Preparation method of total flavonoids in albizia julibrissin durazz and medicinal composition thereof
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A technology of Albizia Julibrissin and total flavonoids, which is applied in the directions of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc.
Inactive Publication Date: 2011-10-12
BEIJING SL PHARMA +1
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However, there is no information that the total flavonoids of Albizia julibrissin is prepared into medicine so far. The inventor has confirmed through a large number of experimental studies that the total flavonoids of Albizia juliensis prepared by the process of the present invention can exert obvious antidepressant or anti-anxiety effects. Pharmacological effects, completed the research on the preparation process of total flavonoids from Albizia julibrissin and the research on pharmaceutical preparations with total flavonoids from Albizia juliensis as the basic active ingredient
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Embodiment 1
[0072] Embodiment 1 (preparation of Albizia Julibrissin total flavonoids)
[0073] Weigh 1.5kg of dried Albizia Julibrissin, extract twice with 12 times the amount of 70% ethanol, each time for 1.5h, combine the extracts, filter, concentrate under reduced pressure at 60-70°C to 1 / 10 volume, and add 1.5 times ethyl acetate Extracted 3 times, combined the ethyl acetate extracts, concentrated under reduced pressure at 60-70°C, and dried under reduced pressure to obtain 45 g of total flavonoids from Albizia Julibrissin.
Embodiment 2
[0074] Embodiment 2 (preparation of Albizia Julibrissin total flavonoids)
[0075] Weigh 1.2kg of dried Albizia Julibrissin, extract 3 times with 12 times the amount of 60% ethanol, successively 1.5h, 1h, 1h, combine the extracts, filter, and concentrate under reduced pressure at 60-70°C to 1 / 10 volume, 1.5 Extracted three times with ethyl acetate, combined the ethyl acetate extracts, concentrated under reduced pressure at 60-70°C, and dried under reduced pressure to obtain 48 g of total flavonoids from Albizia Julibrissin.
Embodiment 3
[0076] Embodiment 3 (preparation of Albizia Julibrissin total flavonoids)
[0077] Take 1.5 kg of dried Albizia Julibrissin, add 10 times the amount of 70% ethanol to extract 3 times, each time for 1 hour, combine the extracts, filter, concentrate under reduced pressure to 1 / 10 of the original volume, place in a cool place for 12 hours, filter, Add the filtrate to the macroporous adsorption resin column that has been treated with acid and alkali, wash it with deionized water until it is colorless, and then use 4 times the concentration of 30% and 60% ethanol solution for gradient elution, and collect the concentration The 60% ethanol eluate was evaporated to dryness to obtain 40 g of total flavonoids from Albizia Julibrissin.
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Abstract
The invention relates to the field of Chinese medicines, in particular to a preparation method of total flavonoids in albizia julibrissin durazz and a medicinal composition thereof. The total flavonoids in albizia julibrissin durazz is prepared by using dry inflorescence or flower buds of albizia julibrissin durazz which is a plant of leguminous family as a raw material, extracting with water or aqueous solution of ethanol, concentrating the extract to a proper volume, and extracting the obtained extract with ethyl acetate, wherein the total flavonoid content accounts for over 50 weight percent of the total extract and the content of the main ingredient is measured. The extract and the medical composition containing the extract can be used for preparing medicines for preventing and treating nervous disorder diseases such as depression, dysphoria, Parkinson, senile dementia and the like. The preparation method has the advantages that: the medicinally active ingredients, namely total flavonoids, in albizia julibrissin durazz are obtained; and new medicinal resources are provided for preventing and treating nervous disorder diseases such as depression, dysphoria, Parkinson, senile dementia and the like.
Description
Technical field: [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to the dried inflorescence or flower bud of Albizzia julibrissin Durazz., namely the total flavonoid extract of Chinese medicinal material Albizzia julibrissin Durazz. Pharmaceutical compositions and medical uses of substances. Background technique: [0002] Depression is a common mental illness that seriously endangers human physical and mental health. With the acceleration of people's life rhythm and increasing work pressure, depression patients are increasing day by day. Depression ranks fourth among the top ten diseases in the world at present. According to the World Health Organization (WHO) prediction, depression will rise to the second most common disease by 2020. Therefore, the development of new antidepressants with higher efficacy and fewer adverse reactions has become a common goal pursued by pharmaceutical developers. [0003] Accordi...
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