tortoise shell can nourish the kidney and strengthen bones, and is suitable for treating symptoms such as spermatorrhea, leucorrhea, low back pain, bone atrophy, weak tendons and bones, weak waist and knees, and fontanelle malfunction in children. 3) Nourishing the heart and calming the mind: the tortoise shell also has the effect of nourishing the heart and calming the mind, and can be used to treat symptoms such as loss of nourishment of the mind, palpitations and insomnia, forgetfulness, dizziness, etc. 4) Strengthening menstruation and stopping bleeding: In addition, turtle shell can also strengthen menstruation and stop bleeding, and is used to treat vomiting blood, epistaxis, menorrhagia, metrorrhagia, non-healing wounds and other symptoms.

[0012] The lotus seeds, as the seeds of the aquatic herbaceous plant lotus of the Nymphaeaceae family, are not only a food material, but also a Chinese medicinal material with extremely high edible and medicinal value. Lotus seeds are flat in nature, sweet and slightly astringent, and are in the spleen, kidney, and heart meridians. In traditional Chinese medicine, lotus seeds have the following effects and functions: 1) Clearing away heat and reducing fire: Lotus seeds can clear away heat and reduce fire, especially for people with strong heart fire, eating some lotus seeds can effectively reduce heart fire, clear the heart and calm the mind. 2) Promote sleep: Lotus seeds contain a lot of vitamins and trace elements, which have a good effect of regulating emotions and relaxing emotions. Eating lotus seeds frequently can effectively calm the mind, promote sleep, and improve sleep quality. 3) Lower blood pressure: Lotus seeds contain a large amount of trace elements, especially potassium. Potassium ions can effectively maintain the function of the heart, participate in the metabolism in the body, reduce the risk of stroke in the middle-aged and elderly, and can also dilate peripheral blood vessels, effectively helping to lower blood pressure. 4) Anti-cancer and anti-cancer: The oxidized yellow heart tree alkaloids contained in lotus seeds can effectively inhibit cancers such as nasopharyngeal cancer, uterine cancer, and lung cancer. 5) Tonify sperm: Lotus seeds are beneficial to the formation of sperm and improve male fertility. The phosphorus contained in lotus seeds is the main component of cell nucleoprotein, which can help the body to carry out normal metabolism, effectively maintain acid-base balance, and promote sperm formation.

[0013] The polygonatum sibiricum, as an important Chinese medicinal material, is known as the essence of loess, symbolizing the depth and nourishment of the earth. In traditional Chinese medicine, polygonatum sibiricum has the following effects and functions: 1) Tonifying the kidney and lungs: polygonatum sibiricum can nourish the kidneys and lungs and enhance their functions, and is a commonly used tonic medicinal material. 2) Tonifying qi and nourishing blood: polygonatum sibiricum is widely used in the symptoms of qi and blood deficiency in traditional Chinese medicine theory, which can replenish qi and blood, improve fatigue, pale complexion, palpitations and other problems. 3) Strengthening the spleen and nourishing the stomach: polygonatum sibiricum has a certain regulating effect on the symptoms of spleen and stomach weakness, can help digestion, increase appetite and relieve discomfort such as abdominal distension. 4) Antioxidant: polygonatum sibiricum contains rich polyphenol compounds, has strong antioxidant capacity, can remove free radicals in the body, and protect cells from oxidative damage. 5) Relieve inflammation: polygonatum sibiricum has a certain anti-inflammatory effect, can reduce inflammatory reactions, and relieve inflammation-related pain and discomfort. 6) In addition, polygonatum sibiricum also has multiple effects such as improving immunity, lowering blood sugar, improving sleep quality, anti-aging, and women's health.

[0014] The river clam is a common aquatic mollusk. It is widely distributed near water sources such as rivers and lakes and prefers clean, oxygen-rich water environments. The river clam is an important economic aquatic animal with delicious meat and rich nutrition, including protein, vitamins, minerals and other nutrients. Eating a moderate amount of river clam can satisfy the taste buds and provide the body with the necessary nutrients.

