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Application of total coumarin of root of whiteflower hogfennel as medication for treating disease of respiratory tract

A kind of technology of Baihuaqianhu and total coumarin, which is applied in the medicine for the treatment of respiratory diseases, and the new field of medical application

Inactive Publication Date: 2007-12-26
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Wherein the organic solvent is preferably petroleum ether

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Take 15 kg of dried root of Peucedanum baicalensis, add six times the amount of petroleum ether, soak for 12 hours, heat and reflux and extract repeatedly 3 times, 1 hour each time, filter the obtained extract while it is hot, combine the filtrates, heat at normal pressure to recover the solvent, and place it for 24 hours A precipitate was formed, which was filtered and dried to obtain 147 grams of total coumarins from Peucedanum radiata.

Embodiment 2

[0089] Take 15kg of dried roots of Peucedanum baicalensis, add double the amount of water to soak for 12 hours, then repeatedly decoct 4 times, each time for 2 hours, filter the obtained decoction while it is hot, combine the filtrates, condense into an extract, add double the volume of Precipitate with 60% ethanol, filter, recover the ethanol from the filtrate and repeatedly extract 3 times with one volume of petroleum ether, heat the extract under normal pressure to recover the solvent, leave it for 24 hours to form a precipitate, filter and dry to obtain 48 grams of total coumarin in Peucedanum radix .

Embodiment 3

[0091] With 10g of the total coumarin of Peucedanum radix obtained in Example 1, add appropriate amount of starch to dilute, moisten with ethanol, make soft material after mixing, make granules, dry, add appropriate amount of lubricant, press into 100 tablets, each tablet contains 0.1g total coumarin of Peucedanum radix, conventionally coated, polished.

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PUM

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Abstract

The present invention belongs to the field of natural medicine, in the concrete, it relates to a medicinal application of peucedanum praeruptorum total coumarin extract. It can be used for preparing medicine for curing the diseases of respiratory tract, such as acute and chronic bronchitis, pneumonitis, brochinal asthma, allergic asthma and whooping cough, etc.

Description

technical field [0001] The invention relates to the field of natural medicines, in particular to a new medical application of the total coumarin extract of Peucedanum candidum, that is, its application as a medicine for treating respiratory diseases. Background technique [0002] Peucedanum praerupterum (Peucedanum Praerupterum Dunn.), a traditional Chinese medicine, is the dried root of Peucedanum praerupterum Dunn. The combination of husk and platycodon grandiflorum is used to treat wind-heat cough with excessive phlegm, full of phlegm-heat, and thick yellow phlegm. CN1433790A discloses the use of Peucedanum radix in treating tumors. Modern Chinese pharmacy studies have found that its effective parts are mainly coumarin compounds, mainly angular dihydropyranocoumarin compounds such as prosperidin and proseridin. It has been reported that the coumarin components of Peucedanum baicalensis are effective for heart and brain ischemia and anti-heart failure ("Chinese Journal o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/23A61P11/00A61K125/00
Inventor 孔令义吴斐华何冬梅
Owner CHINA PHARM UNIV
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