[0015] The wax gourd is one of the common vegetables on the table. It is rich in carbohydrates, a small amount of minerals such as calcium, phosphorus, iron, and a variety of vitamins and other nutrients. Specifically, wax gourd includes major substances such as trigonelline, vitamin C, and dietary fiber. Trigonelline: wax gourd is rich in trigonelline. This ingredient can promote the body's metabolism after consumption, inhibit the conversion of sugar in the body into fat, and thus prevent fat from accumulating in the body. Vitamin C: wax gourd contains a large amount of vitamin C, which is a highly effective antioxidant that can remove excess free radicals in the body and prevent excessive oxidation of free radicals, thereby playing an anti-aging and beauty-enhancing role. Dietary fiber: wax gourd also contains a large amount of dietary fiber. After entering the human stomach, this ingredient can promote the speed of gastrointestinal peristalsis, help digestion and excretion of food, and at the same time increase the body's sense of fullness and effectively prevent constipation.

[0016] The garlic, also known as garlic, garlic cloves, etc., is the bulb of garlic, which is slightly spherical and consists of multiple garlic cloves. Garlic is a nutritious food that contains many nutrients that are beneficial to human health. Garlic specifically contains the following substances: 1) Sulfide: Garlic is rich in sulfide, which can enhance the function of the human immune system and prevent colds and other common diseases. 2) Vitamins and trace elements: Garlic also contains trace elements such as vitamin C, B6 and zinc, which help to improve the body's resistance and reduce the occurrence of infection and inflammation. 3) Natural hormones and antioxidants: The natural hormones and antioxidants in garlic are beneficial to the cardiovascular system, can lower blood pressure, lower cholesterol levels, and reduce the risk of cardiovascular diseases such as coronary heart disease. 4) Ferrous sulfide: Garlic is rich in ferrous sulfide, which can promote the synthesis of hemoglobin and is beneficial to the prevention of anemia. 5) Detoxification ingredients: Garlic also contains rich nutrients that can help the liver detoxify, which helps to protect liver health.

[0017] The rock sugar is a block of sugar, which is made by dissolving white sugar into sugar juice with water, and then evaporating and crystallizing. The appearance of rock sugar is transparent or translucent, mostly white, and hard and brittle. In terms of consumption, rock sugar is widely used in the production of various desserts and beverages due to its unique sweetness and taste. For example, common rock sugar snow pear, rock sugar white fungus soup, etc., all use the sweetness and moisturizing effect of rock sugar to enhance the taste and nutritional value of the whole food. In addition, rock sugar also has certain medicinal value. Eating rock sugar in moderation can play the role of moistening the lungs and relieving coughs, replenishing the middle and replenishing qi, replenishing energy, and nourishing yin and promoting body fluid. This has a certain alleviating effect on some symptoms such as dry cough, weak spleen and stomach, and physical fatigue. In general, rock sugar is a food that is both delicious and has certain medicinal value. It needs to be controlled in moderation when eating to give full play to its nutritional and health-care effects.

[0018] The winter honey refers to honey harvested in winter. Winter honey is rich in monosaccharides, a small amount of disaccharides and polysaccharides, and also contains nutrients such as minerals, vitamins, proteins, and amino acids. These ingredients give winter honey a variety of health benefits: 1) Intestinal moistening and laxative: The fructose and glucose in winter honey can increase the osmotic pressure of the intestine, promote gastrointestinal peristalsis, help digestion, and moisten the intestine and laxative. 2) Moistening the lungs and relieving coughs: Winter honey has the effects of nourishing yin and moistening dryness, moistening the lungs and relieving coughs, and can eliminate lung inflammation, relieve lung heat and dryness, and prevent lung infection. 3) Clearing away heat and detoxifying: Winter honey is slightly cold in nature and can clear away heat and detoxify. It has a significant preventive effect on a variety of high-incidence diseases such as upper respiratory tract infections, sore throats, and tonsillitis. 4) Antibacterial and anti-inflammatory: Winter honey contains certain antibacterial ingredients that can inhibit bacterial reproduction, reduce inflammatory reactions, and help promote the recovery of the body. 5) Protect the liver: Winter honey can form a protective film on the surface of the human liver, reduce drug damage to the liver, improve the liver's detoxification function, and reduce the incidence of fatty liver and alcoholic liver. 6) Beauty and skin care: Winter honey can eliminate skin inflammation, repair damaged skin cells, accelerate wound healing, and has a certain alleviating effect on fungal dermatitis, rough and aging skin, as well as burns, frostbite and other adverse symptoms.

[0019] The main component of the edible salt is sodium chloride, which contains sodium, potassium, magnesium, calcium and other minerals. An appropriate intake of salt can supplement the above substances for the body and maintain the normal physiological functions of the human body. For example, sodium is essential for maintaining the osmotic pressure and acid-base balance of the extracellular fluid, while potassium is involved in the electrolyte balance inside and outside the cell and nerve conduction.

[0020] The bamboo ginger, as a kind of ginger plant, has its unique charm and value. Bamboo ginger is widely used in traditional Chinese medicine. It is believed to be able to enter the lung meridian and spleen meridian, and play a variety of functions such as dispersing wind and cold, stopping vomiting, resolving phlegm and relieving cough. It is called the "holy medicine for vomiting" and has a significant effect on relieving symptoms such as nausea and vomiting. In addition, bamboo ginger can also be used to make tea, stew soup, cook, etc. Adding an appropriate amount of bamboo ginger can enhance the aroma and taste, and also help remove the fishy smell and coldness of the ingredients. Its unique spicy and slightly warm characteristics make it an indispensable ingredient in many medicinal diets and delicacies.

[0021] A method for preparing a liver-nourishing medicinal and edible composition comprises the following steps:

[0022] S1. According to weight, 750-850 parts of tortoise shell, 360-440 parts of lotus seeds and 700-800 parts of polygonatum were crushed, mixed evenly, put into a bamboo bag and tied the bag tightly, then put the bamboo bag into a casserole, added purified water, boiled and simmered, concentrated to the desired concentration, and filtered to obtain extract A;

[0023] S2, after uniformly mixing 2450-2550 parts of river clams, 1450-1550 parts of wax gourd, 180-220 parts of garlic and 45-55 parts of bamboo ginger, put them into a casserole, add purified water to boil and simmer, concentrate to the desired concentration, filter and obtain extract B;

[0024] S3. Combine the extract A and the extract B, put them back into the casserole for boiling and simmering, and after concentrating to the required concentration, add 25-35 parts of edible salt, 460-540 parts of crystal sugar and 230-270 parts of winter honey, remove the fishy smell, and season to obtain the liver-nourishing medicinal and edible composition.

[0025] Preferably, in step S1, the amount of purified water added is 3 times the total amount of tortoise shell, lotus seeds and polygonatum, the amount of extract A after concentration is 60%-65% of the purified water before boiling, and the boiling time is 2-2.5 hours.

[0026] Preferably, in step S2, the amount of purified water added is twice the total amount of clams, wax gourd, garlic and ginger, the amount of extract B after concentration is 65%-75% of the purified water before boiling, and the boiling time is 1.5-2.0 hours.

[0027] Preferably, in step S3, the mixture of extract A and extract B is boiled and concentrated to 70%-80% of the original volume.

[0028] Preferably, in steps S1 to S3, mulberry wood fire is used to heat the casserole.

[0029] An application of a liver-nourishing edible and medicinal composition, and application of the liver-nourishing edible and medicinal composition in the preparation of a liver-nourishing edible and medicinal product, wherein the dosage form of the liver-nourishing edible and medicinal product is selected from the group consisting of oral liquid, tablets, capsules, granules, and pills.

[0030] After adopting the above technical scheme, the present invention has the following beneficial effects: in the liver-nourishing medicinal and edible composition of the present invention, various medicinal and edible ingredients or food materials contain active ingredients that are beneficial to liver maintenance, and after reasonable compatibility, a synergistic effect is produced, so that the liver can be nourished in a healthy, rapid and effective manner; among them, tortoise shell, lotus seeds and polygonatum play a major role as monarch medicines, brook clams and winter melon play auxiliary roles as ministerial medicines, garlic, edible salt and bamboo ginger play auxiliary roles as adjuvants, and rock sugar and winter honey play auxiliary roles as adjuvants. Specifically, firstly, tortoise shell, as a traditional Chinese medicinal material, has the effects of nourishing yin and suppressing yang, benefiting the kidney and strengthening bones, and has a positive effect on nourishing the liver and improving liver function; lotus seeds can nourish the spleen and stop diarrhea, nourish the heart and calm the mind, and help regulate the liver's drainage function; polygonatum, with its effects of nourishing qi and nourishing yin, strengthening the spleen and moistening the lungs, can assist the liver in metabolism and detoxification. Secondly, brook clams and winter melon have the effects of clearing away heat and detoxification, promoting dampness and reducing swelling, and help to clear damp heat and toxins in the liver. Then, garlic, as a natural antibacterial food, can enhance the liver's detoxification ability and protect the liver from damage; at the same time, the appropriate amount of edible salt can regulate the electrolyte balance in the body and promote the normal metabolism of the liver; bamboo ginger, with its unique pungent and warm properties, can warm the middle and dispel cold, promote blood circulation and resolve phlegm, and help improve the blood circulation of the liver. Finally, the addition of rock sugar and winter honey not only increases the taste of the composition, but also plays a role in moistening the lungs and relieving coughs, nourishing and nourishing the skin, and further promotes the health of the liver. Therefore, the liver-nourishing medicinal and edible composition has the effects of nourishing the liver, protecting liver health, reducing transaminase, and promoting liver cell regeneration through the synergistic effect of multiple raw materials. It is suitable for people who need to nourish and protect the liver, such as those with liver discomfort caused by staying up late for a long time, drinking, and high work pressure. In addition, since each raw material is a medicine and food homology or a food material, it contains active ingredients that are beneficial to liver care, which is healthy and safe, and can be taken relatively long-term and continuously. DETAILED DESCRIPTION

[0031] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0032] Embodiment 1:

[0033] A method for preparing a liver-nourishing medicinal and edible composition comprises the following steps:

[0034] S1. Grind 800 parts of tortoise shell, 400 parts of lotus seeds and 750 parts of polygonatum by weight, mix them evenly, put them into a bamboo bag and tie the bag tightly, then put the bamboo bag into a casserole, add purified water and heat the casserole with mulberry wood fire to boil it, then boil it, concentrate it to the required concentration, and filter it to obtain extract A; in step S1, the amount of purified water added is 3 times the total amount of tortoise shell, lotus seeds and polygonatum, the amount of extract A after concentration is 65% of the purified water before boiling, and the boiling time is 2 hours.

[0035] S2. Mix 2500 parts of clams, 1500 parts of wax gourds, 200 parts of garlics and 50 parts of bamboo gingers evenly, put them into a casserole, add purified water, heat the casserole with mulberry wood fire, boil it, and then boil it. After concentrating it to the required concentration, filter it to obtain extract B; in step S2, the amount of purified water added is twice the total amount of clams, wax gourds, garlics and bamboo gingers, the amount of extract B after concentration is 70% of the purified water before boiling, and the boiling time is 1.5 hours.

[0036] S3, extract A and extract B are combined, put back into a casserole, and heated with mulberry wood fire to boil and boil, and after concentrating to the desired concentration, 30 parts of edible salt, 500 parts of crystal sugar and 250 parts of winter honey are added to remove the fishy smell and season to obtain a liver-nourishing medicinal and edible composition. In step S3, the mixed solution of extract A and extract B is boiled and concentrated to 75% of the original volume.

[0037] Embodiment 2:

[0038] A method for preparing a liver-nourishing medicinal and edible composition comprises the following steps:

[0039] S1. According to weight, 750 parts of tortoise shell, 360 parts of lotus seeds and 700 parts of polygonatum are crushed, mixed evenly, put into a bamboo bag and tie the bag tightly, then put the bamboo bag into a casserole, add purified water and heat the casserole with mulberry wood fire to boil and then boil, concentrate to the required concentration, filter and obtain extract A; in step S1, the amount of purified water added is 3 times the total amount of tortoise shell, lotus seeds and polygonatum, the amount of extract A after concentration is 65% of the purified water before boiling, and the boiling time is 2 hours.

[0040] S2. Mix 2450 parts of clams, 1450 parts of wax gourds, 180 parts of garlics and 45 parts of bamboo gingers evenly, put them into a casserole, add purified water, heat the casserole with mulberry wood fire to boil, and then boil. After concentrating to the required concentration, filter to obtain extract B; in step S2, the amount of purified water added is twice the total amount of clams, wax gourds, garlics and bamboo gingers, the amount of extract B after concentration is 70% of the purified water before boiling, and the boiling time is 1.5 hours.

[0041] S3, extract A and extract B are combined, put back into a casserole, and heated with mulberry wood fire to boil and boil, and after concentrating to the required concentration, 25 parts of edible salt, 460 parts of crystal sugar and 230 parts of winter honey are added to remove the fishy smell and season to obtain a liver-nourishing medicinal and edible composition. In step S3, the mixed solution of extract A and extract B is boiled and concentrated to 70%-80% of the original volume.

[0042] Embodiment 3:

[0043] A method for preparing a liver-nourishing medicinal and edible composition comprises the following steps:

[0044] S1. Grind 850 parts of tortoise shell, 440 parts of lotus seeds and 800 parts of polygonatum by weight, mix them evenly, put them into a bamboo bag and tie the bag tightly, then put the bamboo bag into a casserole, add purified water and heat the casserole with mulberry wood fire to boil it, then boil it, concentrate it to the required concentration, and filter it to obtain extract A; in step S1, the amount of purified water added is 3 times the total amount of tortoise shell, lotus seeds and polygonatum, the amount of extract A after concentration is 65% of the purified water before boiling, and the boiling time is 2 hours.

[0045] S2. Mix 2550 parts of clams, 1550 parts of wax gourds, 220 parts of garlics and 55 parts of bamboo gingers evenly, put them into a casserole, add purified water, heat the casserole with mulberry wood fire to boil, and then boil. After concentrating to the required concentration, filter to obtain extract B; in step S2, the amount of purified water added is twice the total amount of clams, wax gourds, garlics and bamboo gingers, the amount of extract B after concentration is 70% of the purified water before boiling, and the boiling time is 1.5 hours.

[0046] S3, extract A and extract B are combined, put back into a casserole, and heated with mulberry wood fire to boil and boil, and after concentrating to the desired concentration, 35 parts of edible salt, 540 parts of crystal sugar and 270 parts of winter honey are added to remove the fishy smell and season to obtain a liver-nourishing medicinal and edible composition. In step S3, the mixed solution of extract A and extract B is boiled and concentrated to 75% of the original volume.

[0047] Comparative Example 1:

[0048] A method for preparing a liver-nourishing medicinal and edible composition comprises the following steps:

[0049] According to the weight ratio, 800 parts of tortoise shell, 400 parts of lotus seeds and 750 parts of polygonatum are crushed, mixed evenly, put into a bamboo bag and tied tightly, then put the bamboo bag into a casserole, add purified water and heat the casserole with mulberry wood fire to boil and boil, concentrate to the required concentration, filter and obtain extract A; the amount of purified water added is 3 times the total amount of tortoise shell, lotus seeds and polygonatum, the amount of extract A after concentration is 65% of the purified water before boiling, and the boiling time is 2 hours. Extract A is directly used as a liver nourishing medicinal and edible composition.

[0050] Comparative Example 2:

[0051] A method for preparing a liver-nourishing medicinal and edible composition comprises the following steps:

[0052] 2500 parts of clams, 1500 parts of wax gourd, 200 parts of garlic and 50 parts of bamboo ginger are mixed evenly, put into a casserole, add purified water, heat the casserole with mulberry wood fire, boil and boil, concentrate to the required concentration, filter and obtain extract B; the amount of purified water added is 2 times the total amount of clams, wax gourd, garlic and bamboo ginger, the amount of extract B after concentration is 70% of the purified water before boiling, and the boiling time is 1.5 hours. Extract B is directly used as a liver nourishing medicinal and edible composition.

[0053] Comparative Example 3:

[0054] A method for preparing a liver-nourishing medicinal and edible composition comprises the following steps:

[0055] 30 parts of edible salt, 500 parts of crystal sugar and 250 parts of winter honey were added to purified water to remove the fishy smell and season the mixture, thereby obtaining a liver-nourishing medicinal and edible composition; wherein the amount of purified water added was the total amount of the extract A and the extract B in Example 1 combined.

[0056] Test Example 1:

[0057] The liver nourishing edible medicinal compositions obtained in Example 1, Example 2, Example 3, Comparative Example 1, Comparative Example 2 and Comparative Example 3 were subjected to a mouse sobering-up test.

[0058] 70 mice (half male and half female, with a weight error of no more than 10g in each group) were taken, and they were fasted and deprived of water the night before the experiment. The mice were gavaged with 0.15ml / (10kg body weight) 50-degree Erguotou liquor, and the drunk mice were randomly divided into 7 groups, 10 in each group, the control group was gavaged with 0.25ml / (10g body weight) of normal saline, and the other 6 groups were gavaged with 0.25ml / (10g body weight) of the liver-nourishing medicinal and edible composition obtained in Example 1, Example 2, Example 3, Comparative Example 1, Comparative Example 2 and Comparative Example 3, respectively. The sobering-up situation of the mice was observed, wherein the time (min) when the drunkenness symptoms disappeared was recorded with the righting reflex as an indicator, and the drunkenness time of each group of mice is shown in Table 1.

[0059] Table 1: Intoxication time of mice in each group

[0060]

[0061]

[0062] As can be seen from Table 1, compared with the control group, the rats in the experimental group had a significantly faster sobering speed. In particular, the liver-nourishing medicinal and edible compositions obtained in Example 1, Example 2 and Example 3 can greatly accelerate the sobering speed and have an obvious liver-protecting and sobering effect. At the same time, the liver-nourishing medicinal and edible compositions obtained in Example 1, Example 2 and Example 3 also have a faster sobering speed than the liver-nourishing medicinal and edible compositions obtained in Comparative Examples 1, 2 and 3, indicating that the liver-nourishing medicinal and edible compositions of the present invention can only play a better sobering effect under the synergistic effect of the four aspects of monarch medicine, ministerial medicine, adjuvant medicine and guiding medicine.

[0063] Test Example 2:

[0064] The liver nourishing edible medicinal compositions obtained in Example 1, Example 2, Example 3, Comparative Example 1, Comparative Example 2 and Comparative Example 3 were subjected to a mouse sobering-up test.

[0065] Take 70 mice (half male and half female, the weight error of each group does not exceed 10g), fasting and water deprivation the night before the experiment. The mice were randomly divided into 7 groups, 10 in each group, wherein the control group was gavaged with 0.3ml normal saline every day, and 0.3ml50 degree Erguotou liquor was gavaged after 30min, and the other 6 groups were given 0.3ml of the liver nourishing medicine and food composition obtained by Example 1, Example 2, Example 3, Comparative Example 1, Comparative Example 2 and Comparative Example 3 every day, and 0.3ml 50 degree Erguotou liquor was gavaged after 30min. Each group of mice was gavaged continuously for 5 weeks. 30min after the end of gavage on the last day, the blood was taken from the eyeball of the ball, the serum was separated, and the activity of ALT and AST in the serum of each group of mice was determined using a spectrophotometer according to the ALT test kit and the AST assay kit instructions. The test results are shown in Table 2.

[0066] Table 2: Statistical results of serum ALT and AST activity in mice of each group

[0067]

[0068]

[0069] As shown in Table 2, compared with the control group, the liver nourishing edible and medicinal compositions of the experimental group can effectively reduce alanine aminotransferase (ALT) and aspartate aminotransferase (AST). In particular, the liver nourishing edible and medicinal compositions obtained in Examples 1, 2 and 3 have a significant effect in reducing alanine aminotransferase and aspartate aminotransferase. At the same time, the liver-nourishing food and medicine compositions obtained in Examples 1, 2 and 3 also have a faster rate of reduction of alanine aminotransferase and aspartate aminotransferase than the liver-nourishing food and medicine compositions obtained in Comparative Examples 1, 2 and 3, indicating that the liver-nourishing food and medicine compositions of the present invention can better reduce alanine aminotransferase and aspartate aminotransferase under the synergistic action of the main drug, the ministerial drug, the adjuvant drug and the guiding drug. This is because the effective ingredients and efficacy in the liver-nourishing food and medicine compositions of the present invention can repair and protect liver damage; specifically, first, the liver-nourishing food and medicine compositions of the present invention contain some Chinese medicinal ingredients with liver-protecting effects, such as tortoise shell, polygonatum, wax gourd, rock sugar, winter honey, etc. These ingredients can reduce inflammation and damage to the liver, thereby helping to reduce the levels of alanine aminotransferase and aspartate aminotransferase, and they promote the repair and regeneration of damaged liver cells by regulating the metabolic function of the liver, thereby improving the overall health of the liver. Secondly, the liver-nourishing edible and medicinal composition of the present invention can also promote the regeneration of liver cells and anti-oxidation, such as lotus seeds, polygonatum, wax gourd, garlic, etc., which can promote the regeneration of liver cells, which helps to restore the normal function of the liver, thereby reducing the level of transaminase. At the same time, the antioxidant components in these drugs can protect liver cells from further damage and prevent further increase of transaminase.

[0070] Test Example 3:

[0071] The liver-nourishing medicinal and edible composition prepared in Example 1 was tested for its efficacy on human body.

[0072] 50 volunteers who often drink a lot of alcohol took the liver nourishing food and medicine composition in Example 1 after drinking, and all of them were in a slightly drunk state, and observed its efficacy. After 6 hours of taking the liver nourishing food and medicine composition in Example 1, the 50 volunteers had no clinical symptoms such as nausea and vomiting, dizziness and headache, palpitations and fatigue, indicating that the liver nourishing food and medicine composition of the present invention has good effects of sobering up, nourishing the liver and protecting the liver.

[0073] The above is only a preferred specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any changes or substitutions that can be easily thought of by a person skilled in the art within the technical scope disclosed by the present invention should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.

Claims

1. A liver-nourishing medicinal and edible composition, characterized in that: The liver nourishing medicinal and edible composition is composed of the following raw materials in parts by weight: 750-850 parts of tortoise shell, 360-440 parts of lotus seeds, 700-800 parts of polygonatum, 2450-2550 parts of river clams, 1450-1550 parts of wax gourd, 180-220 parts of garlic, 25-35 parts of edible salt, 45-55 parts of ginger, 460-540 parts of rock sugar and 230-270 parts of winter honey.

2. A liver-nourishing medicinal and edible composition according to claim 1, characterized in that: The liver nourishing medicinal and edible composition is composed of the following raw materials in parts by weight: 800 parts of tortoise shell, 400 parts of lotus seeds, 750 parts of polygonatum, 2500 parts of river clams, 1500 parts of wax gourds, 200 parts of garlic, 30 parts of edible salt, 50 parts of bamboo ginger, 500 parts of crystal sugar and 250 parts of winter honey.

3. A liver-nourishing medicinal and edible composition according to claim 1, characterized in that: The wax gourd is a wax gourd with the rough outer skin removed and the real skin retained.

4. A liver-nourishing medicinal and edible composition according to claim 1, characterized in that: The winter honey is honey produced by winter flowering plants; wherein the winter flowering plants include loquat and wild osmanthus.

5. A method for preparing the liver nourishing medicinal and edible composition according to any one of claims 1 to 4, characterized in that: The following steps are involved: S1. According to weight, 750-850 parts of tortoise shell, 360-440 parts of lotus seeds and 700-800 parts of polygonatum were crushed, mixed evenly, put into a bamboo bag and tied the bag tightly, then put the bamboo bag into a casserole, added purified water, boiled and simmered, concentrated to the desired concentration, and filtered to obtain extract A; S2, after uniformly mixing 2450-2550 parts of river clams, 1450-1550 parts of wax gourd, 180-220 parts of garlic and 45-55 parts of bamboo ginger, put them into a casserole, add purified water to boil and simmer, concentrate to the desired concentration, filter and obtain extract B; S3. Combine the extract A and the extract B, put them back into the casserole for boiling and simmering, and after concentrating to the required concentration, add 25-35 parts of edible salt, 460-540 parts of crystal sugar and 230-270 parts of winter honey, remove the fishy smell, and season to obtain the liver-nourishing medicinal and edible composition.

6. The method for preparing the liver-nourishing medicinal and edible composition according to claim 5, characterized in that: In step S1, the amount of purified water added is 3 times the total amount of tortoise shell, lotus seeds and polygonatum, the amount of the concentrated extract A is 60%-65% of the purified water before boiling, and the boiling time is 2-2.5 hours.

7. The method for preparing the liver-nourishing medicinal and edible composition according to claim 5, characterized in that: In step S2, the amount of purified water added is twice the total amount of clams, wax gourd, garlic and ginger, the amount of the concentrated extract B is 65%-75% of the purified water before boiling, and the boiling time is 1.5-2.0 hours.

8. The method for preparing the liver-nourishing edible and medicinal composition according to claim 5, characterized in that: In step S3, the mixed solution of the extract A and the extract B is boiled and concentrated to 70%-80% of the original volume.

9. The method for preparing a liver-nourishing edible and medicinal composition according to claim 5, characterized in that: In step S1 to step S3, mulberry wood fire is used to heat the casserole.

10. An application of the liver nourishing medicinal and edible composition according to any one of claims 1 to 4, characterized in that: The liver-nourishing edible and medicinal composition is used in the preparation of a liver-nourishing edible and medicinal product, wherein the dosage form of the liver-nourishing edible and medicinal product is selected from the group consisting of oral liquid, tablet, capsule, granule, and pill.

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